Ras/ERK signaling pathway is involved in curcumin-induced cell cycle arrest and apoptosis in human gastric carcinoma AGS cells

Journal of Asian Natural Products Research

Volumn 17, Issue 1, 2015, Pages 56-63

  Cao, Ai Li ^a   Tang, Qing Feng ^a   Zhou, Wen Chao ^a   Qiu, Yan Yan ^a   Hu, Song Jiao ^a   Yin, Pei Hao ^a  

^a SHANGHAI UNIVERSITY OF TRADITIONAL CHINESE MEDICINE   (China)

Author keywords

apoptosis; cell cycle; curcumin; gastric carcinoma; Ras ERK

Indexed keywords

1,4 DIAMINO 1,4 BIS(2 AMINOPHENYLTHIO) 2,3 DICYANOBUTADIENE; BENZYLOXYCARBONYLVALYLALANYLASPARTYL FLUOROMETHYL KETONE; CASPASE 3; CASPASE 8; CASPASE 9; CURCUMIN; CYCLIN B1; CYCLIN D1; DNA; MITOGEN ACTIVATED PROTEIN KINASE; RAS PROTEIN; BENZYLOXYCARBONYL-VALYL-ALANYL-ASPARTIC ACID; BENZYLOXYCARBONYLVALYL-ALANYL-ASPARTYL FLUOROMETHYL KETONE; CASPASE; OLIGOPEPTIDE; PEPTIDE CHLOROMETHYL KETONE;

AGS CELL LINE; ANTIPROLIFERATIVE ACTIVITY; APOPTOSIS; ARTICLE; CANCER INHIBITION; CELL CYCLE PROGRESSION; CELL PROLIFERATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; CURCUMA LONGA; CYTOTOXICITY; DNA FRAGMENTATION; DOWN REGULATION; ENZYME ACTIVATION; ENZYME ACTIVITY; FLOW CYTOMETRY; G2 PHASE CELL CYCLE CHECKPOINT; GASTRIC CANCER CELL LINE; GEL ELECTROPHORESIS; HUMAN; HUMAN CELL; PROTEIN EXPRESSION; PROTEIN INDUCTION; SIGNAL TRANSDUCTION; UPREGULATION; WESTERN BLOTTING; CELL CYCLE; CELL CYCLE CHECKPOINT; CHEMICAL STRUCTURE; CHEMISTRY; CURCUMA; DRUG EFFECTS; METABOLISM; STOMACH NEOPLASMS;

AMINO ACID CHLOROMETHYL KETONES; APOPTOSIS; CASPASE 3; CASPASES; CELL CYCLE; CELL CYCLE CHECKPOINTS; CURCUMA; CURCUMIN; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; HUMANS; MOLECULAR STRUCTURE; OLIGOPEPTIDES; SIGNAL TRANSDUCTION; STOMACH NEOPLASMS;

EID: 84921435055     PISSN: 10286020     EISSN: 14772213     Source Type: Journal    
DOI: 10.1080/10286020.2014.951923     Document Type: Article

References (18)

1. Y.T. Ahn, I.J. Shin, J.M. Kim, Y.S. Kim, C. Lee, S.A. Ju, and W.G. An, Oncol. Lett. 6, 1383 (2013)
2. J.A. Ajani, Gastrointest. Cancer Res. 1, S16 (2007)
3. J.S. Jurenka, Altern. Med. Rev. 14, 141 (2009)
4. R. De, P. Kundu, S. Swarnakar, T. Ramamurthy, A. Chowdhury, G. B. Nair, and A.K. Mukhopadhyay, Antimicrob. Agents. Chemother. 53, 1592 (2009)
5. H.G. Zhang, H. Kim, C. Liu, S. Yu, J. Wang, W.E. Grizzle, R.P. Kimberly, and S. Barnes, Biochim. Biophys. Acta. 1773, 1116 (2007)
6. G. Sa and T. Das, Cell. Div. 3, 14 (2008)
7. N.M. Weir, K. Selvendiran, V.K. Kutala, L. Tong, S. Vishwanath, M. Rajaram, S. Tridandapani, S. Anant, and P. Kuppusamy, Cancer. Biol. Ther. 6, 178 (2007)
8. R.P. Sahu, S. Batra, and S.K. Srivastava, Br. J. Cancer. 100, 1425 (2009)
9. A. Cao, Q. Li, P. Yin, Y. Dong, H. Shi, L. Wang, G. Ji, J. Xie, and D. Wu, Apoptosis 18, 1391 (2013)
10. E.E. Ayli, S. Dugas-Breit, W. Li, C. Marshall, L. Zhao, M. Meulener, T. Griffin, J.M. Gelfand, and J. T. Seykora, Exp. Dermatol. 19, 493 (2010)
11. L. Yang, World. J. Gastroenterol. 12, 17 (2006)
12. S.F. Kan, W.J. Huang, L.C. Lin, and P.S. Wang, Int. J. Cancer. 110, 641 (2004)
13. M.O. Hengartner, Nature 407, 770 (2000)
14. J.A. McCubrey, L.S. Steelman, W. H. Chappell, S.L. Abrams, E.W. Wong, F. Chang, B. Lehmann, D.M. Terrian, M. Milella, A. Tafuri, F. Stivala, M. Libra, J. Basecke, C. Evangelisti, A. M. Martelli, and R.A. Franklin, Biochim. Biophys. Acta 1773, 1263 (2007)
15. D. Bar-Sagi and A. Hall, Cell 103, 227 (2000)
16. X. Wang, Y. Zheng, Q. Fan, and X. Zhang, J. Tradit. Chin. Med. 33, 361 (2013)
17. A.A. Chowdhury, J. Chaudhuri, N. Biswas, A. Manna, S. Chatterjee, S.K. Mahato, U. Chaudhuri, P. Jaisankar, and S. Bandyopadhyay, PLoS. One. 8, e73672 (2013)
18. S.C. Gupta, K.S. Francis, M.S. Nair, Y.Y. Mo, and B.B. Aggarwal, J. Biol. Chem. 288, 32343 (2013)