Cytomegalovirus and glioma: Putting the cart before the horse

Journal of Neurology, Neurosurgery and Psychiatry

Volumn 86, Issue 2, 2015, Pages 191-199

  Dey, Mahua ^a   Ahmed, Atique U ^a   Lesniak, Maciej S ^a  

^a UNIVERSITY OF CHICAGO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIVIRUS AGENT; CHEMOKINE RECEPTOR; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; CYTOMEGALOVIRUS ANTIGEN PP65; FRACTALKINE; MACROPHAGE INFLAMMATORY PROTEIN 1ALPHA; MACROPHAGE INFLAMMATORY PROTEIN 1BETA; MONOCYTE CHEMOTACTIC PROTEIN 1; PROTEIN P107; PROTEIN P53; RANTES; STAT3 PROTEIN; TEMOZOLOMIDE; TRANSCRIPTION FACTOR E2F;

ASTROCYTOMA; BRAIN TUMOR; CARCINOGENESIS; CYTOMEGALOVIRUS; CYTOMEGALOVIRUS INFECTION; DNA REPLICATION; ENVIRONMENTAL FACTOR; ERYTHROBLASTOSIS; GLIOBLASTOMA; GLIOMA; HEPATITIS B; HEPATITIS C; HORSE; HUMAN; MOUSE; NONHUMAN; ONCOVIRINAE; PROTEIN PHOSPHORYLATION; REVIEW; RISK FACTOR; SEROPREVALENCE; SOCIAL CLASS; TOBACCO CONSUMPTION; WART VIRUS; BRAIN NEOPLASMS; COMPLICATION; CYTOMEGALOVIRUS INFECTIONS; DRUG EFFECTS; GENETICS; METABOLISM; SIGNAL TRANSDUCTION; VIROLOGY;

ANTIVIRAL AGENTS; BRAIN NEOPLASMS; CARCINOGENESIS; CYTOMEGALOVIRUS INFECTIONS; GLIOMA; HUMANS; SIGNAL TRANSDUCTION;

EID: 84921279869     PISSN: 00223050     EISSN: 1468330X     Source Type: Journal    
DOI: 10.1136/jnnp-2014-307727     Document Type: Review

References (98)

1. Epstein MA, Achong BG, Barr YM. Virus Particles in Cultured Lymphoblasts from Burkitt's Lymphoma. Lancet 1964;1:702-3.
2. Moore PS, Chang Y. Why do viruses cause cancer? Highlights of the first century of human tumour virology. Nat Rev Cancer 2010;10:878-89.
3. Strong K, Mathers C, Epping-Jordan J, et al. Preventing cancer through tobacco and infection control: how many lives can we save in the next 10 years? Eur J Cancer Prev 2008;17:153-61.
4. Stupp R, Mason WP, van den Bent MJ, et al. Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma. N Engl J Med 2005;352:987-96.
5. Stragliotto G, Rahbar A, Solberg NW, et al. Effects of valganciclovir as an add-on therapy in patients with cytomegalovirus-positive glioblastoma: a randomized, double-blind, hypothesis-generating study. Int J Cancer 2013;133:1204-13.
6. Woller N, Kuhnel F. Virus infection, inflammation and prevention of cancer. Recent Results Cancer Res 2014;193:33-58.
7. Alibek K, Kakpenova A, Baiken Y. Role of infectious agents in the carcinogenesis of brain and head and neck cancers. Infect Agent Cancer 2013;8:7.
8. Mu A, Rutledge J, Mills P, et al. Incidence of Kaposi Sarcoma and Associated Mortality in Fresno, California, 1998 to 2012. J Int Association Providers AIDS Care 2014. PubMed PMID: 24739208.
9. Chang MH, Chen CJ, Lai MS, et al. Universal hepatitis B vaccination in Taiwan and the incidence of hepatocellular carcinoma in children. Taiwan Childhood Hepatoma Study Group. N Engl J Med 1997;336:1855-9.
10. Boeckh M, Geballe AP. Cytomegalovirus: pathogen, paradigm, and puzzle. J Clin Invest 2011;121:1673-80.
11. Dowd JB, Aiello AE, Alley DE. Socioeconomic disparities in the seroprevalence of cytomegalovirus infection in the US population: NHANES III. Epidemiol Infect 2009;137:58-65.
12. Reeves M, Sinclair J. Aspects of human cytomegalovirus latency and reactivation. Curr Top Microbiol Immunol 2008;325:297-313.
13. Gu J, Liu Y, Kyritsis AP, et al. Molecular epidemiology of primary brain tumors. Neurotherapeutics 2009;6:427-35.
14. Bondy ML, Scheurer ME, Malmer B, et al. Brain tumor epidemiology: consensus from the Brain Tumor Epidemiology Consortium. Cancer 2008;113(7 Suppl):1953-68.
15. Chakrabarti I, Cockburn M, Cozen W, et al. A population-based description of glioblastoma multiforme in Los Angeles County, 1974-1999. Cancer 2005;104:2798-806.
16. Corle C, Makale M, Kesari S. Cell phones and glioma risk: a review of the evidence. J Neurooncol 2012;106:1-13.
17. Hardell L, Carlberg M, Hansson Mild K. Use of mobile phones and cordless phones is associated with increased risk for glioma and acoustic neuroma. Pathophysiology 2013;20:85-110.
18. Huang H, Reis R, Yonekawa Y, et al. Identification in human brain tumors of DNA sequences specific for SV40 large T antigen. Brain Pathol 1999;9:33-42.
19. Martini F, Iaccheri L, Lazzarin L, et al. SV40 early region and large T antigen in human brain tumors, peripheral blood cells, and sperm fluids from healthy individuals. Cancer Res 1996;56:4820-5.
20. Carbone M, Rizzo P, Pass HI. Simian virus 40, poliovaccines and human tumors: a review of recent developments. Oncogene 1997;15:1877-88.
21. Ohgaki H, Huang H, Haltia M, et al. More about: cell and molecular biology of simian virus 40: implications for human infections and disease. J Natl Cancer Inst 2000;92:495-7.
22. Geissler E. SV40 and human brain tumors. Prog Med Virol 1990;37:211-22.
23. Cobbs CS, Harkins L, Samanta M, et al. Human cytomegalovirus infection and expression in human malignant glioma. Cancer Res 2002;62:3347-50.
24. Tang KW, Alaei-Mahabadi B, Samuelsson T, et al. The landscape of viral expression and host gene fusion and adaptation in human cancer. Nature Communications 2013;4:2513.
25. Dziurzynski K, Chang SM, Heimberger AB, et al. Consensus on the role of human cytomegalovirus in glioblastoma. Neuro-oncology 2012;14:246-55.
26. Fredericks DN, Relman DA. Sequence-based identification of microbial pathogens: a reconsideration of Koch's postulates. Clin Microbiol Rev 1996;9:18-33.
27. Bate SL, Dollard SC, Cannon MJ. Cytomegalovirus seroprevalence in the United States: the national health and nutrition examination surveys, 1988-2004. Clin Infect Dis 2010;50:1439-47.
28. Davis FG, Kupelian V, Freels S, et al. Prevalence estimates for primary brain tumors in the United States by behavior and major histology groups. Neuro-oncology 2001;3:152-8.
29. Yamashita Y, Ito Y, Isomura H, et al. Lack of presence of the human cytomegalovirus in human glioblastoma. Mod Pathol 2013. PubMed PMID: 24336154. Epub 2013/12/18. Eng.
30. Bhattacharjee B, Renzette N, Kowalik TF. Genetic analysis of cytomegalovirus in malignant gliomas. J Virol 2012;86:6815-24.
31. Dos Santos CJ, Stangherlin LM, Figueiredo EG, et al. High prevalence of HCMV and viral load in tumor tissues and peripheral blood of glioblastoma multiforme patients. J Med Virol 2013. PubMed PMID: 24173908.
32. Beisser PS, Laurent L, Virelizier JL, et al. Human cytomegalovirus chemokine receptor gene US28 is transcribed in latently infected THP-1 monocytes. J Virol 2001;75:5949-57.
33. Fonseca RF, Kawamura MT, Oliveira JA, et al. The prevalence of human cytomegalovirus DNA in gliomas of Brazilian patients. Mem Inst Oswaldo Cruz 2012;107:953-4.
34. Lucas KG, Bao L, Bruggeman R, et al. The detection of CMV pp65 and IE1 in glioblastoma multiforme. J Neurooncol 2011;103:231-8.
35. Kizilarslanoglu MC, Aksoy S, Yildirim NO, et al. Temozolomide-related infections: review of the literature. J BUON 2011;16:547-50.
36. Meije Y, Lizasoain M, Garcia-Reyne A, et al. Emergence of cytomegalovirus disease in patients receiving temozolomide: report of two cases and literature review. Clin Infect Dis 2010;50:e73-6.
37. Soroceanu L, Akhavan A, Cobbs CS. Platelet-derived growth factor-alpha receptor activation is required for human cytomegalovirus infection. Nature 2008;455:391-5.
38. Toepoel M, Joosten PH, Knobbe CB, et al. Haplotype-specific expression of the human PDGFRA gene correlates with the risk of glioblastomas. Int J Cancer 2008;123:322-9.
39. Price RL, Song J, Bingmer K, et al. Cytomegalovirus contributes to glioblastoma in the context of tumor suppressor mutations. Cancer Res 2013;73:3441-50.
40. Mutnal MB, Cheeran MC, Hu S, et al. Murine cytomegalovirus infection of neural stem cells alters neurogenesis in the developing brain. PloS one 2011;6:e16211.
41. Tsutsui Y, Kosugi I, Kawasaki H, et al. Roles of neural stem progenitor cells in cytomegalovirus infection of the brain in mouse models. Pathol Int 2008;58:257-67.
42. Cheeran MC, Hu S, Ni HT, et al. Neural precursor cell susceptibility to human cytomegalovirus diverges along glial or neuronal differentiation pathways. J Neurosci Res 2005;82:839-50.
43. Henle W, Diehl V, Kohn G, et al. Herpes-type virus and chromosome marker in normal leukocytes after growth with irradiated Burkitt cells. Science 1967;157:1064-5.
44. Barami K. Oncomodulatory mechanisms of human cytomegalovirus in gliomas. J Clin Neurosci 2010;17:819-23.
45. Geder KM, Lausch R, O'Neill F, et al. Oncogenic transformation of human embryo lung cells by human cytomegalovirus. Science 1976;192:1134-7.
46. Geder L, Laychock AM, Gorodecki J, et al. Alterations in biological properties of different lines of cytomegalorivus-transformed human embryo lung cells following in vitro cultivation. IARC Sci Publ 1978(24 Pt 2):591-601.
47. Doniger J, Muralidhar S, Rosenthal LJ. Human cytomegalovirus and human herpesvirus 6 genes that transform and transactivate. Clin Microbiol Rev 1999;12:367-82.
48. Nelson JA, Fleckenstein B, Jahn G, et al. Structure of the transforming region of human cytomegalovirus AD169. J Virol 1984;49:109-15.
49. Shen Y, Zhu H, Shenk T. Human cytomagalovirus IE1 and IE2 proteins are mutagenic and mediate "hit-and-run" oncogenic transformation in cooperation with the adenovirus E1A proteins. Proc Natl Acad Sci U S A 1997;94:3341-5.
50. Mitchell DA, Xie W, Schmittling R, et al. Sensitive detection of human cytomegalovirus in tumors and peripheral blood of patients diagnosed with glioblastoma. Neuro-oncology 2008;10:10-8.
51. Scheurer ME, Bondy ML, Aldape KD, et al. Detection of human cytomegalovirus in different histological types of gliomas. Acta Neuropathol 2008;116:79-86.
52. Dziurzynski K, Wei J, Qiao W, et al. Glioma-associated cytomegalovirus mediates subversion of the monocyte lineage to a tumor propagating phenotype. Clin Cancer Res 2011;17:4642-9.
53. Poma EE, Kowalik TF, Zhu L, et al. The human cytomegalovirus IE1-72 protein interacts with the cellular p107 protein and relieves p107-mediated transcriptional repression of an E2F-responsive promoter. J Virol 1996;70:7867-77.
54. Pajovic S, Wong EL, Black AR, et al. Identification of a viral kinase that phosphorylates specific E2Fs and pocket proteins. Mol Cell Biol 1997;17:6459-64.
55. Castillo JP, Yurochko AD, Kowalik TF. Role of human cytomegalovirus immediate-early proteins in cell growth control. J Virol 2000;74:8028-37.
56. Cobbs CS, Soroceanu L, Denham S, et al. Modulation of oncogenic phenotype in human glioma cells by cytomegalovirus IE1-mediated mitogenicity. Cancer Res 2008;68:724-30.
57. Cobbs CS, Soroceanu L, Denham S, et al. Human cytomegalovirus induces cellular tyrosine kinase signaling and promotes glioma cell invasiveness. J Neurooncol 2007;85:271-80.
58. Shih C, Shilo BZ, Goldfarb MP, et al. Passage of phenotypes of chemically transformed cells via transfection of DNA and chromatin. Proc Natl Acad Sci U S A 1979;76:5714-8.
59. Brune W. Inhibition of programmed cell death by cytomegaloviruses. Virus Res 2011;157:144-50.
60. Tomtishen JP 3rd. Human cytomegalovirus tegument proteins (pp65, pp71, pp150, pp28). Virol J 2012;9:22.
61. Gilbert MJ, Riddell SR, Plachter B, et al. Cytomegalovirus selectively blocks antigen processing and presentation of its immediate-early gene product. Nature 1996;383:720-2.
62. Odeberg J, Plachter B, Branden L, et al. Human cytomegalovirus protein pp65 mediates accumulation of HLA-DR in lysosomes and destruction of the HLA-DR alpha-chain. Blood 2003;101:4870-7.
63. Facoetti A, Nano R, Zelini P, et al. Human leukocyte antigen and antigen processing machinery component defects in astrocytic tumors. Clin Cancer Res 2005;11:8304-11.
64. Mehling M, Simon P, Mittelbronn M, et al. WHO grade associated downregulation of MHC class I antigen-processing machinery components in human astrocytomas: does it reflect a potential immune escape mechanism? Acta Neuropathol 2007;114:111-9.
65. Neote K, DiGregorio D, Mak JY, et al. Molecular cloning, functional expression, and signaling characteristics of a C-C chemokine receptor. Cell 1993;72:415-25.
66. Vischer HF, Leurs R, Smit MJ. HCMV-encoded G-protein-coupled receptors as constitutively active modulators of cellular signaling networks. Trends Pharmacol Sci 2006;27:56-63.
67. Soroceanu L, Matlaf L, Bezrookove V, et al. Human cytomegalovirus US28 found in glioblastoma promotes an invasive and angiogenic phenotype. Cancer Res 2011;71:6643-53.
68. de la Iglesia N, Konopka G, Puram SV, et al. Identification of a PTEN-regulated STAT3 brain tumor suppressor pathway. Genes Dev 2008;22:449-62.
69. de la Iglesia N, Konopka G, Lim KL, et al. Deregulation of a STAT3-interleukin 8 signaling pathway promotes human glioblastoma cell proliferation and invasiveness. J Neurosci 2008;28:5870-8.
70. Bongers G, Maussang D, Muniz LR, et al. The cytomegalovirus-encoded chemokine receptor US28 promotes intestinal neoplasia in transgenic mice. J Clin Invest 2010;120:3969-78.
71. Linos E, Raine T, Alonso A, et al. Atopy and risk of brain tumors: a meta-analysis. J Natl Cancer Inst 2007;99:1544-50.
72. Wrensch M, Weinberg A, Wiencke J, et al. Prevalence of antibodies to four herpesviruses among adults with glioma and controls. Am J Epidemiol 2001;154:161-5.
73. Wrensch M, Weinberg A, Wiencke J, et al. History of chickenpox and shingles and prevalence of antibodies to varicella-zoster virus and three other herpesviruses among adults with glioma and controls. Am J Epidemiol 2005;161:929-38.
74. Sjostrom S, Hjalmars U, Juto P, et al. Human immunoglobulin G levels of viruses and associated glioma risk. Cancer Causes Control 2011;22:1259-66.
75. Lehrer S, Green S, Ramanathan L, et al. No consistent relationship of glioblastoma incidence and cytomegalovirus seropositivity in whites, blacks, and Hispanics. Anticancer Res 2012;32:1113-5.
76. Lehrer S. Cytomegalovirus infection in early childhood may be protective against glioblastoma multiforme, while later infection is a risk factor. Med Hypotheses 2012;78:657-8.
77. Susan Amirian E, Marquez-Do D, Bondy ML, et al. Anti-human-cytomegalovirus immunoglobulin G levels in glioma risk and prognosis. Cancer Med 2013;2:57-62.
78. Poland SD, Costello P, Dekaban GA, et al. Cytomegalovirus in the brain: in vitro infection of human brain-derived cells. J Infect Dis 1990;162:1252-62.
79. Ranganathan P, Clark PA, Kuo JS, et al. Significant association of multiple human cytomegalovirus genomic Loci with glioblastoma multiforme samples. J Virol 2012;86:854-64.
80. Crough T, Beagley L, Smith C, et al. Ex vivo functional analysis, expansion and adoptive transfer of cytomegalovirus-specific T-cells in patients with glioblastoma multiforme. Immunol Cell Biol 2012;90:872-80.
81. Prins RM, Cloughesy TF, Liau LM. Cytomegalovirus immunity after vaccination with autologous glioblastoma lysate. N Engl J Med 2008;359:539-41.
82. Ghazi A, Ashoori A, Hanley PJ, et al. Generation of polyclonal CMV-specific T cells for the adoptive immunotherapy of glioblastoma. J Immunother 2012;35:159-68.
83. Murayama T, Mukaida N, Sadanari H, et al. The immediate early gene 1 product of human cytomegalovirus is sufficient for up-regulation of interleukin-8 gene expression. BBRC 2000;279:298-304.
84. Kim J, Kwon YJ, Park ES, et al. Human cytomegalovirus (HCMV) IE1 plays role in resistance to apoptosis with etoposide in cancer cell line by Cdk2 accumulation. Microbiol Immunol 2003;47:959-67.
85. Straat K, Liu C, Rahbar A, et al. Activation of telomerase by human cytomegalovirus. J Natl Cancer Inst 2009;101:488-97.
86. Brat DJ, Bellail AC, Van Meir EG. The role of interleukin-8 and its receptors in gliomagenesis and tumoral angiogenesis. Neuro Oncol 2005;7:122-33.
87. Slinger E, Maussang D, Schreiber A, et al. HCMV-encoded chemokine receptor US28 mediates proliferative signaling through the IL-6-STAT3 axis. Sci Signal 2010;3:ra58.
88. Liu B, Stinski MF. Human cytomegalovirus contains a tegument protein that enhances transcription from promoters with upstream ATF and AP-1 cis-acting elements. J virol 1992;66:4434-44.
89. Matlaf LA, Harkins LE, Bezrookove V, et al. Cytomegalovirus pp71 protein is expressed in human glioblastoma and promotes pro-angiogenic signaling by activation of stem cell factor. PLoS One Published Online First 05 July 2013 PLOS ONE 10.1371/journal.pone.0068176
90. Trgovcich J, Cebulla C, Zimmerman P, et al. Human cytomegalovirus protein pp71 disrupts major histocompatibility complex class I cell surface expression. J virol 2006;80:951-63.
91. Stinski MF, Petrik DT. Functional roles of the human cytomegalovirus essential IE86 protein. Curr Top Microbiol Immunol 2008;325:133-52.
92. Speir E, Modali R, Huang ES, et al. Potential role of human cytomegalovirus and p53 interaction in coronary restenosis. Science 1994;265:391-4.
93. Yoo YD, Chiou CJ, Choi KS, et al. The IE2 regulatory protein of human cytomegalovirus induces expression of the human transforming growth factor beta1 gene through an Egr-1 binding site. J Virol 1996;70:7062-70.
94. Wiebusch L, Asmar J, Uecker R, et al. Human cytomegalovirus immediate-early protein 2 (IE2)-mediated activation of cyclin E is cell-cycle-independent and forces S-phase entry in IE2-arrested cells. J gen virol 2003;84:51-60.
95. Wang J, Marker PH, Belcher JD, et al. Human cytomegalovirus immediate early proteins upregulate endothelial p53 function. FEBS Lett 20002;474:213-6.
96. Zhang Z, Huong SM, Wang X, et al. Interactions between human cytomegalovirus IE1-72 and cellular p107: functional domains and mechanisms of up-regulation of cyclin E/cdk2 kinase activity. J Virol 2003;77:12660-70.
97. Sabatier J, Uro-Coste E, Pommepuy I, et al. Detection of human cytomegalovirus genome and gene products in central nervous system tumours. Br J Cancer 200528;92:747-50.
98. Lau SK, Chen YY, Chen WG, et al. Lack of association of cytomegalovirus with human brain tumors. Mod Pathol 2005;18:838-43.