Antinociceptive properties of morusin, a prenylflavonoid isolated from Morus nigra root bark

Zeitschrift fur Naturforschung - Section C Journal of Biosciences

Volumn 55, Issue 3-4, 2000, Pages 256-260

  De Souza, Márcia Maria ^a   Bittar, Magali ^a   Cechinel Filho, Valdir ^a   Yunes, Rosendo Augusto ^b   Messana, Irene ^c   Monache, Franco Delle ^c   Ferrari, Franco ^c  

^a UNIVERSIDADE DO VALE DO ITAJAÍ   (Brazil)

^b FEDERAL UNIVERSITY OF SANTA CATARINA   (Brazil)

^c CATHOLIC UNIVERSITY   (Italy)

Author keywords

Antinociception; Morus nigra; Morusin

Indexed keywords

ANTINOCICEPTIVE AGENT; DISEASE MODEL; DRUG TESTING; MORUSIN; MOUSE; OPIATE RECEPTOR; PRENYLFLAVONOID;

MORUS NIGRA;

EID: 0034102253     PISSN: 09395075     EISSN: None     Source Type: Journal    
DOI: 10.1515/znc-2000-3-418     Document Type: Article

References (15)

1. Abbott F. V. and Melzack R. (1982), Brainstem lesions dissociated neural mechanisms of morphine analgesia in different kinds of pain. Brain Res. 251, 149-155.
2. Abbott F. V. and Franklin K. B. J. (1986), Noncompetitive antagonism of morphine analgesia by diazepan in the formalin test. Pharmacol. Biochem. Behav. 24, 319-321.
3. Alves L. F., Chimiak A., Milewska M. J. and Nomura T. (1988), Progress in the chemistry of organic natural products, 188-191 (Eds. W. Herz, H. Grisebach, G. W. Kirby and Ch. Tamm). Springer Publ., New York.
4. Collier H. D. J., Dinnin L. C., Johnson C. A. and Schneider, C. (1968), The abdominal constriction response and its supression by analgesic drugs in the mouse. Br. J. Pharmac. Chemother. 32, 295-310.
5. Eddy N. B. and Leimback, D. (1953), Synthetic analgesic. II. Dithienylbutenyl and dithienylbutylamines. J. Pharmacol. Exp. Ther. 107, 385-393.
6. Ferrari F., Monacelli B., Messana I. (1999), Comparison between in vivo and in vitro metabolite production of Morus nigra. Planta Med. 65, 85-87.
7. Gaertner M., Müller L., Roos J. F., Cani G., Santos A. R. S., Niero R., Calixto J. B., Yunes R. A., Delle Monache F., Cechinel Filho V. (1999), Analgesic triterpenes from Sebastiania schottiana roots. Phytomedicine 6, 41-44.
8. Graves G. (1996), Medicinal plants, Bracken Books, London.
9. Hunskaar S., Fasmer O. B. and Hole, K. (1985), Formalin test in mice, a useful technique for evaluating mild analgesics. J. Neurosci. Methods 14, 69-76.
10. Hunskaar S., and Hole K. (1987), The formalin test in mice: dissociation between inflammatory and non-inflammatory pain. Pain 30, 103-114.
11. Ko H. H., Yu S. M., Ko F. N., Teng C. M. and Lin C. N. (1997), Bioactive constituents of Morus australis and Broussonetia papyrifera. J. Nat. Prod. 60, 1008-1011.
12. Michalak E. (1997), Apontamentos fitoterápicos da Irmã Eva Michalak, Ed. EPAGRI, Florianópolis, Brazil.
13. Nomura T. and Fukai T. (1981), Prenylflavonoids from the root bark of the cultivated mulberry tree. Heterocycles 15, 1531-1567.
14. Souza M. M., De Jesus R. A. P., Cechinel Filho V. and Schlemper V. (1998), Analgesic profile of hydroalcoholic extract obtained from Marrubium vulgare. Phytomedicine 5, 103-107.
15. Vaz Z. R., Cechinel Filho V., Yunes R. A. and Calixto J. B. (1996), Antinociceptive action of 2-(4-bromobenzoyl)-3-methyl-4,6-dimethoxybenzofuran, a novel xanthoxyline derivative on chemical and thermal models of nociception in mice. J. Pharm. Exp. Ther. 278, 304-312.