A strategy for efficient discovery of new natural compounds by integrating orthogonal column chromatography and liquid chromatography/mass spectrometry analysis: Its application in Panax ginseng, Panax quinquefolium and Panax notoginseng to characterize 437 potential new ginsenosides

Analytica Chimica Acta

Volumn 739, Issue , 2012, Pages 56-66

  Yang, Wen Zhi ^a   Ye, Min ^a   Qiao, Xue ^a   Liu, Chun Fang ^a   Miao, Wen Juan ^a   Bo, Tao ^b   Tao, Hai Yan ^a   Guo, De An ^a  

^a PEKING UNIVERSITY HEALTH SCIENCE CENTER   (China)

^b AGILENT TECHNOLOGIES   (China)

Author keywords

Ginsenoside; Liquid chromatography coupled with mass spectrometry; Natural compounds discovery; Orthogonal chromatography; Panax species

Indexed keywords

ACYLATIONS; ELECTROSPRAY IONIZATION TANDEM MASS SPECTROMETRY; ETHANOL EXTRACT; GINSENOSIDES; HERBAL EXTRACT; HERBAL MEDICINES; ION MASS; LIQUID CHROMATOGRAPHY/MASS SPECTROMETRY; MOBILE PHASE; NATURAL COMPOUNDS; NMR SPECTROSCOPIC ANALYSIS; PANAX GINSENG; PANAX NOTOGINSENG; PANAX SPECIES; SIDE-CHAINS; STRUCTURAL CHARACTERIZATION; STRUCTURAL ELUCIDATION; THREE-COMPONENT;

COLUMN CHROMATOGRAPHY; ELECTROSPRAY IONIZATION; ETHANOL; LIQUID CHROMATOGRAPHY; LIQUIDS; MASS SPECTROMETRY; PLANT EXTRACTS; SILICA GEL; SPECTROSCOPIC ANALYSIS;

PHARMACODYNAMICS;

GINSENG EXTRACT; GINSENOSIDE; GINSENOSIDE 4; GINSENOSIDE 5; GINSENOSIDE RB 1; GINSENOSIDE RB 2; GINSENOSIDE RC; GINSENOSIDE RD; GINSENOSIDE RE; GINSENOSIDE RE 1; GINSENOSIDE RE 2; GINSENOSIDE RE 3; GINSENOSIDE RE 4; GINSENOSIDE RG 1; GINSENOSIDE RG 2; OLIGOSACCHARIDE; PANAX NOTOGINSENG EXTRACT; PANAX QUINQUEFOLIUM EXTRACT; PLANT EXTRACT; SAPOGENIN; SILICA GEL; UNCLASSIFIED DRUG;

ACYLATION; ARTICLE; COLUMN CHROMATOGRAPHY; DRUG ISOLATION; DRUG RESEARCH; DRUG SCREENING; DRUG STRUCTURE; ELECTROSPRAY MASS SPECTROMETRY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PANAX; PANAX QUINQUEFOLIUM; PHYTOCHEMISTRY; PLANT ROOT; PRIORITY JOURNAL;

BIOLOGICAL AGENTS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; GINSENOSIDES; MAGNETIC RESONANCE SPECTROSCOPY; PANAX; PLANTS, MEDICINAL; SOLID PHASE EXTRACTION; TANDEM MASS SPECTROMETRY;

PANAX; PANAX GINSENG; PANAX NOTOGINSENG; PANAX QUINQUEFOLIUS; TETRA;

EID: 84864022932     PISSN: 00032670     EISSN: 18734324     Source Type: Journal    
DOI: 10.1016/j.aca.2012.06.017     Document Type: Article

References (37)

1. Newman D.J., Cragg G.M. J. Nat. Prod. 2012, 75:311-335.
2. Sticher O. Nat. Prod. Rep. 2008, 25:517-554.
3. Fuzzati N., Gabetta B., Jayakar K., Pace R., Peterlongo F. J. Chromatogr. A 1999, 854:69-79.
4. Ma X.Q., Liang X.M., Xu Q., Zhang X.Z., Xiao H.B. Phytochem. Anal. 2005, 16:181-187.
5. Liu Y.Y., Li J.B., He J.M., Abliz Z., Qu J., Yu S.S., Ma S.G., Liu J., Du D. Rapid Commun. Mass Spectrom. 2009, 23:667-679.
6. Livilompolo M., Hyötyläinen T. J. Chromatogr. A 2007, 1145:155-164.
7. Zeng J., Zhang X.L., Guo Z.M., Feng J.T., Xue X.Y., Liang X.M. J. Chromatogr. A 2011, 1218:1749-1755.
8. Chinese Pharmacopoeia Commission Pharmacopoeia of the People's Republic of China 2010, vol. 1. Chinese Medical Science and Technology Press, Beijing, pp. 8, 11, 122. 2010 ed.
9. Qi L.W., Wang C.Z., Yuan C.S. Nat. Prod. Rep. 2011, 28:467-495.
10. Christensen L.P. Adv. Food Nutr. Res. 2009, 55:1-99.
11. Tung N.H., Song G.Y., Park Y.J., Kim Y.H. Chem. Pharm. Bull. 2009, 57:1412-1414.
12. Cui M., Song F.R., Zhou Y., Liu Z.Q., Liu S.Y. Rapid Commun. Mass Spectrom. 2000, 14:1280-1286.
13. Nakamura S., Sugimoto S., Matsuda H., Yoshikawa M. Chem. Pharm. Bull. 2007, 55:1342-1348.
14. Tung N.H., Song G.Y., Nhiem N.X., Ding Y., Tai B.H., Jin L.G., Lim C.M., Hyun J.W., Park C.J., Kang H.K., Kim Y.H. J. Agric. Food Chem. 2010, 58:868-872.
15. Yang G.Y., Fen W.B., Lei C., Xiao W.L., Sun H.D. J. Hazard. Mater. 2009, 162:44-49.
16. Perreault H., Costello C.E. Org. Mass Spectrom. 1994, 29:720-735.
17. Hunter E.P., Lias S.G. J. Phys. Chem. Ref. Data 1998, 27:413-656.
18. Zehl M., Pittenauer E., Jirovetz L., Bandhari P., Singh B., Kaul V.K., Rizzi A., Allmaier G. Anal. Chem. 2007, 79:8214-8221.
19. Ma X.Q., Xiao H.B., Liang X.M. Chromatographia 2006, 64:31-36.
20. Li Y.J., Wei H.L., Qi L.W., Chen J., Ren M.T., Li P. Rapid Commun. Mass Spectrom. 2010, 24:2975-2985.
21. Kite G.C., Howes M.J.R., Leon C.J., Simmonds M.S.J. J. Pharm. Biomed. Anal. 2003, 17:238-244.
22. Yoshikawa M., Murakami T., Yashiro K., Yamahara J., Matsuda H., Saijoh R., Tanaka O. Chem. Pharm. Bull. 1998, 46:647-654.
23. Decroos K., Vincken J.P., Heng L., Bakker R., Gruppen H., Verstraete W. J. Chromatogr. A 2005, 1072:185-193.
24. Qiu F., Ma Z.Z., Xu S.X., Yao X.S., Che C.T., Chen Y.J. J. Asian Nat. Prod. Res. 2001, 3:235-240.
25. Yoshikawa M., Sugimoto S., Nakamura S., Matsuda H. Chem. Pharm. Bull. 2007, 55:571-576.
26. Cho J.G., Lee M.K., Lee J.W., Park H.J., Lee D.Y., Lee Y.H., Yang D.C., Baek N.I. J. Ginseng Res. 2010, 34:113-121.
27. Dou D.Q., Chen Y.J., Liang L.H., Pang F.G., Shimizu N., Takeda T. Chem. Pharm. Bull. 2001, 49:442-446.
28. Sanada S., Kondo N., Shoji J., Tanaka O., Shibata S. Chem. Pharm. Bull. 1974, 22:421-428.
29. Besso H., Kasai R., Saruwatari Y., Fuwa T., Tanaka O. Chem. Pharm. Bull. 1982, 30:2380-2385.
30. Matsuura H., Kasai R., Tanaka O., Saruwatari Y.I., Kunihiro K., Fuwa T. Chem. Pharm. Bull. 1984, 32:1188-1192.
31. Zhu G.Y., Li Y.W., Hau D.K.P., Jiang Z.H., Yu Z.L., Fong W.F. J. Agric. Food Chem. 2011, 59:200-205.
32. Sanada S., Shoji J. Chem. Pharm. Bull. 1978, 26:1694-1697.
33. Teng R.W., Li H.Z., Chen J.T., Wang D.Z., He Y.N., Yang C.R. Magn. Reson. Chem. 2002, 40:483-488.
34. Matsuura H., Kasai R., Tanaka O., Saruwatari Y.I. T. fuwa, J. Zhou. Chem. Pharm. Bull. 1983, 31:2281-2287.
35. Yoshikawa M., Murakami T., Ueno T., Yashiro K., Hirokawa N., Murakami N., Yamahara J., Matsuda H., Sauoh R., Tanaka O. Chem. Pharm. Bull. 1997, 45:1039-1045.
36. Yoshikawa M., Sugimoto S., Nakamura S., Sakumae H., Matsuda H. Chem. Pharm. Bull. 2007, 55:1034-1038.
37. Yoshikawa M., Morikawa T., Yashiro K., Murakami T., Matsuda H. Chem. Pharm. Bull. 2001, 49:1452-1456.