The effects of antenatal depression and antidepressant treatment on placental gene expression

Frontiers in Cellular Neuroscience

Volumn 8, Issue JAN, 2015, Pages 1-17

  Olivier, Jocelien D A ^a,b,c   Åkerud, Helena ^a   Skalkidou, Alkistis ^a   Kaihola, Helena ^a   Sundström Poromaa, Inger ^a  

^a UPPSALA UNIVERSITY   (Sweden)

^b UNIVERSITY OF GRONINGEN   (Netherlands)

^c KAROLINSKA INSTITUTE   (Sweden)

Author keywords

Antenatal depression; Antidepressants; Fetal; Gene expression; Microarray; Placenta

Indexed keywords

ANTIDEPRESSANT AGENT; COMPLEMENTARY DNA; ESCITALOPRAM; FLUOXETINE; HEMOGLOBIN; SERTRALINE;

ADULT; ANTENATAL DEPRESSION; ARTICLE; CONTROLLED STUDY; DEPRESSION; DNM1L GENE; DOWN REGULATION; EDINBURGH POSTNATAL DEPRESSION SCALE; FEMALE; FETUS; FIRST TRIMESTER PREGNANCY; GCC2 GENE; GENE; GENE EXPRESSION; GESTATIONAL AGE; HUMAN; HUMAN TISSUE; KTN1 GENE; MAJOR CLINICAL STUDY; MICROARRAY ANALYSIS; NEXN GENE; PLACENTA; PRENATAL EXPOSURE; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA EXTRACTION; ROCK2 GENE; UPREGULATION; VALIDATION STUDY;

EID: 84920952985     PISSN: 16625102     EISSN: None     Source Type: Journal    
DOI: 10.3389/fncel.2014.00465     Document Type: Article

References (61)

1. Alwan, S., Reefhuis, J., Rasmussen, S. A., and Friedman, J. M. (2011). Patterns of antidepressant medication use among pregnant women in a United States population. J. Clin. Pharmacol. 51, 264-270. doi: 10.1177/0091270010373928
2. Amano, M., Fukata, Y., and Kaibuchi, K. (2000). Regulation and functions of Rho-associated kinase. Exp. Cell Res. 261, 44-51. doi: 10.1006/excr.2000.5046
3. American Psychiatric Association. (2013). Diagnostic and Statistical Manual of Mental Disorders, 5th Edn. Arlington, TX: American Psychiatric Publishing.
4. Andrade, S. E., Raebel, M. A., Brown, J., Lane, K., Livingston, J., Boudreau, D., et al. (2008). Use of antidepressant medications during pregnancy: a multisite study. Am. J. Obstet. Gynecol. 198, 194-195. doi: 10.1016/j.ajog.2007.07.036
5. Babenko, O., Kovalchuk, I., and Metz, G. A. (2015). Stress-induced perinatal and transgenerational epigenetic programming of brain development and mental health. Neurosci. Biobehav. Rev. 48C, 70-91. doi: 10.1016/j.neubiorev.2014.11.013
6. Bai, J. Z., Mon, Y., and Krissansen, G. W. (2006). Kinectin participates in microtubule-dependent hormone secretion in pancreatic islet beta-cells. Cell Biol. Int. 30, 885-894. doi: 10.1016/j.cellbi.2006.06.008
7. Barker, E. D., Jaffee, S. R., Uher, R., and Maughan, B. (2011). The contribution of prenatal and postnatal maternal anxiety and depression to child maladjustment. Depress. Anxiety 28, 696-702. doi: 10.1002/da.20856
8. Benjamini, Y., and Hochberg, Y. (1995). Controlling the false discovery rate: a practical and powerful approach to multiple testing. J. R. Stat. Soc. Series B Methodol. 57, 289-300.
9. Bergvink, V., Kooistra, L., Lambregtse-van den Berg, M. P., Wijnen, H., Bunevicius, R., van Baar, A., et al. (2011). Validation of the Edinburgh depression scale during pregnancy. J. Psychosom. Res. 70, 385-389. doi: 10.1016/j.jpsychores.2010.07.008
10. Bonnin, A., Goeden, N., Chen, K., Wilson, M. L., King, J., Shih, J. C., et al. (2011). A transient placental source of serotonin for the fetal forebrain. Nature 472, 347-350. doi: 10.1038/nature09972
11. Bourke, C. H., Stowe, Z. N., and Owens, M. J. (2014). Prenatal antidepressant exposure: clinical and preclinical findings. Pharmacol. Rev. 66, 435-465. doi: 10.1124/pr.111.005207
12. Brown, F. C., Schindelhaim, C. H., and Pfeffer, S. R. (2011). GCC185 plays independent roles in Golgi structure maintenance and AP-1-mediated vesicle tethering. J. Cell Biol. 194, 779-787. doi: 10.1083/jcb.201104019
13. Chambers, C. D., Hernandez-Diaz, S., Van Marter, L. J., Werler, M. M., Louik, C., Jones, K. L., et al. (2006). Selective serotonin-reuptake inhibitors and risk of persistent pulmonary hypertension of the newborn. N. Engl. J. Med. 354, 579-587. doi: 10.1056/NEJMoa052744
14. Chambers, C. D., Johnson, K. A., Dick, L. M., Felix, R. J., and Jones, K. L. (1996). Birth outcomes in pregnant women taking fluoxetine. N. Engl. J. Med. 335, 1010-1015. doi: 10.1056/NEJM199610033351402
15. Clements, C. C., Castro, V. M., Blumenthal, S. R., Rosenfield, H. R., Murphy, S. N., Fava, M., et al. (2014). Prenatal antidepressant exposure is associated with risk for attention-deficit hyperactivity disorder but not autism spectrum disorder in a large health system. Mol. Psychiatry. doi: 10.1038/mp.2014.90 [Epub ahead of print].
16. Croen, L. A., Grether, J. K., Yoshida, C. K., Odouli, R., and Hendrick, V. (2011). Antidepressant use during pregnancy and childhood autism spectrum disorders. Arch. Gen. Psychiatry 68, 1104-1112. doi: 10.1001/archgenpsychiatry.2011.73
17. Di, C. F., Imarisio, S., Hirsch, E., Broccoli, V., Bulfone, A., Migheli, A., et al. (2000). Defective neurogenesis in citron kinase knockout mice by altered cytokinesis and massive apoptosis. Neuron 28, 115-127. doi: 10.1016/S0896-6273(00)00090-8
18. Diav-Citrin, O., Shechtman, S., Weinbaum, D., Arnon, J., di Gianantonio, E., Clementi, M., et al. (2008). Paroxetine and fluoxetine in pregnancy: a multicenter, prospective, controlled study. Reprod. Toxicol. 20, 459. doi: 10.1111/j.1365-2125.2008.03261.x
19. Field, T. (2011). Prenatal depression effects on early development: a review. Infant Behav. Dev. 34, 1-14. doi: 10.1016/j.infbeh.2010.09.008
20. Field, T., Diego, M., Dieter, J., Hernandez-Reif, M., Schanberg, S., Kuhn, C., et al. (2004). Prenatal depression effects on the fetus and the newborn. Infant Behav. Dev. 27, 216-229. doi: 10.1016/j.infbeh.2003.09.010
21. Friel, A. M., Hynes, P. G., Sexton, D. J., Smith, T. J., and Morrison, J. J. (2008). Expression levels of mRNA for Rho A/Rho kinase and its role in isoprostane-induced vasoconstriction of human placental and maternal vessels.Reprod. Sci. 15, 179-188. doi: 10.1177/1933719107310306
22. Gentile, S. (2005). SSRIs in pregnancy and lactation: emphasis on neurodevelopmental outcome. CNS Drugs 19, 623-633. doi: 10.2165/00023210-200519070-00004
23. Gibson, J., McKenzie-McHarg, K., Shakespeare, J., Price, J., and Gray, R. (2009). A systematic review of studies validating the Edinburgh Postnatal Depression Scale in antepartum and postpartum women. Acta Psychiatr. Scand. 119, 350-364. doi: 10.1111/j.1600-0447.2009.01363.x
24. Hassel, D., Dahme, T., Erdmann, J., Meder, B., Huge, A., Stoll, M., et al. (2009). Nexilin mutations destabilize cardiac Z-disks and lead to dilated cardiomyopathy. Nat. Med. 15, 1281-1288. doi: 10.1038/nm.2037
25. Hay, D. F., Pawlby, S., Waters, C. S., Perra, O., and Sharp, D. (2010). Mothers' antenatal depression and their children's antisocial outcomes. Child Dev. 81, 149-165. doi: 10.1111/j.1467-8624.2009.01386.x
26. Helmestam, M., Andersson, H., Stavreus-Evers, A., Brittebo, E., and Olovsson, M. (2012). Tamoxifen modulates cell migration and expression of angiogenesis-related genes in human endometrial endothelial cells. Am. J. Pathol. 180, 2527-2535. doi: 10.1016/j.ajpath.2012.02.026
27. Hostetter, A., Stowe, Z. N., Strader, J. R. Jr., McLaughlin, E., and Llewellyn, A. (2000). Dose of selective serotonin uptake inhibitors across pregnancy: clinical implications. Depress. Anxiety 11, 51-57. doi: 10.1002/(SICI)1520-6394(2000)11:2<51::AID-DA1>3.0.CO;2-R
28. Hotta, K., Tanaka, K., Mino, A., Kohno, H., and Takai, Y. (1996). Interaction of the Rho family small G proteins with kinectin, an anchoring protein of kinesin motor. Biochem. Biophys. Res. Commun. 225, 69-74. doi: 10.1006/bbrc.1996.1132
29. Hsiao, E. Y., and Patterson, P. H. (2012). Placental regulation of maternal-fetal interactions and brain development.Dev. Neurobiol. 72, 1317-1326. doi: 10.1002/dneu.22045
30. Irizarry, R. A., Hobbs, B., Collin, F., Beazer-Barclay, Y. D., Antonellis, K. J., Scherf, U., et al. (2003). Exploration, normalization, and summaries of high density oligonucleotide array probe level data. Biostatistics 4, 249-264. doi: 10.1093/biostatistics/4.2.249
31. Källén, B., and Olausson, P. O. (2008). Maternal use of selective serotonin re-uptake inhibitors and persistent pulmonary hypertension of the newborn. Pharmacoepidemiol. Drug Saf. 17, 801-806. doi: 10.1002/pds.1570
32. Kieler, H., Artama, M., Engeland, A., Ericsson, O., Furu, K., Gissler, M., et al. (2012). Selective serotonin reuptake inhibitors during pregnancy and risk of persistent pulmonary hypertension in the newborn: population based cohort study from the five Nordic countries. BMJ 344:d8012. doi: 10.1136/bmj.d8012
33. Laeno, A. M., Tamashiro, D. A., and Alarcon, V. B. (2013). Rho-associated kinase activity is required for proper morphogenesis of the inner cell mass in the mouse blastocyst. Biol. Reprod. 89, 122. doi: 10.1095/biolreprod.113.109470
34. Li, C., and Wong, W. H. (2001). Model-based analysis of oligonucleotide arrays: expression index computation and outlier detection. Proc. Natl. Acad. Sci. U.S.A. 98, 31-36. doi: 10.1073/pnas.98.1.31
35. Loughhead, A. M., Fisher, A. D., Newport, D. J., Ritchie, J. C., Owens, M. J., DeVane, C. L., et al. (2006). Antidepressants in amniotic fluid: another route of fetal exposure. Am. J. Psychiatry 163, 145-147. doi: 10.1176/appi.ajp.163.1.145
36. Luke, M. R., Kjer-Nielsen, L., Brown, D. L., Stow, J. L., and Gleeson, P. A. (2003). GRIP domain-mediated targeting of two new coiled-coil proteins, GCC88 and GCC185, to subcompartments of the trans-Golgi network. J. Biol. Chem. 278, 4216-4226. doi: 10.1074/jbc.M210387200
37. Lunghi, L., Ferretti, M. E., Medici, S., Biondi, C., and Vesce, F. (2007). Control of human trophoblast function.Reprod. Biol. Endocrinol. 5:6. doi: 10.1186/1477-7827-5-6
38. Malm, H., Artama, M., Brown, A. S., Gissler, M., Gyllenberg, D., Hinkka-Yli-Salomaki, S., et al. (2012). Infant and childhood neurodevelopmental outcomes following prenatal exposure to selective serotonin reuptake inhibitors: overview and design of a Finnish Register-Based Study (FinESSI). BMC Psychiatry 12:217. doi: 10.1186/1471-244X-12-217
39. Miller, L. J., and LaRusso, E. M. (2011). Preventing postpartum depression. Psychiatr. Clin. North Am. 34, 53-65. doi: 10.1016/j.psc.2010.11.010
40. Muller, P. Y., Janovjak, H., Miserez, A. R., and Dobbie, Z. (2002). Processing of gene expression data generated by quantitative real-time RT-PCR. Biotechniques 32, 1372-1379.
41. Nakagawa, O., Fujisawa, K., Ishizaki, T., Saito, Y., Nakao, K., and Narumiya, S. (1996). ROCK-I and ROCK-II, two isoforms of Rho-associated coiled-coil forming protein serine/threonine kinase in mice. FEBS Lett. 392, 189-193. doi: 10.1016/0014-5793(96)00811-3
42. O'Keane, V., and Marsh, M. S. (2007). Depression during pregnancy. BMJ 334, 1003-1005. doi: 10.1136/bmj.39189.662581.55
43. Olivier, J. D., Åkerud, H., Kaihola, H., Pawluski, J. L., Skalkidou, A., Hogberg, U., et al. (2013). The effects of maternal depression and maternal selective serotonin reuptake inhibitor exposure on offspring. Front. Cell Neurosci. 7:73. doi: 10.3389/fncel.2013.00073
44. Olivier, J. D., Akerud, H., and Sundström-Poromaa, I. (2014). Antenatal depression and antidepressants during pregnancy: unraveling the complex interactions for the offspring. doi: 10.1016/j.ejphar.2014.07.049 [Epub ahead of print].
45. Palmsten, K., Setoguchi, S., Margulis, A. V., Patrick, A. R., and Hernandez-Diaz, S. (2012). Elevated risk of preeclampsia in pregnant women with depression: depression or antidepressants? Am. J. Epidemiol. 175, 988-997. doi: 10.1093/aje/kwr394
46. Pawlby, S., Hay, D. F., Sharp, D., Waters, C. S., and O'Keane, V. (2009). Antenatal depression predicts depression in adolescent offspring: prospective longitudinal community-based study. J. Affect. Disord. 113, 236-243. doi: 10.1016/j.jad.2008.05.018
47. Pearson, R. M., Evans, J., Kounali, D., Lewis, G., Heron, J., Ramchandani, P. G., et al. (2013). Maternal depression during pregnancy and the postnatal period: risks and possible mechanisms for offspring depression at age 18 years.JAMA Psychiatry 70, 1312-1319. doi: 10.1001/jamapsychiatry.2013.2163
48. Rai, D., Lee, B. K., Dalman, C., Golding, J., Lewis, G., and Magnusson, C. (2013). Parental depression, maternal antidepressant use during pregnancy, and risk of autism spectrum disorders: population based case-control study.BMJ 346:f2059. doi: 10.1136/bmj.f2059
49. Rubertsson, C., Borjesson, K., Berglund, A., Josefsson, A., and Sydsjo, G. (2011). The Swedish validation of Edinburgh Postnatal Depression Scale (EPDS) during pregnancy. Nord. J. Psychiatry 65, 414-418. doi: 10.3109/08039488.2011.590606
50. Schofield, A. V., and Bernard, O. (2013). Rho-associated coiled-coil kinase (ROCK) signaling and disease. Crit. Rev. Biochem. Mol. Biol. 48, 301-316. doi: 10.3109/10409238.2013.786671
51. Shi, J., and Wei, L. (2013). Rho kinases in cardiovascular physiology and pathophysiology: the effect of fasudil. J. Cardiovasc. Pharmacol. 62, 341-354. doi: 10.1097/FJC.0b013e3182a3718f
52. Smyth, G. K. (2004). Linear models and empirical Bayes methods for assessing differential expression in microarray experiments. Stat. Appl. Genet. Mol. Biol. 3:Article 3. doi: 10.2202/1544-6115.1027
53. Smyth, G. K. (2005). "Limma:linear models for microarray data," in Bioinformatics and Computational Biology Solutions using R and Bioconductor, eds R. Gentlemen, V. Carey, S. Dudoit, R. Irizarry, and W. Huber (NewYork, NY: Springer), 397-420.
54. Sturn, A., Quackenbush, J., and Trajanoski, Z. (2002). Genesis: cluster analysis of microarray data. Bioinformatics18, 207-208. doi: 10.1093/bioinformatics/18.1.207
55. Tran, H., Pankov, R., Tran, S. D., Hampton, B., Burgess, W. H., and Yamada, K. M. (2002). Integrin clustering induces kinectin accumulation. J. Cell Sci. 115, 2031-2040.
56. Van Batenburg-Eddes, T., Brion, M. J., Henrichs, J., Jaddoe, V. W., Hofman, A., Verhulst, F. C., et al. (2012). Parental depressive and anxiety symptoms during pregnancy and attention problems in children: a cross-cohort consistency study. J. Child Psychol. Psychiatry 54, 591-600. doi: 10.1111/jcpp.12023
57. Wakabayashi, J., Zhang, Z., Wakabayashi, N., Tamura, Y., Fukaya, M., Kensler, T. W., et al. (2009). The dynamin-related GTPase Drp1 is required for embryonic and brain development in mice. J. Cell Biol. 186, 805-816. doi: 10.1083/jcb.200903065
58. Wan, B., Wang, X. R., Zhou, Y. B., Zhang, X., Huo, K., and Han, Z. G. (2010). C12ORF39, a novel secreted protein with a typical amidation processing signal. Biosci. Rep. 30, 1-10. doi: 10.1042/BSR20080156
59. Waters, C. S., Hay, D. F., Simmonds, J. R., and van Goozen, S. H. (2014). Antenatal depression and children's developmental outcomes: potential mechanisms and treatment options. Eur. Child Adolesc. Psychiatry 23, 957-971. doi: 10.1007/s00787-014-0582-3
60. Wei, L., Roberts, W., Wang, L., Yamada, M., Zhang, S., Zhao, Z., et al. (2001). Rho kinases play an obligatory role in vertebrate embryonic organogenesis. Development 128, 2953-2962.
61. Zeck, W., Widberg, C., Maylin, E., Desoye, G., Lang, U., McIntyre, D., et al. (2008). Regulation of placental growth hormone secretion in a human trophoblast model-the effects of hormones and adipokines. Pediatr. Res. 63, 353-357. doi: 10.1203/01.pdr.0000304935.19183.07