Cilostazol improves high glucose-induced impaired angiogenesis in human endothelial progenitor cells and vascular endothelial cells as well as enhances vasculoangiogenesis in hyperglycemic mice mediated by the adenosine monophosphate-activated protein kinase pathway

Journal of Vascular Surgery

Volumn 63, Issue 4, 2016, Pages 1051-1062.e3

  Tseng, Shih Ya ^a,b   Chao, Ting Hsing ^a   Li, Yi Heng ^a   Liu, Ping Yen ^a   Lee, Cheng Han ^a   Cho, Chung Lung ^b   Wu, Hua Lin ^a   Chen, Jyh Hong ^a  

^a NATIONAL CHENG KUNG UNIVERSITY   (Taiwan)

^b NATIONAL SUN YAT SEN UNIVERSITY   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYL COENZYME A CARBOXYLASE; CILOSTAZOL; CYCLIC AMP; CYCLIC AMP DEPENDENT PROTEIN KINASE; ENDOTHELIAL NITRIC OXIDE SYNTHASE; GLUCOSE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; MESSENGER RNA; AMPK ALPHA1 SUBUNIT, MOUSE; ANGIOGENIC FACTOR; PRKAA1 PROTEIN, HUMAN; TETRAZOLE DERIVATIVE;

ANGIOGENESIS; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; CAPILLARY DENSITY; CELL ACTIVATION; CELL ADHESION; CELL MIGRATION; CELL PROLIFERATION; COLONY FORMATION; COLONY FORMING UNIT; CONTROLLED STUDY; CORONARY RISK; DIABETIC PATIENT; DRUG MECHANISM; ENDOTHELIAL DYSFUNCTION; ENDOTHELIAL PROGENITOR CELL; ENZYME ACTIVATION; HINDLIMB; HUMAN; HUMAN CELL; HYPERGLYCEMIA; IN VITRO STUDY; IN VIVO STUDY; LIMB ISCHEMIA; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; SINGLE DRUG DOSE; UMBILICAL VEIN ENDOTHELIAL CELL; VASCULAR ENDOTHELIUM; ANIMAL; BLOOD FLOW; CELL CULTURE; CELL MOTION; CONVALESCENCE; DOSE RESPONSE; DRUG EFFECTS; ENZYMOLOGY; EXPERIMENTAL DIABETES MELLITUS; GENETIC TRANSFECTION; GENETICS; INSTITUTE FOR CANCER RESEARCH MOUSE; ISCHEMIA; METABOLISM; PATHOLOGY; PATHOPHYSIOLOGY; PHOSPHORYLATION; RNA INTERFERENCE; SKELETAL MUSCLE; TIME FACTOR; VASCULARIZATION;

AMP-ACTIVATED PROTEIN KINASES; ANGIOGENESIS INDUCING AGENTS; ANIMALS; CELL ADHESION; CELL MOVEMENT; CELL PROLIFERATION; CELLS, CULTURED; DIABETES MELLITUS, EXPERIMENTAL; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDOTHELIAL PROGENITOR CELLS; GLUCOSE; HINDLIMB; HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS; HUMANS; ISCHEMIA; MALE; MICE, INBRED ICR; MUSCLE, SKELETAL; NEOVASCULARIZATION, PHYSIOLOGIC; PHOSPHORYLATION; RECOVERY OF FUNCTION; REGIONAL BLOOD FLOW; RNA INTERFERENCE; SIGNAL TRANSDUCTION; TETRAZOLES; TIME FACTORS; TRANSFECTION;

EID: 84921368293     PISSN: 07415214     EISSN: 10976809     Source Type: Journal    
DOI: 10.1016/j.jvs.2014.10.103     Document Type: Article

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