Functional knock down of VCAM1 in mice mediated by endoplasmatic reticulum retained intrabodies

mAbs

Volumn 6, Issue 6, 2014, Pages 1394-1401

  Marschall, Andrea L J ^a   Single, Frank N ^b   Schlarmann, Katrin ^c   Bosio, Andreas ^b   Strebe, Nina ^a   Van Den Heuvel, Joop ^c   Frenzel, André ^a   Dübel, Stefan ^a  

^a TECHNICAL UNIVERSITY OF BRAUNSCHWEIG   (Germany)

^b MILTENYI BIOTEC GMBH   (Germany)

^c HELMHOLTZ CENTRE FOR INFECTION RESEARCH   (Germany)

Author keywords

Endoplasmatic reticulum; In vivo knockdown; Intrabody; KDEL; Knockdown; Knockout; Membrane protein mouse model; VCAM1

Indexed keywords

CD45 ANTIGEN; ENDOPLASMATIC RETICULUM RETAINED ANTIBODY; IMMUNOGLOBULIN D; IMMUNOGLOBULIN M; MEMBRANE PROTEIN; PLASMA PROTEIN; PROTEIN; PROTEIN KDEL; RECOMBINANT ANTIBODY; SINGLE CHAIN FRAGMENT VARIABLE ANTIBODY; UNCLASSIFIED DRUG; VASCULAR CELL ADHESION MOLECULE 1;

ANIMAL CELL; ANIMAL EXPERIMENT; ANTIBODY DETECTION; ANTIBODY PRODUCTION; ARTICLE; BLOOD; BONE MARROW; CONTROLLED STUDY; FEMALE; GENE SILENCING; HETEROZYGOTE; HOMOZYGOTE; IN VIVO STUDY; MOUSE; MOUSE MODEL; NONHUMAN; PHENOTYPE; PRE B LYMPHOCYTE; PROTEIN EXPRESSION; PROTEIN FUNCTION; ANIMAL; ANIMAL EMBRYO; C57BL MOUSE; CELL LINE; CYTOLOGY; DOWN REGULATION; DRUG EFFECTS; EMBRYOLOGY; EMBRYONIC STEM CELL; ENDOPLASMIC RETICULUM; FLOW CYTOMETRY; GENETICS; HEK293 CELL LINE; HUMAN; IMMUNOBLOTTING; IMMUNOLOGY; MALE; METABOLISM; TRANSGENIC MOUSE; TRANSPLANTATION;

ANIMALS; BONE MARROW; CELL LINE; DOWN-REGULATION; EMBRYO, MAMMALIAN; EMBRYONIC STEM CELLS; ENDOPLASMIC RETICULUM; FEMALE; FLOW CYTOMETRY; HEK293 CELLS; HUMANS; IMMUNOBLOTTING; MALE; MICE, INBRED C57BL; MICE, TRANSGENIC; PRECURSOR CELLS, B-LYMPHOID; SINGLE-CHAIN ANTIBODIES; VASCULAR CELL ADHESION MOLECULE-1;

EID: 84920987748     PISSN: 19420862     EISSN: 19420870     Source Type: Journal    
DOI: 10.4161/mabs.34377     Document Type: Article

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