Role of sialylation in the anti-inflammatory activity of intravenous immunoglobulin - F(ab')2 versus Fc sialylation

Clinical and Experimental Immunology

Volumn 178, Issue S1, 2014, Pages 97-99

  Schwab, I ^a   Nimmerjahn, F ^a  

^a UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIINFLAMMATORY AGENT; IMMUNOGLOBULIN; IMMUNOGLOBULIN F(AB) FRAGMENT; IMMUNOGLOBULIN FC FRAGMENT; IMMUNOGLOBULIN G;

GLYCOSYLATION; HUMAN; IMMUNOLOGY;

ANTI-INFLAMMATORY AGENTS; GLYCOSYLATION; HUMANS; IMMUNOGLOBULIN FAB FRAGMENTS; IMMUNOGLOBULIN FC FRAGMENTS; IMMUNOGLOBULIN G; IMMUNOGLOBULINS, INTRAVENOUS;

EID: 84921466105     PISSN: 00099104     EISSN: 13652249     Source Type: Journal    
DOI: 10.1111/cei.12527     Document Type: Article

References (23)

1. Albert H, Collin M, Dudziak D, Ravetch JV, Nimmerjahn F. In vivo enzymatic modulation of IgG glycosylation inhibits autoimmune disease in an IgG subclass-dependent manner. Proc Natl Acad Sci USA 2008; 105:15005-15009.
2. Lauc G, Huffman JE, Pucic M etal. Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. PLoS Genet 2013; 9:e1003225.
3. Parekh RB, Dwek RA, Sutton BJ etal. Association of rheumatoid arthritis and primary osteoarthritis with changes in the glycosylation pattern of total serum IgG. Nature 1985; 316:452-457.
4. Scherer HU, van der Woude D, Ioan-Facsinay A etal. Glycan profiling of anti-citrullinated protein antibodies isolated from human serum and synovial fluid. Arthritis Rheum 2010; 62:1620-1629.
5. Shinzaki S, Iijima H, Nakagawa T etal. IgG oligosaccharide alterations are a novel diagnostic marker for disease activity and the clinical course of inflammatory bowel disease. Am J Gastroenterol 2008; 103:1173-1181.
6. Ogata S, Shimizu C, Franco A etal. Treatment response in Kawasaki disease is associated with sialylation levels of endogenous but not therapeutic intravenous immunoglobulin G. PLoS One 2013; 8:e81448.
7. Debre M, Bonnet MC, Fridman WH etal. Infusion of Fc gamma fragments for treatment of children with acute immune thrombocytopenic purpura. Lancet 1993; 342:945-949.
8. Kaneko Y, Nimmerjahn F, Ravetch JV. Anti-inflammatory activity of immunoglobulin G resulting from Fc sialylation. Science 2006; 313:670-673.
9. Schwab I, Mihai S, Seeling M, Kasperkiewicz M, Ludwig RJ, Nimmerjahn F. Broad requirement for terminal sialic acid residues and FcgammaRIIB for the preventive and therapeutic activity of intravenous immunoglobulins in vivo. Eur J Immunol 2014; 44:1444-1453.
10. Schwab I, Seeling M, Biburger M, Aschermann S, Nitschke L, Nimmerjahn F. B cells and CD22 are dispensable for the immediate antiinflammatory activity of intravenous immunoglobulins in vivo. Eur J Immunol 2012; 42:3302-3309.
11. Ahmed AA, Giddens J, Pincetic A etal. Structural characterization of anti-inflammatory immunoglobulin G Fc proteins. J Mol Biol 2014; 426:3166-3179.
12. Schwab I, Nimmerjahn F. Intravenous immunoglobulin therapy: how does IgG modulate the immune system? Nat Rev Immunol 2013; 13:176-189.
13. Sondermann P, Pincetic A, Maamary J, Lammens K, Ravetch JV. Reply to Crispin etal.: molecular model that accounts for the biological and physical properties of sialylated Fc. Proc Natl Acad Sci USA 2013; 110:E3547.
14. Campbell IK, Miescher S, Branch DR etal. Therapeutic effect of IVIG on inflammatory arthritis in mice is dependent on the Fc portion and independent of sialylation or basophils. J Immunol 2014; 192:5031-5038.
15. Käsermann F, Boerema DJ, Ruegsegger M etal. Analysis and functional consequences of increased Fab-sialylation of intravenous immunoglobulin (IVIG) after lectin fractionation. PLoS One 2012; 7:e37243.
16. Guhr T, Bloem J, Derksen NI etal. Enrichment of sialylated IgG by lectin fractionation does not enhance the efficacy of immunoglobulin G in a murine model of immune thrombocytopenia. PLoS One 2011; 6:e21246.
17. Leontyev D, Katsman Y, Ma XZ, Miescher S, Käsermann F, Branch DR. Sialylation-independent mechanism involved in the amelioration of murine immune thrombocytopenia using intravenous gammaglobulin. Transfusion 2012; 52:1799-1805.
18. Wiedeman AE, Santer DM, Yan W, Miescher S, Käsermann F, Elkon KB. Contrasting mechanisms of interferon-alpha inhibition by intravenous immunoglobulin after induction by immune complexes versus Toll-like receptor agonists. Arthritis Rheum 2013; 65:2713-2723.
19. Stadlmann J, Weber A, Pabst M etal. A close look at human IgG sialylation and subclass distribution after lectin fractionation. Proteomics 2009; 9:4143-4153.
20. Seite JF, Cornec D, Renaudineau Y, Youinou P, Mageed RA, Hillion S. IVIg modulates BCR signaling through CD22 and promotes apoptosis in mature human B lymphocytes. Blood 2010; 116:1698-1704.
21. Tackenberg B, Jelcic I, Baerenwaldt A etal. Impaired inhibitory Fcgamma receptor IIB expression on B cells in chronic inflammatory demyelinating polyneuropathy. Proc Natl Acad Sci USA 2009; 106:4788-4792.
22. Massoud AH, Yona M, Xue D etal. Dendritic cell immunoreceptor: a novel receptor for intravenous immunoglobulin mediates induction of regulatory T cells. J Allergy Clin Immunol 2014; 133:853-863 e5.
23. Hess C, Winkler A, Lorenz AK etal. T cell-independent B cell activation induces immunosuppressive sialylated IgG antibodies. J Clin Invest 2013; 123:3788-3796.