Discovery of inter-domain stabilizers-a novel assay system for allosteric Akt inhibitors

ACS Chemical Biology

Volumn 10, Issue 1, 2015, Pages 279-288

  Fang, Zhizhou ^a,b   Simard, Jeffrey R ^b   Plenker, Dennis ^c   Nguyen, Hoang D ^b   Phan, Trang ^b   Wolle, Patrik ^a   Baumeister, Stefan ^a   Rauh, Daniel ^a,b  

^a TU DORTMUND UNIVERSITY   (Germany)

^b CHEMICAL GENOMICS CENTRE OF THE MAX PLANCK SOCIETY   (Germany)

^c UNIVERSITY OF COLOGNE   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN KINASE B INHIBITOR; STABILIZING AGENT; FLUORESCENT DYE; MOLECULAR LIBRARY; PROTEIN KINASE B; PROTEIN KINASE INHIBITOR;

ALLOSTERISM; ARTICLE; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; ENZYME ANALYSIS; ENZYME CONFORMATION; FLUORESCENCE ANALYSIS; IN VITRO STUDY; INTERFACE FLUORESCENT LABELS IN KINASES; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN PROTEIN INTERACTION; ANTAGONISTS AND INHIBITORS; BINDING SITE; CHEMICAL STRUCTURE; CHEMISTRY; DRUG DEVELOPMENT; ENZYME ACTIVE SITE; HUMAN; MOLECULAR LIBRARY; PHARMACOLOGY; PROCEDURES; PROTEIN CONFORMATION; TUMOR CELL LINE;

ALLOSTERIC REGULATION; ALLOSTERIC SITE; CATALYTIC DOMAIN; CELL LINE, TUMOR; DRUG DISCOVERY; FLUORESCENT DYES; HUMANS; MODELS, MOLECULAR; PROTEIN CONFORMATION; PROTEIN KINASE INHIBITORS; PROTO-ONCOGENE PROTEINS C-AKT; SMALL MOLECULE LIBRARIES;

EID: 84921367741     PISSN: 15548929     EISSN: 15548937     Source Type: Journal    
DOI: 10.1021/cb500355c     Document Type: Article

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