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Volumn 11, Issue 12, 2014, Pages

Genomic Predictors for Recurrence Patterns of Hepatocellular Carcinoma: Model Derivation and Validation

(23)  Kim, Ji Hoon a,b   Sohn, Bo Hwa a   Lee, Hyun Sung a   Kim, Sang Bae a   Yoo, Jeong Eun c   Park, Yun Yong d   Jeong, Woojin e   Lee, Sung Sook f   Park, Eun Sung c   Kaseb, Ahmed a   Kim, Baek Hui b   Kim, Wan Bae b   Yeon, Jong Eun b   Byun, Kwan Soo b   Chu, In Sun g   Kim, Sung Soo h   Wang, Xin Wei i   Thorgeirsson, Snorri S i   Luk, John M j   Kang, Koo Jeong k   more..


Author keywords

[No Author keywords available]

Indexed keywords

NOTCH1 RECEPTOR; STAT3 PROTEIN;

EID: 84920973424     PISSN: 15491277     EISSN: 15491676     Source Type: Journal    
DOI: 10.1371/journal.pmed.1001770     Document Type: Article
Times cited : (88)

References (55)
  • 1
    • 84920984529 scopus 로고    scopus 로고
    • International Agency for Research on Cancer (2013) GLOBOCAN 2012: estimated cancer incidence, mortality and prevalence worldwide in 2012. Lyon (France): International Agency for Research on Cancer.
    • (2012)
  • 2
    • 7044264264 scopus 로고    scopus 로고
    • Hepatitis C infection and the increasing incidence of hepatocellular carcinoma: a population-based study
    • Davila JA, Morgan RO, Shaib Y, McGlynn KA, El Serag HB, (2004) Hepatitis C infection and the increasing incidence of hepatocellular carcinoma: a population-based study. Gastroenterology 127: 1372–1380.
    • (2004) Gastroenterology , vol.127 , pp. 1372-1380
    • Davila, J.A.1    Morgan, R.O.2    Shaib, Y.3    McGlynn, K.A.4    El Serag, H.B.5
  • 3
    • 0033545541 scopus 로고    scopus 로고
    • Rising incidence of hepatocellular carcinoma in the United States
    • El Serag HB, Mason AC, (1999) Rising incidence of hepatocellular carcinoma in the United States. N Engl J Med 340: 745–750.
    • (1999) N Engl J Med , vol.340 , pp. 745-750
    • El Serag, H.B.1    Mason, A.C.2
  • 4
    • 7044231396 scopus 로고    scopus 로고
    • Hepatocellular carcinoma: recent trends in the United States
    • El Serag HB, (2004) Hepatocellular carcinoma: recent trends in the United States. Gastroenterology 127: S27–S34.
    • (2004) Gastroenterology , vol.127 , pp. S27-S34
    • El Serag, H.B.1
  • 5
    • 0036189111 scopus 로고    scopus 로고
    • Prognostic prediction and treatment strategy in hepatocellular carcinoma
    • Bruix J, Llovet JM, (2002) Prognostic prediction and treatment strategy in hepatocellular carcinoma. Hepatology 35: 519–524.
    • (2002) Hepatology , vol.35 , pp. 519-524
    • Bruix, J.1    Llovet, J.M.2
  • 6
    • 28844480321 scopus 로고    scopus 로고
    • Management of hepatocellular carcinoma
    • Bruix J, Sherman M, (2005) Management of hepatocellular carcinoma. Hepatology 42: 1208–1236.
    • (2005) Hepatology , vol.42 , pp. 1208-1236
    • Bruix, J.1    Sherman, M.2
  • 7
    • 0037308463 scopus 로고    scopus 로고
    • Risk factors contributing to early and late phase intrahepatic recurrence of hepatocellular carcinoma after hepatectomy
    • Imamura H, Matsuyama Y, Tanaka E, Ohkubo T, Hasegawa K, et al. (2003) Risk factors contributing to early and late phase intrahepatic recurrence of hepatocellular carcinoma after hepatectomy. J Hepatol 38: 200–207.
    • (2003) J Hepatol , vol.38 , pp. 200-207
    • Imamura, H.1    Matsuyama, Y.2    Tanaka, E.3    Ohkubo, T.4    Hasegawa, K.5
  • 8
    • 0032742183 scopus 로고    scopus 로고
    • Intention-to-treat analysis of surgical treatment for early hepatocellular carcinoma: resection versus transplantation
    • Llovet JM, Fuster J, Bruix J, (1999) Intention-to-treat analysis of surgical treatment for early hepatocellular carcinoma: resection versus transplantation. Hepatology 30: 1434–1440.
    • (1999) Hepatology , vol.30 , pp. 1434-1440
    • Llovet, J.M.1    Fuster, J.2    Bruix, J.3
  • 9
    • 0034255520 scopus 로고    scopus 로고
    • Different risk factors and prognosis for early and late intrahepatic recurrence after resection of hepatocellular carcinoma
    • Poon RT, Fan ST, Ng IO, Lo CM, Liu CL, et al. (2000) Different risk factors and prognosis for early and late intrahepatic recurrence after resection of hepatocellular carcinoma. Cancer 89: 500–507.
    • (2000) Cancer , vol.89 , pp. 500-507
    • Poon, R.T.1    Fan, S.T.2    Ng, I.O.3    Lo, C.M.4    Liu, C.L.5
  • 12
    • 34250020201 scopus 로고    scopus 로고
    • Hepatocellular carcinoma: epidemiology and molecular carcinogenesis
    • El-Serag HB, Rudolph KL, (2007) Hepatocellular carcinoma: epidemiology and molecular carcinogenesis. Gastroenterology 132: 2557–2576.
    • (2007) Gastroenterology , vol.132 , pp. 2557-2576
    • El-Serag, H.B.1    Rudolph, K.L.2
  • 13
    • 84888270793 scopus 로고    scopus 로고
    • Inflammation and liver tumorigenesis
    • Sun B, Karin M, (2013) Inflammation and liver tumorigenesis. Front Med 7: 242–254.
    • (2013) Front Med , vol.7 , pp. 242-254
    • Sun, B.1    Karin, M.2
  • 14
    • 0022891340 scopus 로고
    • Tumors: wounds that do not heal. Similarities between tumor stroma generation and wound healing
    • Dvorak HF, (1986) Tumors: wounds that do not heal. Similarities between tumor stroma generation and wound healing. N Engl J Med 315: 1650–1659.
    • (1986) N Engl J Med , vol.315 , pp. 1650-1659
    • Dvorak, H.F.1
  • 15
    • 0015489740 scopus 로고
    • Molecular repair, wound healing, and carcinogenesis: tumor production a possible overhealing?
    • Haddow A, (1972) Molecular repair, wound healing, and carcinogenesis: tumor production a possible overhealing? Adv Cancer Res 16: 181–234.
    • (1972) Adv Cancer Res , vol.16 , pp. 181-234
    • Haddow, A.1
  • 16
    • 0037443891 scopus 로고    scopus 로고
    • Oligonucleotide microarray for prediction of early intrahepatic recurrence of hepatocellular carcinoma after curative resection
    • Iizuka N, Oka M, Yamada-Okabe H, Nishida M, Maeda Y, et al. (2003) Oligonucleotide microarray for prediction of early intrahepatic recurrence of hepatocellular carcinoma after curative resection. Lancet 361: 923–929.
    • (2003) Lancet , vol.361 , pp. 923-929
    • Iizuka, N.1    Oka, M.2    Yamada-Okabe, H.3    Nishida, M.4    Maeda, Y.5
  • 17
    • 4544273428 scopus 로고    scopus 로고
    • Classification and prediction of survival in hepatocellular carcinoma by gene expression profiling
    • Lee JS, Chu IS, Heo J, Calvisi DF, Sun Z, et al. (2004) Classification and prediction of survival in hepatocellular carcinoma by gene expression profiling. Hepatology 40: 667–676.
    • (2004) Hepatology , vol.40 , pp. 667-676
    • Lee, J.S.1    Chu, I.S.2    Heo, J.3    Calvisi, D.F.4    Sun, Z.5
  • 18
    • 42249087302 scopus 로고    scopus 로고
    • Gene expression-based recurrence prediction of hepatitis B virus-related human hepatocellular carcinoma
    • Woo HG, Park ES, Cheon JH, Kim JH, Lee JS, et al. (2008) Gene expression-based recurrence prediction of hepatitis B virus-related human hepatocellular carcinoma. Clin Cancer Res 14: 2056–2064.
    • (2008) Clin Cancer Res , vol.14 , pp. 2056-2064
    • Woo, H.G.1    Park, E.S.2    Cheon, J.H.3    Kim, J.H.4    Lee, J.S.5
  • 19
    • 0037391756 scopus 로고    scopus 로고
    • Predicting hepatitis B virus-positive metastatic hepatocellular carcinomas using gene expression profiling and supervised machine learning
    • Ye QH, Qin LX, Forgues M, He P, Kim JW, et al. (2003) Predicting hepatitis B virus-positive metastatic hepatocellular carcinomas using gene expression profiling and supervised machine learning. Nat Med 9: 416–423.
    • (2003) Nat Med , vol.9 , pp. 416-423
    • Ye, Q.H.1    Qin, L.X.2    Forgues, M.3    He, P.4    Kim, J.W.5
  • 20
    • 57349090407 scopus 로고    scopus 로고
    • Gene expression in fixed tissues and outcome in hepatocellular carcinoma
    • Hoshida Y, Villanueva A, Kobayashi M, Peix J, Chiang DY, et al. (2008) Gene expression in fixed tissues and outcome in hepatocellular carcinoma. N Engl J Med 359: 1995–2004.
    • (2008) N Engl J Med , vol.359 , pp. 1995-2004
    • Hoshida, Y.1    Villanueva, A.2    Kobayashi, M.3    Peix, J.4    Chiang, D.Y.5
  • 21
    • 33747029250 scopus 로고    scopus 로고
    • Prediction of venous metastases, recurrence, and prognosis in hepatocellular carcinoma based on a unique immune response signature of the liver microenvironment
    • Budhu A, Forgues M, Ye QH, Jia HL, He P, et al. (2006) Prediction of venous metastases, recurrence, and prognosis in hepatocellular carcinoma based on a unique immune response signature of the liver microenvironment. Cancer Cell 10: 99–111.
    • (2006) Cancer Cell , vol.10 , pp. 99-111
    • Budhu, A.1    Forgues, M.2    Ye, Q.H.3    Jia, H.L.4    He, P.5
  • 22
    • 35948981211 scopus 로고    scopus 로고
    • Identification and validation of a novel gene signature associated with the recurrence of human hepatocellular carcinoma
    • Wang SM, Ooi LL, Hui KM, (2007) Identification and validation of a novel gene signature associated with the recurrence of human hepatocellular carcinoma. Clin Cancer Res 13: 6275–6283.
    • (2007) Clin Cancer Res , vol.13 , pp. 6275-6283
    • Wang, S.M.1    Ooi, L.L.2    Hui, K.M.3
  • 23
    • 80052867878 scopus 로고    scopus 로고
    • Upregulation of Rac GTPase-activating protein 1 is significantly associated with the early recurrence of human hepatocellular carcinoma
    • Wang SM, Ooi LL, Hui KM, (2011) Upregulation of Rac GTPase-activating protein 1 is significantly associated with the early recurrence of human hepatocellular carcinoma. Clin Cancer Res 17: 6040–6051.
    • (2011) Clin Cancer Res , vol.17 , pp. 6040-6051
    • Wang, S.M.1    Ooi, L.L.2    Hui, K.M.3
  • 24
    • 77956249298 scopus 로고    scopus 로고
    • microRNA-122 as a regulator of mitochondrial metabolic gene network in hepatocellular carcinoma
    • Burchard J, Zhang C, Liu AM, Poon RT, Lee NP, et al. (2010) microRNA-122 as a regulator of mitochondrial metabolic gene network in hepatocellular carcinoma. Mol Syst Biol 6: 402.
    • (2010) Mol Syst Biol , vol.6 , pp. 402
    • Burchard, J.1    Zhang, C.2    Liu, A.M.3    Poon, R.T.4    Lee, N.P.5
  • 25
    • 84859393351 scopus 로고    scopus 로고
    • Integrative genomic identification of genes on 8p associated with hepatocellular carcinoma progression and patient survival
    • Roessler S, Long EL, Budhu A, Chen Y, Zhao X, et al. (2011) Integrative genomic identification of genes on 8p associated with hepatocellular carcinoma progression and patient survival. Gastroenterology 142: 957–966.
    • (2011) Gastroenterology , vol.142 , pp. 957-966
    • Roessler, S.1    Long, E.L.2    Budhu, A.3    Chen, Y.4    Zhao, X.5
  • 26
    • 63349083847 scopus 로고    scopus 로고
    • Unique early gene expression patterns in human adult-to-adult living donor liver grafts compared to deceased donor grafts
    • de Jonge J, Kurian S, Shaked A, Reddy KR, Hancock W, et al. (2009) Unique early gene expression patterns in human adult-to-adult living donor liver grafts compared to deceased donor grafts. Am J Transplant 9: 758–772.
    • (2009) Am J Transplant , vol.9 , pp. 758-772
    • de Jonge, J.1    Kurian, S.2    Shaked, A.3    Reddy, K.R.4    Hancock, W.5
  • 27
    • 0037316303 scopus 로고    scopus 로고
    • A comparison of normalization methods for high density oligonucleotide array data based on variance and bias
    • Bolstad BM, Irizarry RA, Astrand M, Speed TP, (2003) A comparison of normalization methods for high density oligonucleotide array data based on variance and bias. Bioinformatics 19: 185–193.
    • (2003) Bioinformatics , vol.19 , pp. 185-193
    • Bolstad, B.M.1    Irizarry, R.A.2    Astrand, M.3    Speed, T.P.4
  • 28
    • 34447560961 scopus 로고    scopus 로고
    • Analysis of gene expression data using BRB-Array Tools
    • Simon R, Lam A, Li M-C, Ngan M, Menenzes S, et al. (2007) Analysis of gene expression data using BRB-Array Tools. Cancer Inform 3: 11–17.
    • (2007) Cancer Inform , vol.3 , pp. 11-17
    • Simon, R.1    Lam, A.2    Li, M.-C.3    Ngan, M.4    Menenzes, S.5
  • 29
    • 0348143180 scopus 로고    scopus 로고
    • A random variance model for detection of differential gene expression in small microarray experiments
    • Wright GW, Simon RM, (2003) A random variance model for detection of differential gene expression in small microarray experiments. Bioinformatics 19: 2448–2455.
    • (2003) Bioinformatics , vol.19 , pp. 2448-2455
    • Wright, G.W.1    Simon, R.M.2
  • 30
    • 0035991757 scopus 로고    scopus 로고
    • A paradigm for class prediction using gene expression profiles
    • Radmacher MD, McShane LM, Simon R, (2002) A paradigm for class prediction using gene expression profiles. J Comput Biol 9: 505–511.
    • (2002) J Comput Biol , vol.9 , pp. 505-511
    • Radmacher, M.D.1    McShane, L.M.2    Simon, R.3
  • 31
    • 0037076272 scopus 로고    scopus 로고
    • Diagnosis of multiple cancer types by shrunken centroids of gene expression
    • Tibshirani R, Hastie T, Narasimhan B, Chu G, (2002) Diagnosis of multiple cancer types by shrunken centroids of gene expression. Proc Natl Acad Sci U S A 99: 6567–6572.
    • (2002) Proc Natl Acad Sci U S A , vol.99 , pp. 6567-6572
    • Tibshirani, R.1    Hastie, T.2    Narasimhan, B.3    Chu, G.4
  • 32
    • 0000336139 scopus 로고
    • Regression models with life tables
    • Cox DR, (1972) Regression models with life tables. J R Stat Soc 34: 187–220.
    • (1972) J R Stat Soc , vol.34 , pp. 187-220
    • Cox, D.R.1
  • 33
    • 84894571860 scopus 로고    scopus 로고
    • Causal analysis approaches in Ingenuity Pathway Analysis
    • Kramer A, Green J, Pollard J, JrTugendreich S, (2014) Causal analysis approaches in Ingenuity Pathway Analysis. Bioinformatics 30: 523–530.
    • (2014) Bioinformatics , vol.30 , pp. 523-530
    • Kramer, A.1    Green, J.2    Pollard, J.3    Tugendreich, S.4
  • 34
    • 84862808163 scopus 로고    scopus 로고
    • Sixty-five gene-based risk score classifier predicts overall survival in hepatocellular carcinoma
    • Kim SM, Leem SH, Chu IS, Park YY, Kim SC, et al. (2011) Sixty-five gene-based risk score classifier predicts overall survival in hepatocellular carcinoma. Hepatology 55: 1443–1452.
    • (2011) Hepatology , vol.55 , pp. 1443-1452
    • Kim, S.M.1    Leem, S.H.2    Chu, I.S.3    Park, Y.Y.4    Kim, S.C.5
  • 35
    • 30944460078 scopus 로고    scopus 로고
    • Factors associated with early recurrence after resection for hepatocellular carcinoma and outcomes
    • Shah SA, Greig PD, Gallinger S, Cattral MS, Dixon E, et al. (2006) Factors associated with early recurrence after resection for hepatocellular carcinoma and outcomes. J Am Coll Surg 202: 275–283.
    • (2006) J Am Coll Surg , vol.202 , pp. 275-283
    • Shah, S.A.1    Greig, P.D.2    Gallinger, S.3    Cattral, M.S.4    Dixon, E.5
  • 36
    • 0348047632 scopus 로고    scopus 로고
    • Risk factors for early death due to recurrence after liver resection for hepatocellular carcinoma: results of a multicenter study
    • Regimbeau JM, Abdalla EK, Vauthey JN, Lauwers GY, Durand F, et al. (2004) Risk factors for early death due to recurrence after liver resection for hepatocellular carcinoma: results of a multicenter study. J Surg Oncol 85: 36–41.
    • (2004) J Surg Oncol , vol.85 , pp. 36-41
    • Regimbeau, J.M.1    Abdalla, E.K.2    Vauthey, J.N.3    Lauwers, G.Y.4    Durand, F.5
  • 37
    • 0029810042 scopus 로고    scopus 로고
    • Prognosis of recurrent hepatocellular carcinoma: a 10-year surgical experience in Japan
    • Shimada M, Takenaka K, Gion T, Fujiwara Y, Kajiyama K, et al. (1996) Prognosis of recurrent hepatocellular carcinoma: a 10-year surgical experience in Japan. Gastroenterology 111: 720–726.
    • (1996) Gastroenterology , vol.111 , pp. 720-726
    • Shimada, M.1    Takenaka, K.2    Gion, T.3    Fujiwara, Y.4    Kajiyama, K.5
  • 38
    • 44449132236 scopus 로고    scopus 로고
    • The significance of acute phase small-for-size graft injury on tumor growth and invasiveness after liver transplantation
    • Man K, Lo CM, Xiao JW, Ng KT, Sun BS, et al. (2008) The significance of acute phase small-for-size graft injury on tumor growth and invasiveness after liver transplantation. Ann Surg 247: 1049–1057.
    • (2008) Ann Surg , vol.247 , pp. 1049-1057
    • Man, K.1    Lo, C.M.2    Xiao, J.W.3    Ng, K.T.4    Sun, B.S.5
  • 39
    • 79959857459 scopus 로고    scopus 로고
    • Growth of hepatocellular carcinoma in the regenerating liver
    • Shi JH, Huitfeldt HS, Suo ZH, Line PD, (2011) Growth of hepatocellular carcinoma in the regenerating liver. Liver Transpl 17: 866–874.
    • (2011) Liver Transpl , vol.17 , pp. 866-874
    • Shi, J.H.1    Huitfeldt, H.S.2    Suo, Z.H.3    Line, P.D.4
  • 40
    • 21344466512 scopus 로고    scopus 로고
    • Ischemia/reperfusion accelerates the outgrowth of hepatic micrometastases in a highly standardized murine model
    • van der Bilt JD, Kranenburg O, Nijkamp MW, Smakman N, Veenendaal LM, et al. (2005) Ischemia/reperfusion accelerates the outgrowth of hepatic micrometastases in a highly standardized murine model. Hepatology 42: 165–175.
    • (2005) Hepatology , vol.42 , pp. 165-175
    • van der Bilt, J.D.1    Kranenburg, O.2    Nijkamp, M.W.3    Smakman, N.4    Veenendaal, L.M.5
  • 41
    • 41549146578 scopus 로고    scopus 로고
    • Ageing and hepatic steatosis exacerbate ischemia/reperfusion-accelerated outgrowth of colorectal micrometastases
    • van der Bilt JD, Kranenburg O, Borren A, van HR, Borel Rinkes IH, (2008) Ageing and hepatic steatosis exacerbate ischemia/reperfusion-accelerated outgrowth of colorectal micrometastases. Ann Surg Oncol 15: 1392–1398.
    • (2008) Ann Surg Oncol , vol.15 , pp. 1392-1398
    • van der Bilt, J.D.1    Kranenburg, O.2    Borren, A.3    van, H.R.4    Borel Rinkes, I.H.5
  • 42
    • 37549030135 scopus 로고    scopus 로고
    • Ischemia-reperfusion of small liver remnant promotes liver tumor growth and metastases—activation of cell invasion and migration pathways
    • Man K, Ng KT, Lo CM, Ho JW, Sun BS, et al. (2007) Ischemia-reperfusion of small liver remnant promotes liver tumor growth and metastases—activation of cell invasion and migration pathways. Liver Transpl 13: 1669–1677.
    • (2007) Liver Transpl , vol.13 , pp. 1669-1677
    • Man, K.1    Ng, K.T.2    Lo, C.M.3    Ho, J.W.4    Sun, B.S.5
  • 43
    • 0035800524 scopus 로고    scopus 로고
    • Methylation of histone H4 at arginine 3 facilitating transcriptional activation by nuclear hormone receptor
    • Wang H, Huang ZQ, Xia L, Feng Q, Erdjument-Bromage H, et al. (2001) Methylation of histone H4 at arginine 3 facilitating transcriptional activation by nuclear hormone receptor. Science 293: 853–857.
    • (2001) Science , vol.293 , pp. 853-857
    • Wang, H.1    Huang, Z.Q.2    Xia, L.3    Feng, Q.4    Erdjument-Bromage, H.5
  • 44
    • 84885361397 scopus 로고    scopus 로고
    • The STAT3-Ser/Hes3 signaling axis: an emerging regulator of endogenous regeneration and cancer growth
    • Poser SW, Park DM, Androutsellis-Theotokis A, (2013) The STAT3-Ser/Hes3 signaling axis: an emerging regulator of endogenous regeneration and cancer growth. Front Physiol 4: 273.
    • (2013) Front Physiol , vol.4 , pp. 273
    • Poser, S.W.1    Park, D.M.2    Androutsellis-Theotokis, A.3
  • 45
    • 74549217325 scopus 로고    scopus 로고
    • Hepatocyte IKKbeta/NF-kappaB inhibits tumor promotion and progression by preventing oxidative stress-driven STAT3 activation
    • He G, Yu GY, Temkin V, Ogata H, Kuntzen C, et al. (2010) Hepatocyte IKKbeta/NF-kappaB inhibits tumor promotion and progression by preventing oxidative stress-driven STAT3 activation. Cancer Cell 17: 286–297.
    • (2010) Cancer Cell , vol.17 , pp. 286-297
    • He, G.1    Yu, G.Y.2    Temkin, V.3    Ogata, H.4    Kuntzen, C.5
  • 46
    • 70350500225 scopus 로고    scopus 로고
    • STATs in cancer inflammation and immunity: a leading role for STAT3
    • Yu H, Pardoll D, Jove R, (2009) STATs in cancer inflammation and immunity: a leading role for STAT3. Nat Rev Cancer 9: 798–809.
    • (2009) Nat Rev Cancer , vol.9 , pp. 798-809
    • Yu, H.1    Pardoll, D.2    Jove, R.3
  • 47
    • 34447327216 scopus 로고    scopus 로고
    • Gender disparity in liver cancer due to sex differences in MyD88-dependent IL-6 production
    • Naugler WE, Sakurai T, Kim S, Maeda S, Kim K, et al. (2007) Gender disparity in liver cancer due to sex differences in MyD88-dependent IL-6 production. Science 317: 121–124.
    • (2007) Science , vol.317 , pp. 121-124
    • Naugler, W.E.1    Sakurai, T.2    Kim, S.3    Maeda, S.4    Kim, K.5
  • 48
    • 2342462460 scopus 로고    scopus 로고
    • Interleukin 22 (IL-22) plays a protective role in T cell-mediated murine hepatitis: IL-22 is a survival factor for hepatocytes via STAT3 activation
    • Radaeva S, Sun R, Pan HN, Hong F, Gao B, (2004) Interleukin 22 (IL-22) plays a protective role in T cell-mediated murine hepatitis: IL-22 is a survival factor for hepatocytes via STAT3 activation. Hepatology 39: 1332–1342.
    • (2004) Hepatology , vol.39 , pp. 1332-1342
    • Radaeva, S.1    Sun, R.2    Pan, H.N.3    Hong, F.4    Gao, B.5
  • 49
    • 34047250349 scopus 로고    scopus 로고
    • Concomitant activation of the JAK/STAT, PI3K/AKT, and ERK signaling is involved in leptin-mediated promotion of invasion and migration of hepatocellular carcinoma cells
    • Saxena NK, Sharma D, Ding X, Lin S, Marra F, et al. (2007) Concomitant activation of the JAK/STAT, PI3K/AKT, and ERK signaling is involved in leptin-mediated promotion of invasion and migration of hepatocellular carcinoma cells. Cancer Res 67: 2497–2507.
    • (2007) Cancer Res , vol.67 , pp. 2497-2507
    • Saxena, N.K.1    Sharma, D.2    Ding, X.3    Lin, S.4    Marra, F.5
  • 50
    • 77956331142 scopus 로고    scopus 로고
    • Notch signaling in the regulation of stem cell self-renewal and differentiation
    • Liu J, Sato C, Cerletti M, Wagers A, (2010) Notch signaling in the regulation of stem cell self-renewal and differentiation. Curr Top Dev Biol 92: 367–409.
    • (2010) Curr Top Dev Biol , vol.92 , pp. 367-409
    • Liu, J.1    Sato, C.2    Cerletti, M.3    Wagers, A.4
  • 51
    • 84903534965 scopus 로고    scopus 로고
    • RalA signaling pathway as a therapeutic target in hepatocellular carcinoma (HCC)
    • Ezzeldin M, Borrego-Diaz E, Taha M, Esfandyari T, Wise AL, et al. (2014) RalA signaling pathway as a therapeutic target in hepatocellular carcinoma (HCC). Mol Oncol 8: 1043–1053.
    • (2014) Mol Oncol , vol.8 , pp. 1043-1053
    • Ezzeldin, M.1    Borrego-Diaz, E.2    Taha, M.3    Esfandyari, T.4    Wise, A.L.5
  • 52
    • 84858709292 scopus 로고    scopus 로고
    • High expression of CCL20 is associated with poor prognosis in patients with hepatocellular carcinoma after curative resection
    • Ding X, Wang K, Wang H, Zhang G, Liu Y, et al. (2012) High expression of CCL20 is associated with poor prognosis in patients with hepatocellular carcinoma after curative resection. J Gastrointest Surg 16: 828–836.
    • (2012) J Gastrointest Surg , vol.16 , pp. 828-836
    • Ding, X.1    Wang, K.2    Wang, H.3    Zhang, G.4    Liu, Y.5
  • 53
    • 50449106127 scopus 로고    scopus 로고
    • SOCS-3 is associated with vascular invasion and overall survival in hepatocellular carcinoma
    • Yang SF, Yeh YT, Wang SN, Hung SC, Chen WT, et al. (2008) SOCS-3 is associated with vascular invasion and overall survival in hepatocellular carcinoma. Pathology 40: 558–563.
    • (2008) Pathology , vol.40 , pp. 558-563
    • Yang, S.F.1    Yeh, Y.T.2    Wang, S.N.3    Hung, S.C.4    Chen, W.T.5
  • 55
    • 84860630975 scopus 로고    scopus 로고
    • Targeting the interleukin-6/Jak/stat pathway in human malignancies
    • Sansone P, Bromberg J, (2012) Targeting the interleukin-6/Jak/stat pathway in human malignancies. J Clin Oncol 30: 1005–1014.
    • (2012) J Clin Oncol , vol.30 , pp. 1005-1014
    • Sansone, P.1    Bromberg, J.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.