Human cytomegalovirus and human herpesvirus 6 genes that transform and transactivate

Clinical Microbiology Reviews

Volumn 12, Issue 3, 1999, Pages 367-382

  Doniger, Jay ^a   Muralidhar, Sumitra ^a   Rosenthal, Leonard J ^a  

^a GEORGETOWN UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN P53; VIRUS DNA;

ARTICLE; COLON ADENOCARCINOMA; DISEASE ASSOCIATION; GENE LOCATION; HUMAN; HUMAN CYTOMEGALOVIRUS; HUMAN HERPESVIRUS 6; NONHUMAN; ONCOGENE; OPEN READING FRAME; PROMOTER REGION; PROSTATE ADENOCARCINOMA; TRANSACTIVATION; TUMOR SUPPRESSOR GENE; UTERINE CERVIX CANCER; VIRUS TRANSFORMATION;

ADENOVIRIDAE; DNA VIRUSES; HERPESVIRIDAE; HUMAN HERPESVIRUS 5; HUMAN HERPESVIRUS 6; HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1; SIMIAE; SIMIAN VIRUS; SIMIAN VIRUS 40; TUMOR VIRUS;

EID: 0032771737     PISSN: 08938512     EISSN: None     Source Type: Journal    
DOI: 10.1128/cmr.12.3.367     Document Type: Article

References (198)

1. Ablashi, D. V., S. F. Josephs, A. Buchbinder, K. Hellman, S. Nakamura, T. Llana, P. Lusso, M. Kaplan, J. Dahlberg, S. Memon, F. Imam, K. L. Ablashi, P. D. Markham, B. Kramarsky, G. R. F. Krueger, P. Biberfeld, F. Wong-Staal, S. Z. Salahuddin, and R. C. Gallo. 1988. Human B-lymphotropic virus (human herpesvirus-6). J. Virol. Methods 21:29-48.
2. Ablashi, D. V., S. Z. Salahuddin, S. F. Josephs, F. Imam, P. Lusso, R. C. Gallo, C. Hung, J. Lemp, and P. D. Markham. 1987. HBLV (or HHV-6) in human cell lines. Nature 329:207. (Letter.)
3. Albrecht, T., and F. Rapp. 1973. Malignant transformation of hamster embryo fibroblasts exposure to ultraviolet-irradiated human cytomegalovirus. Virology 55:53-61.
4. Altschul, S. F., W. Gish, W. Miller, E. W. Myers, and D. J. Lipman. 1990. Basic local alignment search tool. J. Mol. Biol. 215:403-410.
5. Asano, Y., T. Yoshikawa, S. Suga, T. Yazaki, K. Kondo, and K. Yamanishi. 1990. Fatal fulminant hepatitis in an infant with human herpesvirus-6 infection. Lancet 335:862-863. (Letter.)
6. Bairoch, A. 1992. PROSITE: a dictionary of sites and patterns in proteins. Nucleic Acids Res. 20:2013-2018.
7. Bairoch, A. 1993. The PROSITE dictionary of sites and patterns in proteins, its current status. Nucleic Acids Res. 21:3097-3103.
8. Bandara, L. R., and N. B. La Thangue. 1991. Adenovirus E1A prevents the retinoblastoma gene product from complexing with a cellular transcription factor. Nature 351:494-497.
9. Barak, Y., T. Juven, R. Haffner, and M. Oren. 1993. mdm2 expression is induced by wild-type p53 activity. EMBO J. 12:461-468.
10. Bertram, G., N. Dreiner, G. R. Krueger, A. Ramon, D. V. Ablashi, S. Z. Salahuddin, and N. Balachandran. 1991. Frequent double infection with Epstein-Barr virus and human herpesvirus-6 in patients with acute infectious mononucleosis. In Vivo 5:271-279.
11. Boldogh, I., S. Abu Bakar, M. P. Fons, C. Z. Deng, and T. Albrecht. 1991. Activation of cellular oncogenes by clinical isolates and laboratory strains of human cytomegalovirus. J. Med. Virol. 34:241-247.
12. Boldogh, I., S. Abu Bakar, D. Millinoff, C. Z. Deng, and T. Albrecht. 1991. Cellular oncogene activation by human cytomegalovirus. Lack of correlation with virus infectivity and immediate early gene expression. Arch. Virol. 118:163-177.
13. Boldogh, I., S. AbuBakar, and T. Albrecht. 1990. Activation of protooncogenes: an immediate early event in human cytomegalovirus infection. Science 247:561-564.
14. Boldogh, I., S. AbuBakar, C. Z. Deng, and T. Albrecht. 1991. Transcriptional activation of cellular oncogenes fos, jun, and myc by human cytomegalovirus. J. Virol. 65:1568-1571.
15. Boldogh, I., J. F. Baskar, E. Mar, and E. Huang. 1983. Human cytomegalovirus and herpes simplex type 2 virus in normal and adenocarcinomatous prostate glands. JNCI 70:819-826.
16. Boldogh, I., E. Beth, E. Huang, S. K. Kyalwazi, and G. Giraldo. 1981. Kaposi's sarcoma. IV. Detection of CMV DNA, CMV RNA and CMNA tumor biopsies. Int. J. Cancer 28:469-474.
17. Boldogh, I., E. Gonczol, and L. Vaczi. 1978. Transformation of hamster embryonic fibroblast cells by UV-irradiated human cytomegalovirus. Acta Microbiol. Acad. Sci. Hung. 25:269-275.
18. Boldogh, I., E. S. Huang, P. Rady, I. Arany, S. Tyring, and T. Albrecht. 1994. Alteration in the coding potential and expression of h-ras in human cytomegalovirus-transformed cells. Intervirology 37:321-329.
19. 1 checkpoint function. J. Virol. 71:5861-5870.
20. Bresnahan, W. A., T. Albrecht, and E. A. Thompson. 1998. The cyclin E promoter is activated by human cytomegalovirus 86-kDa immediate early protein. J. Biol. Chem. 273:22075-22082.
21. Bresnahan, W. A., E. A. Thompson, and T. Albrecht. 1997. Human cytomegalovirus infection results in altered Cdk2 subcellular localization. J. Gen. Virol. 78:1993-1997.
22. Brichacek, B., I. Hirsch, H. Zavadora, M. Prochazka, J. Faltyn, and V. Vonka. 1980. Absence of cytomegalovirus DNA from adenocarcinoma of the colon. Intervirology 14:223-227.
23. Buchwald, D., P. R. Cheney, D. L. Peterson, B. Henry, S. B. Wormsley, A. Geiger, D. V. Ablashi, S. Z. Salahuddin, C. Saxinger, R. Biddle, R. Kikinis, F. A. Jolesz, T. Folks, N. Balachandran, J. B. Peter, R. C. Gallo, and A. L. Komaroff. 1992. A chronic illness characterized by fatigue, neurologic and immunologic disorders, and active human herpesvirus type 6 infection. Ann. Intern. Med. 116:103-113.
24. Carrigan, D. R., W. R. Drobyski, S. K. Russler, M. A. Tapper, K. K. Knox, and R. C. Ash. 1991. Interstitial pneumonitis associated with human herpesvirus-6 infection after marrow transplantation. Lancet 338:147-149.
25. Centifanto, Y. M., H. E. Kaufman, Z. S. Zam, D. M. Drylie, and S. L. Deardourff. 1973. Herpesvirus particles in prostatic carcinoma cells. J. Virol. 12:1608-1611.
26. Challoner, P. B., K. T. Smith, J. D. Parker, D. L. MacLeod, S. N. Coulter, T. M. Rose, E. R. Schultz, J. L. Bennett, R. L. Garber, M. Chang, P. A. Schad, P. M. Stewart, R. C. Nowinski, J. P. Brown, and G. C. Burner. 1995. Plaque-associated expression of human herpesvirus 6 in multiple sclerosis. Proc. Natl. Acad. Sci. USA 92:7440-7444.
27. Chang, Y., E. Cesarman, M. S. Pessin, F. Lee, J. Culpepper, D. M. Knowles, and P. S. Moore. 1994. Identification of herpesvirus-like DNA sequences in AIDS-associated Kaposi's sarcoma. Science 266:1865-1869.
28. Chee, M. S., A. T. Bankier, S. Beck, R. Bohni, C. M. Brown, R. Cerny, T. Horsnell, C. A. Hutchison III, T. Kouzarides, J. A. Martignetti, E. Preddie, S. C. Satchwell, P. Tomlinson, K. M. Weston, and B. G. Barrell. 1990. Analysis of the protein-coding content of the sequence of human cytomegalovirus strain AD169. Curr. Top. Microbiol. Immunol. 154:125-169.
29. Chen, C. Y., J. D. Oliner, Q. Zhan, A. J. Fornace, Jr., B. Vogelstein, and M. B. Kastan. 1994. Interactions between p53 and MDM2 in a mammalian cell cycle checkpoint pathway. Proc. Natl. Acad. Sci. USA 91:2684-2688.
30. Cherrington, J. M., E. L. Khoury, and E. S. Mocarski. 1991. Human cytomegalovirus ie2 negatively regulates alpha gene expression via a short target sequence near the transcription start site. J. Virol. 65:887-896.
31. Cherrington, J. M., and E. S. Mocarski. 1989. Human cytomegalovirus IE1 transactivates the alpha promoter-enhancer via an 18-base-pair repeat element. J. Virol. 63:1435-1440.
32. Chiou, C. J., J. Zong, I. Waheed, and G. S. Hayward. 1993. Identification and mapping of dimerization and DNA-binding domains in the C terminus of the IE2 regulatory protein of human cytomegalovirus. J. Virol. 67:6201-6214.
33. Chretien, J. H., C. G. McGinniss, and A. Muller. 1977. Venereal causes of cytomegalovirus mononucleosis. JAMA 238:1644-1645.
34. Chuck, S., R. M. Grant, E. Katongole-Mbidde, M. Conant, and D. Ganem. 1996. Frequent presence of a novel herpesvirus genome in lesions of human immunodeficiency virus-negative Kaposi's sarcoma. J. Infect. Dis. 173:248-251.
35. Cinatl, J., Jr., J. Cinatl, J. U. Vogel, H. Rabenau, B. Kornhuber, and H. W. Doerr. 1996. Modulatory effects of human cytomegalovirus infection on malignant properties of cancer cells. Intervirology 39:259-269.
36. Clanton, D. J., R. J. Jariwalla, C. Kress, and L. J. Rosenthal. 1983. Neoplastic transformation by a cloned human cytomegalovirus DNA fragment uniquely homologous to one of the transforming regions of herpes simplex virus type 2. Proc. Natl. Acad. Sci. USA 80:3826-3830.
37. Cone, R. W., M. L. Huang, R. Ashley, and L. Corey. 1993. Human herpesvirus 6 DNA in peripheral blood cells and saliva from immunocompetent individuals. J. Clin. Microbiol. 31:1262-1267.
38. Crook, T., N. J. Marston, E. A. Sara, and K. H. Vousden. 1994. Transcriptional activation by p53 correlates with suppression of growth but not with transformation. Cell 79:817-827.
39. Demmler, G. J. 1991. Infectious Diseases Society of America and Centers for Disease Control. Summary of a workshop on surveillance for congenital cytomegalovirus disease. Rev. Infect. Dis. 13:315-329.
40. Dictor, M., E. Rambech, D. Way, M. Witte, and N. Bendsoe. 1996. Human herpesvirus 8 (Kaposi's sarcoma-associated herpesvirus) DNA in Kaposi's sarcoma lesions, AIDS Kaposi's sarcoma cell lines, endothelial Kaposi's sarcoma simulators, and the skin of immunosuppressed patients. Am. J. Pathol. 148:2009-2016.
41. Drew, W. L., M. A. Conant, R. C. Miner, E. Huang, J. L. Ziegler, J. R. Groundwater, J. H. Gullett, P. Volberding, D. I. Abrams, and L. Mintz. 1982. Cytomegalovirus and Kaposi's sarcoma in young homosexual men. Lancet ii:125-127.
42. Drew, W. L., L. Mintz, R. C. Miner, M. Sands, and B. Ketterer. 1981. Prevalence of cytomegalovirus infection in homosexual men. J. Infect. Dis. 143:188-192.
43. Dutta, A., J. M. Ruppert, J. C. Aster, and E. Winchester. 1993. Inhibition of DNA replication factor RPA by p53. Nature 365:79-82.
44. Dyson, N., P. M. Howley, K. Munger, and E. Harlow. 1989. The human papilloma virus-16 E7 oncoprotein is able to bind to the retinoblastoma gene product. Science 243:934-937.
45. Efstathiou, S., G. L. Lawrence, C. M. Brown, and B. G. Barrell. 1992. Identification of homologues to the human cytomegalovirus US22 gene family in human herpesvirus 6. J. Gen. Virol. 73:1661-1671.
46. El-Beik, T., A. Razzaque, R. Jariwalla, R. L. Cihlar, and L. J. Rosenthal. 1986. Multiple transforming regions of human cytomegalovirus DNA. J. Virol. 60:645-652.
47. el-Deiry, W. S., T. Tokino, V. E. Velculescu, D. B. Levy, R. Parsons, J. M. Trent, D. Lin, W. E. Mercer, K. W. Kinzler, and B. Vogelstein. 1993. WAF1, a potential mediator of p53 tumor suppression. Cell 75:817-825.
48. Ellinger, K., F. Neipel, S. Seidl, B. Borisch-Chappius, K. Muller-Hermelink, and B. Fleckenstein. 1992. Detection of HHV-6 genomes in lympho-proliferative diseases, p. 209-226. In D. V. Ablashi, G. R. F. Krueger, and S. Z. Salahuddin (ed.), Human herpesvirus-6: epidemiology, molecular biology, and clinical pathology. Elsevier Science Publishing, New York, N.Y.
49. Ensoli, B., P. Lusso, F. Schachter, S. F. Josephs, J. Rappaport, F. Negro, R. C. Gallo, and F. Wong-Staal. 1989. Human herpes virus-6 increases HIV-1 expression in co-infected T cells via nuclear factors binding to the HIV-1 enhancer. EMBO J. 8:3019-3027.
50. Fenoglio, C. M., M. W. Oster, P. Lo Gerfo, T. Reynolds, R. Edelson, J. A. Patterson, E. Madeiros, and J. K. McDougall. 1982. Kaposi's sarcoma following chemotherapy for testicular cancer in a homosexual man: demonstration of cytomegalovirus RNA in sarcoma cells. Hum. Pathol. 13:955-959.
51. Fletcher, K., J. W. Cordiner, and J. C. Macnab. 1986. Detection of sequences that hybridize to human DNA in cervical neoplastic tissue. Dis. Markers 4:219-229.
52. Fortunato, E. A., M. H. Sommer, K. Yoder, and D. H. Spector. 1997. Identification of domains within the human cytomegalovirus major immediate-early 86-kilodalton protein and the retinoblastoma protein required for physical and functional interaction with each other. J. Virol. 71:8176-8185.
53. Fuccillo, D. A., J. L. Sever, F. L. Moder, T. C. Chen, L. W. Catalano, and L. D. Johnson. 1971. Cytomegalovirus antibody in patients with carcinoma of the uterine cervix. Obstet. Gynecol. 38:599-601.
54. Gao, S. J., L. Kingsley, M. Li, W. Zheng, C. Parravicini, J. Ziegler, R. Newton, C. R. Rinaldo, A. Saah, J. Phair, R. Detels, Y. Chang, and P. S. Moore. 1996. KSHV antibodies among Americans, Italians and Ugandans with and without Kaposi's sarcoma. Nat. Med. 2:925-928.
55. Geder, L., R. Lausch, F. O'Neill, and F. Rapp. 1976. Oncogenic transformation of human embryo lung cells by human cytomegalovirus. Science 192:1134-1137.
56. Geder, L., A. M. Laychock, J. Gorodecki, and F. Rapp. 1978. Alterations in biological properties of different lines of cytomegalovirus-transformed human embryo lung cells following in vitro cultivation. IARC Sci. Publ. 24: 591-601.
57. Geng, Y. Q., B. Chandran, S. F. Josephs, and C. Wood. 1992. Identification and characterization of a human herpesvirus 6 gene segment that trans activates the human immunodeficiency virus type 1 promoter. J. Virol. 66:1564-1570.
58. Ginsberg, D., F. Mechta, M. Yaniv, and M. Oren. 1991. Wild-type p53 can down-modulate the activity of various promoters. Proc. Natl. Acad. Sci. USA 88:9979-9983.
59. Giraldo, G., E. Beth, W. Henle, G. Henle, V. Mike, B. Safai, J. M. Huraux, J. McHardy, and G. De-The. 1978. Antibody patterns to herpesviruses in Kaposi's sarcoma. II Serological association of American Kaposi's sarcoma with cytomegalovirus. Int. J. Cancer 22:126-131.
60. Giraldo, G., E. Beth, and E. Huang. 1980. Kaposi's sarcoma and its relationship to cytomegalovirus (CMV). III. CMV DNA and CMV early antigens in Kaposi's sarcoma. Int. J. Cancer 26:23-29.
61. Hart, H., W. A. Neill, and M. Noval. 1982. Lack of association of cytomegalovirus with adenocarcinoma of the colon. Gut 23:21-30.
62. Hart, H., A. Springbett, and M. Norval. 1982. Lack of association of cytomegalovirus antibody level with carcinoma of the uterine cervix. Gynecol. Obstet. Investig. 14:300-308.
63. Hashiro, G. M., S. Horikami, and P. C. Loh. 1979. Cytomegalovirus isolations from cell cultures of human adenocarcinomas of the colon. Intervirology 12:84-88.
64. Hayashi, S., and H. C. Wu. 1990. Lipoproteins in bacteria. J. Bioenerg. Biomembr. 22:451-471.
65. Hendrix, M. G. R., M. M. Salimans, C. P. van Boven, and C. A. Bruggeman. 1990. High prevalence of latently present cytomegalovirus in arterial walls of patients suffering from grade III atherosclerosis. Am. J. Pathol. 136:23-28.
66. Hermiston, T. W., C. L. Malone, and M. F. Stinski. 1990. Human cytomegalovirus immediate-early two protein region involved in negative regulation of the major immediate-early promoter. J. Virol. 64:3532-3536.
67. Hirsch, M. S. 1984. Cytomegalovirus-leukocyte interactions. Birth Defects Orig. Artic. Ser. 20:161-173.
68. Hollstein, M., D. Sidransky, B. Vogelstein, and C. C. Harris. 1991. p53 mutations in human cancers. Science 253:49-53.
69. Horikoshi, N., K. Maguire, A. Kralli, E. Maldonado, D. Reinberg, and R. Weinmann. 1991. Direct interaction between adenovirus E1A protein and the TATA box binding transcription factor IID. Proc. Natl. Acad. Sci. USA 88:5124-5128.
70. Hu, Q., N. Dyson, and E. Harlow. 1990. The regions of the retinoblastoma protein needed for binding to adenovirus E1A or SV40 large T antigen are common sites for mutation. EMBO J. 9:1147-1155.
71. Huang, E., I. Boldogh, and E. Mar. 1983. Human cytomegaloviruses: evidence for possible association with human cancer, p. 161-193. In L. A. Philips (ed.), Viruses associated with human cancer. Marcel Dekker, Inc., New York, N. Y.
72. Huang, E., M. G. Davis, J. F. Baskar, and S. Huong. 1986. Molecular epidemiology and oncogenicity of human cytomegalovirus, p. 323-344. In C. C. Harris (ed.), Biochemical and molecular epidemiology of cancer. Alan R. Liss, Inc., New York, N.Y.
73. Huang, E., and J. K. Roche. 1978. Cytomegalovirus DNA and adenocarcinoma of the colon: evidence for latent viral infection. Lancet i:957-960.
74. Huang, S., N. P. Wang, B. Y. Tseng, W.-H. Lee, and E. Y.-H. P. Lee. 1990. Two distinct and frequently mutated regions of retinoblastoma protein are required for binding to SV40 T antigen. EMBO J. 9:1815-1822.
75. Huibregtse, J. M., M. Scheffner, and P. M. Howley. 1994. E6-AP directs the HPV E6-dependent inactivation of p53 and is representative of a family of structurally and functionally related proteins. Cold Spring Harbor Symp. Quant. Biol. 59:237-245.
76. Inamdar, A., J. Thompson, F. Kashanchi, J. Doniger, J. N. Brady, and L. J. Rosenthal. 1992. Identification of two promoters within human cytomegalovirus morphologic transforming region II. Intervirology 34:146-153.
77. Ishiguro, N., S. Yamada, T. Takahashi, Y. Takahashi, T. Togashi, T. Okuno, and K. Yamanishi. 1990. Meningo-encephalitis associated with HHV-6 related exanthem subitum. Acta Paediatr. Scand. 79:987-989.
78. Jabs, D. A., C. Enger, and J. G. Bartlett. 1989. Cytomegalovirus retinitis and acquired immunodeficiency syndrome. Arch. Ophthalmol. 107:75-80.
79. Jahan, N., A. Razzaque, J. Brady, and L. J. Rosenthal. 1989. The human cytomegalovirus mtrII colinear region in strain Tanaka is transformation defective. J. Virol. 63:2866-2869.
80. Jahan, N., A. Razzaque, J. Greenspan, M. A. Conant, S. F. Josephs, S. Nakamura, and L. J. Rosenthal. 1989. Analysis of human KS biopsies and cloned cell lines for cytomegalovirus, HIV-1, and other selected DNA virus sequences. AIDS Res. Hum. Retroviruses 5:225-231.
81. Jariwalla, R. J., A. Razzaque, S. Lawson, and L. J. Rosenthal. 1989. Tumor progression mediated by two cooperating DNA segments of human cytomegalovirus. J. Virol. 63:425-428.
82. Jarrett, R. F., S. Gledhill, F. Qureshi, S. H. Crae, R. Madhok, I. Brown, I. Evans, A. Krajewski, C. J. O'Brien, R. A. Cartwright, P. Venables, and D. E. Onions. 1988. Identification of human herpesvirus 6-specific DNA sequences in two patients with non-Hodgkin's lymphoma. Leukemia 2:496-502.
83. Jault, F. M., J. M. Jault, F. Ruchti, E. A. Fortunato, C. Clark, J. Corbeil, D. D. Richman, and D. H. Spector. 1995. Cytomegalovirus infection induces high levels of cyclins, phosphorylated Rb, and p53, leading to cell cycle arrest. J. Virol. 69:6697-6704.
84. Josephs, S. F., A. Buchbinder, H. Z. Streicher, D. V. Ablashi, S. Z. Salahuddin, H. G. Guo, F. Wong-Staal, J. Cossman, M. Raffeld, J. Sundeen, P. Levine, R. Biggar, G. R. F. Krueger, R. I. Fox, and R. C. Gallo. 1988. Detection of human B-lymphotropic virus (human herpesvirus 6) sequences in B cell lymphoma tissues of three patients. Leukemia 2:132-135.
85. Josephs, S. F., S. Z. Salahuddin, D. V. Ablashi, F. Schachter, F. Wong-Staal, and R. C. Gallo. 1986. Genomic analysis of the human B-lymphotropic virus (HBLV). Science 234:601-603.
86. Kashanchi, F., J. C. Araujo, J. Doniger, S. Muralidhar, S. Khleif, E. Mendleson, J. Thompson, N. Azumi, J. N. Brady, M. Luppi, G. Torelli, and L. J. Rosenthal. 1997. Human herpesvirus type 6 (HHV-6) ORF-1 transactivating gene exhibits malignant transforming activity and its protein binds to p53. Oncogene 14:359-367.
87. Kashanchi, F., J. Thompson, M. R. Sadaie, J. Doniger, J. Duvall, J. N. Brady, and L. J. Rosenthal. 1994. Transcriptional activation of minimal HIV-1 promoter by ORF-1 protein expressed from the SaII-L fragment of human herpesvirus 6. Virology 201:95-106.
88. Kastan, M. B., Q. Zhan, W. S. el-Deiry, F. Carrier, T. Jacks, W. V. Walsh, B. S. Plunkett, B. Vogelstein, and A. J. Fornace, Jr. 1992. A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxiatelangiectasia. Cell 71:587-597.
89. Kikuchi, M., Y. Sumiyoshi, and Y. Minamishima. 1992. Kikuchi's disease (histiocytic necrotizing lymphadenitis), p. 175-184. In D. V. Ablashi, G. R. F. Krueger, and S. Z. Salahuddin (ed.), Human herpesvirus-6: epidemiology, molecular biology, and clinical pathology. Elsevier Science Publishing, New York, N.Y.
90. Klemola, E. 1973. Cytomegalovirus infection in previously healthy adults. Ann. Intern. Med. 79:267-268.
91. Kouzarides, T., A. T. Bankier, S. C. Satchwell, E. Preddy, and B. G. Barrell. 1988. An immediate early gene of human cytomegalovirus encodes a potential membrane glycoprotein. Virology 165:151-164.
92. Krueger, G. R., C. Sander, A. Hoffmann, A. Barth, B. Koch, and M. Braun. 1991. Isolation of human herpesvirus-6 (HHV-6) from patients with collagen vascular diseases. In Vivo 5:217-225.
93. Kuerbitz, S. J., B. S. Plunkett, W. V. Walsh, and M. B. Kastan. 1992. Wild-type p53 is a cell cycle checkpoint determinant following irradiation. Proc. Natl. Acad. Sci. USA 89:7491-7495.
94. Kumar, A., M. S. Selim, D. L. Madden, W. C. Wallen, H. H. Vasquez, and G. A. Nankervis. 1980. Humoral and cell-mediated immune responses to herpesvirus antigens in patients with cervical carcinoma. Gynecol. Oncol. 10:18-25.
95. Kyte, J., and R. F. Doolittle. 1982. A simple method for displaying the hydropathic character of a protein. J. Mol. Biol. 157:105-132.
96. Lang, D., and T. Stamminger. 1993. The 86-kilodalton IE-2 protein of human cytomegalovirus is a sequence-specific DNA-binding protein that interacts directly with the negative autoregulatory response element located near the cap site of the IE-1/2 enhancer-promoter. J. Virol. 67:323-331.
97. Lang, D. J., and J. F. Kummer. 1972. Demonstration of cytomegalovirus in semen. N. Engl. J. Med. 287:756-758.
98. Lang, D. J., and J. F. Kummer. 1975. Cytomegalovirus in semen: observations in selected populations. J. Infect. Dis. 132:472-473.
99. Lawrence, G. L., M. Chee, M. A. Craxton, U. A. Gompels, R. W. Honess, and B. G. Barrell. 1990. Human herpesvirus 6 is closely related to human cytomegalovirus. J. Virol. 64:287-299.
100. Lee, W. S., C. C. Kao, G. O. Bryant, X. Liu, and A. J. Berk. 1991. Adenovirus E1A activation domain binds the basic repeat in the TATA box transcription factor. Cell 67:365-376.
101. Levine, A. J. 1993. The tumor suppressor genes. Annu. Rev. Biochem. 62:623-651.
102. Levine, P. H., N. Jahan, P. Murari, M. Manak, and E. S. Jaffe. 1992. Detection of human herpesvirus 6 in tissues involved by sinus histiocytosis with massive lymphadenopathy (Rosai-Dorfman disease). J. Infect. Dis. 166:291-295.
103. Lin, J., J. Chen, B. Elenbaas, and A. J. Levine. 1994. Several hydrophobic amino acids in the p53 amino-terminal domain are required for transcriptional activation, binding to mdm-2 and the adenovirus 5 E1B 55-kDa protein. Genes Dev. 8:1235-1246.
104. Lin, Y. S., I. Ha, E. Maldonado, D. Reinberg, and M. R. Green. 1991. Binding of general transcription factor TFIIB to an acidic activating region. Nature 353:569-571.
105. Liu, B., T. W. Hermiston, and M. F. Stinski. 1991. A cis-acting element in the major immediate-early (IE) promoter of human cytomegalovirus is required for negative regulation by IE2. J. Virol. 65:897-903.
106. Liu, X., C. W. Miller, P. H. Koeffler, and A. J. Berk. 1993. The p53 activation domain binds the TATA box-binding polypeptide in Holo-TFIID, and a neighboring p53 domain inhibits transcription. Mol. Cell. Biol. 13:3291-3300.
107. Lowe, S. W., E. M. Schmitt, S. W. Smith, B. A. Osborne, and T. Jacks. 1993. p53 is required for radiation-induced apoptosis in mouse thymocytes. Nature 362:847-849.
108. Luppi, M., R. Marasca, P. Barozzi, S. Ferrari, L. Ceccherini-Nelli, G. Batoni, E. Merelli, and G. Torelli. 1993. Three cases of human herpesvirus-6 latent infection: integration of viral genome in peripheral blood mononuclear cell DNA. J. Med. Virol. 40:44-52.
109. Lusso, P., A. De Maria, M. Malnati, F. Lori, S. E. DeRocco, M. Baseler, and R. C. Gallo. 1991. Induction of CD4 and susceptibility to HIV-1 infection in human CDS+ T lymphocytes by human herpesvirus 6. Nature 349:533-535.
110. Lusso, P., B. Ensoli, P. D. Markham, D. V. Ablashi, S. Z. Salahuddin, E. Tschachler, F. Wong-Staal, and R. C. Gallo. 1989. Productive dual infection of human CD4+ T lymphocytes by HIV-1 and HHV-6. Nature 337:370-373.
111. Lusso, P., A. Garzino-Demo, R. W. Crowley, and M. S. Malnati. 1995. Infection of gamma/delta T lymphocytes by human herpesvirus 6: transcriptional induction of CD4 and susceptibility to HIV infection. J. Exp. Med. 181:1303-1310.
112. Lusso, P., P. D. Markham, E. Tschachler, F. DiMarzo Veronese, S. Z. Salahuddin, D. V. Ablashi, S. Pahwa, K. Krohn, and R. C. Gallo. 1988. In vitro cellular tropism of human B-lymphotropic virus (human herpesvirus-6). J. Exp. Med. 167:1659-1670.
113. Macias, M. P., and M. F. Stinski. 1993. An in vitro system for human cytomegalovirus immediate early 2 protein (IE2)-mediated site-dependent repression of transcription and direct binding of IE2 to the major immediate early promoter. Proc. Natl. Acad. Sci. USA 90:707-711.
114. Malkin, D., F. P. Li, L. C. Strong, J. F. Fraumeni, Jr., C. M. Nelson, D. H. Kim, J. Kassel, M. A. Gryka, F. Z. Bischoff, M. A. Tainsky, and S. H. Friend. 1990. Germline mutations in familial syndrome of breast cancer, sarcomas and other neoplasias. Science 250:1233-1238.
115. Malone, C. L., D. H. Vesole, and M. F. Stinski. 1990. Transactivation of a human cytomegalovirus early promoter by gene products from the immediate-early gene IE2 and augmentation by IE1: mutational analysis of the viral proteins. J. Virol. 64:1498-1506
116. Mansur, C. P., B. Marcus, S. Dalal, and E. J. Androphy. 1995. The domain of p53 required for binding HPV 16 E6 is separable from the degradation domain. Oncogene 10:457-465.
117. Martin, M. E., J. Nicholas, B. J. Thomson, C. Newman, and R. W. Honess. 1991. Identification of a transactivating function mapping to the putative immediate-early locus of human herpesvirus 6. J. Virol. 65:5381-5390.
118. Maudsley, D. J., and J. D. Pound. 1991. Modulation of MHC antigen expression by viruses and oncogenes. Immunol. Today 12:429-431.
119. McDougall, J. K., D. A. Galloway, and C. M. Fenoglio. 1980. Cervical carcinoma: detection of herpes simplex virus RNA in cells undergoing neoplastic change. Int. J. Cancer 25:1-8.
120. McDougall, J. K., J. A. Nelson, D. Myerson, A. M. Beckmann, and D. A. Galloway. 1984. HSV, CMV, and HPV in human neoplasia. J. Investig. Dermatol. 83:72s-76s.
121. Melnick, J. L., C. Hu, J. Burek, E Adam, and M. E. DeBakey. 1994. Cytomegalovirus DNA in arterial walls of patients with atherosclerosis. J. Med. Virol. 42:170-174.
122. Melnick, J. L., R. Lewis, I. Wimberly, R. H. Kaufman, and E. Adam. 1978. Association of cytomegalovirus (CMV) infection with cervical cancer: isolation of CMV from cell cultures derived from cervical biopsy. Intervirology 10:115-119.
123. Miller, G., M. O. Rigsby, L. Heston, E. Grogan, R. Sun, C. Metroka, J. A. Levy, S. J. Gao, Y. Chang, and P. S. Moore. 1996. Antibodies to butyrate-inducible antigens of Kaposi's sarcoma-associated herpesvirus in patients with HIV-1 infection. N. Engl. J. Med. 334:1292-1297.
124. Miyashita, T., and J. C. Reed. 1995. Tumor suppressor p53 is a direct transcriptional activator of the human bax gene. Cell 80:293-299.
125. Moore, P. S., S. J. Gao, G. Dominguez, E. Cesarman, O. Lungu, D. M. Knowles, R. Garber, P. E. Pellett, D. J. McGeoch, and Y. Chang. 1996. Primary characterization of a herpesvirus agent associated with Kaposi's sarcoma. J. Virol. 70:549-558.
126. Muganda, P., O. Mendoza, J. Hernandez, and Q. Qian. 1994. Human cytomegalovirus elevates levels of the cellular protein p53 in infected fibroblasts. J. Virol. 68:8028-8034.
127. Muralidhar, S., J. Doniger, E. Mendelson, J. C. Araujo, F. Kashanchi, N. Azumi, J. N. Brady, and L. J. Rosenthal. 1996. Human cytomegalovirus mtrII oncoprotein binds to p53 and down-regulates p53 activated transcription. J. Virol. 70:8691-8700.
128. Myerson, D., R. C. Hackman, J. A. Nelson, D. C. Ward, and J. K. McDougall. 1984. Widespread presence of histologically occult cytomegalovirus. Hum. Pathol. 15:430-439.
129. Nelson, J. A., B. Fleckenstein, G. Jahn, D. A. Galloway, and J. K. McDougall. 1984. Structure of the transforming region of human cytomegalovirus AD169. J. Virol. 49:109-115.
130. Nevins, J. R. 1992. E2F: a link between the Rb tumor suppressor protein and viral oncoproteins. Science 258:4:24-429.
131. Niederman, J. C., C. R. Liu, M. H. Kaplan, and N. A. Brown. 1988. Clinical and serological features of human herpesvirus-6 infection in three adults. Lancet ii:817-819.
132. Oren, M., W. Maltzman, and A. J. Levine. 1981. Posttranslational regulation of the 54K cellular tumor antigen in normal and transformed cells. Mol. Cell. Biol. 1:101-110.
133. Pacsa, A. S., L. Kummerländer, B. Pejtsik, and K. Pali. 1975. Herpesvirus antibodies and antigens in patients with cervical anaplasia and in controls. J. Natl. Cancer Inst. 55:775-781.
134. Pizzorno, M. C., and G. S. Hayward. 1990. The IE2 gene products of human cytomegalovirus specifically down-regulate expression from the major immediate-early promoter through a target sequence located near the cap site. J. Virol. 64:6154-6165.
135. Pizzorno, M. C., P. O'Hare, L. Sha, R. L. La Femina, and G. S. Hayward. 1988. trans-activation and autoregulation of gene expression by the immediate-early region 2 gene products of human cytomegalovirus. J. Virol. 62:1167-1179.
136. Quinnan, G. V., Jr., H. Masur, A. H. Rook, G. Armstrong, W. R. Frederick, J. Epstein, J. F. Manischewitz, A. M. Macher, L. Jackson, J. Ames, H. A. Smith, M. Parker, G. R. Pearson, J. Parrillo, C. Mitchell, and S. E. Strauss. 1984. Herpesvirus infections in the acquired immune deficiency syndrome. JAMA 252:72-77.
137. Rapp, F. 1984. Cytomegalovirus and carcinogenesis. JNCI 72:783-787.
138. Rapp, F., L. Geder, D. Murasko, R. Lausch, R. Ladda, E. Huang, and M. M. Webber. 1975. Long-term persistence of cytomegalovirus genome in cultured cells of prostatic origin. J. Virol. 16:982-990.
139. Rawls, W. E., S. Bacchetti, and F. L. Graham. 1977. Relation of herpes simplex viruses to human malignancies. Curr. Top. Microbiol. Immunol. 77:71-95.
140. Razzaque, A. 1990. Oncogenic potential of human herpesvirus-6 DNA. Oncogene 5:1365-1370.
141. Razzaque, A., N. Jahan, D. McWeeney, R. J. Jariwalla, C. Jones, J. Brady, and L. J. Rosenthal. 1988. Localization and DNA sequence analysis of the transforming domain (mtrII) of human cytomegalovirus. Proc. Natl. Acad. Sci. USA 85:5709-5713.
142. Razzaque, A., F. Zhu, and C. Jones. 1991. Functional analysis of human cytomegalovirus morphological transforming region II (mtrII). Virology 181:399-402.
143. Reich, N. C., and A. J. Levine. 1984. Growth regulation of a cellular tumor antigen, p53, in nontransformed cells. Nature 308:199-201.
144. Rogel, A., M. Popliker, C. G. Webb, and M. Oren. 1985. p53 cellular tumor antigen: analysis of mRNA levels in normal adult tissues, embryos, and tumors. Mol. Cell. Biol. 5:2851-2855.
145. Roizman, B. 1996. Herpesviridae, p. 2221-2230. In B. N. Fields, D. M. Knipe, and P. M. Howley (ed.), Virology. Lippincott-Raven, Philadelphia, Pa.
146. Ruppert, J. M., and B. Stillman. 1993. Analysis of a protein-binding domain of p53. Mol. Cell. Biol. 13:3811-3820.
147. Russo, J. J., R. A. Bohenzky, M. C. Chien, J. Chen, M. Yan, D. Maddalena, J. P. Parry, D. Peruzzi, I. S. Edelman, Y. Chang, and P. S. Moore. 1996. Nucleotide sequence of the Kaposi sarcoma-associated herpesvirus (HHV8). Proc. Natl. Acad. Sci. USA 93:14862-14867.
148. Salahuddin, S. Z., D. V. Ablashi, P. D. Markham, S. F. Josephs, S. Sturzenegger, M. Kaplan, G. Halligan, P. Biberfeld, F. Wong-Staal, B. Kramarsky, and R. C. Gallo. 1986. Isolation of a new virus, HBLV, in patients with lymphoproliferative disorders. Science 234:596-601.
149. Sanford, E. J., J. E. Dagen, L. Geder, T. J. Rohner, Jr., and F. Rapp. 1977. Lymphocyte reactivity against virally transformed cells in patients with urologie cancer. J. Urol. 118:809-810.
150. Sanford, E. J., L. Geder, A. Laychock, T. J. Rohner, Jr., and F. Rapp. 1977. Evidence for the association of cytomegalovirus with carcinoma of the prostate. J. Urol. 118:789-792.
151. Sarnow, P., Y. S. Ho, J. Williams, and A. J. Levine. 1982. Adenovirus E1B-58kd tumor antigen and SV40 large T antigen are associated with the same 54kd cellular protein in transformed cells. Cell 28:387-394.
152. Schreier, A. A., and J. Gruber. 1990. Viral T antigen interactions with cellular proto-oncogene and anti-oncogene products. J. Natl. Cancer. Inst. 582:354-360.
153. Schuler, G. D., S. F. Altschul, and D. J. Lipman. 1991. A workbench for multiple alignment construction and analysis. Proteins Struct. Fund. Genet. 9:180-190.
154. Seto, E., A. Usheva, G. P. Zambetti, J. Momand, N. Horikoshi, R. Weinmann, A. J. Levine, and T. Shenk. 1992. Wild-type p53 binds to the TATA-binding protein and represses transcription. Proc. Natl. Acad. Sci. USA 89:12028-12032.
155. Shen, Y., H. Zhu, and T. Shenk. 1997. Human cytomegalovirus IE1 and IE2 proteins are mutagenic and mediate "hit-and-run" oncogenic transformation in cooperation with the adenovirus E1A proteins. Proc. Natl. Acad. Sci. USA 94:3341-3345.
156. Smiley, M. L., E. Mar, and E. Huang. 1988. Cytomegalovirus infection and viral-induced transformation of human endothelial cells. J. Med. Virol. 25:213-226.
157. Smith, M. L., I. T. Chen, Q. Zhan, I. Bae, C. Y. Chen, T. M. Gilmer, M. B. Kastan, P. M. O'Conner, and A. J. Fornace, Jr. 1994. Interaction of the p53-regulated protein Gadd45 with proliferating cell nuclear antigen. Science 266:1376-1380.
158. Sommer, M. H., A. L. Scully, and D. H. Spector. 1994. Transactivation by the human cytomegalovirus IE2 86-kilodalton protein requires a domain that binds to both the TATA box-binding protein and the retinoblastoma protein. J. Virol. 68:6223-6231.
159. Sorlie, P. D., E. Adam, S. L. Melnick, A. Folsom, T. Skelton, L. E. Chambless, R. Barnes, and J. L. Melnick. 1994. Cytomegalovirus/herpesvirus and carotid atherosclerosis: the ARIC study. J. Med. Virol. 42:33-37.
160. Soussi, T., C. Caron de Fromentel, and P. May. 1990. Structural aspects of the p53 protein in relation to gene evolution. Oncogene 5:945-952.
161. Speir, E., R. Modali, E. Huang, M. B. Leon, F. Shawl, T. Finkel, and S. E. Epstein. 1994. Potential role of human cytomegalovirus and p53 interaction in coronary restenosis. Science 265:391-394.
162. Sprecher-Goldberger, S., L. Thiry, N. Lefebvere, D. Dekegel, and F. De-Halleux. 1971. Complement fixation antibodies to adeno-associated viruses, cytomegaloviruses, and herpes simplex viruses in patients with tumors and in control individual. Am. J. Epidemiol. 94:351-358.
163. Stagno, S., R. F. Pass, G. Cloud, W. J. Britt, R. E. Henderson, P. D. Walton, D. A. Veren, F. Page, and C. A. Alford. 1986. Primary cytomegalovirus infection in pregnancy. Incidence, transmission to fetus, and clinical outcome. JAMA 256:1904-1908.
164. Stagno, S., D. W. Reynolds, R. F. Pass, and C. A. Alford. 1980. Breast milk and the risk of cytomegalovirus infection. N. Engl. J. Med. 302:1073-1076.
165. Stasiak, P. C., and E. S. Mocarski. 1992. Transactivation of the cytomegalovirus ICP36 gene promoter requires the alpha gene product TRS1 in addition to IE1 and IE2. J. Virol. 66:1050-1058.
166. Staskus, K. A., W. Zhong, K. Gebhard, B. Herndier, H. Wang, R. Renne, J. Beneke, J. Pudney, D. J. Anderson, D. Ganem, and A. T. Haase. 1997. Kaposi's sarcoma-associated herpesvirus gene expression in endothelial (spindle) tumor cells. J. Virol. 71:715-719.
167. Steeper, T. A., C. A. Horwitz, D. V. Ablashi, S. Z. Salahuddin, C. Saxinger, R. Saltzman, and B. Schwartz. 1990. The spectrum of clinical and laboratory findings resulting from human herpesvirus-6 (HHV-6) in patients with mononucleosis-like illnesses not resulting from Epstein-Barr virus or cytomegalovirus. Am. J. Clin. Pathol. 93:776-783.
168. Stenberg, R. M., A. S. Depto, J. Fortney, and J. A. Nelson. 1989. Regulated expression of early and late RNAs and proteins from the human cytomegalovirus immediate-early gene region. J. Virol. 63:2699-2708.
169. Stenberg, R. M., J. Fortney, S. W. Barlow, B. P. Magrane, J. A. Nelson, and P. Ghazal. 1990. Promoter-specific trans activation and repression by human cytomegalovirus immediate-early proteins involves common and unique protein domains. J. Virol. 64:1556-1565.
170. Stenberg, R. M., D. R. Thomsen, and M. F. Stinski. 1984. Structural analysis of the major immediate early gene of human cytomegalovirus. J. Virol. 49:190-199.
171. Stenberg, R. M., P. R. Witte, and M. F. Stinski. 1985. Multiple spliced and unspliced transcripts from human cytomegalovirus immediate-early region 2 and evidence for a common initiation site within immediate-early region 1. J. Virol. 56:665-675.
172. Stoian, M., M. Hozoc, M. Iosipenco, J. Bolocan, and E. Nastac. 1982. Presence of antibodies to human cytomegalovirus in patients with different forms of cancer and in other categories of subjects. Virologie 33:153-161.
173. Stringer, K. F., C. J. Ingles, and J. Greenblatt. 1990. Direct and selective binding of an acidic transcriptional activation domain to the TATA-box factor TFIID. Nature 345:783-786.
174. Subler, M. A., D. W. Martin, and S. Deb. 1992. Inhibition of viral and cellular promoters by human wild-type p53. J. Virol. 66:4757-4762.
175. Takahashi, K., S. Sonoda, K. Higashi, T. Kondo, H. Takahashi, M. Takahashi, and K. Yamanishi. 1989. Predominant CD4 T-lymphocyte tropism of human herpesvirus 6-related virus. J. Virol. 63:3161-3163.
176. Takahashi, K., S. Sonoda, K. Kawakami, K. Miyata, T. Oki, T. Nagata, T. Okuno, and K. Kamanishi. 1988. Human herpesvirus 6 and exanthem subitum. Lancet i:1463. (Letter.)
177. Taya, Y. 1997. RB kinases and RB-binding proteins: new points of view. Trends Biochem. Sci. 22:14-17.
178. Thompson, J., S. Choudhury, F. Kashanchi, J. Doniger, Z. Berneman, N. Frenkel, and L. J. Rosenthal. 1994. A transforming fragment within the direct repeat region of human herpesvirus type 6 that transactivates HIV-1. Oncogene 9:1167-1175.
179. Thompson, J., J. Doniger, and L. J. Rosenthal. 1994. A 79 amino acid oncogene is responsible for human cytomegalovirus mtrII induced malignant transformation. Arch. Virol. 136:161-172.
180. Thompson, J., A. Inamdar, N. Jahan, J. Doniger, and L. J. Rosenthal. 1993. Localization and sequence analysis of morphological transforming region III within human cytomegalovirus strain Towne. Intervirology 36:121-127.
181. Thomson, B. J., F. W. Weindler, D. Gray, V. Schwaab, and R. Heilbronn. 1994. Human herpesvirus 6 (HHV-6) is a helper virus for adeno-associated virus type 2 (AAV-2) and the AAV-2 rep gene homologue in HHV-6 can mediate AAV-2 DNA replication and regulate gene expression. Virology 204:304-311.
182. Torelli, G., P. Barozzi, R. Marasca, P. Cocconcelli, E. Merelli, L. Ceccherini-Nelli, S. Ferrari, and M. Luppi. 1995. Targeted integration of human herpesvirus 6 in the p arm of chromosome 17 of human peripheral blood mononuclear cells in vivo. J. Med. Virol. 46:178-188.
183. Torelli, G., R. Marasca, M. Luppi, L. Selleri, S. Ferrari, F. Narni, M. T. Mariano, M. Federico, L. Ceccherini-Nelli, M. Bendinelli, G. Montagnani, M. Montorsi, and T. Artusi. 1991. Human herpesvirus-6 in human lymphomas: identification of specific sequences in Hodgkin's lymphomas by polymerase chain reaction. Blood 77:2251-2258.
184. Vestergaard, B. F., A. Hornsleth, and S. N. Pedersen. 1972. Occurrence of herpes-and adenovirus antibodies in patients with carcinoma of the cervix uteri. Measurement of antibodies to herpesvirus hominis (types 1 and 2), cytomegalovirus, EB-virus, and adenovirus. Cancer 30:68-74.
185. Wang, J., C. Jones, M. Norcross, E. Bohnlein, and A. Razzaque. 1994. Identification and characterization of a human herpesvirus 6 gene segment capable of transactivating the human immunodeficiency virus type 1 long terminal repeat in an Sp1 binding site-dependent manner. J. Virol. 68: 1706-1713.
186. Wang, J. Y. 1997. Retinoblastoma protein in growth suppression and death protection. Curr. Opin. Genet. Dev. 7:39-45.
187. Wang, J. Y., E. S. Knudsen, and P. J. Welch. 1994. The retinoblastoma tumor suppressor protein. Adv. Cancer Res. 64:25-85.
188. Wang, P., M. Reed, Y. Wang, G. Mayr, J. E. Stenger, M. E. Anderson, J. F. Schwedes, and P. Tegtmeyer. 1994. p53 domains: structure, oligomerization, and transformation. Mol. Cell. Biol. 14:5182-5191.
189. Wang, Y., M. Reed, P. Wang, J. E. Stenger, G. Mayr, M. E. Anderson, J. F. Schwedes, and P. Tegtmeyer. 1993. p53 domains: identification and characterization of two autonomous DNA-binding regions. Genes Dev. 7:2575-2586.
190. Weinberg, R. A. 1995. The retinoblastoma protein and cell cycle control. Cell 81:323-330.
191. Werness, B. A., A. J. Levine, and P. M. Howley. 1990. Association of human papillomavirus type 16 and 18 E6 proteins with p53. Science 248:76-79.
192. Weston, K., and B. G. Barrell. 1986. Sequence of the short unique region, short repeats, and part of the long repeats of human cytomegalovirus. J. Mol. Biol. 192:177-208.
193. Whyte, P., K. J. Buchkovich, J. M. Horowitz, S. H. Friend, M. Raybuck, R. A. Weinberg, and E. Harlow. 1988. Association between an oncogene and an antioncogene: the adenovirus E1A proteins bind to the retinoblastoma gene product. Nature 334:124-129.
194. Yamanishi, K., T. Okuno, K. Shiraki, M. Takahashi, T. Kondo, Y. Asano, and T. Kurata. 1988. Identification of human herpesvirus-6 as a causal agent for exanthem subitum. Lancet i:1065-1067.
195. Yeung, K. C., C. M. Stoltzfus, and M. F. Stinski. 1993. Mutations of the human cytomegalovirus immediate-early 2 protein defines regions and amino acid motifs important in transactivation of transcription from the HIV-1 LTR promoter. Virology 195:786-792.
196. Zhou, Y., C. K. Chang, G. Qian, B. Chandran, and C. Wood. 1994. Transactivation of the HIV promoter by a cDNA and its genomic clones of human herpesvirus 6. Virology 199:311-322.
197. Zhu, H., Y. Shen, and T. Shenk. 1995. Human cytomegalovirus IE1 and IE2 proteins block apoptosis. J. Virol. 69:7960-7970.
198. zur Hausen, H., H. Schulte-Holthausen, G. Klein, W. Henle, G. Henle, P. Clifford, and L. Santesson. 1970. EBV DNA in biopsies of Burkitt tumours and anaplastic carcinomas of the nasopharynx. Nature 228:1056-1058.