A review of post-concussion syndrome and psychological factors associated with concussion

Brain Injury

Volumn 29, Issue 2, 2015, Pages 228-237

  Broshek, Donna K ^a   De Marco, Anthony P ^a   Freeman, Jason R ^a  

^a UNIVERSITY OF VIRGINIA   (United States)

Author keywords

Anxiety; Depression; Mild traumatic brain injury

Indexed keywords

ANXIETY; BRAIN CONCUSSION; COGNITIVE BIAS; COGNITIVE THERAPY; CONVALESCENCE; DEPRESSION; EMOTION; EXERCISE; FEAR; HUMAN; LIMBIC CORTEX; NEUROBIOLOGY; NONHUMAN; PATHOPHYSIOLOGY; PHYSICAL ACTIVITY; POSTCONCUSSION SYNDROME; PREFRONTAL CORTEX; PSYCHOLOGICAL ASPECT; REST; REVIEW; SPORT INJURY; SPORT RELATED CONCUSSION; SYMPTOMATOLOGY; TRAUMATIC BRAIN INJURY; TREATMENT INDICATION; ANIMAL; COMPLICATION; DISEASE MODEL; MILD COGNITIVE IMPAIRMENT; NEUROPSYCHOLOGICAL TEST; PREDICTIVE VALUE; PSYCHOLOGY; REACTION TIME;

ANIMALS; ANXIETY; DEPRESSION; DISEASE MODELS, ANIMAL; HUMANS; MILD COGNITIVE IMPAIRMENT; NEUROPSYCHOLOGICAL TESTS; POST-CONCUSSION SYNDROME; PREDICTIVE VALUE OF TESTS; REACTION TIME;

EID: 84921318678     PISSN: 02699052     EISSN: 1362301X     Source Type: Journal    
DOI: 10.3109/02699052.2014.974674     Document Type: Review

References (81)

1. Goldman B, Bush P, Klatz R. Death in the locker room: steroids and sports. South Bend, IN: Icarus Press; 1984. p 370.
2. Bamberger M, Yaeger D. Over the edge. Sports Illustrated; 1997 Available online at: http://sportsillustrated.cnn.com/vault/article/magazine/MAG1009868/index.htm, accessed 14 April 2014.
3. Conner J, Woolf J, Mazanov J. Would they dope? Revisiting the Goldman dilemma. Br J Sports Med 2013;47:697-700.
4. Keim J. Most would play Super Bowl with concussion. 2014. Available online at: http://espn.go.com/nfl/story/-/id/10358874/majority-nfl-players-play-super-bowl-concussion-espn-survey, accessed 9 April 2014.
5. Kay T, Newman B, Cavallo M, Ezrachi O, Resnick M. Toward a neuropsychological model of functional disability after mild traumatic brain injury. Neuropsychology 1992;6:371-384.
6. Montgomery GK. A multi-factor account of disability after brain injury: implication for neuropsychological counselling. Brain Injury 1995;9:453-469.
7. th International Conference on Concussion in Sport held in Zurich, November 2012. British Journal of Sports Medicine 2013;47:250-258.
8. Chen J, Johnston KM, Petrides M, Ptito A. Neural substrates of symptoms of depression following concussion in male athletes with persisting postconcussion symptoms. Archives of General Psychiatry 2008;65:81-89.
9. Hudak A, Warner M, Marquez de la Plata C, Moore, Harper C, Diaz-Arrastia R. Brain morphometry changes and depressive symptoms after traumatic brain injury. Psychiatry Research 2011;191:160-165.
10. Reger ML, Poulos AM, Buen F, Giza CC, Hovda DA, Fanselow MS. Concussive brain injury enhances fear learning and excitatory processes in the amygdala. Biological Psychiatry 2012;71:335-343.
11. Mayberg HS. Modulating dysfunctional limbic-cortical circuits in depression: towards development of brain-based alogorithms for diagnosis and optimized treatment. British Medical Bulletin 2003;65:193-207.
12. Cummings JL. Frontal-subcortical circuits and human behavior. Archives of Neurology 1993;50:873-880.
13. Kempton MJ, Salvador Z, Munafò MR, Geddes JR, Simmons A, Frangou S, Williams SC. Structural neuroimaging studies in major depressive disorder: meta-analysis and comparison with bipolar disorder. Archives of General Psychiatry 2011;68:675-690.
14. Koenigs M, Grafman J. The functional neuroanatomy of depression: distinct roles for the ventromedial and dorsolateral prefrontal cortex. Behavioral Brain Research 2009;201:239-243.
15. Langenecker SA, Jin Lee H, Bieliauskas LA. Neuropsychlogy of depression and related mood disorders. In: Grant I, Adams KM, editors. Neuropsychological assessment of neuropsychiatric and neuromedical disorders. 3rd ed. New York, NY: Oxford University Press; 2009. p 523-559.
16. Korgaonkar MS, Fornito A, Williams LM, Grieve SM. Abnormal structural networks characterize major depressive disorder: a connectome analysis. Biological Psychiatry 2014; Available online at: http://dx.doi.org/10/1016/j.biopsych.2014.02.018, accessed.
17. Mayberg HS. Limbic-cortical dysregulation: a proposed model of depression. Journal of Neuropsychiatry & Clinical Neurosciences 1997;9:471-481.
18. Mayberg HS, Liotti M, Brannan SK, McGinnis S, Mahurin RK, Jerabek PA, Silva JA, Tekell JL, Martin CC, Lancaster JL, Fox PT. Reciprocal limbic cortical function and negative mood converging PET findings in depression and normal sadness. American Journal of Psychiatry 1999;156:675-682.
19. Treadway MT, Pizzagalli DA. Imaging the pathophysiology of major depressive disorder- from localist models to circuit-based analysis. Biology of Mood & Anxiety Disorders 2014;4:1-13.
20. Iverson GL, Lange RT. Mild traumatic brain injury. In: Schoenberg MR, Scott JG, editors. The little black book of neuropsychology. New York, NY: Springer; 2011. p 697-720.
21. Levin HS, Amparo E, Eisenberg HM, Williams DH, High Jr WM, McArdle CB, Weiner RL. Magnetic resonance imaging and computerized tomography in relation to the neurobehavioral sequelae of mild and moderate head injuries. Journal of Neurosurgery 1987;66:706-713.
22. Dikmen SS, Bombardier CH, Machamer JE, Fann JR, Temkin NR. Natural history of depression in traumatic brain injury. Archives of Physical Medicine & Rehabilitation 2004;85:1457-1464.
23. Gale SD, Baxter L, Roundy N, Johnson SC. Traumatic brain injury and grey matter concentration: a preliminary voxel based morphometry study. Journal of Neurology, Neurosurgery & Psychiatry 2005;76:984-988.
24. Etkin A. Functional neuroanatomy of anxiety: a neural circuit perspective. Current Topics in Behavioral Neuroscience 2010;2:251-277.
25. Etkin A. Neurobiology of anxiety: from neural circuits to novel solutions? Depression & Anxiety 2012;29:355-358.
26. Rauch SL, Shin LM, Phelps EA. Neurocircuitry models of posttraumatic stress disorder and extinction: human neuroimaging research - past, present, and future. Biological Psychiatry 2006;60:376-382.
27. Motzkin JC, Philippi CL, Wolf RC, Baskaya MK. Ventromedial prefrontal cortex is critical for the regulation of amygdala activity in humans. Biological Psychiatry [internet] 2014; Available online at: http://dx.doi.org/10.1016/j.biopsych.2014.02.014, accessed.
28. Bremner JD, Randall P, Scott TM, Bronen RA, Seibyl JP, Southwick SM, Delaney RC, McCarthy G, Charney DS, Innis RB. MRI-based measurement of hippocampal volume in combat-related post-traumatic stress disorder. American Journal of Psychiatry 1995;152:973-981.
29. Sapolsky Rm, Uno H, Revert CS, Finch CE. Hippocampal damage associated with prolonged glucocorticoid exposure in primates. Journal of Neuroscience 1990;10:2897-2902.
30. Levita L, Bois CC, Healey A, Smyllie E, Papakonstantiou E. The behavioural inhibition system, anxiety and hippocampal volume in a non-clinical population. Biology of Mood & Anxiety Disorders 2014;4:1-10.
31. Kennedy JE, Jaffee MS, Leskin GA, Stokes JW, Leal FO, Fitzpatrick PJ. Posttraumatic stress disorder and posttraumatic stress disorder-like symptoms and mild traumatic brain injury. Journal of Rehabilitation Research & Development 2007;44:895-920.
32. Shultz SR, MacFabe DF, Foley KA, Taylor R, Cain DP. A single mild fluid percussion injury induces short-term behavioral and neuropathological changes in the long-Evans rat: Support for an animal model of concussion. Behavioral Brain Research 2011;224:326-335.
33. Jones NC, Cardamone L, Williams JP, Salzberg MR, Myers D, O'Brien TJ. Experimental traumatic brain injury induces pervasive hyperanxious phenotype in rats. Journal of Neurotrauma 2008;25:1367-1374.
34. Bolouri H, Saljo A, Viano DC, Hamberger A. Animal model for sport-related concussion; ICP and cognitive function. Acta Neurologica Scandinavica 2012;124:241-247.
35. Didehbani N, Cullum CM, Mansinghani S, Conover H, Hart Jr J. Depressive symptoms and concussion in aging retired NFL players. Archives of Clinical Neuropsychology 2013;28:418-424.
36. Guskiewicz KM, Marshall SW, Bailes J, McCrea M, Harding Jr HP, Matthews A, Mihalik JR, Cantu RC. Recurrent concussion and risk of depression in retired professional football players. Medicine & Science in Sports & Exercise 2007;39:903-909.
37. Hart JKM, Womack K, Strain J, Didehbani N, Bartz E, Conover H, Mansinghani S, Lu H, Cullum CM. Neuroimaging of cognitive dysfunction and depression in aging retired NFL players: a cross-sectional study. JAMA Neurology 2013;70:326-335.
38. Kerr ZY, Marshall SW, Harding Jr HP, Guskiewicz KM. Nine-year risk of depression diagnosis increases with increasing self-reported concussions in retired professional football players. American Journal of Sports Medicine 2012;40:2206-2212.
39. Clarke LA, Genat RC, Anderson JFI. Long-term cognitive complaint and post-concussive symptoms following mild traumatic brain injury: the role of cognitive and affective factors. Brain Injury 2012;26:298-307.
40. Iverson GL, Lange RT. Examination of postconcussion-like symptoms in a healthy sample. Applied Neuropsychology 2003;10:137-144.
41. Iverson GL, McCracken LM. 'Postconcussive' symptoms in persons with chronic pain. Brain Injury 1997;11:783-790.
42. Meares S, Shores EA, Taylor AJ, Batchelor J, Bryant RA, Baquley IJ, Chapman J, Gurka J, Marosszeky JE. The prospective course of postconcussion syndrome: the role of mild traumatic brain injury. Neuropsychology 2011;25:454-465.
43. Fox DD, Lees-Haley PR, Ernest K, Dolezal-Wood S. Postconcussive symptoms: base rates and etiology in psychiatric patients. Clinical Neuropsychology 1995;9:89-92.
44. Iverson GL. Misdiagnosis of the persistent postconcussion syndrome in patients with depression. Archives of Clinical Neuropsychology 2006;21:303-310.
45. Mickeviciene D, Schrader H, Obelieniene D, Surkiene D, Kunickas R, Stovner LJ, Sand T. A controlled prospective inception cohort study on the post-concussion syndrome outside the medicolegal contect. European Journal of Neurology 2004;11:411-419.
46. Iverson GL, Lange RT. Post-concussion syndrome. In: Schoenberg MR, Scott JG, editors. The little black book of neuropsychology. New York, NY: Springer; 2011. p 745-763.
47. Meares S, Shores EA, Taylor AJ, Batchelor J, Bryant RA, Baquley IJ, Chapman J, Gurka J, Dawson K, Capon L, Marosszeky JE. Mild traumatic brain injury does not predict acute postconcussion syndrome. Journal of Neurology, Neurosurgery & Psychiatry 2008;79:300-306.
48. Barth JT, Alves W, Ryan T, Macciocchi S, Rimel RW, Jane JJ, et al. Mild head injury in sports: neuropsychological sequelae and recovery of function. In: Levin H, Eisenberg J, Benton A, editors. Mild head injury. New York: Oxford Press; 1989. p 257-275.
49. Echemendia RJ, Putukian M, Mackin RS, Julian L, Shoss N. Neuropsychological test performance prior to and following sports-related mild traumatic brain injury. Clinical Journal of Sport Medicine 2001;11:23-31.
50. Lishman WA. Physiogenesis and psychogenesis in the 'postconcussional syndrome'. British Journal of Psychiatry 1988;153:460-469.
51. Silverberg ND, Iverson GL. Etiology of the post-concussion syndrome: physiogenesis and psychogenesis revisited. NeuroRehabilitation 2011;29:317-329.
52. Ponsford J, Cameron P, Fitzgerald M, Grant M, Mikocka-Walus A, Schonberger M. Predictors of postconcussive symptoms 3 months after mild traumatic brain injury. Neuropsychology 2012; 26: 304-313.
53. Woodrome SE, Yeates KO, Taylor HG, Rusin J, Bangert B, Dietrich A, Nuss K, Wright M. Coping strategies as a predictor of postconcussive symptoms in children with mild traumatic brain injury versus mild orthopedic injury. Journal of the International Neuropsychological Society 2011;17:317-326.
54. McCauley SR, Wilde EA, Miller ER, Frisby ML, Garza HM, Varghese R, Levin HS, Robertson CS, McCarthy JJ. Preinjury resilience and mood as predictors of early outcome following mild traumatic brain injury. Journal of Neurotrauma 2013;30:642-652.
55. Bailey CM, Samples HL, Broshek DK, Freeman JR, Barth JT. The relationship between psychological distress and baseline sportsrelated concussion testing. Clinical Journal of Sport Medicine 2010;20:272-277.
56. Peterson RA, Heilbronner RL. The anxiety sensitivity index: construct validity and factor analytic structure. Anxiety Disorders 1987;1:117-121.
57. Whittaker R, Kemp S, House A. Illness perceptions and outcome in mild head injury: a longitudinal study. Journal of Neurology, Neurosurgery & Psychiatry 2007;78:644-646.
58. Wood RL, McCabe M, Dwakins J. The role of anxiety sensitivity in symptom perception after minor head injury: an exploratory study. Brain Injury 2011;25:1296-1299.
59. Mittenberg W, DiGiulio DV, Perrin S, Bass AE. Symptoms following mild head injury: expectation as aetiology. Journal of Neurology, Neurosurgery & Psychiatry 1992;55:200-204.
60. Ferguson RJ, Mittenberg W, Barone DF, Schneider B. Postconcussion syndrome following sports-related head injury: expectation as etiology. Neuropsychology 1999;13:582-589.
61. Gunstad J, Suhr JA. "Expectation as etiology" versus "the good old days": postconcussion syndrome symptom reporting in athletes, headache sufferers, and depressed individuals. Journal of the International Neuropsychological Society 2001;7:323-333.
62. Iverson GL, Lange RT, Brooks BL, Rennison VL. Good old days bias following mild traumatic brain injury. Clinical Neuropsychology 2010;24:17-37.
63. Belanger HG, Bardwick FH, Kip KE, Kretzmer T, Vanderpoeg RD. Postconcussive symptoms complaints and potentially malleagble positive predictors. Clinical Neuropsychology 2013;27:343-355.
64. McCrea MA. Mild traumatic brain injury and postconcussion syndrome. New York: Oxford University Press; 2008; p 205.
65. Broshek DK, Freeman JR. Psychiatric and neuropsychological issues in sport medicine. Clinical Sports Medicine 2005;24:663-679.
66. Broshek DK, Samples H, Beard J, Goodkin HP. Current practices of the child neurologist in managing sports concussion. Journal of Child Neurology 2014;29:17-22.
67. Giza CC, Kutcher JS, Ashwal S, Barth J, Getchius TS, Gioia GA, Gronseth GS, Guskiewicz K, Mandel S, Manley G, et al. Summary of evidence-based guideline update: evaluation and management of concussion in sports: report of the Guideline Development Subcommittee of the American Academy of Neurology. Neurology 2013;24:2250-2257.
68. Griesbach GS, Hovda DA, Molteni R, Wu A, Gomez-Pinilla F. Voluntary exercise following traumatic brain injury: brain-derived neurotrophic factor upregulation and recovery of function. Neuroscience 2004;125:129-139.
69. Griesbach GS. Exercise after traumatic brain injury: is it a double-edged sword? Physical Medicine & Rehabilitation 2011;3:S64-S72.
70. Griesbach GS, Gomez-Pinilla F, Hovda DA. Time window for voluntary exercise-induced increases in hippocampal neuroplasticity molecules after traumatic brain injury is severity dependent. Journal of Neurotrauma 2007;24:1161-1171.
71. Miller LJ, Mittenberg W. Brief cognitive behavioral interventions in mild traumatic brain injury. Applied Neuropsychology 1998;5:172-183.
72. Powell KE, Paluch AE, Blair SN. Physical activity for health: what kind? How much? How intense? On top of what? Annual Review of Public Health 2011;32:349-365.
73. Dimeo F, Bauer M, Varahram I, Proest G, Halter U. Benefits for aerobic exercise in patients with major depression: a pilot study. British Journal of Sports Medicine 2001;35:114-117.
74. Yang PY, Ho KH, Chen HC, Chien MY. Exercise training improves sleep quality in middle-aged and older adults with sleep problems: a systematic review. Journal of Physiology 2012;58:157-163.
75. Majerske CW, Mihalik JP, Ren D, Collins MW, Camiolo Reddy C, Lovell MR, Wagner AK. Concussion in sports: postconcussive activity levels, symptoms, and neurocognitive performance. Journal of Athletic Training 2008;43:265-274.
76. Gagnon I, Galli C, Friedman D, Grilli L, Iverson GL. Active rehabilitation for children who are slow to recover following sport-related concussion. Brain Injury 2009;23:956-964.
77. Leddy JJ, Kozlowski K, Donnelly JP, Pendergast DR, Epstein LH, Willer B. A preliminary study of subsymptom threshold exercise training for refractory post-concussion syndrome. Clinical Journal of Sport Medicine 2010;20:21-27.
78. Silverberg ND, Iverson GL. Is rest after concussion "the best medicine?": recommendations for activity resumption following concussion in athletes, civilians, and military service members. Journal of Head Trauma Rehabilitation 2013;28:250-259.
79. Escalona A, Esfandiari A, Broshek DK, Freeman JR. Counseling athletes within the context of neurocognitive concerns. In: Webbe F, editor. NY: Springer Publishing Co; 2011. p 235-249.
80. Silver JM, Kay T. Persistent symptoms after a concussion. In: Arciniegas DB, Zasler ND, Vanderploeg RD, Jaffee MS, editors. Management of adults with traumatic brain injury. Arlington, VA: American Psychiatric Publishing; 2013. p 475-500.
81. Arcienegas DB, Silver JM. Psychopharmacology. In: Silver JM, McAllister TW, Yudofsky SC, editors. Textbook of traumatic brain injury. 2nd ed. Washington, DC: American Psychiatric Publishing; 2011. p 553-569.