In vivo enzymatic modulation of IgG glycosylation inhibits autoimmune disease in an IgG subclass-dependent manner

Proceedings of the National Academy of Sciences of the United States of America

Volumn 105, Issue 39, 2008, Pages 15005-15009

  Albert, Heike ^a   Collin, Mattias ^c   Dudziak, Diana ^b   Ravetch, Jeffrey V ^d   Nimmerjahn, Falk ^a  

^a UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

^b UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

^c LUND UNIVERSITY   (Sweden)

^d ROCKEFELLER UNIVERSITY   (United States)

Author keywords

Autoantibody; Endoglycosidase; Fc receptor; Immunotherapy

Indexed keywords

AUTOANTIBODY; ENDOGLYCOSIDASE S; GLYCOSIDASE; IMMUNOGLOBULIN G; SUGAR; UNCLASSIFIED DRUG; BACTERIAL PROTEIN; NDOS PROTEIN, STREPTOCOCCUS PYOGENES; POLYSACCHARIDE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; AUTOIMMUNE DISEASE; CONTROLLED STUDY; FEMALE; GLYCOSYLATION; HYDROLYSIS; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; STREPTOCOCCUS PYOGENES; ANIMAL; ARTHRITIS; BLOOD; C57BL MOUSE; DRUG EFFECT; IMMUNOLOGY; INTRAARTERIAL DRUG ADMINISTRATION; METABOLISM;

STREPTOCOCCUS PYOGENES;

ANIMALS; ARTHRITIS, EXPERIMENTAL; AUTOANTIBODIES; AUTOIMMUNE DISEASES; BACTERIAL PROTEINS; GLYCOSIDE HYDROLASES; GLYCOSYLATION; HYDROLYSIS; IMMUNOGLOBULIN G; INJECTIONS, INTRA-ARTERIAL; MICE; MICE, INBRED C57BL; POLYSACCHARIDES;

EID: 54449089342     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0808248105     Document Type: Article

References (31)

1. Nimmerjahn F, Ravetch JV (2008) Fcγ receptors as regulators of immune responses. Nat Rev Immunol 8:34-47.
2. Takai T (2002) Roles of Fc receptors in autoimmunity. Nat Rev Immunol 2:580-592.
3. Arnold JN, Wormald MR, Sim RB, Rudd PM, Dwek RA (2007) The impact of glycosylation on the biological function and structure of human immunoglobulins. Annu Rev Immunol 25:21-50.
4. Burton DR, Woof JM (1992) Human antibody effector function. Adv Immunol 51:1-84.
5. Jefferis R, Lund J, Pound JD (1998) IgG-Fc-mediated effector functions: Molecular definition of interaction sites for effector ligands and the role of glycosylation. Immunol Rev 163:59-76.
6. Krapp S, Mimura Y, Jefferis R, Huber R, Sondermann P (2003) Structural analysis of human IgG-Fc glycoforms reveals a correlation between glycosylation and structural integrity. J Mol Biol 325:979-989.
7. Allhorn M, Olin AI, Nimmerjahn F, Collin M (2008) Human IgG-FcγR interactions are modulated by streptococcal IgG glycan hydrolysis. PLoS ONE 3:e1413.
8. Collin M, Olsen A (2001) EndoS, a novel secreted protein from Streptococcus pyogenes with endoglycosidase activity on human IgG. EMBO J 20:3046-3055.
9. Collin M, Shannon O, Bjorck L (2008) IgG glycan hydrolysis by a bacterial enzyme as a therapy against autoimmune conditions. Proc Natl Acad Sci USA 105:4265-4270.
10. Nandakumar KS, et al. (2007) Endoglycosidase treatment abrogates IgG arthritogenicity: Importance of IgG glycosylation in arthritis. Eur J Immunol 37:2973-2982.
11. Baudino L, et al. (2008) Differential contribution of three activating IgG Fc receptors (FcγRI, FcγRIII, and FcγRIV) to IgG2a- and IgG2b-induced autoimmune hemolytic anemia in mice. J Immunol 180:1948-1953.
12. Hamaguchi Y, Xiu Y, Komura K, Nimmerjahn F, Tedder TF (2006) Antibody isotype-specific engagement of Fcγ receptors regulates B lymphocyte depletion during CD20 immunotherapy. J Exp Med 203:743-753.
13. Nimmerjahn F, Ravetch JV (2005) Divergent immunoglobulin G subclass activity through selective Fc receptor binding. Science 310:1510-1512.
14. Ferrara C, Stuart F, Sondermann P, Brunker P, Umana P (2006) The carbohydrate at FcγRIIIa Asn-162:Anelement required for high-affinity binding to non-fucosylated IgG glycoforms. J Biol Chem 281:5032-5036.
15. Vieira P, Rajewsky K (1988) The half-lives of serum immunoglobulins in adult mice. Eur J Immunol 18:313-316.
16. Nandakumar KS, et al. (2003) Induction of arthritis by single monoclonal IgG anticollagen type II antibodies and enhancement of arthritis in mice lacking inhibitory FcγRIIB. Eur J Immunol 33:2269-2277.
17. Nimmerjahn F, Bruhns P, Horiuchi K, Ravetch JV (2005) FcγRIV: A novel FcR with distinct IgG subclass specificity. Immunity 23:41-51.
18. Coutelier JP, van der Logt JT, Heessen FW, Warnier G, Van Snick J (1987) IgG2a restriction of murine antibodies elicited by viral infections. J Exp Med 165:64-69.
19. Markine-Goriaynoff D, Coutelier JP (2002) Increased efficacy of the immunoglobulin G2a subclass in antibody-mediated protection against lactate dehydrogenase-elevating virus-induced polioencephalomyelitis revealed with switch mutants. J Virol 76:432-435.
20. Eisenberg RA, Dyer K, Craven SY, Fuller CR, Yount WJ (1985) Subclass restriction and polyclonality of the systemic lupus erythematosus marker antibody anti-Sm. J Clin Invest 75:1270-1277.
21. Winkler TH, et al. (1988) Constant isotype pattern of anti-dsDNA antibodies in patients with systemic lupus erythematosus. Clin Exp Immunol 72:434-439.
22. Bijl M, et al. (2002) IgG subclass distribution of autoantibodies differs between renal and extrarenal relapses in patients with systemic lupus erythematosus. Rheumatology 41:62-67.
23. Monach PA, Mathis D, Benoist C (2008) The K/BxN arthritis model. Curr Protoc Immunol 15:15.22.
24. Ji H, et al. (2002) Arthritis critically dependent on innate immune system players. Immunity 16:157-168.
25. Andrews BS, et al. (1978) Spontaneous murine lupus-like syndromes: Clinical and immunopathological manifestations in several strains. J Exp Med 148:1198-1215.
26. Santiago-Raber ML, Laporte C, Reininger L, Izui S (2004) Genetic basis of murine lupus. Autoimmun Rev 3:33-39.
27. Lin Q, et al. (2006) Genetic dissection of the effects of stimulatory and inhibitory IgG Fc receptors on murine lupus. J Immunol 177:1646-1654.
28. Nandakumar KS, Johansson BP, Bjorck L, Holmdahl R (2007) Blocking of experimental arthritis by cleavage of IgG antibodies in vivo. Arthritis Rheum 56:3253-3260.
29. Lei B, et al. (2001) Evasion of human innate and acquired immunity by a bacterial homolog of CD11b that inhibits opsonophagocytosis. Nat Med 7:1298-1305.
30. von Pawel-Rammingen U, Johansson BP, Bjorck L (2002) IdeS, a novel streptococcal cysteine proteinase with unique specificity for immunoglobulin G. EMBO J 21:1607-1615.
31. Collin M, Olsen A (2001) Effect of SpeB and EndoS from Streptococcus pyogenes on human immunoglobulins. Infect Immun 69:7187-7189.