Tanshinone IIA prevents the loss of nigrostriatal dopaminergic neurons by inhibiting NADPH oxidase and iNOS in the MPTP model of Parkinson's disease

Journal of the Neurological Sciences

Volumn 348, Issue 1-2, 2015, Pages 142-152

  Ren, Bo ^a   Zhang, Yu Xin ^a   Zhou, Hong Xia ^a   Sun, Fa Wei ^a   Zhang, Zuo Feng ^a   Wei, Zi Feng ^a   Zhang, Cheng Yun ^a   Si, Dao Wen ^a  

^a HEBEI UNITED UNIVERSITY   (China)

Author keywords

iNOS; Microglia; MPTP; NADPH oxidase; Parkinson's disease; Tanshinone IIA

Indexed keywords

1,2,3,6 TETRAHYDRO 1 METHYL 4 PHENYLPYRIDINE; CD11B ANTIGEN; DOPAMINE; INDUCIBLE NITRIC OXIDE SYNTHASE; NEUROPROTECTIVE AGENT; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; TANSHINONE IIA; TYROSINE 3 MONOOXYGENASE; ABIETANE DERIVATIVE; NOS2 PROTEIN, MOUSE; TANSHINONE;

ADULT; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BEHAVIOR CHANGE; CELL ACTIVATION; CELL COUNT; CELL LOSS; CONTROLLED STUDY; DOPAMINERGIC NERVE CELL; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; IN VIVO STUDY; MALE; MICROGLIA; MOTOR PERFORMANCE; MOUSE; NERVE DEGENERATION; NEUROPROTECTION; NEUROTOXICITY; NIGRONEOSTRIATAL SYSTEM; NONHUMAN; PARKINSON DISEASE; PRIORITY JOURNAL; SUBSTANTIA NIGRA; SUBSTANTIA NIGRA PARS COMPACTA; UPREGULATION; WESTERN BLOTTING; ANIMAL; ANIMAL BEHAVIOR; ANTAGONISTS AND INHIBITORS; C57BL MOUSE; DISEASE MODEL; DRUG EFFECTS; METABOLISM; MPTP POISONING; NEOSTRIATUM;

ANIMALS; BEHAVIOR, ANIMAL; DISEASE MODELS, ANIMAL; DITERPENES, ABIETANE; DOPAMINERGIC NEURONS; MALE; MICE; MICE, INBRED C57BL; MICROGLIA; MPTP POISONING; NADPH OXIDASE; NEOSTRIATUM; NEUROPROTECTIVE AGENTS; NITRIC OXIDE SYNTHASE TYPE II; SUBSTANTIA NIGRA;

EID: 84921023128     PISSN: 0022510X     EISSN: 18785883     Source Type: Journal    
DOI: 10.1016/j.jns.2014.11.026     Document Type: Article

References (37)

1. K. Aquilano, S. Baldelli, G. Rotilio, and M.R. Ciriolo Role of nitric oxide synthases in Parkinson's disease: a review on the antioxidant and anti-inflammatory activity of polyphenols Neurochem Res 33 12 2008 2416 2426
2. S. Ayton, J.L. George, P.A. Adlard, A.I. Bush, R.A. Cherny, and D.I. Finkelstein The effect of dopamine on MPTP-induced rotarod disability Neurosci Lett 543 2013 105 109
3. B.M. Babior NADPH oxidase: an update Blood 93 5 1999 1464 1476
4. M.L. Block, and J.S. Hong Microglia and inflammation-mediated neurodegeneration: multiple triggers with a common mechanism Prog Neurobiol 76 2 2005 77 98
5. M.L. Block, and J.S. Hong Chronic microglial activation and progressive dopaminergic neurotoxicity Biochem Soc Trans 35 5 2007 1127 1132
6. M.L. Block, L. Zecca, and J.S. Hong Microglia-mediated neurotoxicity: uncovering the molecular mechanisms Nat Rev Neurosci 8 1 2007 57 69
7. G.C. Brown Mechanisms of inflammatory neurodegeneration: iNOS and NADPH oxidase Biochem Soc Trans 35 5 2007 1119 1121
8. Y. Chen, X. Wu, and S. Yu Neuroprotection of tanshinone IIA against cerebral ischemia/reperfusion injury through inhibition of macrophage migration inhibitory factor in rats PLoS One 7 6 2012 e40165
9. Y. Chen, X. Wu, and S. Yu Neuroprotective capabilities of Tanshinone IIA against cerebral ischemia/reperfusion injury via anti-apoptotic pathway in rats Biol Pharm Bull 35 2 2012 164 170
10. D.K. Choi, S. Pennathur, and C. Perier Ablation of the inflammatory enzyme myeloperoxidase mitigates features of Parkinson's disease in mice J Neurosci 25 28 2005 6594 6600
11. Y.C. Chung, S.R. Kim, and B.K. Jin Paroxetine prevents loss of nigrostriatal dopaminergic neurons by inhibiting brain inflammation and oxidative stress in an experimental model of Parkinson's disease J Immunol 185 2 2010 1230 1237
12. A.R. Cross, and A.W. Segal The NADPH oxidase of professional phagocytes - prototype of the NOX electron transport chain systems Biochim Biophys Acta 1657 1 2004 1 22
13. W. Dauer, and S. Przedborski Parkinson's disease: mechanisms and models Neuron 39 6 2003 889 909
14. J. Fu, H. Huang, J. Liu, R. Pi, J. Chen, and P. Liu Tanshinone IIA protects cardiac myocytes against oxidative stress-triggered damage and apoptosis Eur J Pharmacol 568 1-3 2007 213 221
15. H.M. Gao, B. Liu, W. Zhang, and J.S. Hong Critical role of microglial NADPH oxidase-derived free radicals in the in vitro MPTP model of Parkinson's disease FASEB J 17 13 2003 1954 1956
16. J. Gao, G. Yang, and R. Pi Tanshinone IIA protects neonatal rat cardiomyocytes from adriamycin-induced apoptosis Transl Res 151 2 2008 79 87
17. A. Giovanni, B.A. Sieber, R.E. Heikkila, and P.K. Sonsalla Correlation between the neostriatal content of the 1-methyl-4-phenylpyridinium species and dopaminergic neurotoxicity following 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine administration to several strains of mice J Pharmacol Exp Ther 257 2 1991 691 697
18. H.J. Gundersen, T.F. Bendtsen, and L. Korbo Some new, simple and efficient stereological methods and their use in pathological research and diagnosis APMIS 96 5 1988 379 394
19. E.C. Hirsch, and S. Hunot Neuroinflammation in Parkinson's disease: a target for neuroprotection? Lancet Neurol 8 4 2009 382 397
20. V. Jackson-Lewis, and S. Przedborski Protocol for the MPTP mouse model of Parkinson's disease Nat Protoc 2 1 2007 141 151
21. B.Y. Lam, A.C. Lo, X. Sun, H.W. Luo, S.K. Chung, and N.J. Sucher Neuroprotective effects of tanshinones in transient focal cerebral ischemia in mice Phytomedicine 10 4 2003 286 291
22. G.T. Liberatore, V. Jackson-Lewis, and S. Vukosavic Inducible nitric oxide synthase stimulates dopaminergic neurodegeneration in the MPTP model of Parkinson disease Nat Med 5 12 1999 1403 1409
23. P. Mander, and G.C. Brown Activation of microglial NADPH oxidase is synergistic with glial iNOS expression in inducing neuronal death: a dual-key mechanism of inflammatory neurodegeneration J Neuroinflammation 12 2 2005 20
24. R.L. Miller, M. James-Kracke, G.Y. Sun, and A.Y. Sun Oxidative and inflammatory pathways in Parkinson's disease Neurochem Res 34 1 2009 55 65
25. C.W. Olanow, and W.G. Tatton Etiology and pathogenesis of Parkinson's disease Annu Rev Neurosci 22 1999 123 144
26. S. Przedborski, V. Jackson-Lewis, and R. Djaldetti The parkinsonian toxin MPTP: action and mechanism Restor Neurol Neurosci 16 2 2000 135 142
27. Y.H. Qian, Q. Xiao, and J. Xu The protective effects of tanshinone IIA on β-amyloid protein (1-42)-induced cytotoxicity via activation of the Bcl-xL pathway in neuron Brain Res Bull 88 4 2012 354 358
28. J.M. Savitt, V.L. Dawson, and T.M. Dawson Diagnosis and treatment of Parkinson disease: molecules to medicine J Clin Invest 116 7 2006 1744 1754
29. Y. Wang, Y. Zhang, Z. Wei, H. Li, H. Zhou, and Z. Zhang JNK inhibitor protects dopaminergic neurons by reducing COX-2 expression in the MPTP mouse model of subacute Parkinson's disease J Neurol Sci 285 1-2 2009 172 177
30. N.P. Whitney, T.M. Eidem, H. Peng, Y. Huang, and J.C. Zheng Inflammation mediates varying effects in neurogenesis: relevance to the pathogenesis of brain injury and neurodegenerative disorders J Neurochem 108 6 2009 1343 1359
31. D.C. Wu, V. Jackson-Lewis, and M. Vila Blockade of microglial activation is neuroprotective in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson disease J Neurosci 22 5 2002 1763 1771
32. D.C. Wu, K. Tieu, and O. Cohen Glial cell response: A pathogenic factor in Parkinson's disease J Neurovirol 8 6 2002 551 558
33. D.C. Wu, P. Teismann, K. Tieu, and M. Vila NADPH oxidase mediates oxidative stress in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine model of Parkinson's disease Proc Natl Acad Sci U S A 100 10 2003 6145 6150
34. R. Yang, A. Liu, X. Ma, L. Li, D. Su, and J. Liu Sodium tanshinone IIA sulfonate protects cardiomyocytes against oxidative stress-mediated apoptosis through inhibiting JNK activation J Cardiovasc Pharmacol 51 4 2008 396 401
35. X. Yin, Y. Yin, and F.L. Cao Tanshinone IIA attenuates the inflammatory response and apoptosis after traumatic injury of the spinal cord in adult rats PLoS One 7 6 2012 e38381
36. C. Zhou, Y. Huang, and S. Przedborski Oxidative stress in Parkinson's disease: a mechanism of pathogenic and therapeutic significance Ann N Y Acad Sci 1147 2008 93 104
37. L. Zhou, Z. Zuo, and M.S. Chow Danshen: an overview of its chemistry, pharmacology, pharmacokinetics, and clinical use J Clin Pharmacol 45 12 2005 1345 1359