Reply to Crispin et al.: Molecular model that accounts for the biological and physical properties of sialylated Fc

Proceedings of the National Academy of Sciences of the United States of America

Volumn 110, Issue 38, 2013, Pages

  Sondermann, Peter ^a   Pincetic, Andrew ^b   Maamary, Jad ^b   Lammens, Katja ^c   Ravetch, Jeffrey V ^b  

^a SuppreMol GmbH   (Germany)

^b ROCKEFELLER UNIVERSITY   (United States)

^c UNIVERSITY OF MUNICH   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CD209 ANTIGEN; CD23 ANTIGEN; IMMUNOGLOBULIN FC FRAGMENT; IMMUNOGLOBULIN G; SIALOPROTEIN;

ANTIBODY COMBINING SITE; CIRCULAR DICHROISM; CONFORMATIONAL TRANSITION; CRYSTAL STRUCTURE; HUMAN; IMMUNOGLOBULIN STRUCTURE; LETTER; MOLECULAR MODEL; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN TERTIARY STRUCTURE; SIALYLATION; X RAY CRYSTALLOGRAPHY;

ANIMALS; CELL ADHESION MOLECULES; HUMANS; IMMUNOGLOBULIN FC FRAGMENTS; LECTINS, C-TYPE; RECEPTORS, CELL SURFACE; RECEPTORS, IGE; RECEPTORS, IGG;

EID: 84884344335     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1311721110     Document Type: Letter

References (6)

1. Sondermann P, Pincetic A, Maamary J, Lammens K, Ravetch JV (2013) General mechanism for modulating immunoglobulin effector function. Proc Natl Acad Sci USA 110(24):9868-9872.
2. Crispin M, Yu X, Bowden TA (2013) Crystal structure of sialylated IgG Fc: Implications for the mechanism of intravenous immunoglobulin therapy. Proc Natl Acad Sci USA 110:E3544-E3546.
3. Krapp S,Mimura Y, Jefferis R, Huber R, Sondermann P (2003) Structural analysis of human IgG-Fc glycoforms reveals a correlation between glycosylation and structural integrity. J Mol Biol 325(5):979-989.
4. Borrok MJ, Jung ST, Kang TH, Monzingo AF, Georgiou G (2012) Revisiting the role of glycosylation in the structure of human IgG Fc. ACS Chem Biol 7(9):1596-1602.
5. Barb AW, et al. (2012) NMR characterization of immunoglobulin G Fc glycan motion on enzymatic sialylation. Biochemistry 51(22):4618-4626.
6. Kaneko Y, Nimmerjahn F, Ravetch JV (2006) Anti-inflammatory activity of immunoglobulin G resulting from Fc sialylation. Science 313(5787):670-673.