Glial metabotropic glutamate receptor-4 increases maturation and survival of oligodendrocytes

Frontiers in Cellular Neuroscience

Volumn 8, Issue JAN, 2015, Pages

  Spampinato, Simona Federica ^a   Merlo, Sara ^a   Chisari, Mariangela ^a   Nicoletti, Ferdinando ^b,c   Sortino, Maria Angela ^a  

^a UNIVERSITY OF CATANIA   (Italy)

^b SAPIENZA UNIVERSITY OF ROME   (Italy)

^c IRCCS NEUROMED   (Italy)

Author keywords

Astrocytes; Experimental autoimmune encephalomyelitis; Multiple sclerosis; Oligodendrocytes; Transforming growth factor

Indexed keywords

2 AMINO 4 PHOSPHONOBUTYRIC ACID; ALPHA CYCLOPROPYL 4 PHOSPHONOPHENYLGLYCINE; KAINIC ACID; METABOTROPIC RECEPTOR 4; SMALL INTERFERING RNA; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA ANTIBODY;

ANIMAL CELL; ARTICLE; ASTROCYTE; CELL DEATH; CELL DIFFERENTIATION; CELL MATURATION; CELL SURVIVAL; CONTROLLED STUDY; EXCITOTOXICITY; FLOW CYTOMETRY; GENE EXPRESSION; GENE SILENCING; GLIA CELL; IMMUNOCYTOCHEMISTRY; IMMUNOHISTOCHEMISTRY; MICROGLIA; MTT ASSAY; NEUROPROTECTION; NONHUMAN; OLIGODENDROGLIA; POLYACRYLAMIDE GEL ELECTROPHORESIS; RADIOIMMUNOPRECIPITATION; RAT; REAL TIME POLYMERASE CHAIN REACTION; RNA EXTRACTION; WESTERN BLOTTING;

EID: 84920973616     PISSN: 16625102     EISSN: None     Source Type: Journal    
DOI: 10.3389/fncel.2014.00462     Document Type: Article

References (37)

1. Arganda-Carreras, I., Fernandez-Gonzalez, R., Munoz-Barrutia, A., and Ortiz-De-Solorzano, C. (2010). 3D reconstruction of histological sections: application to mammary gland tissue. Microsc. Res. Tech. 73, 1019-1029. doi: 10.1002/jemt.20829
2. Besong, G., Battaglia, G., D'Onofrio, M., Di Marco, R., Ngomba, R. T., Storto, M., et al. (2002). Activation of group III metabotropic glutamate receptors inhibits the production of RANTES in glial cell cultures. J. Neurosci. 22, 5403-5411.
3. Blazevski, J., Petkovic, F., Momcilovic, M., Jevtic, B., Miljkovic, D., and Mostarica Stojkovic, M. (2013). High interleukin-10 expression within the central nervous system may be important for initiation of recovery of Dark Agouti rats from experimental autoimmune encephalomyelitis. Immunobiology 218, 1192-1199. doi: 10.1016/j.imbio.2013.04.004
4. Brionne, T. C., Tesseur, I., Masliah, E., and Wyss-Coray, T. (2003). Loss of TGF-beta 1 leads to increased neuronal cell death and microgliosis in mouse brain. Neuron 40, 1133-1145. doi: 10.1016/s0896-6273(03)00766-9
5. Bruno, V., Battaglia, G., Casabona, G., Copani, A., Caciagli, F., and Nicoletti, F. (1998). Neuroprotection by glial metabotropic glutamate receptors is mediated by transforming growth factor-beta. J. Neurosci. 18, 9594-9600.
6. Caraci, F., Battaglia, G., Sortino, M. A., Spampinato, S., Molinaro, G., Copani, A., et al. (2012). Metabotropic glutamate receptors in neurodegeneration/neuroprotection: still a hot topic? Neurochem. Int. 61, 559-565. doi: 10.1016/j.neuint.2012.01.017
7. Cautain, B., Damoiseaux, J., Bernard, I., van Straaten, H., van Breda Vriesman, P., Boneu, B., et al. (2001). Essential role of TGF-beta in the natural resistance to experimental allergic encephalomyelitis in rats. Eur. J. Immunol. 31, 1132-1140. doi: 10.1002/1521-4141(200104)31:4<1132::aid-immu1132>3.3.co;2-e
8. Conn, P. J., and Pin, J. P. (1997). Pharmacology and functions of metabotropic glutamate receptors. Annu. Rev. Pharmacol. Toxicol. 37, 205-237. doi: 10.1146/annurev.pharmtox.37.1.205
9. Corti, C., Battaglia, G., Molinaro, G., Riozzi, B., Pittaluga, A., Corsi, M., et al. (2007). The use of knock-out mice unravels distinct roles for mGlu2 and mGlu3 metabotropic glutamate receptors in mechanisms of neurodegeneration/neuroprotection. J. Neurosci. 27, 8297-8308. doi: 10.1523/jneurosci.1889-07.2007
10. Deng, W., Wang, H., Rosenberg, P. A., Volpe, J. J., and Jensen, F. E. (2004). Role of metabotropic glutamate receptors in oligodendrocyte excitotoxicity and oxidative stress. Proc. Natl. Acad. Sci. U S A 101, 7751-7756. doi: 10.1073/pnas.0307850101
11. Fallarino, F., Volpi, C., Fazio, F., Notartomaso, S., Vacca, C., Busceti, C., et al. (2010). Metabotropic glutamate receptor-4 modulates adaptive immunity and restrains neuroinflammation. Nat. Med. 16, 897-902. doi: 10.1038/nm.2183
12. Fazio, F., Lionetto, L., Molinaro, G., Bertrand, H. O., Acher, F., Ngomba, R. T., et al. (2012). Cinnabarinic acid, an endogenous metabolite of the kynurenine pathway, activates type 4 metabotropic glutamate receptors. Mol. Pharmacol. 81, 643-656. doi: 10.1124/mol.111.074765
13. Fazio, F., Notartomaso, S., Aronica, E., Storto, M., Battaglia, G., Vieira, E., et al. (2008). Switch in the expression of mGlu1 and mGlu5 metabotropic glutamate receptors in the cerebellum of mice developing experimental autoimmune encephalomyelitis and in autoptic cerebellar samples from patients with multiple sclerosis.Neuropharmacology 55, 491-499. doi: 10.1016/j.neuropharm.2008.06.066
14. Fazio, F., Zappulla, C., Notartomaso, S., Busceti, C., Bessede, A., Scarselli, P., et al. (2014). Cinnabarinic acid, an endogenous agonist of type-4 metabotropic glutamate receptor, suppresses experimental autoimmune encephalomyelitis in mice. Neuropharmacology 81, 237-243. doi: 10.1016/j.neuropharm.2014.02.011
15. Geurts, J. J., Wolswijk, G., Bo, L., Redeker, S., Ramkema, M., Troost, D., et al. (2005). Expression patterns of group III metabotropic glutamate receptors mGluR4 and mGluR8 in multiple sclerosis lesions. J. Neuroimmunol. 158, 182-190. doi: 10.1016/j.jneuroim.2004.08.012
16. Geurts, J. J., Wolswijk, G., Bo, L., van der Valk, P., Polman, C. H., Troost, D., et al. (2003). Altered expression patterns of group I and II metabotropic glutamate receptors in multiple sclerosis. Brain 126, 1755-1766. doi: 10.1093/brain/awg179
17. Johns, L. D., Flanders, K. C., Ranges, G. E., and Sriram, S. (1991). Successful treatment of experimental allergic encephalomyelitis with transforming growth factor-beta 1. J. Immunol. 147, 1792-1796.
18. Johns, L. D., and Sriram, S. (1993). Experimental allergic encephalomyelitis: neutralizing antibody to TGF beta 1 enhances the clinical severity of the disease. J. Neuroimmunol. 47, 1-7. doi: 10.1016/0165-5728(93)90278-7
19. Kuruvilla, A. P., Shah, R., Hochwald, G. M., Liggitt, H. D., Palladino, M. A., and Thorbecke, G. J. (1991). Protective effect of transforming growth factor beta 1 on experimental autoimmune diseases in mice. Proc. Natl. Acad. Sci. U S A 88, 2918-2921. doi: 10.1073/pnas.88.7.2918
20. Lassmann, H. (1998). Neuropathology in multiple sclerosis: new concepts. Mult. Scler. 4, 93-98. doi: 10.1177/135245859800400301
21. Luo, J., Ho, P. P., Buckwalter, M. S., Hsu, T., Lee, L. Y., Zhang, H., et al. (2007). Glia-dependent TGF-beta signaling, acting independently of the TH17 pathway, is critical for initiation of murine autoimmune encephalomyelitis. J. Clin. Invest. 117, 3306-3315. doi: 10.1172/jci31763
22. McMullan, S. M., Phanavanh, B., Li, G. G., and Barger, S. W. (2012). Metabotropic glutamate receptors inhibit microglial glutamate release. ASN Neuro 4:e00094. doi: 10.1042/an20120044
23. Mead, E. L., Mosley, A., Eaton, S., Dobson, L., Heales, S. J., and Pocock, J. M. (2012). Microglial neurotransmitter receptors trigger superoxide production in microglia; consequences for microglial-neuronal interactions. J. Neurochem. 121, 287-301. doi: 10.1111/j.1471-4159.2012.07659.x
24. Murphy, A. C., Lalor, S. J., Lynch, M. A., and Mills, K. H. (2010). Infiltration of Th1 and Th17 cells and activation of microglia in the CNS during the course of experimental autoimmune encephalomyelitis. Brain Behav. Immun. 24, 641-651. doi: 10.1016/j.bbi.2010.01.014
25. Newcombe, J., Uddin, A., Dove, R., Patel, B., Turski, L., Nishizawa, Y., et al. (2008). Glutamate receptor expression in multiple sclerosis lesions. Brain Pathol. 18, 52-61. doi: 10.1111/j.1750-3639.2007.00101.x
26. Nicoletti, F., Bockaert, J., Collingridge, G. L., Conn, P. J., Ferraguti, F., Schoepp, D. D., et al. (2011). Metabotropic glutamate receptors: from the workbench to the bedside. Neuropharmacology 60, 1017-1041. doi: 10.1016/j.neuropharm.2010.10.022
27. Pinteaux-Jones, F., Sevastou, I. G., Fry, V. A., Heales, S., Baker, D., and Pocock, J. M. (2008). Myelin-induced microglial neurotoxicity can be controlled by microglial metabotropic glutamate receptors. J. Neurochem. 106, 442-454. doi: 10.1111/j.1471-4159.2008.05426.x
28. Pitt, D., Werner, P., and Raine, C. S. (2000). Glutamate excitotoxicity in a model of multiple sclerosis. Nat. Med. 6, 67-70. doi: 10.1038/71555
29. Schulz, R., Vogel, T., Dressel, R., and Krieglstein, K. (2008). TGF-beta superfamily members, ActivinA and TGF-beta1, induce apoptosis in oligodendrocytes by different pathways. Cell Tissue Res. 334, 327-338. doi: 10.1007/s00441-008-0714-5
30. Schuster, N., Bender, H., Philippi, A., Subramaniam, S., Strelau, J., Wang, Z., et al. (2002). TGF-beta induces cell death in the oligodendroglial cell line OLI-neu. Glia 40, 95-108. doi: 10.1002/glia.10110
31. Spampinato, S. F., Molinaro, G., Merlo, S., Iacovelli, L., Caraci, F., Battaglia, G., et al. (2012). Estrogen receptors and type 1 metabotropic glutamate receptors are interdependent in protecting cortical neurons against beta-amyloid toxicity. Mol. Pharmacol. 81, 12-20. doi: 10.1124/mol.111.074021
32. Taylor, D. L., Diemel, L. T., and Pocock, J. M. (2003). Activation of microglial group III metabotropic glutamate receptors protects neurons against microglial neurotoxicity. J. Neurosci. 23, 2150-2160.
33. Taylor, D. L., Pirianov, G., Holland, S., McGinnity, C. J., Norman, A. L., Reali, C., et al. (2010). Attenuation of proliferation in oligodendrocyte precursor cells by activated microglia. J. Neurosci. Res. 88, 1632-1644. doi: 10.1002/jnr.22335
34. Vivien, D., and Ali, C. (2006). Transforming growth factor-beta signalling in brain disorders. Cytokine Growth Factor Rev. 17, 121-128. doi: 10.1016/j.cytogfr.2005.09.011
35. Williams, C. J., and Dexter, D. T. (2013). Neuroprotective and symptomatic effects of targeting group III mGlu receptors in neurodegenerative disease. J. Neurochem. 129, 4-20. doi: 10.1111/jnc.12608
36. Yao, H. H., Ding, J. H., Zhou, F., Wang, F., Hu, L. F., Sun, T., et al. (2005). Enhancement of glutamate uptake mediates the neuroprotection exerted by activating group II or III metabotropic glutamate receptors on astrocytes. J. Neurochem. 92, 948-961. doi: 10.1111/j.1471-4159.2004.02937.x
37. Zhou, F., Yao, H. H., Wu, J. Y., Yang, Y. J., Ding, J. H., Zhang, J., et al. (2006). Activation of group II/III metabotropic glutamate receptors attenuates LPS-induced astroglial neurotoxicity via promoting glutamate uptake. J. Neurosci. Res. 84, 268-277. doi: 10.1002/jnr.20897