Distinct Neuroblastoma-associated Alterations of PHOX2B Impair Sympathetic Neuronal Differentiation in Zebrafish Models

PLoS Genetics

Volumn 9, Issue 6, 2013, Pages

  Pei, Desheng ^a   Luther, William ^a   Wang, Wenchao ^a   Paw, Barry H ^a,b   Stewart, Rodney A ^c   George, Rani E ^a  

^a BOSTON CHILDREN S HOSPITAL   (United States)

^b BRIGHAM AND WOMEN S HOSPITAL   (United States)

^c UNIVERSITY OF UTAH SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN PHOX2B; RETINOIC ACID; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG;

ADRENERGIC SYSTEM; ALLELE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; AUTOREGULATION; CONTROLLED STUDY; EMBRYO; FRAMESHIFT MUTATION; GENE EXPRESSION; HETEROZYGOSITY; IMMUNOFLUORESCENCE; IN SITU HYBRIDIZATION; MISSENSE MUTATION; NERVE CELL DIFFERENTIATION; NERVOUS SYSTEM DEVELOPMENT; NEUROBLASTOMA; NONHUMAN; PHOX2B GENE; PROTEIN EXPRESSION; REGULATOR GENE; SYMPATHETIC NERVE CELL; WESTERN BLOTTING; ZEBRA FISH;

ANIMALS; BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS; CELL DIFFERENTIATION; GENE EXPRESSION REGULATION, DEVELOPMENTAL; GENETIC PREDISPOSITION TO DISEASE; HETEROZYGOTE; HOMEODOMAIN PROTEINS; HU PARANEOPLASTIC ENCEPHALOMYELITIS ANTIGENS; HUMANS; NEUROBLASTOMA; NEUROGENESIS; NEURONS; SYMPATHETIC NERVOUS SYSTEM; TRANSCRIPTION FACTORS; ZEBRAFISH; ZEBRAFISH PROTEINS;

DANIO RERIO;

EID: 84879619673     PISSN: 15537390     EISSN: 15537404     Source Type: Journal    
DOI: 10.1371/journal.pgen.1003533     Document Type: Article

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