Preparation of morusin from Ramulus mori and its effects on mice with transplanted H22 hepatocarcinoma

BioFactors

Volumn 40, Issue 6, 2014, Pages 636-645

  Wan, Liang Ze ^a   Ma, Bin ^a   Zhang, Yu Qing ^a  

^a SOOCHOW UNIVERSITY   (China)

Author keywords

Alcohol extract; HPLC DAD; Morusin; Mulberry; NF B

Indexed keywords

ANTINEOPLASTIC AGENT; CASPASE 3; CYCLIN B1; FLUOROURACIL; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; ISOFLAVONE DERIVATIVE; MONOMER; MORUSIN; PROTEIN P53; SEPHADEX; SURVIVIN; UNCLASSIFIED DRUG; ALCOHOL; BIRC5 PROTEIN, MOUSE; CCNB1 PROTEIN, MOUSE; FLAVONOID; INHIBITOR OF APOPTOSIS PROTEIN; PLANT EXTRACT; REPRESSOR PROTEIN; SOLVENT;

ABSENCE OF SIDE EFFECTS; ANALYTIC METHOD; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; ARTICLE; BARK; BRANCHLET; CANCER INHIBITION; CONTROLLED STUDY; DIODE ARRAY DETECTION; DOWN REGULATION; DRUG DETERMINATION; DRUG MECHANISM; DRUG MEGADOSE; DRUG PURITY; ETHNOPHARMACOLOGY; EXPERIMENTAL LIVER NEOPLASM; GENE EXPRESSION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; LIVER CANCER CELL LINE; LIVER CELL CARCINOMA; LOW DRUG DOSE; MALE; MOUSE; MULBERRY; NONHUMAN; PLANT ROOT; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAMULUS MORI; REAL TIME POLYMERASE CHAIN REACTION; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; ULTRAVIOLET SPECTROSCOPY; UPREGULATION; AGONISTS; ANIMAL; ANTAGONISTS AND INHIBITORS; CARCINOMA, HEPATOCELLULAR; CELL SURVIVAL; CHEMISTRY; DRUG EFFECTS; GENE EXPRESSION REGULATION; GENETICS; INSTITUTE FOR CANCER RESEARCH MOUSE; ISOLATION AND PURIFICATION; LIVER NEOPLASMS, EXPERIMENTAL; METABOLISM; MORUS; PATHOLOGY; TUMOR VOLUME;

MORUS (PLANT); MORUS MULTICAULIS; MUS;

ANIMALS; ANTINEOPLASTIC AGENTS, PHYTOGENIC; CARCINOMA, HEPATOCELLULAR; CASPASE 3; CELL SURVIVAL; CYCLIN B1; ETHANOL; FLAVONOIDS; GENE EXPRESSION REGULATION, NEOPLASTIC; INHIBITOR OF APOPTOSIS PROTEINS; LIVER NEOPLASMS, EXPERIMENTAL; MALE; MICE; MICE, INBRED ICR; MORUS; NF-KAPPA B; PLANT BARK; PLANT EXTRACTS; PLANT ROOTS; REPRESSOR PROTEINS; SOLVENTS; TUMOR BURDEN; TUMOR SUPPRESSOR PROTEIN P53;

EID: 84920992421     PISSN: 09516433     EISSN: 18728081     Source Type: Journal    
DOI: 10.1002/biof.1191     Document Type: Article

References (27)

1. Wang, L., Guo, H., Yang, L., Dong, L., Lin, C., et al. (2013) Morusin inhibits human cervical cancer stem cell growth and migration through attenuation of NF-κ B activity and apoptosis induction Mol. Cell. Biochem. 379, 7-18.
2. Lee, J. C., Won, S. J., Chao, C. L., Wu, F. L., Liu, H. S., et al. (2008) Morusin induces apoptosis and suppresses NF-κ B activity in humancolorectal cancer HT-29 cells Biochem. Biophys. Res. Commun. 372, 236-242.
3. Lee, H. J., Ryu, J., Park, S. H., Woo, E. R., Kim, A. R., et al. (2014) Effects of Morus alba L. and natural products including morusin on in vivo secretion and in vitro production of Airway MUC5AC Mucin. Tuberculosis Resp. Dis. 77, 94-97.
4. Zha, X. M., Chen, L., Li, X., Kenichi, K., Yao, X., et al. (2009) Three major metabolites of mulberroside A in rat intestinal contents and feces. Plant. Med. 76, 362-364.
5. Vichasilp, C., Nakagawa, K., Sookwong, P., Higuchi, O., Luemunkong, S., et al. (2012) Development of high 1-deoxynojirimycin (DNJ) content mulberry tea and use of response surface methodology to optimize tea-makingV conditions for highest DNJ extraction. LWT Food Sci. Technol. 45, 226-232.
6. Nomura, T, Fukai, T., Yamada, S., and Katayanagi, M. (1978) Studies on the constituents of the cultivated Mulberry Tree. I. Three new prenylflavones from the root bark of Morus alba L. Chem. Pharm. Bull. 26, 1394-1402.
7. Chi, Y. S., Jong, H. G., Son, K. H., Chang, H. W., Kang, S. K., et al. (2001) Effects of naturally occurring prenylated flavonoids on enzymes metabolizing arachidonic acid: cyclooxygenases and lipoxygenases. Biochem. Pharm. 62, 1185-1191.
8. Kimura, Y., Okuda, H., Nomura, T., Fukai, T., and Arichi, S. (1986) Effects of phenolic constituents from the mulberry tree on arachidonate metabolism in rat platelets. J. Nat. Prod. 49, 639-644.
9. Ko, H. H., Wang, J. J., Lin, H. C., Wang, J. P., and Lin, C. N. (1999) Chemistry and biological activities of constituents from Morus australis. Biochim. Biophys. Acta (BBA) Gen. Subj. 1428, 293-299.
10. De Souza, M. M., Bittar, M., Cechinel-Filho, V., Augusto Yunes . R., Messana, I., et al. (2000) Antinociceptive properties of morusin, a prenylflavonoid isolated from Morus nigra root bark. Zeitschrift Fur Naturforschung C 55, 256-260.
11. Fukai, T., Satoh, K., Nomura, T., and Sakagami, H. (2003) Antinephritis and radical scavenging activity of prenylflavonoids. Fitoterapia 74, 720-724.
12. Sohn, H. Y., Son, K. H., Kwon, C. S., Kwon, G. S., and Kang, S. S. (2004) Antimicrobial and cytotoxic activity of 18 prenylated flavonoids isolated from medicinal plants: Morus alba L., Morus mongolica Schneider, Broussnetia papyrifera (L.) Vent, Sophora flavescens Ait and Echinosophora koreensis Nakai. Phytomedicine 11, 666-672.
13. Kuete, V., Fozing, D. C., Kapche, W., Mbaveng, A. T., Kuiate, J. R., et al. (2009) Antimicrobial activity of the methanolic extract and compounds from Morus mesozygia stem bark. J. Ethnopharmacol. 124, 551-555.
14. Yang, Z. G., Matsuzaki, K., Takamatsu, S., and Kitanaka, S. (2011) Inhibitory effects of constituents from Morus alba var. multicaulis on differentiation of 3T3-L1 cells and nitric oxide production in RAW264.7 Cells Mol. 16, 6010-6022.
15. Dat, N. T., Binh, P. T. X., Quynh, L. T. P., Minh, C. V., Huong, H. T., et al. (2010) Cytotoxic prenylated flavonoids from Morus alba. Fitoterapia 81, 1224-1227.
16. Zhou, D. W. and Li, C. M. (1997) The white mulberry's pharmacological activity. Pharm Ind Arch Plant Med 12, 115-117.
17. Lee, J. C., Won, S. J., Chao, C. L., Wu, F. L., Liu, H. S., et al. (2008) Morusin induces apoptosis and suppresses NF-κB activity in humancolorectal cancer HT-29 cells. Biochem. Biophys. Res. Commun. 372, 236-242.
18. Wang, L., Guo, H., Yang, L., Dong, L., Lin, C., et al. (2013) Morusin inhibits human cervical cancer stem cell growth and migration through attenuation of NF-κB activity and apoptosis induction. Mol. Cell. Biochem. 379, 7-18.
19. Longley, D. B. Harkin, D. P., Johnston, P. G. (2003) 5-fluorouracil: mechanisms of actions and clinical strategies. Nat. Rev. Cancer 3, 330-338.
20. Song, M. K., Park, M. Y., and Sung, M. K. (2013) 5-Fluorouracil-induced changes of intestinal integrity biomarkers in BALB/c mice. J. Cancer Prev. 18, 322-329.
21. Weng, Q., Tan, B., Wang, J., Wang, J., Zhou, H., et al. (2014) 5-Fluorouracil causes severe CNS demyelination by disruption of TCF7L2/HDAC1/HDAC2 complex in adolescent mice. Toxicology 325, 114-150.
22. Pfaffl, M. W. (2001) A new mathematical model for relative quantification in real-time RT-PCR. Nucleic Acids Res. 29, e45-e45.
23. Ke, L. D., Chen, Z., and Yung, W. K. A. (2000) A reliability test of standard-based quantitative PCR: exogenous vs endogenous standards. Mol. Cell. Probes 14, 127-135.
24. Liu, W. and Saint, D. A. (2002) Validation of a quantitative method for real time PCR kinetics. Biochem. Biophys. Res. Commun. 294, 347-353.
25. Merritt, A. J., Potten, C. S., Kemp, C. J., Hickman, J. A., Balmain, A., et al. (1994) The role of p53 in spontaneous and radiation-induced apoptosis in the gastrointestinal tract of normal and p53-deficient mice. Cancer Res. 54, 614-617.
26. Rodrigues, N. R., Rowan, A., Smith, M. E., Kerr, I. B., Bodmer, W. F., et al. (1990) p53 mutations in colorectal cancer. Proc. Natl. Acad. Sci. 87, 7555-7559.
27. Visakorpi, T., Kallioniemi, O. P., Heikkinen, A., Koivula, T., and Isola, J. (1992) Small subgroup of aggressive, highly proliferative prostatic carcinomas defined by p53 accumulation. J. Natl. Cancer Inst. 84, 883-887.