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Volumn 20, Issue 1, 2015, Pages 72-78

Mesenchymal stromal cells for prevention and treatment of graft-versus-host disease: Successes and hurdles

Author keywords

graft versus host disease; haematopoietic stem cell transplantation; mesenchymal stromal cells; platelet lysate

Indexed keywords

BONE MARROW CELL; CLINICAL TRIAL (TOPIC); GRAFT VERSUS HOST REACTION; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HUMAN; IMMUNOMODULATION; INFLAMMATION; MESENCHYMAL STROMA CELL; NONHUMAN; REVIEW; ANIMAL; GRAFT VS HOST DISEASE; MESENCHYMAL STEM CELL TRANSPLANTATION; PHYSIOLOGY;

EID: 84921396543     PISSN: 10872418     EISSN: 15317013     Source Type: Journal    
DOI: 10.1097/MOT.0000000000000158     Document Type: Review
Times cited : (44)

References (60)
  • 1
    • 2342482526 scopus 로고    scopus 로고
    • Treatment of severe acute graftversus-host disease with third party haploidentical mesenchymal stem cells
    • Le Blanc K, Rasmusson I, Sundberg B, et al. Treatment of severe acute graftversus-host disease with third party haploidentical mesenchymal stem cells. Lancet 2004; 363:1439-1441.
    • (2004) Lancet , vol.363 , pp. 1439-1441
    • Le Blanc, K.1    Rasmusson, I.2    Sundberg, B.3
  • 2
    • 84898466874 scopus 로고    scopus 로고
    • Mesenchymal stem cells: Immune evasive, not immune privileged
    • Ankrum JA, Ong JF, Karp JM. Mesenchymal stem cells: immune evasive, not immune privileged. Nat Biotechnol 2014; 32:252-260.
    • (2014) Nat Biotechnol , vol.32 , pp. 252-260
    • Ankrum, J.A.1    Ong, J.F.2    Karp, J.M.3
  • 3
    • 84868091993 scopus 로고    scopus 로고
    • Safety of cell therapy with mesenchymal stromal cells (SafeCell): A systematic review and meta-Analysis of clinical trials
    • Lalu MM, McIntyre L, Pugliese C, et al. Safety of cell therapy with mesenchymal stromal cells (SafeCell): a systematic review and meta-Analysis of clinical trials. PLoS One 2012; 7:e47559.
    • (2012) PLoS One , vol.7 , pp. e47559
    • Lalu, M.M.1    McIntyre, L.2    Pugliese, C.3
  • 5
    • 84883898505 scopus 로고    scopus 로고
    • Mesenchymal stem cells for the treatment and prevention of graft-versus-host disease: Experiments and practice
    • Kim N, Im KI, Lim JY, et al. Mesenchymal stem cells for the treatment and prevention of graft-versus-host disease: experiments and practice. Ann Hematol 2013; 92:1295-1308.
    • (2013) Ann Hematol , vol.92 , pp. 1295-1308
    • Kim, N.1    Im, K.I.2    Lim, J.Y.3
  • 6
    • 84875468183 scopus 로고    scopus 로고
    • The mesenchymal stromal cells dilemma: Does a negative phase III trial of random donor mesenchymal stromal cells in steroid-resistant graftversus-host disease represent a death knell or a bump in the road?
    • Galipeau J. The mesenchymal stromal cells dilemma: does a negative phase III trial of random donor mesenchymal stromal cells in steroid-resistant graftversus-host disease represent a death knell or a bump in the road?. Cytotherapy 2013; 15:2-8.
    • (2013) Cytotherapy , vol.15 , pp. 2-8
    • Galipeau, J.1
  • 7
    • 84860835823 scopus 로고    scopus 로고
    • Mesenchymal stromal cells: A new tool against graft-versushost disease?
    • Baron F, Storb R. Mesenchymal stromal cells: a new tool against graft-versushost disease?. Biol Blood Marrow Transplant 2012; 18:822-840.
    • (2012) Biol Blood Marrow Transplant , vol.18 , pp. 822-840
    • Baron, F.1    Storb, R.2
  • 8
    • 79951699743 scopus 로고    scopus 로고
    • Treatment of graft-versus-host-disease with mesenchymal stromal cells
    • Kebriaei P, Robinson S. Treatment of graft-versus-host-disease with mesenchymal stromal cells. Cytotherapy 2011; 13:262-268.
    • (2011) Cytotherapy , vol.13 , pp. 262-268
    • Kebriaei, P.1    Robinson, S.2
  • 9
    • 43049103438 scopus 로고    scopus 로고
    • Mesenchymal stem cells for treatment of steroid-resistant, severe, acute graft-versus-host disease: A phase II study
    • Le Blanc K, Frassoni F, Ball L, et al. Mesenchymal stem cells for treatment of steroid-resistant, severe, acute graft-versus-host disease: a phase II study. Lancet 2008; 371:1579-1586.
    • (2008) Lancet , vol.371 , pp. 1579-1586
    • Le Blanc, K.1    Frassoni, F.2    Ball, L.3
  • 10
    • 84875279067 scopus 로고    scopus 로고
    • Treatment of severe acute graft-versus-host disease with mesenchymal stromal cells: A comparison with non-MSC treated patients
    • Remberger M, Ringden O. Treatment of severe acute graft-versus-host disease with mesenchymal stromal cells: a comparison with non-MSC treated patients. Int J Hematol 2012; 96:822-824.
    • (2012) Int J Hematol , vol.96 , pp. 822-824
    • Remberger, M.1    Ringden, O.2
  • 11
    • 84886404127 scopus 로고    scopus 로고
    • Multiple infusions ofmesenchymal stromal cells induce sustained remission in children with steroid-refractory grade III-IV acute graft-versus-host disease
    • Ball LM,BernardoME,Roelofs H, et al.Multiple infusions ofmesenchymal stromal cells induce sustained remission in children with steroid-refractory, grade III-IV acute graft-versus-host disease. Br J Haematol 2013; 163:501-509.
    • (2013) Br J Haematol , vol.163 , pp. 501-509
    • Ball, L.M.1    Bernardo, M.E.2    Roelofs, H.3
  • 12
    • 84893106561 scopus 로고    scopus 로고
    • Allogeneic human mesenchymal stem cell therapy (remestemcel-L, Prochymal) as a rescue agent for severe refractory acute graft-versus-host disease in pediatric patients
    • Kurtzberg J, Prockop S, Teira P, et al. Allogeneic human mesenchymal stem cell therapy (remestemcel-L, Prochymal) as a rescue agent for severe refractory acute graft-versus-host disease in pediatric patients. Biol Blood Marrow Transplant 2014; 20:229-235.
    • (2014) Biol Blood Marrow Transplant , vol.20 , pp. 229-235
    • Kurtzberg, J.1    Prockop, S.2    Teira, P.3
  • 13
    • 68049116669 scopus 로고    scopus 로고
    • The washouts of discarded bone marrow collection bags and filters are a very abundant source of hMSCs
    • Capelli C, Salvade A, Pedrini O, et al. The washouts of discarded bone marrow collection bags and filters are a very abundant source of hMSCs. Cytotherapy 2009; 11:403-413.
    • (2009) Cytotherapy , vol.11 , pp. 403-413
    • Capelli, C.1    Salvade, A.2    Pedrini, O.3
  • 14
    • 84896710813 scopus 로고    scopus 로고
    • Treatment of graft versus host disease with mesenchymal stromal cells: A phase i study on 40 adult and pediatric patients
    • Introna M, Lucchini G, Dander E, et al. Treatment of graft versus host disease with mesenchymal stromal cells: a phase I study on 40 adult and pediatric patients. Biol Blood Marrow Transplant 2014; 20:375-381.
    • (2014) Biol Blood Marrow Transplant , vol.20 , pp. 375-381
    • Introna, M.1    Lucchini, G.2    Dander, E.3
  • 15
    • 60349129494 scopus 로고    scopus 로고
    • Treatment of refractory acute GVHD with third-party MSC expanded in platelet lysate-containing medium
    • von Bonin M, Stolzel F, Goedecke A, et al. Treatment of refractory acute GVHD with third-party MSC expanded in platelet lysate-containing medium. Bone Marrow Transplant 2008; 43:245-251.
    • (2008) Bone Marrow Transplant , vol.43 , pp. 245-251
    • Von Bonin, M.1    Stolzel, F.2    Goedecke, A.3
  • 16
    • 84912530901 scopus 로고    scopus 로고
    • Sequential third-party mesenchymal stromal cell therapy for refractory acute graft-versushost disease
    • Sanchez-Guijo F, Caballero-Velazquez T, Lopez-Villar O, et al. Sequential third-party mesenchymal stromal cell therapy for refractory acute graft-versushost disease. Biol Blood Marrow Transplant 2014; 20:1580-1585.
    • (2014) Biol Blood Marrow Transplant , vol.20 , pp. 1580-1585
    • Sanchez-Guijo, F.1    Caballero-Velazquez, T.2    Lopez-Villar, O.3
  • 17
    • 84888127420 scopus 로고    scopus 로고
    • Cotransplantation of haploidentical hematopoietic and umbilical cord mesenchymal stem cells with a myeloablative regimen for refractory/relapsed hematologic malignancy
    • Wu Y, Wang Z, Cao Y, et al. Cotransplantation of haploidentical hematopoietic and umbilical cord mesenchymal stem cells with a myeloablative regimen for refractory/relapsed hematologic malignancy. Ann Hematol 2013; 92:1675-1684.
    • (2013) Ann Hematol , vol.92 , pp. 1675-1684
    • Wu, Y.1    Wang, Z.2    Cao, Y.3
  • 18
    • 84881375828 scopus 로고    scopus 로고
    • Co-Transplantation of third-party umbilical cord blood-derived MSCs promotes engraftment in children undergoing unrelated umbilical cord blood transplantation
    • Lee SH, Lee MW, Yoo KH, et al. Co-Transplantation of third-party umbilical cord blood-derived MSCs promotes engraftment in children undergoing unrelated umbilical cord blood transplantation. Bone Marrow Transplant 2013; 48:1040-1045.
    • (2013) Bone Marrow Transplant , vol.48 , pp. 1040-1045
    • Lee, S.H.1    Lee, M.W.2    Yoo, K.H.3
  • 19
    • 84855552728 scopus 로고    scopus 로고
    • Multipotent mesenchymal stromal cells for the prophylaxis of acute graft-versus-host disease: A phase II study
    • Kuzmina LA, Petinati NA, Parovichnikova EN, et al. Multipotent mesenchymal stromal cells for the prophylaxis of acute graft-versus-host disease: a phase II study. Stem Cells Int 2012; 2012:968213.
    • (2012) Stem Cells Int , vol.2012 , pp. 968213
    • Kuzmina, L.A.1    Petinati, N.A.2    Parovichnikova, E.N.3
  • 20
    • 80053422428 scopus 로고    scopus 로고
    • Coinfusion of mesenchymal stromal cells facilitates platelet recovery without increasing leukemia recurrence in haploidentical hematopoietic stem cell transplantation: A randomized, controlled clinical study
    • Liu K, Chen Y, Zeng Y, et al. Coinfusion of mesenchymal stromal cells facilitates platelet recovery without increasing leukemia recurrence in haploidentical hematopoietic stem cell transplantation: a randomized, controlled clinical study. Stem Cells Dev 2011; 20:1679-1685.
    • (2011) Stem Cells Dev , vol.20 , pp. 1679-1685
    • Liu, K.1    Chen, Y.2    Zeng, Y.3
  • 21
    • 77952584405 scopus 로고    scopus 로고
    • Cotransplantation of mesenchymal stem cells might prevent death from graft-versus-host disease (GVHD) without abrogating graft-versus-Tumor effects after HLA-mismatched allogeneic transplantation following nonmyeloablative conditioning
    • Baron F, Lechanteur C, Willems E, et al. Cotransplantation of mesenchymal stem cells might prevent death from graft-versus-host disease (GVHD) without abrogating graft-versus-Tumor effects after HLA-mismatched allogeneic transplantation following nonmyeloablative conditioning. Biol Blood Marrow Transplant 2010; 16:838-847.
    • (2010) Biol Blood Marrow Transplant , vol.16 , pp. 838-847
    • Baron, F.1    Lechanteur, C.2    Willems, E.3
  • 22
    • 67650145156 scopus 로고    scopus 로고
    • Results of a pilot study on the use of third-party donor mesenchymal stromal cells in cord blood transplantation in adults
    • Gonzalo-Daganzo R, Regidor C, Martin-Donaire T, et al. Results of a pilot study on the use of third-party donor mesenchymal stromal cells in cord blood transplantation in adults. Cytotherapy 2009; 11:278-288.
    • (2009) Cytotherapy , vol.11 , pp. 278-288
    • Gonzalo-Daganzo, R.1    Regidor, C.2    Martin-Donaire, T.3
  • 23
    • 40749112327 scopus 로고    scopus 로고
    • The correlation between cotransplantation of mesenchymal stem cells and higher recurrence rate in hematologic malignancy patients: Outcome of a pilot clinical study
    • Ning H, Yang F, Jiang M, et al. The correlation between cotransplantation of mesenchymal stem cells and higher recurrence rate in hematologic malignancy patients: outcome of a pilot clinical study. Leukemia 2008; 22:593-599.
    • (2008) Leukemia , vol.22 , pp. 593-599
    • Ning, H.1    Yang, F.2    Jiang, M.3
  • 24
    • 79951679002 scopus 로고    scopus 로고
    • Co-infusion of ex vivo-expanded, parental MSCs prevents life-Threatening acute GVHD, but does not reduce the risk of graft failure in pediatric patients undergoing allogeneic umbilical cord blood transplantation
    • Bernardo ME, Ball LM, Cometa AM, et al. Co-infusion of ex vivo-expanded, parental MSCs prevents life-Threatening acute GVHD, but does not reduce the risk of graft failure in pediatric patients undergoing allogeneic umbilical cord blood transplantation. Bone Marrow Transplant 2010; 46:200-207.
    • (2010) Bone Marrow Transplant , vol.46 , pp. 200-207
    • Bernardo, M.E.1    Ball, L.M.2    Cometa, A.M.3
  • 25
    • 33745752842 scopus 로고    scopus 로고
    • Progenitor cells trapped in marrow filters can reduce GvHD and transplant mortality
    • Vicente D, Podesta M, Pitto A, et al. Progenitor cells trapped in marrow filters can reduce GvHD and transplant mortality. Bone Marrow Transplant 2006; 38:111-117.
    • (2006) Bone Marrow Transplant , vol.38 , pp. 111-117
    • Vicente, D.1    Podesta, M.2    Pitto, A.3
  • 26
    • 84904498956 scopus 로고    scopus 로고
    • The biology of graft-versus-host disease: Experimental systems instructing clinical practice
    • Markey KA, MacDonald KP, Hill GR. The biology of graft-versus-host disease: experimental systems instructing clinical practice. Blood 2014; 124:354-362.
    • (2014) Blood , vol.124 , pp. 354-362
    • Markey, K.A.1    MacDonald, K.P.2    Hill, G.R.3
  • 27
    • 84904471984 scopus 로고    scopus 로고
    • Acute graft-versus-host disease: A bench-To-bedside update
    • Holtan SG, Pasquini M, Weisdorf DJ. Acute graft-versus-host disease: a bench-To-bedside update. Blood 2014; 124:363-373.
    • (2014) Blood , vol.124 , pp. 363-373
    • Holtan, S.G.1    Pasquini, M.2    Weisdorf, D.J.3
  • 29
    • 84861576998 scopus 로고    scopus 로고
    • Advances in graft-versus-host disease biology and therapy
    • Blazar BR, Murphy WJ, Abedi M. Advances in graft-versus-host disease biology and therapy. Nat Rev Immunol 2012; 12:443-458.
    • (2012) Nat Rev Immunol , vol.12 , pp. 443-458
    • Blazar, B.R.1    Murphy, W.J.2    Abedi, M.3
  • 30
    • 84862241567 scopus 로고    scopus 로고
    • Diagnosis and management of acute graft-versus-host disease
    • Dignan FL, Clark A, Amrolia P, et al. Diagnosis and management of acute graft-versus-host disease. Br J Haematol 2012; 158:30-45.
    • (2012) Br J Haematol , vol.158 , pp. 30-45
    • Dignan, F.L.1    Clark, A.2    Amrolia, P.3
  • 31
    • 84861885570 scopus 로고    scopus 로고
    • Dendritic cells and regulation of graft-versus-host disease and graft-versus-leukemia activity
    • Stenger EO, Turnquist HR, Mapara MY, Thomson AW. Dendritic cells and regulation of graft-versus-host disease and graft-versus-leukemia activity. Blood 2012; 119:5088-5103.
    • (2012) Blood , vol.119 , pp. 5088-5103
    • Stenger, E.O.1    Turnquist, H.R.2    Mapara, M.Y.3    Thomson, A.W.4
  • 32
    • 77957753981 scopus 로고    scopus 로고
    • Glucocorticoid-refractory acute graft-versus-host disease
    • Pidala J, Anasetti C. Glucocorticoid-refractory acute graft-versus-host disease. Biol Blood Marrow Transplant 2010; 16:1504-1518.
    • (2010) Biol Blood Marrow Transplant , vol.16 , pp. 1504-1518
    • Pidala, J.1    Anasetti, C.2
  • 33
    • 77955902702 scopus 로고    scopus 로고
    • The best endpoint for acute GVHD treatment trials
    • MacMillan ML, DeFor TE, Weisdorf DJ. The best endpoint for acute GVHD treatment trials. Blood 2010; 115:5412-5417.
    • (2010) Blood , vol.115 , pp. 5412-5417
    • MacMillan, M.L.1    De For, T.E.2    Weisdorf, D.J.3
  • 34
    • 84855613742 scopus 로고    scopus 로고
    • Novel treatment concepts for graft-versus-host disease
    • Wolf D, von Lilienfeld-Toal M, Wolf AM, et al. Novel treatment concepts for graft-versus-host disease. Blood 2012; 119:16-25.
    • (2012) Blood , vol.119 , pp. 16-25
    • Wolf, D.1    Von Lilienfeld-Toal, M.2    Wolf, A.M.3
  • 35
    • 36348977575 scopus 로고    scopus 로고
    • Immunomodulatory properties of mesenchymal stromal cells
    • Nauta AJ, Fibbe WE. Immunomodulatory properties of mesenchymal stromal cells. Blood 2007; 110:3499-3506.
    • (2007) Blood , vol.110 , pp. 3499-3506
    • Nauta, A.J.1    Fibbe, W.E.2
  • 36
    • 35448996504 scopus 로고    scopus 로고
    • Immunomodulation by mesenchymal stem cells and clinical experience
    • Le Blanc K, Ringden O. Immunomodulation by mesenchymal stem cells and clinical experience. J Intern Med 2007; 262:509-525.
    • (2007) J Intern Med , vol.262 , pp. 509-525
    • Le Blanc, K.1    Ringden, O.2
  • 37
    • 50249158511 scopus 로고    scopus 로고
    • Mesenchymal stem cells in health and disease
    • Uccelli A, Moretta L, Pistoia V. Mesenchymal stem cells in health and disease. Nat Rev Immunol 2008; 8:726-736.
    • (2008) Nat Rev Immunol , vol.8 , pp. 726-736
    • Uccelli, A.1    Moretta, L.2    Pistoia, V.3
  • 38
    • 77955820309 scopus 로고    scopus 로고
    • Concise review: Hitting the right spot with mesenchymal stromal cells
    • Tolar J, Le Blanc K, Keating A, Blazar BR. Concise review: hitting the right spot with mesenchymal stromal cells. Stem Cells 2010; 28:1446-1455.
    • (2010) Stem Cells , vol.28 , pp. 1446-1455
    • Tolar, J.1    Le Blanc, K.2    Keating, A.3    Blazar, B.R.4
  • 39
    • 84862534451 scopus 로고    scopus 로고
    • Mesenchymal stromal cells new directions
    • Keating A. Mesenchymal stromal cells: new directions. Cell Stem Cell 2012;10:709-716.
    • (2012) Cell Stem Cell , vol.10 , pp. 709-716
    • Keating, A.1
  • 40
    • 44849121129 scopus 로고    scopus 로고
    • Paracrine factors of mesenchymal stem cells recruit macrophages and endothelial lineage cells and enhance wound healing
    • Chen L, Tredget EE, Wu PY, Wu Y. Paracrine factors of mesenchymal stem cells recruit macrophages and endothelial lineage cells and enhance wound healing. PLoS One 2008; 3:e1886.
    • (2008) PLoS One , vol.3 , pp. e1886
    • Chen, L.1    Tredget, E.E.2    Wu, P.Y.3    Wu, Y.4
  • 41
    • 0036142769 scopus 로고    scopus 로고
    • Mesenchymal stem cells suppress lymphocyte proliferation in vitro and prolong skin graft survival in vivo
    • Bartholomew A, Sturgeon C, Siatskas M, et al. Mesenchymal stem cells suppress lymphocyte proliferation in vitro and prolong skin graft survival in vivo. Exp Hematol 2002; 30:42-48.
    • (2002) Exp Hematol , vol.30 , pp. 42-48
    • Bartholomew, A.1    Sturgeon, C.2    Siatskas, M.3
  • 42
    • 77954084921 scopus 로고    scopus 로고
    • Mesenchymal stem cell and islet cotransplantation promotes graft revascularization and function
    • Ito T, Itakura S, Todorov I, et al. Mesenchymal stem cell and islet cotransplantation promotes graft revascularization and function. Transplantation 2010; 89:1438-1445.
    • (2010) Transplantation , vol.89 , pp. 1438-1445
    • Ito, T.1    Itakura, S.2    Todorov, I.3
  • 43
    • 56149110595 scopus 로고    scopus 로고
    • Pretransplant infusion of mesenchymal stem cells prolongs the survival of a semiallogeneic heart transplant through the generation of regulatory T cells
    • Casiraghi F, Azzollini N, Cassis P, et al. Pretransplant infusion of mesenchymal stem cells prolongs the survival of a semiallogeneic heart transplant through the generation of regulatory T cells. J Immunol 2008; 181:3933-3946.
    • (2008) J Immunol , vol.181 , pp. 3933-3946
    • Casiraghi, F.1    Azzollini, N.2    Cassis, P.3
  • 44
    • 84865578483 scopus 로고    scopus 로고
    • Localization of mesenchymal stromal cells dictates their immune or proinflammatory effects in kidney transplantation
    • Casiraghi F, Azzollini N, Todeschini M, et al. Localization of mesenchymal stromal cells dictates their immune or proinflammatory effects in kidney transplantation. Am J Transplant 2012; 12:2373-2383.
    • (2012) Am J Transplant , vol.12 , pp. 2373-2383
    • Casiraghi, F.1    Azzollini, N.2    Todeschini, M.3
  • 45
    • 23944519424 scopus 로고    scopus 로고
    • Mesenchymal stem cells ameliorate experimental autoimmune encephalomyelitis inducing T-cell anergy
    • Zappia E, Casazza S, Pedemonte E, et al. Mesenchymal stem cells ameliorate experimental autoimmune encephalomyelitis inducing T-cell anergy. Blood 2005; 106:1755-1761.
    • (2005) Blood , vol.106 , pp. 1755-1761
    • Zappia, E.1    Casazza, S.2    Pedemonte, E.3
  • 46
    • 34147126415 scopus 로고    scopus 로고
    • Mesenchymal stem cells effectively modulate pathogenic immune response in experimental autoimmune encephalomyelitis
    • Gerdoni E, Gallo B, Casazza S, et al. Mesenchymal stem cells effectively modulate pathogenic immune response in experimental autoimmune encephalomyelitis. Ann Neurol 2007; 61:219-227.
    • (2007) Ann Neurol , vol.61 , pp. 219-227
    • Gerdoni, E.1    Gallo, B.2    Casazza, S.3
  • 47
    • 84872935957 scopus 로고    scopus 로고
    • Mesenchymal stromal cells to promote solid organ transplantation tolerance
    • Casiraghi F, Perico N, Remuzzi G. Mesenchymal stromal cells to promote solid organ transplantation tolerance. Curr Opin Organ Transplant 2013; 18:51-58.
    • (2013) Curr Opin Organ Transplant , vol.18 , pp. 51-58
    • Casiraghi, F.1    Perico, N.2    Remuzzi, G.3
  • 48
    • 84872139846 scopus 로고    scopus 로고
    • Antidonor immune responses elicited by allogeneic mesenchymal stem cells: What have we learned so far?
    • Griffin MD, Ryan AE, Alagesan S, et al. Antidonor immune responses elicited by allogeneic mesenchymal stem cells: what have we learned so far?. Immunol Cell Biol 2013; 91:40-51.
    • (2013) Immunol Cell Biol , vol.91 , pp. 40-51
    • Griffin, M.D.1    Ryan, A.E.2    Alagesan, S.3
  • 49
    • 0036839143 scopus 로고    scopus 로고
    • Macrophage polarization: Tumorassociated macrophages as a paradigm for polarized M2 mononuclear phagocytes
    • Mantovani A, Sozzani S, Locati M, et al. Macrophage polarization: tumorassociated macrophages as a paradigm for polarized M2 mononuclear phagocytes. Trends Immunol 2002; 23:549-555.
    • (2002) Trends Immunol , vol.23 , pp. 549-555
    • Mantovani, A.1    Sozzani, S.2    Locati, M.3
  • 50
    • 84885099905 scopus 로고    scopus 로고
    • Mesenchymal stromal cells: Sensors and switchers of inflammation
    • Bernardo ME, Fibbe WE. Mesenchymal stromal cells: sensors and switchers of inflammation. Cell Stem Cell 2013; 13:392-402.
    • (2013) Cell Stem Cell , vol.13 , pp. 392-402
    • Bernardo, M.E.1    Fibbe, W.E.2
  • 51
    • 84857601884 scopus 로고    scopus 로고
    • Emerging roles for multipotent, bone marrow-derived stromal cells in host defense
    • Auletta JJ, Deans RJ, Bartholomew AM. Emerging roles for multipotent, bone marrow-derived stromal cells in host defense. Blood 2012; 119:1801-1809.
    • (2012) Blood , vol.119 , pp. 1801-1809
    • Auletta, J.J.1    Deans, R.J.2    Bartholomew, A.M.3
  • 52
    • 77956420421 scopus 로고    scopus 로고
    • A new mesenchymal stem cell (MSC) paradigm: Polarization into a pro-inflammatory MSC1 or an immunosuppressive MSC2 phenotype
    • Waterman RS, Tomchuck SL, Henkle SL, Betancourt AM. A new mesenchymal stem cell (MSC) paradigm: polarization into a pro-inflammatory MSC1 or an immunosuppressive MSC2 phenotype. PLoS One 2010; 5:e10088.
    • (2010) PLoS One , vol.5 , pp. e10088
    • Waterman, R.S.1    Tomchuck, S.L.2    Henkle, S.L.3    Betancourt, A.M.4
  • 53
    • 58149326737 scopus 로고    scopus 로고
    • Bone marrow stromal cells attenuate sepsis via prostaglandin E(2)-dependent reprogramming of host macrophages to increase their interleukin-10 production
    • NemethK, Leelahavanichkul A,YuenPS, et al.Bone marrow stromal cells attenuate sepsis via prostaglandin E(2)-dependent reprogramming of host macrophages to increase their interleukin-10 production. Nat Med 2009; 15:42-49.
    • (2009) Nat Med , vol.15 , pp. 42-49
    • Nemeth, K.1    Leelahavanichkul, A.2    Yuen, P.S.3
  • 54
    • 79960464308 scopus 로고    scopus 로고
    • Anti-inflammatory protein TSG-6 secreted by activated MSCs attenuates zymosan-induced mouse peritonitis by decreasing TLR2/NF-kappaB signaling in resident macrophages
    • Choi H, Lee RH, Bazhanov N, et al. Anti-inflammatory protein TSG-6 secreted by activated MSCs attenuates zymosan-induced mouse peritonitis by decreasing TLR2/NF-kappaB signaling in resident macrophages. Blood 2011; 118:330-338.
    • (2011) Blood , vol.118 , pp. 330-338
    • Choi, H.1    Lee, R.H.2    Bazhanov, N.3
  • 55
    • 38649105374 scopus 로고    scopus 로고
    • Mesenchymal stem cell-mediated immunosuppression occurs via concerted action of chemokines and nitric oxide
    • Ren G, Zhang L, Zhao X, et al. Mesenchymal stem cell-mediated immunosuppression occurs via concerted action of chemokines and nitric oxide. Cell Stem Cell 2008; 2:141-150.
    • (2008) Cell Stem Cell , vol.2 , pp. 141-150
    • Ren, G.1    Zhang, L.2    Zhao, X.3
  • 56
    • 84865184497 scopus 로고    scopus 로고
    • Mesenchymal stem cells: A double-edged sword in regulating immune responses
    • Li W, Ren G, Huang Y, et al. Mesenchymal stem cells: a double-edged sword in regulating immune responses. Cell Death Differ 2012; 19:1505-1513.
    • (2012) Cell Death Differ , vol.19 , pp. 1505-1513
    • Li, W.1    Ren, G.2    Huang, Y.3
  • 57
    • 84881256541 scopus 로고    scopus 로고
    • ST2 as a marker for risk of therapy-resistant graft-versus-host disease and death
    • Vander Lugt MT, Braun TM, Hanash S, et al. ST2 as a marker for risk of therapy-resistant graft-versus-host disease and death. N Engl J Med 2013; 369:529-539.
    • (2013) N Engl J Med , vol.369 , pp. 529-539
    • Vander Lugt, M.T.1    Braun, T.M.2    Hanash, S.3
  • 58
    • 84860345135 scopus 로고    scopus 로고
    • Acute graft-versus-host disease biomarkers measured during therapy can predict treatment outcomes: A blood and marrow transplant clinical trials network study
    • Levine JE, Logan BR, Wu J, et al. Acute graft-versus-host disease biomarkers measured during therapy can predict treatment outcomes: a Blood and Marrow Transplant Clinical Trials Network study. Blood 2012; 119:3854-3860.
    • (2012) Blood , vol.119 , pp. 3854-3860
    • Levine, J.E.1    Logan, B.R.2    Wu, J.3
  • 59
    • 77955509074 scopus 로고    scopus 로고
    • Platelet-lysate-expanded mesenchymal stromal cells as a salvage therapy for severe resistant graft-versus-host disease in a pediatric population
    • Lucchini G, Introna M, Dander E, et al. Platelet-lysate-expanded mesenchymal stromal cells as a salvage therapy for severe resistant graft-versus-host disease in a pediatric population. Biol Blood Marrow Transplant 2010; 16:1293-1301.
    • (2010) Biol Blood Marrow Transplant , vol.16 , pp. 1293-1301
    • Lucchini, G.1    Introna, M.2    Dander, E.3
  • 60
    • 84863755249 scopus 로고    scopus 로고
    • Mesenchymal stromal cells for the treatment of graft-versus-host disease: Understanding the in vivo biological effect through patient immune monitoring
    • Dander E, Lucchini G, Vinci P, et al. Mesenchymal stromal cells for the treatment of graft-versus-host disease: understanding the in vivo biological effect through patient immune monitoring. Leukemia 2012; 26:1681-1684.
    • (2012) Leukemia , vol.26 , pp. 1681-1684
    • Dander, E.1    Lucchini, G.2    Vinci, P.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.