Integrated evaluation of malonyl ginsenosides, amino acids and polysaccharides in fresh and processed ginseng

Journal of Pharmaceutical and Biomedical Analysis

Volumn 107, Issue , 2015, Pages 89-97

  Wan, Jin Yi ^a,c   Fan, Yong ^a   Yu, Qing Tao ^b   Ge, Ya Zhong ^b   Yan, Chen Pu ^a   Alolga, Raphael N ^a   Li, Ping ^a   Ma, Zhong Hua ^b   Qi, Lian Wen ^a  

^a CHINA PHARMACEUTICAL UNIVERSITY   (China)

^b Infinitus (China) Company Ltd   (China)

^c JIANGSU UNIVERSITY   (China)

Author keywords

Amino acids; Growth age; Malonyl ginsenosides; Polysaccharides; Processed ginseng

Indexed keywords

AMINO ACID DERIVATIVE; ARGININE; ASPARTIC ACID; GINSENG POLYSACCHARIDE; GINSENOSIDE; GLUTAMIC ACID; MALONYL GINSENOSIDE; POLYSACCHARIDE; SULFURIC ACID; UNCLASSIFIED DRUG; AMINO ACID; PLANT EXTRACT;

ARTICLE; COLLISIONALLY ACTIVATED DISSOCIATION; DRUG SCREENING; GINSENG; LIQUID CHROMATOGRAPHY; NONHUMAN; PLANT GROWTH; PRIORITY JOURNAL; QUALITY CONTROL; TIME OF FLIGHT MASS SPECTROMETRY; CHEMISTRY; MASS SPECTROMETRY; MEDICINAL PLANT; PANAX; PROCEDURES;

AMINO ACIDS; CHROMATOGRAPHY, LIQUID; GINSENOSIDES; MASS SPECTROMETRY; PANAX; PLANT EXTRACTS; PLANTS, MEDICINAL; POLYSACCHARIDES; QUALITY CONTROL;

EID: 84921292435     PISSN: 07317085     EISSN: 1873264X     Source Type: Journal    
DOI: 10.1016/j.jpba.2014.11.014     Document Type: Article

References (31)

1. Yun T.-K. Panax ginseng - a non-organ-specific cancer preventive. Lancet Oncol. 2001, 2:49-55.
2. Qi L.-W., Wang C.-Z., Yuan C.-S. Isolation and analysis of ginseng: advances and challenges. Nat. Prod. Rep. 2011, 28:467-495.
3. Luo D., Fang B. Structural identification of ginseng polysaccharides and testing of their antioxidant activities. Carbohydr. Polym. 2008, 72:376-381.
4. Kuo Y.-H., Ikegami F., Lambein F. Neuroactive and other free amino acids in seed and young plants of Panax ginseng. Phytochemistry 2003, 62:1087-1091.
5. Qi L.-W., Wang H.-Y., Zhang H., Wang C.-Z., Li P., Yuan C.-S. Diagnostic ion filtering to characterize ginseng saponins by rapid liquid chromatography with time-of-flight mass spectrometry. J. Chromatogr. A 2012, 1230:93-99.
6. Qiu Y.-Q., Lu X., Pang T., Ma C.-F., Li X., Xu G.-W. Determination of radix ginseng volatile oils at different ages by comprehensive two-dimensional gas chromatography/time-of-flight mass spectrometry. J. Sep. Sci. 2008, 31:3451-3457.
7. Zhang J.-S., Wang Y.-M., Song X.-H., Sun L.-X., Sun Y.-Z. A comparison of mineral element contents among different types of ginseng using inductively coupled plasma-atomic emission spectroscopy. Microchem. J. 1994, 50:131-135.
8. Ng T.-B., Yeung H.-W. Hypoglycemic constituents of Panax ginseng. Gen. Pharmacol. 1985, 16:549-552.
9. Gillis C.-N. Panax ginseng pharmacology: a nitric oxide link?. Biochem. Pharmacol. 1997, 54:1-8.
10. Chohachi K., Miki M., Yoshiteru O., Hiroshi H. Isolation and hypoglycemic activity of Panaxans Q, R, S, T AND U, glycans of Panax ginseng roots. J. Ethnopharmacol. 1985, 14:69-74.
11. Shin H.-J., Kim Y.-S., Kwak Y.-S., Song Y.-B., Kim Y.-S., Park J.-D. Enhancement of antitumor effects of paclitaxel (taxol) in combination with red ginseng acidic polysaccharide (RGAP). Planta Med. 2004, 70:1033-1038.
12. Lam S., Ng T. Isolation of a small chitinase-like antifungal protein from Panax notoginseng (sanchi ginseng) roots. Int. J. Biochem. Cell B 2001, 33:287-292.
13. Sun B.-S., Gu L.-J., Fang Z.-M., Wang C.-Y., Wang Z., Lee M.-R., Li Z., Li J.-J., Sung C.-K. Simultaneous quantification of 19 ginsenosides in black ginseng developed from Panax ginseng by HPLC-ELSD. J. Pharm. Biomed. Anal. 2009, 50:15-22.
14. Sun S., Qi L.-W., Du G.-J., Mehendale S.R., Wang C.-Z., Yuan C.-S. Red not ginseng: higher ginsenoside content and stronger anticancer potential than Asian and American ginseng. Food Chem. 2011, 125:1299-1305.
15. Kim W.-Y., Kim J.-M., Han S.-B., Lee S.-K., Kim N.-D., Park M.-K., Kim C.-K., Park J.-H. Steaming of ginseng at high temperature enhances biological activity. J. Nat. Prod. 2000, 63:1702-1704.
16. Wang C.-Z., Zhang B., Song W.-X., Wang A., Ni M., Luo X., Aung H.H., Xie J.-T., Tong R., He T.-C. Steamed American ginseng berry: ginsenoside analyses and anticancer activities. J. Agric. Food Chem. 2006, 54:9936-9942.
17. Wang C.-Z., Aung H.H., Ni M., Wu J.-A., Tong R., Wicks S., He T.-C., Yuan C.-S. Red American ginseng: ginsenoside constituents and antiproliferative activities of heat-processed Panax quinquefolius roots. Planta Med. 2007, 73:669.
18. Liu Z., Li Y., Li X., Ruan C.-C., Wang L.-J., Sun G.-Z. The effects of dynamic changes of malonyl ginsenosides on evaluation and quality control of Panax ginseng CA Meyer. J. Pharm. Biomed. Anal. 2012, 64:56-63.
19. Chu C., Xu S., Li X., Yan J., Liu L. Profiling the ginsenosides of three ginseng products by LC-Q-TOF/MS. J. Food Sci. 2013, 78:C653-C659.
20. Xie Y.-Y., Luo D., Cheng Y.-J., Ma J.-F., Wang Y.-M., Liang Q.-L., Luo G.-A. Steaming-induced chemical transformations and holistic quality assessment of red ginseng derived from Panax ginseng by means of HPLC-ESI-MS/MS n-based multicomponent quantification fingerprint. J. Agric. Food Chem. 2012, 60:8213-8224.
21. Kite G.-C., Howes M.-J.-R., Leon C.-J., Simmonds M.-S. Liquid chromatography/mass spectrometry of malonyl-ginsenosides in the authentication of ginseng. Rapid Commun. Mass Spectrom. 2003, 17:238-244.
22. Du X., Wills R., Stuart D. Changes in neutral and malonyl ginsenosides in American ginseng (Panax quinquefolium) during drying, storage and ethanolic extraction. Food Chem. 2004, 86:155-159.
23. Yang W.-Z., Ye M., Qiao X., Liu C.-F., Miao W.-J., Bo T., Tao H.-Y., Guo D.-A. A strategy for efficient discovery of new natural compounds by integrating orthogonal column chromatography and liquid chromatography/mass spectrometry analysis: its application in Panax ginseng, Panax quinquefolium and Panax notoginseng to characterize 437 potential new ginsenosides. Anal. Chim. Acta 2012, 739:56-66.
24. Kim S.-N., Ha Y.-W., Shin H., Son S.-H., Wu S.-J., Kim Y.-S. Simultaneous quantification of 14 ginsenosides in Panax ginseng CA Meyer (Korean red ginseng) by HPLC-ELSD and its application to quality control. J. Pharm. Biomed. Anal. 2007, 45:164-170.
25. Sun S., Wang C.-Z., Tong R., Li X.-L., Fishbein A., Wang Q., He T.-C., Du W., Yuan C.-S. Effects of steaming the root of Panax notoginseng on chemical composition and anticancer activities. Food Chem. 2010, 118:307-314.
26. Naval M., Gómez-Serranillos M., Carretero M., De Arce C. Value of high-performance liquid chromatographic analysis of amino acids in the determination of Panax ginseng radix extract effect in cultured neurons. J. Chromatogr. A 2006, 1121:242-247.
27. Cho E.-J., Piao X.-L., Jang M.-H., Baek S.-H., Kim H.-Y., Kang K.-S., Kwon S.-W., Park J.-H. The effect of steaming on the free amino acid contents and antioxidant activity of Panax ginseng. Food Chem. 2008, 107:876-882.
28. Grula E., Grula M.-M. Cell division in a species of Erwinia III. Reversal of inhibition of cell division caused by d-amino acids, penicillin, and ultraviolet light. J. Bacteriol. 1962, 83:981-988.
29. Wijewickreme A.-N., Kitts D.-D. Influence of reaction conditions on the oxidative behavior of model Maillard reaction products. J. Agric. Food Chem. 1997, 45:4571-4576.
30. Kim Y.-S., Kang K.-S., Kim S.-I. Study on antitumor and immunomodulating activities of polysaccharide fractions from Panax ginseng: comparison of effects of neutral and acidic polysaccharide fraction. Arch. Pharm. Res. 1990, 13:330-337.
31. Javed M.-S., Khan M.-I., Randhawa M.-A., Sajid M.-W., Ahmad A., Khan M.-A.-N. Garlic (Allium Sativum L.) as an antimicrobial and antioxidant agents in beef sausages. Pak. J. Food Sci. 2011, 21:22-32.