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Volumn 90, Issue 1, 2010, Pages 104-115

Curcumin limits the fibrogenic evolution of experimental steatohepatitis

Author keywords

Curcumin; Fibrosis; Hepatic stellate cells; Nonalcoholic steatohepatitis; Tissue inhibitor of metalloprotease 1

Indexed keywords

8 HYDROXYDEOXYGUANOSINE; ALANINE AMINOTRANSFERASE; ALPHA SMOOTH MUSCLE ACTIN; BIOLOGICAL MARKER; CD11B ANTIGEN; CHOLINE; CURCUMIN; DIMETHYL SULFOXIDE; METHIONINE; MONOCYTE CHEMOTACTIC PROTEIN 1; PROCOLLAGEN C PROTEINASE; REACTIVE OXYGEN METABOLITE; TISSUE INHIBITOR OF METALLOPROTEINASE 1;

EID: 73349133313     PISSN: 00236837     EISSN: 15300307     Source Type: Journal    
DOI: 10.1038/labinvest.2009.112     Document Type: Article
Times cited : (91)

References (39)
  • 1
    • 56649123256 scopus 로고    scopus 로고
    • The epidemiology of nonalcoholic Fatty liver disease: A global perspective.
    • Lazo M, Clark JM. The epidemiology of nonalcoholic Fatty liver disease: a global perspective. Semin Liver Dis 2008;28:339-350.
    • (2008) Semin Liver Dis , vol.28 , pp. 339-350
    • Lazo, M.1    Clark, J.M.2
  • 2
    • 33750606061 scopus 로고    scopus 로고
    • Long-term follow-up of patients with NAFLD and elevated liver enzymes.
    • Ekstedt M, Franzen LE, Mathiesen UL, et al. Long-term follow-up of patients with NAFLD and elevated liver enzymes. Hepatology 2006;44:865-873.
    • (2006) Hepatology , vol.44 , pp. 865-873
    • Ekstedt, M.1    Franzen, L.E.2    Mathiesen, U.L.3
  • 3
    • 0033038672 scopus 로고    scopus 로고
    • Nonalcoholic fatty liver disease: A spectrum of clinical and pathological severity.
    • Matteoni CA, Younossi ZM, Gramlich T, et al. Nonalcoholic fatty liver disease: a spectrum of clinical and pathological severity. Gastroenterology 1999;116:1413-1419.
    • (1999) Gastroenterology , vol.116 , pp. 1413-1419
    • Matteoni, C.A.1    Younossi, Z.M.2    Gramlich, T.3
  • 4
    • 0028875908 scopus 로고
    • The natural history of nonalcoholic fatty liver: A follow-up study.
    • Teli MR, James OF, Burt AD, et al. The natural history of nonalcoholic fatty liver: a follow-up study. Hepatology 1995;22:1714-1719.
    • (1995) Hepatology , vol.22 , pp. 1714-1719
    • Teli, M.R.1    James, O.F.2    Burt, A.D.3
  • 5
    • 36249009634 scopus 로고    scopus 로고
    • Pathology of nonalcoholic fatty liver disease.
    • Yeh MM, Brunt EM. Pathology of nonalcoholic fatty liver disease. Am J Clin Pathol 2007;128:837-847.
    • (2007) Am J Clin Pathol , vol.128 , pp. 837-847
    • Yeh, M.M.1    Brunt, E.M.2
  • 6
    • 0019152816 scopus 로고
    • Nonalcoholic steatohepatitis: Mayo Clinic experiences with a hitherto unnamed disease.
    • Ludwig J, Viggiano TR, McGill DB, et al. Nonalcoholic steatohepatitis: Mayo Clinic experiences with a hitherto unnamed disease. Mayo Clin Proc 1980;55:434-438.
    • (1980) Mayo Clin Proc , vol.55 , pp. 434-438
    • Ludwig, J.1    Viggiano, T.R.2    McGill, D.B.3
  • 7
    • 34547946930 scopus 로고    scopus 로고
    • Suppression of diacylglycerol acyltransferase-2 (DGAT2), but not DGAT1, with antisense oligo-nucleotides reverses diet-induced hepatic steatosis and insulin resistance.
    • 27 May
    • Choi CS, Savage DB, Kulkarni A, et al. Suppression of diacylglycerol acyltransferase-2 (DGAT2), but not DGAT1, with antisense oligo-nucleotides reverses diet-induced hepatic steatosis and insulin resistance. J Biol Chem 27 May 2007.
    • (2007) J Biol Chem
    • Choi, C.S.1    Savage, D.B.2    Kulkarni, A.3
  • 8
    • 39149104311 scopus 로고    scopus 로고
    • Molecular basis and mechanisms of progression of non-alcoholic steatohepatitis.
    • Marra F, Gastaldelli A, Svegliati Baroni G, et al. Molecular basis and mechanisms of progression of non-alcoholic steatohepatitis. Trends Mol Med 2008;14:72-81.
    • (2008) Trends Mol Med , vol.14 , pp. 72-81
    • Marra, F.1    Gastaldelli, A.2    Svegliati Baroni, G.3
  • 9
    • 34249746761 scopus 로고    scopus 로고
    • Pathogenesis of non-alcoholic steatohepatitis: Human data.
    • Edmison J, McCullough AJ. Pathogenesis of non-alcoholic steatohepatitis: human data. Clin Liver Dis 2007;11:75-104 ix.
    • (2007) Clin Liver Dis , vol.11 , pp. 75-104
    • Edmison, J.1    McCullough, A.J.2
  • 10
    • 0034869459 scopus 로고    scopus 로고
    • Oxidative stress-related molecules and liver fibrosis.
    • Parola M, Robino G. Oxidative stress-related molecules and liver fibrosis. J Hepatol 2001;35:297-306.
    • (2001) J Hepatol , vol.35 , pp. 297-306
    • Parola, M.1    Robino, G.2
  • 11
    • 0035078599 scopus 로고    scopus 로고
    • Animal models of steatosis.
    • Koteish A, Diehl A. Animal models of steatosis. Sem Liv Dis 2001;21: 89-104.
    • (2001) Sem Liv Dis , vol.21 , pp. 89-104
    • Koteish, A.1    Diehl, A.2
  • 12
    • 34249681974 scopus 로고    scopus 로고
    • Pathogenesis of NASH: Animal models.
    • London RM, George J. Pathogenesis of NASH: animal models. Clin Liver Dis 2007;11:55-74 viii.
    • (2007) Clin Liver Dis , vol.11 , pp. 55-74
    • London, R.M.1    George, J.2
  • 13
    • 9644295733 scopus 로고    scopus 로고
    • Curcumin inhibits NF-kappaB activation and reduces the severity of experimental steatohepatitis in mice.
    • Leclercq IA, Farrell GC, Sempoux C, dela Pena A, Horsmans Y. Curcumin inhibits NF-kappaB activation and reduces the severity of experimental steatohepatitis in mice. J Hepatol 2004;41:926-934.
    • (2004) J Hepatol , vol.41 , pp. 926-934
    • Leclercq, I.A.1    Farrell, G.C.2    Sempoux, C.3    Dela Pena, A.4    Horsmans, Y.5
  • 14
    • 0034092716 scopus 로고    scopus 로고
    • CYP2E1 and CYP4A as microsomal catalysts of lipid peroxides in murine nonalcoholic steatohepatitis.
    • Leclercq IA, Farrell GC, Field J, et al. CYP2E1 and CYP4A as microsomal catalysts of lipid peroxides in murine nonalcoholic steatohepatitis. J Clin Invest 2000;105:1067-1075.
    • (2000) J Clin Invest , vol.105 , pp. 1067-1075
    • Leclercq, I.A.1    Farrell, G.C.2    Field, J.3
  • 15
    • 55949084512 scopus 로고    scopus 로고
    • Biological activities of curcumin and its analogues (Congeners) made by man and Mother Nature.
    • Anand P, Thomas SG, Kunnumakkara AB, et al. Biological activities of curcumin and its analogues (Congeners) made by man and Mother Nature. Biochem Pharmacol 2008; 76:1590-1611.
    • (2008) Biochem Pharmacol , vol.76 , pp. 1590-1611
    • Anand, P.1    Thomas, S.G.2    Kunnumakkara, A.B.3
  • 16
    • 38549153486 scopus 로고    scopus 로고
    • Curcumin protects the rat liver from CCl4-caused injury and fibrogenesis by attenuating oxidative stress and suppressing inflammation.
    • Fu Y, Zheng S, Lin J, et al. Curcumin protects the rat liver from CCl4-caused injury and fibrogenesis by attenuating oxidative stress and suppressing inflammation. Mol Pharmacol 2008;73:399-409.
    • (2008) Mol Pharmacol , vol.73 , pp. 399-409
    • Fu, Y.1    Zheng, S.2    Lin, J.3
  • 17
    • 0037305472 scopus 로고    scopus 로고
    • Curcumin prevents alcohol-induced liver disease in rats by inhibiting the expression of NF-kappa B-dependent genes.
    • Nanji AA, Jokelainen K, Tipoe GL, et al. Curcumin prevents alcohol-induced liver disease in rats by inhibiting the expression of NF-kappa B-dependent genes. Am J Physiol Gastrointest Liver Physiol 2003;284:G321-G327.
    • (2003) Am J Physiol Gastrointest Liver Physiol , vol.284
    • Nanji, A.A.1    Jokelainen, K.2    Tipoe, G.L.3
  • 18
    • 0347986777 scopus 로고    scopus 로고
    • NADPH oxidase signal transduces angiotensin II in hepatic stellate cells and is critical in hepatic fibrosis.
    • Bataller R, Schwabe RF, Choi YH, et al. NADPH oxidase signal transduces angiotensin II in hepatic stellate cells and is critical in hepatic fibrosis. J Clin Invest 2003;112:1383-1394.
    • (2003) J Clin Invest , vol.112 , pp. 1383-1394
    • Bataller, R.1    Schwabe, R.F.2    Choi, Y.H.3
  • 19
    • 33845752399 scopus 로고    scopus 로고
    • Prevention of severe toxic liver injury and oxidative stress in MCP-1-deficient mice.
    • Zamara E, Galastri S, Aleffi S, et al. Prevention of severe toxic liver injury and oxidative stress in MCP-1-deficient mice. J Hepatol 2007;46:230-238.
    • (2007) J Hepatol , vol.46 , pp. 230-238
    • Zamara, E.1    Galastri, S.2    Aleffi, S.3
  • 20
    • 2942572700 scopus 로고    scopus 로고
    • Measuring reactive species and oxidative damage in vivo and in cell culture: How should you do it and what do the results mean?
    • Halliwell B, Whiteman M. Measuring reactive species and oxidative damage in vivo and in cell culture: how should you do it and what do the results mean? Br J Pharmacol 2004;142:231-255.
    • (2004) Br J Pharmacol , vol.142 , pp. 231-255
    • Halliwell, B.1    Whiteman, M.2
  • 21
    • 0030948596 scopus 로고    scopus 로고
    • 0-deoxyguanosine by a monoclonal antibody N45.1: Its application to ferric nitrilotriacetate-induced renal carcinogenesis model.
    • 0-deoxyguanosine by a monoclonal antibody N45.1: its application to ferric nitrilotriacetate-induced renal carcinogenesis model. Lab Invest 1997;76:365-374.
    • (1997) Lab Invest , vol.76 , pp. 365-374
    • Toyokuni, S.1    Tanaka, T.2    Hattori, Y.3
  • 22
    • 39549118017 scopus 로고    scopus 로고
    • Adenosine monophosphate-activated protein kinase modulates the activated phenotype of hepatic stellate cells.
    • Caligiuri A, Bertolani C, Guerra CT, et al. Adenosine monophosphate-activated protein kinase modulates the activated phenotype of hepatic stellate cells. Hepatology 2008;47:668-676.
    • (2008) Hepatology , vol.47 , pp. 668-676
    • Caligiuri, A.1    Bertolani, C.2    Guerra, C.T.3
  • 23
    • 57349164238 scopus 로고    scopus 로고
    • Redox mechanisms switch on hypoxia-dependent epithelial-mesenchymal transition in cancer cells.
    • Cannito S, Novo E, Compagnone A, et al. Redox mechanisms switch on hypoxia-dependent epithelial-mesenchymal transition in cancer cells. Carcinogenesis 2008;29:2267-2278.
    • (2008) Carcinogenesis , vol.29 , pp. 2267-2278
    • Cannito, S.1    Novo, E.2    Compagnone, A.3
  • 24
    • 0742295936 scopus 로고    scopus 로고
    • Chemokines in liver inflammation and fibrosis.
    • Marra F. Chemokines in liver inflammation and fibrosis. Front Biosci 2002;7:d1899-d1914.
    • (2002) Front Biosci , vol.7
    • Marra, F.1
  • 25
    • 0031826446 scopus 로고    scopus 로고
    • Effect of curcumin on cell cycle progression and apoptosis in vascular smooth muscle cells.
    • Chen HW, Huang HC. Effect of curcumin on cell cycle progression and apoptosis in vascular smooth muscle cells. Br J Pharmacol 1998;124:1029-1040.
    • (1998) Br J Pharmacol , vol.124 , pp. 1029-1040
    • Chen, H.W.1    Huang, H.C.2
  • 26
    • 0031973638 scopus 로고    scopus 로고
    • Effect of turmeric, turmerin and curcumin on H2O2-induced renal epithelial (LLC-PK1) cell injury.
    • Cohly HH, Taylor A, Angel MF, et al. Effect of turmeric, turmerin and curcumin on H2O2-induced renal epithelial (LLC-PK1) cell injury. Free Radic Biol Med 1998;24:49-54.
    • (1998) Free Radic Biol Med , vol.24 , pp. 49-54
    • Cohly, H.H.1    Taylor, A.2    Angel, M.F.3
  • 27
    • 34548321204 scopus 로고    scopus 로고
    • Nuclear factor-kappaB and the hepatic inflammation-fibrosis-cancer axis.
    • Elsharkawy AM, Mann DA. Nuclear factor-kappaB and the hepatic inflammation-fibrosis-cancer axis. Hepatology 2007;46:590-597.
    • (2007) Hepatology , vol.46 , pp. 590-597
    • Elsharkawy, A.M.1    Mann, D.A.2
  • 28
    • 38849166772 scopus 로고    scopus 로고
    • Curcumin inhibits connective tissue growth factor gene expression in activated hepatic stellate cells in vitro by blocking NF-kappaB and ERK signalling.
    • Chen A, Zheng S. Curcumin inhibits connective tissue growth factor gene expression in activated hepatic stellate cells in vitro by blocking NF-kappaB and ERK signalling. Br J Pharmacol 2008;153:557-567.
    • (2008) Br J Pharmacol , vol.153 , pp. 557-567
    • Chen, A.1    Zheng, S.2
  • 29
    • 30944443965 scopus 로고    scopus 로고
    • Curcumin blocks fibrosis in anti-Thy 1 glomerulonephritis through up-regulation of heme oxygenase 1.
    • Gaedeke J, Noble NA, Border WA. Curcumin blocks fibrosis in anti-Thy 1 glomerulonephritis through up-regulation of heme oxygenase 1. Kidney Int 2005;68:2042-2049.
    • (2005) Kidney Int , vol.68 , pp. 2042-2049
    • Gaedeke, J.1    Noble, N.A.2    Border, W.A.3
  • 30
    • 43849094318 scopus 로고    scopus 로고
    • The NF-kappaB inhibitor curcumin blocks sepsis-induced muscle proteolysis.
    • Poylin V, Fareed MU, O'Neal P, et al. The NF-kappaB inhibitor curcumin blocks sepsis-induced muscle proteolysis. Mediators Inflamm 2008;2008:317851.
    • (2008) Mediators Inflamm , vol.2008 , pp. 317851
    • Poylin, V.1    Fareed, M.U.2    O'Neal, P.3
  • 31
    • 15744405822 scopus 로고    scopus 로고
    • Curcumin regulates expression and activity of matrix metalloproteinases 9 and 2 during prevention and healing of indomethacin-induced gastric ulcer
    • DOI 10.1074/jbc.M413398200
    • Swarnakar S, Ganguly K, Kundu P, et al. Curcumin regulates expression and activity of matrix metalloproteinases 9 and 2 during prevention and healing of indomethacin-induced gastric ulcer. J Biol Chem 2005;280:9409-9415. (Pubitemid 40409634)
    • (2005) Journal of Biological Chemistry , vol.280 , Issue.10 , pp. 9409-9415
    • Swarnakar, S.1    Ganguly, K.2    Kundu, P.3    Banerjee, A.4    Maity, P.5    Sharma, A.V.6
  • 32
    • 42949163491 scopus 로고    scopus 로고
    • Mechanisms of hepatic fibrogenesis.
    • Friedman SL. Mechanisms of hepatic fibrogenesis. Gastroenterology 2008;134:1655-1669.
    • (2008) Gastroenterology , vol.134 , pp. 1655-1669
    • Friedman, S.L.1
  • 33
    • 42549114387 scopus 로고    scopus 로고
    • Activation of peroxisome proliferator-activated receptor-gamma by curcumin blocks the signaling pathways for PDGF and EGF in hepatic stellate cells.
    • Lin J, Chen A. Activation of peroxisome proliferator-activated receptor-gamma by curcumin blocks the signaling pathways for PDGF and EGF in hepatic stellate cells. Lab Invest 2008;88:529-540.
    • (2008) Lab Invest , vol.88 , pp. 529-540
    • Lin, J.1    Chen, A.2
  • 34
    • 33846146367 scopus 로고    scopus 로고
    • Disruption of transforming growth factor-beta signaling by curcumin induces gene expression of peroxisome proliferator-activated receptor-gamma in rat hepatic stellate cells.
    • Zheng S, Chen A. Disruption of transforming growth factor-beta signaling by curcumin induces gene expression of peroxisome proliferator-activated receptor-gamma in rat hepatic stellate cells. Am J Physiol Gastrointest Liver Physiol 2007;292:G113-G123.
    • (2007) Am J Physiol Gastrointest Liver Physiol , vol.292
    • Zheng, S.1    Chen, A.2
  • 35
    • 34247390710 scopus 로고    scopus 로고
    • The interruption of the PDGF and EGF signaling pathways by curcumin stimulates gene expression of PPARgamma in rat activated hepatic stellate cell in vitro.
    • Zhou Y, Zheng S, Lin J, et al. The interruption of the PDGF and EGF signaling pathways by curcumin stimulates gene expression of PPARgamma in rat activated hepatic stellate cell in vitro. Lab Invest 2007;87:488-498.
    • (2007) Lab Invest , vol.87 , pp. 488-498
    • Zhou, Y.1    Zheng, S.2    Lin, J.3
  • 36
    • 1542513705 scopus 로고    scopus 로고
    • Role of fibroblast growth factor-2 in the expression of matrix metalloproteinases and tissue inhibitors of metalloproteinases in human intestinal myofibroblasts.
    • Yasui H, Andoh A, Bamba S, et al. Role of fibroblast growth factor-2 in the expression of matrix metalloproteinases and tissue inhibitors of metalloproteinases in human intestinal myofibroblasts. Digestion 2004;69:34-44.
    • (2004) Digestion , vol.69 , pp. 34-44
    • Yasui, H.1    Andoh, A.2    Bamba, S.3
  • 37
    • 0037051106 scopus 로고    scopus 로고
    • Curcumin exerts multiple suppressive effects on human breast carcinoma cells.
    • Shao ZM, Shen ZZ, Liu CH, et al. Curcumin exerts multiple suppressive effects on human breast carcinoma cells. Int J Cancer 2002;98: 234-240.
    • (2002) Int J Cancer , vol.98 , pp. 234-240
    • Shao, Z.M.1    Shen, Z.Z.2    Liu, C.H.3
  • 38
    • 42949154244 scopus 로고    scopus 로고
    • Diagnosis and therapy of nonalcoholic steatohepatitis.
    • Torres DM, Harrison SA. Diagnosis and therapy of nonalcoholic steatohepatitis. Gastroenterology 2008;134:1682-1698.
    • (2008) Gastroenterology , vol.134 , pp. 1682-1698
    • Torres, D.M.1    Harrison, S.A.2
  • 39
    • 34548227773 scopus 로고    scopus 로고
    • From exotic spice to modern drug?
    • Singh S. From exotic spice to modern drug? Cell 2007;130: 765-768.
    • (2007) Cell , vol.130 , pp. 765-768
    • Singh, S.1


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