Salinomycin inhibits the tumor growth of glioma stem cells by selectively suppressing glioma-initiating cells

Molecular Medicine Reports

Volumn 11, Issue 4, 2015, Pages 2407-2412

  Chen, Tunan ^a   Yi, Liang ^b   Li, Fei ^a   Hu, Rong ^a   Hu, Shengli ^a   Yin, Yi ^a   Lan, Chuan ^a   Li, Zhao ^a   Fu, Chuhua ^a   Cao, Liu ^a   Chen, Zhi ^a   Xian, Jishu ^a   Feng, Hua ^a  

^a SOUTHWEST HOSPITAL   (China)

^b THIRD MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

Apoptosis; Cell viability; Glioma; Glioma initiating cells; Salinomycin

Indexed keywords

NIMUSTINE; SALINOMYCIN; VINCRISTINE; ANTINEOPLASTIC AGENT; PYRAN DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER CHEMOTHERAPY; CANCER INHIBITION; CANCER STEM CELL; CANCER SURVIVAL; CELL PROLIFERATION; CELL VIABILITY; COMPARATIVE EFFECTIVENESS; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG EFFICACY; EXPERIMENTAL NEOPLASM; GLIOMA; GLIOMA CELL; IN VITRO STUDY; IN VIVO STUDY; MALE; MITOSIS INHIBITION; MOUSE; NONHUMAN; SURVIVAL TIME; TREATMENT RESPONSE; ANIMAL; CELL SURVIVAL; DISEASE MODEL; DRUG EFFECTS; METABOLISM; MORTALITY; PATHOLOGY; TUMOR CELL LINE; TUMOR STEM CELL ASSAY;

MUS;

ANIMALS; ANTINEOPLASTIC AGENTS; APOPTOSIS; CELL LINE, TUMOR; CELL SURVIVAL; DISEASE MODELS, ANIMAL; GLIOMA; MALE; MICE; NEOPLASTIC STEM CELLS; PYRANS; TUMOR STEM CELL ASSAY;

EID: 84921324589     PISSN: 17912997     EISSN: 17913004     Source Type: Journal    
DOI: 10.3892/mmr.2014.3027     Document Type: Article

References (22)

1. Wen PY and Kesari S: Malignant gliomas in adults. N Engl J Med 359: 492-507, 2008.
2. Stiles CD and Rowitch DH: Glioma stem cells: a midterm exam. Neuron 58: 832-846, 2008.
3. Vescovi AL, Galli R and Reynolds BA: Brain tumour stem cells. Nat Rev Cancer 6: 425-436, 2006
4. Natsume A, Kinjo S, Yuki K, et al: Glioma-initiating cells and molecular pathology: implications for therapy. Brain Tumor Pathol 28: 1-12, 2011.
5. Eramo A, Ricci-Vitiani L, Zeuner A, et al: Chemotherapy resistance of glioblastoma stem cells. Cell Death Differ 13: 1238-1241, 2006.
6. Miyazaki Y, Shibuya M, Sugawara H, Kawaguchi O and Hirsoe C: Salinomycin, a new polyether antibiotic. J Antibiot (Tokyo) 27 814-821, 1974
7. Mitani M, Yamanishi T, Miyazaki Y and O¯take N: Salinomycin effects on mitochondrial ion translocation and respiration. Antimicrob Agents Chemother 9: 655-660, 1976.
8. Gupta PB, Onder TT, Jiang G, et al: Identification of selective inhibitors of cancer stem cells by high-throughput screening. Cell 138: 645-659, 2009
9. Riccioni R, Dupuis MI, Bernabei M, et al: The cancer stem cell selective inhibitor salinomycin is a p-glycoprotein inhibitor. Blood Cells Mol Dis 45: 86-92, 2010.
10. Fuchs D, Heinold A, Opelz G, Daniel V and Naujokat C: Salinomycin induces apoptosis and overcomes apoptosis resistance in human cancer cells. Biochem Biophys Res Commun 390: 743-749, 2009.
11. Franklin KBJ and Paxinos G (eds): The Mouse Brain in Stereotaxic Coordinates. 2nd edition. Academic Press, San Diego, pp49-95, 1997.
12. Bao S, Wu Q, McLendon RE, et al: Glioma stem cells promote radioresistance by preferential activation of the DNA damage response. Nature 444: 756-760, 2006.
13. Piccirillo SG, Reynolds BA, Zanetti N, et al: Bone morphogenetic proteins inhibit the tumorigenic potential of human brain tumour-initiating cells. Nature 444: 761-765, 2006.
14. Galli R, Binda E, Orfanelli U, et al: Isolation and characterization of tumorigenic, stem-like neural precursors from human glioblastoma. Cancer Res 64: 7011-7021, 2004.
15. Singh SK, Hawkins C, Clarke ID, et al: Identification of human brain tumour initiating cells. Nature 432: 396-401, 2004.
16. Singh SK, Clarke ID, Terasaki M, et al: Identification of a cancer stem cell in human brain tumors. Cancer Res 63: 5821-5828, 2003.
17. Beier D, Hau P, Proescholdt M, et al: CD133(+) and CD133(-) glioblastoma-derived cancer stem cells show differential growth characteristics and molecular profiles. Cancer Res 67: 4010-4015, 2007.
18. Joo KM, Kim SY, Jin X, et al: Clinical and biological implications of CD133-positive and CD133-negative cells in glioblastomas. Lab Invest 88: 808-815, 2008.
19. Yi L, Zhou C, Wang B, et al: Implantation of GL261 neurospheres into C57/BL6 mice: A more reliable syngeneic graft model for research on glioma-initiating cells. Int J Oncol 43: 477-484, 2013.
20. Sarkaria JN, Kitange GJ, James CD, et al: Mechanisms of chemoresistance to alkylating agents in malignant glioma. Clin Cancer Res 14: 2900-2908, 2008.
21. Singh A and Settleman J: EMT, cancer stem cells and drug resistance: an emerging axis of evil in the war on cancer. Oncogene 29: 4741-4751, 2010.
22. Kim KY, Yu SN, Lee SY, et al: Salinomycin-induced apoptosis of human prostate cancer cells due to accumulated reactive oxygen species and mitochondrial membrane depolarization. Biochem Biophys Res Commun 413: 80-86, 2011.