Expression of aromatase P450 is increased in spontaneous prolactinomas of aged rats

Pituitary

Volumn 5, Issue 1, 2002, Pages 5-10

  Carretero, José ^a,b   Burks, Deborah Jane ^a,c   Vázquez, Gabriel ^b   Rubio, Manuel ^a,b   Hernández, Elena ^b   Bodego, Pilar ^a   Vázquez, Ricardo ^a,b  

^a UNIVERSITY OF SALAMANCA   (Spain)

^b UNIVERSITY OF SALAMANCA   (Spain)

^c HARVARD UNIVERSITY   (United States)

Author keywords

Aromatase P450; Hypophysis; Immunohistochemistry; Prolactinoma

Indexed keywords

AROMATASE; AROMATASE P450; CORTICOTROPIN; ENZYME ANTIBODY; ESTRADIOL; LUTEINIZING HORMONE; PROLACTIN; TESTOSTERONE; UNCLASSIFIED DRUG;

AGED; AGING; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AROMATIZATION; ARTICLE; CARCINOGENESIS; CELL LABELING; CONTROLLED STUDY; CORRELATION ANALYSIS; ENZYME ACTIVITY; ENZYME LOCALIZATION; FEMALE; FREQUENCY ANALYSIS; HORMONE DETERMINATION; HORMONE METABOLISM; HYPOPHYSIS ADENOMA; HYPOPHYSIS CELL; HYPOPHYSIS TUMOR; IMMUNOCOMPETENT CELL; IMMUNOHISTOCHEMISTRY; NONHUMAN; PRIORITY JOURNAL; PROLACTINOMA; PROTEIN EXPRESSION; RAT; TESTOSTERONE METABOLISM; TUMOR CELL; TUMOR CLASSIFICATION; WESTERN BLOTTING;

AGE FACTORS; ANIMALS; AROMATASE; FEMALE; IMMUNOHISTOCHEMISTRY; PITUITARY GLAND; PITUITARY NEOPLASMS; PROLACTINOMA; RATS; RATS, WISTAR;

EID: 0036462206     PISSN: 1386341X     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1022176631922     Document Type: Article

References (32)

1. Horvath E, Kovacs K. Pathology of the pituitary. In: Ezrin C, Horvath E, Kaufman B, Kovac K, Weiss NH, eds. Pituitary Disease. Boca Raton, FL: CRC Press, 1980.
2. Herman Y, Fagi J, Gonsky R, Kovacs K, Melmed S. Clonal origin of pituitary adenomas. J Clin Endocrinol Metab 1990;71:1427-1433.
3. Kovacs K, Horvath E, Ilse RG, Ezrin C, Ilse D. Spontaneous pituitary adenomas in aging rats. A light microscopic, immunocytochemical and fine structural study. Beitr Pathol 1977;161:1-16.
4. Berkvens JM, Van Nesselrooy JHJ, Kroes R. Spontaneous tumors in the pituitary gland of old Wistar rats. A morphological and immunocytochemical study. J Pathol 1980;130:179-191.
5. McComb DJ, Kovacs K, Beri J, Zak F. Pituitary adenomas in old Sprague-Dawley rats: A histologic, ultrastructural, and immunocytochemical study. JNCL 1984;73:1143-1166.
6. Herzog T, Schlothe W. Pituitary adenomas: Tumor cell growth by cluster formation. Pattern analysis based on immunohistochemistry. Acta Neuropathol 1992;84:509-515.
7. Phelps CJ, Hymer WC. Characterization of estrogen-induced adenohypophyseal tumors in the fisher 344 rat. Neuroendocrinology 1983;37:23-31.
8. Hsu DW, Riskind PN, Hedley-Whyte ET. Vasoactive intestinal peptide in human pituitary gland and adenomas: An immunocytochemical study. Am J Pathol 1989;135:329-338.
9. Lloyd RV, Fields K, Jin L, Horvath E, Kovacs K. Analysis of endocrine active and clinically silent corticotropic adenomas by in situ hybridization. Am J Pathol 1990;137:479-488.
10. Lloyd RV, Jin L, Fields K, Chandler WF, Horvath E, Stefaneanu L, Kovacs K. Analysis of pituitary hormones and chromogranin A mRNAs in null cell adenomas, oncocytomas, and gonadotroph adenomas by in situ hybridization. Am J Pathol 1991;139:553-564.
11. Carretero J. Vázquez O, Blanco E, Rubio M, Santos M, Martin-Clavijo A, Torres JL, Vázquez R. Immunohistochemical evidence of the presence of aromatase P450 in the rat hypophysis. Cell Tissue Res 1999;295:419-423.
12. Hickey GJ, Krasnow JS, Beattie WG, Richards JS. Aromatase cytochrome P450 in rat ovarian granulose cells before and after luteinization: Adenosine 3′,5′-monophosphathe-dependent and independent regulation. Cloning and sequencing of rat aromatase cDNA and 5′ genomic DNA. Mol Endocrinol 1990; 4:3-12.
13. Dada DA, Blake MJ, Stein EA. Pars distalis cell quantification in normal adult male and female rats. J. Endocr 1984;101: 87-94.
14. Lephart ED, Peterson KG, Noble JF, George FW, McPhaul MJ. The structure of cDNA clones encoding the aromatase P450 isolated from a rat Leydig cell tumor line demonstrates differential processing of aromatase mRNA in rat ovary and a neoplastic cell line. Mol Cell Endocrinol 1990;70:31-40.
15. Beyer C, Green SJ, Hutchison JB. Androgens influence sexual differentiation of mouse hypothalamic neurons in vitro. Endocrinology 1994;135:1220-1226.
16. Beyer C, Oreen SJ, Barker PJ, Huskinsson NS, Hutchison JB. Aromatase immunoreactivity is localised specifically in neurons in the developing mouse hypothalamus and cortex. Brain Res 1994;638:203-210.
17. Beyer C, Tramonthe R, Hutchison RE, Sharp PJ, Barker PJ, Huskinsson NS, Hutchison JB. Aromatase immunoreactive neurons in the adult female chicken detected using a specific antibody. Brain Res Bull 1994;33:583-588.
18. Benda C. Beitrage zur normalen und pathologischen histologie der menschlichen hypophysis cerebri. Klin W ochenschr 1900;36:1205.
19. Meites J. Changes in neuroendocrine control of anterior pituitary function during aging. Neuroendocrinology 1982;34:151-156.
20. Sarkar DK, Gottschall PE, Meites J. Damage to hypothalamus dopaminergic neurons is associated with development of prolactin-secreting pituitary tumors. Science 1982;218:684-686.
21. Levy A, Lightman S. The pathophysiology and pathogenesis of pituitary tumours. In: M Powell, SL Lightman, eds. The Management of Pituitary Tumours. A Handbook. New York: Churchill Livingstone, 1996:5-29.
22. Reymond MJ. Age-related loss of the responsiveness of the tuberoinfundibular dopaminergic neurons to prolactin in the female rat. Neuroendocrinology 1990;59:490-496.
23. McEuen CS, Selyle H, Collip JB. Some effects of prolonged administration of oestrin in rats. Lancet 1936;i:775-776.
24. Dunning WF, Curtis MR, Segaloff A. Strain differences in response to diethylstilbestrol and the induction of mammary gland and bladder cancer in the rat. Cancer Res 1947;7:511-521.
25. Clifton KH, Meyer RK. Mechanism of anterior pituitary tumor induction by estrogen. Anat Rec 1956;125:65-81.
26. Stone JP, Holtzman S, Shellabarger A. Neoplastic responses and correlated plasma prolactin levels in diethylstilbestrol-treated ACI and Sprague-Dawley rats. Cancer Res 1979;39:773-778.
27. Donehower LA, Harvey M, Slagle BL, McArthur MJ, Montgomery CA Jr, Buthel JS, Bradley A. Mice deficient for p53 are develop prenatally normal but susceptible to spontaneous tumors. Nature 1992;356:215-221.
28. Harvey M, McArthur MJ, Montgomery CA Jr, Buthel JS, Bradley A, Donehower LA. Spontaneous and carcinogen-induced tumorigenesis in P53-deficient mice. Nature Genet 1993;5:225-229.
29. Harvey M, Vogel H, Lee EY, Bradley A, Donehower LA. Mice deficient in both P53 and Rb develop tumors primarily of endocrine origin. Cancer Res 1995;55:1146-1151.
30. Purdie CA, Harrison DJ, Peter A, Dobbie L, White S, Howie SEM, Salter DM, Bird CC, Wyllie A, Hooper ML, Clarke AR. Tumour incidence, spectrum and ploidy in mice with a large deletion in the p53 gene. Oncogene 1994;9:603-609.
31. Heaney AP, Fernando M, Melmed S. Functional role of estrogen in pituitary tumor pathogenesis. J Clin Invest 2002;109:277-283.
32. Carretero J, Vázquez G, Rubio M, Blanco E, Juanes JA, Pérez E, Burks D, Vázquez R. Postnatal differentiation of the immunohistochemical expression of aromatase P450 in the rat pituitary gland. Histol Histopathol 2003.