Aromatase P450 expression in human pituitary adenomas

Neuropathology

Volumn 35, Issue 1, 2015, Pages 16-23

  Gonzales, Paulo Henrique ^a   Mezzomo, Lisiane Cervieri ^a   Ferreira, Nelson Pires ^b   Roehe, Adriana Vial ^a   Kohek, Maria Beatriz Fonte ^a   Oliveira, Miriam da Costa ^a,b  

^a UNIVERSIDADE FEDERAL DE CIÊNCIAS DA SAÚDE DE PORTO ALEGRE   (Brazil)

^b Neuroendocrinology Center   (Brazil)

Author keywords

Aromatase; Enzyme; Estrogen; Pituitary adenoma; Tumorigenesis

Indexed keywords

AROMATASE; CYP19A1 PROTEIN, HUMAN;

ACTH SECRETING ADENOMA; ADULT; AGED; ARTICLE; CROSS-SECTIONAL STUDY; FEMALE; GENDER; GROWTH HORMONE SECRETING ADENOMA; HUMAN; HUMAN TISSUE; HYPOPHYSIS ADENOMA; IMMUNOHISTOCHEMISTRY; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; PROLACTINOMA; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TUMOR VOLUME; ADENOMA; ADOLESCENT; CLASSIFICATION; CUSHING DISEASE; ENZYMOLOGY; HYPOPHYSIS TUMOR; METABOLISM; MIDDLE AGED; PATHOLOGY; SEX DIFFERENCE; YOUNG ADULT;

ADENOMA; ADOLESCENT; ADULT; AGED; AROMATASE; CROSS-SECTIONAL STUDIES; FEMALE; HUMANS; MALE; MIDDLE AGED; PITUITARY ACTH HYPERSECRETION; PITUITARY NEOPLASMS; SEX FACTORS; YOUNG ADULT;

EID: 84920972658     PISSN: 09196544     EISSN: 14401789     Source Type: Journal    
DOI: 10.1111/neup.12145     Document Type: Article

References (50)

1. Simpson ER, Clyne C, Rubin G etal. Aromatase - a brief overview. Annu Rev Physiol 2002; 64: 93-127.
2. Bhawar SB, Dighe NS, Laware RB, Shinde HV, Gaware VM. Aromatase enzyme: a review. Int J Drug Form Res 2010; 1: 240-251.
3. Achermann J, Hughes L. Disorders of sex development. In: Kronenberg HM, Shlomo M, Polonsky KS, Larsen PR, eds. Williams Textbook of Endocrinology, 11th edn. Philadelphia: Saunders Elsevier, 2008; 783-848.
4. Santen RJ, Brodie H, Simpson ER, Siiteri PK, Brodie A. History of aromatase: saga of an important biological mediator and therapeutic target. Endocr Rev 2009; 30: 343-375.
5. Singer CF, Fink-Retter A, Gschwantler-Kaulich D etal. Selective spatial upregulation of intratumoral stromal aromatase in breast cancer patients: evidence for imbalance of local estrogen metabolism. Endocr Relat Cancer 2006; 13: 1101-1107.
6. Leães CG, Meurer RT, Coutinho LB, Ferreira NP, Pereira-Lima JF, da Costa Oliveira M. Immunohistochemical expression of aromatase and estrogen, androgen and progesterone receptors in normal and neoplastic human meningeal cells. Neuropathology 2010; 30: 44-49.
7. Lombardi G, Zarrilli S, Colao A etal. Estrogen and health in males. Mol Cell Endocrinol 2001; 178: 51-55.
8. Shupnik MA. Oestrogen receptors, receptor variants and oestrogen actions in the hypothalamic-pituitary axis. J Neuroendocrinol 2002; 14: 85-94.
9. Rosen MP, Female CMI. Reproductive endocrinology & infertility. In: Gardner DG, Shoback D, eds. Greenspan's Basic & Clinical Endocrinology, 7th edn. New York: McGraw-Hill Companies, 2004; 511-563.
10. Braunstein GD. Testes. Gardner DG, Shoback D (eds) Greenspan's Basic & Clinical Endocrinology, 7th edn. New York: McGraw-Hill Companies, 2004; 478-510.
11. Pereira-Lima JF, Marroni CP, Pizarro CB, Barbosa-Coutinho LM, Ferreira NP, Oliveira MC. Immunohistochemical detection of estrogen receptor alpha in pituitary adenomas and its correlation with cellular replication. Neuroendocrinology 2004; 79: 119-124.
12. Manoranjan B, Salehi F, Scheithauer BW, Rotondo F, Kovacs K, Cusimano MD. Estrogen receptors alpha and beta immunohistochemical expression: clinicopathological correlations in pituitary adenomas. Anticancer Res 2010; 30: 2897-2904.
13. Friend KE, Chiou YK, Lopes MB, Laws ER Jr, Hughes KM, Shupnik MA. Estrogen receptor expression in human pituitary: correlation with immunohistochemistry in normal tissue, and immunohistochemistry and morphology in macroadenomas. J Clin Endocrinol Metab 1994; 78: 1497-1504.
14. Gittoes NJ, McCabe CJ, Sheppard MC, Franklyn JA. Estrogen receptor beta mRNA expression in normal and adenomatous pituitaries. Pituitary 1999; 1: 99-104.
15. Zhou W, Song Y, Xu H etal. In nonfunctional pituitary adenomas, estrogen receptors and slug contribute to development of invasiveness. J Clin Endocrinol Metab 2011; 96: E1237-E1245.
16. Shupnik MA, Pitt LK, Soh AY, Anderson A, Lopes MB, Laws ER Jr. Selective expression of estrogen receptor alpha and beta isoforms in human pituitary tumors. J Clin Endocrinol Metab 1998; 83: 3965-3972.
17. Lv H, Li C, Gui S, Sun M, Li D, Zhang Y. Effects of estrogen receptor antagonist on biological behavior and expression of growth factors in the prolactinoma MMQ cell line. J Neurooncol 2011; 102: 237-245.
18. Heaney AP, Horwitz GA, Wang Z, Singson R, Melmed S. Early involvement of estrogen-induced pituitary tumor transforming gene and fibroblast growth factor expression in prolactinoma pathogenesis. Nat Med 1999; 5: 1317-1321.
19. Heaney AP, Fernando M, Melmed S. Functional role of estrogen in pituitary tumor pathogenesis. J Clin Invest 2002; 109: 277-283.
20. Faglia G, Spada A. Genesis of pituitary adenomas: state of the art. J Neurooncol 2001; 54: 95-110.
21. Lloyd RV. Molecular pathology of pituitary adenomas. J Neurooncol 2001; 54: 111-119.
22. Spada A, Mantovani G, Lania A. Pathogenesis of prolactinomas. Pituitary 2005; 8: 7-15.
23. Chen L, Puri R, Lefkowitz EJ, Kakar SS. Identification of the human pituitary tumor transforming gene (hPTTG) family: molecular structure, expression, and chromosomal localization. Gene 2000; 248: 41-50.
24. Zhang X, Horwitz GA, Heaney AP etal. Pituitary tumor transforming gene (PTTG) expression in pituitary adenomas. J Clin Endocrinol Metab 1999; 84: 761-767.
25. Salehi F, Kovacs K, Scheithauer BW etal. Immunohistochemical expression of pituitary tumor transforming gene (PTTG) in pituitary adenomas: a correlative study of tumor subtypes. Int J Surg Pathol 2010; 18: 5-13.
26. Carretero J, Vázquez G, Blanco E etal. Immunohistochemical evidence of the presence of aromatase P450 in the rat hypophysis. Cell Tissue Res 1999; 295: 419-423.
27. Carretero J, Vázquez G, Rubio M etal. Postnatal differentiation of the immunohistochemical expression of aromatase P450 in the rat pituitary gland. Histol Histopathol 2003; 18: 419-423.
28. Galmiche G, Richard N, Corvaisier S, Kottler ML. The expression of aromatase in gonadotropes is regulated by estradiol and gonadotropin-releasing hormone in a manner that differs from the regulation of luteinizing hormone. Endocrinology 2006; 147: 4234-4244.
29. Carretero J, Burks DJ, Vázquez G etal. Expression of aromatase P450 is increased in spontaneous prolactinomas of aged rats. Pituitary 2002; 5: 5-10.
30. Kadioglu P, Oral G, Sayitoglu M etal. Aromatase cytochrome P450 enzyme expression in human pituitary. Pituitary 2008; 11: 29-35.
31. Asa SL, Ezzat S. The pathogenesis of pituitary tumors. Annu Rev Pathol 2009; 4: 97-126.
32. Horvath E, Scheithauer BW, Kovacs K, Lloyd RV. Regional neuropathology: hypothalamus and pituitary. In: Graham DI, Lantos PL, eds. Greenfield's Neuropathology, 6th edn. London: Arnold, 1997; 1007-1093.
33. Lloyd RV, Kovacs K, Young WF Jr etal. Tumours of the pituitary gland. In: DeLellis RA, Lloyd RV, Heitz PU, Eng C, eds. World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of Endocrine Organs. Lyon: IARC Press, 2004; 9-47.
34. Horvath E, Scheithauer BW, Kovacs K, Lloyd RV. Regional neuropathology: hypothalamus and pituitary. In: Graham DI, Lantos PL, eds. Greenfield's Neuropathology, 7th edn. London: Arnold, 2002; 983-1062.
35. Carroll TB, Aron DC, Findling JW, Glucocorticoids TJB. Glucocorticoids & adrenal androgens. In: Gardner DG, Shoback D, eds. Greenspan's Basic & Clinical Endocrinology, 7th edn. New York: McGraw-Hill Companies, 2004; 362-413.
36. Naves LA, Vilar L, Azevedo M, Casulari LA, Mello PA. Adenomas Hipofisários Clinicamente Não-funcionantes. In: Vilar L, ed. Endocrinologia Clínica, 4th edn. Rio de Janeiro: Guanabara Koogan, 2009; 101-112.
37. Akinci H, Kapucu A, Dar KA etal. Aromatase cytochrome P450 enzyme expression in prolactinomas and its relationship to tumor behavior. Pituitary 2013; 16: 386-392.
38. Azcoitia I, Yague JG, Garcia-Segura LM. Estradiol synthesis within the human brain. Neuroscience 2011; 191: 139-147.
39. Pitteloud N, Dwyer AA, DeCruz S etal. Inhibition of luteinizing hormone secretion by testosterone in men requires aromatization for its pituitary but not its hypothalamic effects: evidence from the tandem study of normal and gonadotropin-releasing hormone-deficient men. J Clin Endocrinol Metab 2008; 93: 784-791.
40. Kucherov A, Polotsky AJ, Menke M etal. Aromatase inhibition causes increased amplitude, but not frequency, of hypothalamic-pituitary output in normal women. Fertil Steril 2011; 95: 2063-2066.
41. Kalfa N, Méduri G, Philibert P etal. Unusual virilization in girls with juvenile granulosa cell tumors of the ovary is related to intratumoral aromatase deficiency. Horm Res Paediatr 2010; 74: 83-91.
42. Fleming NI, Knower KC, Lazarus KA, Fuller PJ, Simpson ER, Clyne CD. Aromatase is a direct target of FOXL2: C134W in granulosa cell tumors via a single highly conserved binding site in the ovarian specific promoter. PLoS ONE 2010; 5: e14389.
43. Passos VQ, Fortes MA, Gianella-Neto D, Bronstein MD. Genes differentially expressed in prolactinomas responsive and resistant to dopamine agonists. Neuroendocrinology 2009; 89: 163-170.
44. Pei L, Melmed S. Isolation and characterization of a pituitary tumor-transforming gene (PTTG). Mol Endocrinol 1997; 11: 433-441.
45. Minematsu T, Egashira N, Kajiya H etal. PTTG is a secretory protein in human pituitary adenomas and in mouse pituitary tumor cell lines. Endocr Pathol 2007; 18: 8-15.
46. Molitch ME. Pharmacologic resistance in prolactinoma patients. Pituitary 2005; 8: 43-52.
47. Gillam MP, Middler S, Freed DJ, Molitch ME. The novel use of very high doses of cabergoline and a combination of testosterone and an aromatase inhibitor in the treatment of a giant prolactinoma. J Clin Endocrinol Metab 2002; 87: 4447-4451.
48. Prior JC, Cox TA, Fairholm D, Kostashuk E, Nugent R. Testosterone-related exacerbation of a prolactin-producing macroadenoma: possible role for estrogen. J Clin Endocrinol Metab 1987; 64: 391-394.
49. Sodi R, Fikri R, Diver M, Ranganath L, Vora J. Testosterone replacement-induced hyperprolactinaemia: case report and review of the literature. Ann Clin Biochem 2005; 42: 153-159.
50. Heidari Z, Hosseinpanah F, Shirazian N. Achievement of fertility in an infertile man with resistant macroprolactinoma using high-dose bromocriptine and a combination of human chorionic gonadotropin and an aromatase inhibitor. Endocr Pract 2010; 16: 669-672.