Mutations that disrupt PHOXB interaction with the neuronal calcium sensor HPCAL1 impede cellular differentiation in neuroblastoma

Oncogene

Volumn 33, Issue 25, 2014, Pages 3316-3324

  Wang, W ^a,d   Zhong, Q ^b   Teng, L ^c   Bhatnagar, N ^a   Sharma, B ^a   Zhang, X ^d   Luther, W ^a   Haynes, L P ^e   Burgoyne, R D ^e   Vidal, M ^b   Volchenboum, S ^c   Hill, D E ^b   George, R E ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

^b DANA FARBER CANCER INSTITUTE   (United States)

^c UNIVERSITY OF CHICAGO   (United States)

^d INSTITUTE OF GEOLOGY AND GEOPHYSICS   (China)

^e UNIVERSITY OF LIVERPOOL   (United Kingdom)

Author keywords

differentiation; HPCAL1; network perturbation; neuroblastoma; neuronal calcium sensor; PHOX2B

Indexed keywords

ALANINE; CALCIUM; MUTANT PROTEIN; NEURONAL CALCIUM SENSOR; PROTEIN HPCAL1; PROTEIN PHOXB; PROTEIN VARIANT; SHORT HAIRPIN RNA; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG;

ADRENERGIC SYSTEM; ARTICLE; BINDING AFFINITY; CANCER SUSCEPTIBILITY; CELLULAR DISTRIBUTION; CONTROLLED STUDY; CYTOPLASM; DBH GENE; FRAMESHIFT MUTATION; GENE MUTATION; GERMLINE MUTATION; HPCAL1 GENE; HUMAN; HUMAN CELL; MISSENSE MUTATION; NERVE CELL DIFFERENTIATION; NERVE FIBER GROWTH; NEUROBLASTOMA; NUCLEAR LOCALIZATION SIGNAL; PATHOGENESIS; PHOX2B GENE; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN PROTEIN INTERACTION; REGULATOR GENE; TRANSACTIVATION; TRANSCRIPTION REGULATION; TWO HYBRID SYSTEM; WILD TYPE;

CALCIUM; CELL DIFFERENTIATION; CELL LINE; CELL LINE, TUMOR; CELL NUCLEUS; CYTOPLASM; HEK293 CELLS; HOMEODOMAIN PROTEINS; HUMANS; MUTATION; NEUROBLASTOMA; NEUROCALCIN; PEPTIDES; PROMOTER REGIONS, GENETIC; PROTEIN BINDING; PROTEIN INTERACTION MAPS; TRANSCRIPTION FACTORS; TRANSCRIPTIONAL ACTIVATION;

EID: 84908029880     PISSN: 09509232     EISSN: 14765594     Source Type: Journal    
DOI: 10.1038/onc.2013.290     Document Type: Article

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