Duration and magnitude of nerve growth factor signaling depend on the ratio of p75(LNTR) to TrkA

Journal of Neuroscience Research

Volumn 51, Issue 4, 1998, Pages 442-453

  Twiss, Jeffery L ^a   Wada, H Garrett ^b   Fok, Katherine S ^b   Chan, Samuel D H ^b   Verity, A Neil ^c   Baxter, Gregory T ^b   Shooter, Eric M ^d   Sussman, Howard H ^d  

^a UCLA MEDICAL CENTER   (United States)

^b MOLECULAR DEVICES CORPORATION   (United States)

^c ROCHE BIOSCIENCE   (United States)

^d STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Low affinity neurotrophin receptor; Microphysiometer; Neurotrophin; Signal transduction

Indexed keywords

COMPLEMENTARY DNA; NERVE GROWTH FACTOR; NEUROTROPHIN; NEUROTROPHIN RECEPTOR; POLYCLONAL ANTIBODY; PROTEIN TYROSINE KINASE;

ACIDIFICATION; ANIMAL CELL; ARTICLE; CHO CELL; CONTROLLED STUDY; FIBROBLAST; GENETIC TRANSFECTION; L CELL; MOUSE; NONHUMAN; PHEOCHROMOCYTOMA CELL; PRIORITY JOURNAL; RAT; SCHWANN CELL; SIGNAL TRANSDUCTION;

ANIMALS; ANTIBODIES; CELL LINE; CHO CELLS; CRICETINAE; DNA, ANTISENSE; EXTRACELLULAR SPACE; FIBROBLASTS; NERVE GROWTH FACTORS; PC12 CELLS; PROTO-ONCOGENE PROTEINS; RATS; RECEPTOR PROTEIN-TYROSINE KINASES; RECEPTOR, NERVE GROWTH FACTOR; RECEPTOR, TRKA; RECEPTORS, NERVE GROWTH FACTOR; SCHWANN CELLS; SIGNAL TRANSDUCTION; TRANSFECTION;

EID: 0032519933     PISSN: 03604012     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-4547(19980215)51:4<442::AID-JNR4>3.0.CO;2-C     Document Type: Article

References (50)

1. Anton E, Weskamp G, Reichardt L (1994): Nerve growth factor and its low-affinity receptor promote Schwann cell migration. Proc Natl Acad Sci USA 91:2795-2799.
2. Barde Y-A (1989): Trophic factors and neuronal survival. Neuron 2:1525-1534.
3. Barker PA, Shooter EM (1994): Disruption of NGF binding to the low affinity neurotrophin receptor p75LNTR reduces NGF binding to TrkA on PC12 cells. Neuron 13:203-215.
4. Barker PA, Barbee G, Misko TP, Shooter EM (1994): The low affinity neurotrophin receptor, p75LNTR, is palmitoylated by thioester formation through cysteine 279. J Biol Chem 269:30645-30650.
5. Battleman DS, Geller AI, Chao MV (1993): HSV-I vector-mediated gene transfer of the human nerve growth factor receptor p75hNGFR defines high-affinity NGF binding. J Neurosci 13:941-951.
6. Benedetti M, Levi A, Chao MV (1993): Differential expression of nerve growth factor receptors leads to altered binding affinity and neurotrophin responsivcness. Proc Natl Acad Sci USA 90:7859-7863.
7. Berg MM, Sternberg DW, Hempstead BL, Chao MV (1991): The low-affinity p75 nerve growth factor (NGF) receptor mediates NGF-induced tyrosine phosphorylation. Proc Natl Acad Sci USA 88:7106-7110.
8. 125I-nerve growth factor with PC12 pheochromocytoma cells. Evidence for internalization via high-affinity receptors only and for long-term regulation by nerve growth factor of both high- and low -affinity receptors. J Biol Chem 259:15509-15516.
9. Bonhoeffer T (1996): Neurotrophins and activity-dependent development of the neocortex. Curr Opin Neurobiol 6:119-126.
10. Bothwell M (1995): Functional interactions of neurotrophins and neurotrophin receptors. Annu Rev Neurosci 18:223-253.
11. Cabelli RJ. Hohn A, Shatz CJ (1995): Inhibition of ocular dominance column formation by infusion of NT-4/5 or BDNF. Science 267:1662-1666.
12. Canossa M, Rovelli G, Shooter E (1996a): Transphosphorylation of the neurotrophin Trk receptors. J Biol Chem 271:5812-5818.
13. NGFR- associated protein kinase. EMBO J 15:3369-3376.
14. Carter BD, Lewin GR (1997): Neurotrophins live or let die: Does p75NTR decide? Neuron 18:187-190.
15. Carter B, Kaltschmidt C, Kaltschmidt B, Offenhauser N, BohmMatthaei R, Baeuerle P, Barde Y-A (1996): Selective activation of NF-kB by nerve growth factor through the neurotrophin receptor p75. Science 272:542-545.
16. Casaccia-Bonnefil P, Carter B, Dobrowsky R, Chao M (1996): Death of oligodendrocytes mediated by the interaction of nerve growth factor with its receptor p75. Nature 383:716-719.
17. Chandler L, Parsons M, Hosang M, Shooter E (1984): A monoclonal antibody modulates the interaction of nerve growth factor with PC12 cells. J Biol Chem 259:6882-6889.
18. Chao M (1994): The p75 neurotrophin receptor. J Neurobiol 25:1373-1385.
19. Chao M. Hempstead B (1995): p75 and Trk: A two-receptor system. Trends Neurosci 18:321-326.
20. Crowley C, Spencer S, Nishimura M, Chen K, Pitts-Meek S, Armanini M, Ling L, McMahon S, Shelton D, Levinson A, Phillips H (1994): Mice lacking nerve growth factor display perinatal loss of sensory and sympathetic neurons yet develop basal forebrain cholinergic neurons. Cell 76:1001-1001.
21. Davies AM, Lee KF, Jacnisch R (1993): p75-deficient trigeminal sensory neurons have an altered response to NGF but not to other neurotrophins. Neuron 11:565-574.
22. Dobrowsky R, Werner M, Castellino A, Chao M, Hannun Y (1994): Activation of the sphingomyelin cycle through the low-affinity neurotrophin receptor. Science 265:1596-1599.
23. Dobrowsky R, Jenkins G, Hannun Y (1995): Neurotrophins induce sphingomyelin hydrolysis: Modulation by co-expression of p75NTR with Trk receptors. J Biol Chem 270:22135-22140.
24. Frade J, Rodriguez-Tebar A, Barde Y-A (1996): Induction of cell death by endogenous nerve growth factor through its p75 receptor. Nature 383:166-168.
25. Greene LA, Kaplan DR (1995): Early events in neurotrophin signalling via Trk and p75 receptors. Curr Opin Neurobiol 5:579-587.
26. Hantzopoulos P, Suri C. Glass D, Goldfarb M, Yancopoulos G (1994): The low affinity NGF receptor, p75, can collaborate with each of the Trks to potentiate functional responses to the neurotrophins. Neuron 13:187-201.
27. Hempstead BL, Patil N, Thiel B, Chao MV (1990): Deletion of cytoplasmic sequences of the nerve growth factor receptor leads to loss of high affinity ligand binding. J Biol Chem 265:9595-9598.
28. Hempstead BL, Martin-Zanca D, Kaplan DR, Parada LF, Chao MV (1991): High-affinity NGF binding requires coexpression of the trk proto-oncogene and the low-affinity NGF receptor. Nature 350:678-683.
29. Hosang M, Shooter EM (1987): The internalization of nerve growth factor by high-affinity receptors on pheochromocytoma PC12 cells. EMBO J 6:1197-1202.
30. Huber L. Chao M (1995): A potential interaction of p75 and trkA NGF receptors revealed by affinity crosslinking and immunoprecipitation. J Neurosci Res 40:557-563.
31. Jbanez CF, Ebendal T, Barbany G, Murray-Rust J, Blundell TL, Persson H (1992): Disruption of the low affinity receptorbinding site in NGF allows neuronal survival and differentiation by binding to the trk gene product. Cell 69:329-341.
32. Kahle P, Barker PA, Shooter EM, Hertel C (1994): p75 nerve growth factor receptor modulates p140trkA kinase activity, but not ligand internalization, in PC12 cells. J Neurosci Res 38:599-606.
33. Kaplan DR, Miller FD (1997): Signal transduction by the neurotrophin receptors. Curr Opin Cell Biol 9:213-221.
34. Kokaia M, Ernfors P, Kokaia Z, Elmer E, Jaenisch R. Lindvall O (1995): Suppressed epileptogenesis in BDNF mutant mice. Exp Neurol 133:215-224.
35. Korte M, Carroll P, Wolf E, Brem G, Thoenen H, Bonhoeffer T (1995): Hippocampal long-term potentiation is impaired in mice lacking brain-derived neurotrophic factor. Proc Natl Acad Sci USA 92:8856-8860.
36. Lee KF, Davies AM. Jaenisch R (1994): p75-deficient embryonicdorsal root sensory and neonatal sympathetic neurons display a decreased sensitivity to NGF. Development 120:1027-1033.
37. Lewin G. Barde Y-A (1996): The physiology of the neurotrophins. Annu Rev Neurosci 19:289-318.
38. Lohof A, Ip N, Poo M (1993): Potentiation of developing neuromuscular synapses by the neurotrophins NT-3 and BDNF. Nature 363:350-353.
39. Mahadeo D. Kaplan L. Chao M. Hempstead B (1994): High affinity nerve growth factor binding displays a faster rate of association than pl40trk binding. J Biol Chem 269:6884-6891.
40. Markowska AL, Price D, Koliatsos VE (1996): Selective effects of nerve growth factor on spatial recent memory as assessed by a delayed nonmatching-to-position task in the water maze. J Neurosci 16:3541-3548.
41. Meakin SO, Shooter. EM (1992): The nerve growth factor family of receptors. Trends Neurosci 15:323-331.
42. Owicki J, Bousse L, Hafeman D, Kirk G, Olson J, Wada H, Parce J (1994): The light addressable potentiometric sensor: Principles and biological applications. Annu Rev Biophys Biomol Struct 23:87-113.
43. Parce J, Owicki J, Kereso K, Sigal G, Wada H, Muir V, Bousse L, Ross K, Sikic B, McConnell H (1989): Detection of cell affecting agents with a silicon biosensor. Science 246:243-247.
44. Pitchford S, Moor KD, Glaeser B (1995): Nerve growth factor stimulates rapid metabolic responses in PC12 cells. Am J Physiol 268:C936-C943.
45. Radeke M, Misko T, Hsu C, Herzenberg L. Shooter E (1987): Gene transfer and molecular cloning of the rat nerve growth factor receptor. Nature 325:593-597.
46. Ross AH, Daou MC, McKinnon CA, Condon PJ, Lachyankar MB, Stephens RM, Kaplan DR, Wolf DE (1996): The neurotrophin receptor, gp75, forms a complex with the receptor tyrosine kinase TrkA. J Cell Biol 132:945-953.
47. Rovelli G, Heller RA, Canossa M, Shooter EM (1993): Chimeric tumor necrosis factor-TrkA receptors reveal that ligand-dependent activation of the TrkA tyrosine kinase is sufficient for differentiation and survival of PC12 cells. Proc Natl Acad Sci USA 90:8717-8721.
48. Segal F, Greenberg M (1996): Intracellular signaling pathways activated by neurotrophin factors. Annu Rev Neurosci 19:463-489.
49. Verdi J, Birren S, Inanez C, Persson H, Kaplan D, Benedetti M, Chao M, Anderson D (1994): p75LNGFR regulates Trk signal transduction and NGF-induced neuronal differentiation in MAH cells. Neuron 12:733-745.
50. Weinmaster G, Lemke G (1990): Cell-specific cyclic AMP-mediated induction of the PDGF receptor. EMBO J 9:915-920.