Cilostazol enhances mobilization and proliferation of endothelial progenitor cells and collateral formation by modifying vasculo-angiogenic biomarkers in peripheral arterial disease

International Journal of Cardiology

Volumn 172, Issue 2, 2014, Pages

  Chao, Ting Hsing ^a   Tseng, Shih Ya ^b   Chen, I Chih ^c   Tsai, Yi Shan ^a   Huang, Yao Yi ^d   Liu, Ping Yen ^a   Ou, Horng Yih ^a   Li, Yi Heng ^a   Wu, Hua Lin ^a   Cho, Chung Lung ^b   Tsai, Liang Miin ^a   Chen, Jyh Hong ^a  

^a NATIONAL CHENG KUNG UNIVERSITY   (Taiwan)

^b NATIONAL SUN YAT SEN UNIVERSITY   (Taiwan)

^c TAINAN MUNICIPAL HOSPITAL   (Taiwan)

^d NATIONAL CHENG KUNG UNIVERSITY HOSPITAL   (Taiwan)

Author keywords

Angiogenesis; Biological markers; Cilostazol; Peripheral arterial disease; Progenitor cells

Indexed keywords

ADIPONECTIN; BIOLOGICAL MARKER; CD146 ANTIGEN; CILOSTAZOL; HEMOGLOBIN A1C; INSULIN; PLACEBO; STROMAL CELL DERIVED FACTOR 1ALPHA; THROMBOMODULIN; TRIACYLGLYCEROL; VASCULOTROPIN; ANTITHROMBOCYTIC AGENT; TETRAZOLE DERIVATIVE;

ANGIOGENESIS; ANKLE BRACHIAL INDEX; APOPTOSIS; CELL COUNT; CELL ISOLATION; CELL PROLIFERATION; CELL VIABILITY; CLINICAL ARTICLE; COMPUTED TOMOGRAPHIC ANGIOGRAPHY; COMPUTED TOMOGRAPHY SCANNER; CONTROLLED STUDY; CORONARY ARTERY COLLATERAL CIRCULATION; DISEASE SEVERITY; DOUBLE BLIND PROCEDURE; DRUG PROTEIN BINDING; ENDOTHELIAL PROGENITOR CELL; ENZYME LINKED IMMUNOSORBENT ASSAY; HOMEOSTASIS; HUMAN; HUMAN CELL; INTERMITTENT CLAUDICATION; LETTER; MULTIDETECTOR COMPUTED TOMOGRAPHY; PERIPHERAL BLOOD MONONUCLEAR CELL; PERIPHERAL OCCLUSIVE ARTERY DISEASE; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; STEM CELL MOBILIZATION; UNIVERSITY HOSPITAL; BLOOD; CELL MOTION; COLLATERAL CIRCULATION; DRUG EFFECTS; ENDOTHELIUM CELL; FOLLOW UP; METABOLISM; NEOVASCULARIZATION, PATHOLOGIC; PATHOLOGY; PERIPHERAL ARTERIAL DISEASE; PHYSIOLOGY; PROSPECTIVE STUDY; STEM CELL;

BIOLOGICAL MARKERS; CELL MOVEMENT; CELL PROLIFERATION; COLLATERAL CIRCULATION; DOUBLE-BLIND METHOD; ENDOTHELIAL CELLS; FOLLOW-UP STUDIES; HUMANS; NEOVASCULARIZATION, PATHOLOGIC; PERIPHERAL ARTERIAL DISEASE; PLATELET AGGREGATION INHIBITORS; PROSPECTIVE STUDIES; STEM CELLS; TETRAZOLES;

EID: 84900645161     PISSN: 01675273     EISSN: 18741754     Source Type: Journal    
DOI: 10.1016/j.ijcard.2013.12.295     Document Type: Article

References (10)

1. S. Sen, S.P. McDonald, P.T. Coates, and C.S. Bonder Endothelial progenitor cells: novel biomarker and promising cell therapy for cardiovascular disease Clin Sci 120 2011 263 283
2. J.Y. Li, C.H. Su, and Y.J. Wu et al. Therapeutic angiogenesis of human early endothelial progenitor cells is enhanced by thrombomodulin Arterioscler Thromb Vasc Biol 31 2011 2518 2525
3. T.H. Chao, S.Y. Tseng, and Y.H. Li et al. A novel vasculo-angiogenic effect of cilostazol mediated by cross-talk between multiple signalling pathways including the ERK/p38 MAPK signaling transduction cascade Clin Sci 123 2012 147 159
4. R. Kawabe-Yako, M. Ii, O. Masuo, T. Asahara, and T. Itakura Cilostazol activates function of bone marrow-derived endothelial progenitor cell for re-endothelialization in a carotid balloon injury model PLoS One 6 2011 e24646
5. F. Biscetti, G. Pecorini, and G. Straface et al. Cilostazol promotes angiogenesis after peripheral ischemia through a VEGF-dependent mechanism Int J Cardiol 167 2013 910 916
6. I.C. Chen, W.H. Lee, and T.H. Chao et al. Effects of rosiglitazone on the cardiovascular profile in postmenopausal women without diabetes mellitus: interplay of thiazolidinediones and hormone therapy Menopause 19 2012 812 819
7. S.S. Khan, M.A. Solomon, and J.P. McCoy Jr. Detection of circulating endothelial cells and Rendothelial progenitor cells by flow cytometry Cytometry B Clin Cytom 64 2005 1 8
8. C. Brockmann, S. Jochum, and M. Sadick et al. Dual-energy CT angiography in peripheral arterial occlusive disease Cardiovasc Intervent Radiol 32 2009 630 637
9. C.J. Hsieh, and P.W. Wang Effect of cilostazol treatment on adiponectin and soluble CD40 ligand levels in diabetic patients with peripheral arterial occlusion disease Circ J 73 2009 948 954
10. T.H. Chao, Y.H. Li, W.C. Tsai, J.H. Chen, P.Y. Liu, and L.M. Tsai Elevation of the soluble thrombomodulin levels is associated with inflammation after percutaneous coronary interventions Clin Cardiol 27 2004 407 410