Selective serotonin reuptake inhibitors during pregnancy and risk of persistent pulmonary hypertension in the newborn: Population based cohort study from the five Nordic countries

BMJ (Online)

Volumn 344, Issue 7842, 2012, Pages

  Kieler, Helle ^a   Artama, Miia ^b   Engeland, Anders ^c,d   Ericsson, Or̈jan ^e   Furu, Kari ^c,f   Gissler, Mika ^b,g   Nielsen, Rikke Beck ^h   Nrøgaard, Mette ^h   Stephansson, Olof ^a   Valdimarsdottir, Unnur ⁱ   Zoega, Helga ⁱ   Haglund, Bengt ^a  

^a KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^b NATIONAL PUBLIC HEALTH INSTITUTE   (Finland)

^c NORWEGIAN INSTITUTE OF PUBLIC HEALTH   (Norway)

^d UNIVERSITY OF BERGEN   (Norway)

^e NATIONAL BOARD OF HEALTH AND WELFARE   (Sweden)

^f UNIVERSITY OF TROMSØ   (Norway)

^g NORDIC SCHOOL OF PUBLIC HEALTH   (Sweden)

^h AARHUS UNIVERSITY HOSPITAL   (Denmark)

ⁱ UNIVERSITY OF ICELAND   (Iceland)

Author keywords

[No Author keywords available]

Indexed keywords

AMITRIPTYLINE; CITALOPRAM; CLOMIPRAMINE; DOSULEPIN; DULOXETINE; ESCITALOPRAM; FLUOXETINE; FLUVOXAMINE; IMIPRAMINE; MILNACIPRAN; MOCLOBEMIDE; NEFAZODONE; NORADRENALIN; PAROXETINE; SEROTONIN; SEROTONIN UPTAKE INHIBITOR; SERTRALINE; TRAZODONE; VENLAFAXINE;

ADULT; ARTICLE; COHORT ANALYSIS; CONTROLLED STUDY; DISEASE ASSOCIATION; DRUG MECHANISM; FEMALE; FIRST TRIMESTER PREGNANCY; GEOGRAPHIC DISTRIBUTION; GESTATIONAL AGE; HUMAN; MAJOR CLINICAL STUDY; MENTAL DISEASE; NEWBORN; NORADRENALIN BLOOD LEVEL; OUTCOME ASSESSMENT; PERSISTENT PULMONARY HYPERTENSION; POPULATION RESEARCH; PREGNANCY; PRENATAL DRUG EXPOSURE; PRIORITY JOURNAL; RISK ASSESSMENT; RISK FACTOR; SEROTONIN BLOOD LEVEL; THIRD TRIMESTER PREGNANCY; TREATMENT DURATION; CHEMICALLY INDUCED DISORDER; CLINICAL TRIAL; DEPRESSION; DRUG EFFECT; FETUS; FINLAND; FOLLOW UP; HEALTH SURVEY; ICELAND; INCIDENCE; METHODOLOGY; MIDDLE AGED; MULTICENTER STUDY; PREGNANCY COMPLICATION; PROSPECTIVE STUDY; PULMONARY HYPERTENSION; SCANDINAVIA;

ADULT; DEPRESSIVE DISORDER; FEMALE; FETUS; FINLAND; FOLLOW-UP STUDIES; HUMANS; HYPERTENSION, PULMONARY; ICELAND; INCIDENCE; INFANT, NEWBORN; MIDDLE AGED; POPULATION SURVEILLANCE; PREGNANCY; PREGNANCY COMPLICATIONS; PROSPECTIVE STUDIES; RISK FACTORS; SCANDINAVIA; SEROTONIN UPTAKE INHIBITORS; YOUNG ADULT;

EID: 84857161925     PISSN: 09598146     EISSN: 17561833     Source Type: Journal    
DOI: 10.1136/bmj.d8012     Document Type: Article

References (34)

1. Farrow KN, Fliman P, Steinhorn RH. The diseases treated with ECMO: focus on PPHN. Semin Perinatol 2005;29:8-14. (Pubitemid 40488986)
2. Perreault T. Persistent pulmonary hypertension of the newborn. Paediatr Respir Rev 2006;7:S175-6.
3. Steinhorn RH. Neonatal pulmonary hypertension. Pediatr Crit Care Med 2010;11:S79-84.
4. Hernandez-Diaz S, Van Marter LJ, Werler MM, Louik C, Mitchell AA. Risk factors for persistent pulmonary hypertension of the newborn. Pediatrics 2007;120:e272-82. (Pubitemid 47219476)
5. Bakker MK, Kolling P, van den Berg PB, de Walle HE, de Jong van den Berg LT. Increase in use of selective serotonin reuptake inhibitors in pregnancy during the last decade, a population-based cohort study from the Netherlands. Br J Clin Pharmacol 2008;65:600-6. (Pubitemid 351365128)
6. Cohen LS, Altshuler LL, Harlow BL, Nonacs R, Newport DJ, Viguera AC, et al. Relapse of major depression during pregnancy in women who maintain or discontinue antidepressant treatment. JAMA 2006;295:499-507. (Pubitemid 43200344)
7. Chambers CD, Hernandez-Diaz S, Van Marter LJ, Werler MM, Louik C, Jones KL, et al. Selective serotonin-reuptake inhibitors and risk of persistent pulmonary hypertension of the newborn. N Engl J Med 2006;354:579-87. (Pubitemid 43209105)
8. Andrade SE, McPhillips H, Loren D, Raebel MA, Lane K, Livingston J, et al. Antidepressant medication use and risk of persistent pulmonary hypertension of the newborn. Pharmacoepidemiol Drug Saf 2009;18:246-52.
9. Chambers CD, Johnson KA, Dick LM, Felix RJ, Jones KL. Birth outcomes in pregnant women taking fluoxetine. N Engl J Med 1996;335:1010-5. (Pubitemid 26338730)
10. Kallen B, Olausson PO. Maternal use of selective serotonin re-uptake inhibitors and persistent pulmonary hypertension of the newborn. Pharmacoepidemiol Drug Saf 2008;17:801-6.
11. Wichman CL, Moore KM, Lang TR, St Sauver JL, Heise RH Jr, Watson WJ. Congenital heart disease associated with selective serotonin reuptake inhibitor use during pregnancy. Mayo Clin Proc 2009;84:23-7.
12. Wilson KL, Zelig CM, Harvey JP, Cunningham BS, Dolinsky BM, Napolitano PG. Persistent pulmonary hypertension of the newborn is associated with mode of delivery and not with maternal use of selective serotonin reuptake inhibitors. Am J Perinatol 2011;28:19-24.
13. Rosen M. National health data registers: a Nordic heritage to public health. Scand J Public Health 2002;30:81-5. (Pubitemid 41007498)
14. Gissler M, Louhiala P, Hemminki E. Nordic medical birth registers in epidemiological research. Eur J Epidemiol 1997;13:169-75. (Pubitemid 27100202)
15. Backe B. [Routine ultrasonography in obstetric care in Norway, 1994]. Tidsskr Nor Laegeforen 1997;117:2314-5.
16. Geirsson RT. [Ultrasound screening at 18-20 weeks.]. Laeknabladid 2001;87:403-7.
17. Hogberg U, Larsson N. Early dating by ultrasound and perinatal outcome. A cohort study. Acta Obstet Gynecol Scand 1997;76:907-12. (Pubitemid 27511466)
18. Qvist I, Iversen M, Skajaa K. [Attitudes and expectations of pregnant women to routine ultrasonography in early pregnancy]. Ugeskr Laeger 2002;164:902-5.
19. Salonen R, Ammala P. Prenatal diagnosis in Finland. Eur J Hum Genet 1997;5:22-5. (Pubitemid 27182128)
20. Furu K, Wettermark B, Andersen M, Martikainen JE, Almarsdottir AB, Sorensen HT. The Nordic countries as a cohort for pharmacoepidemiological research. Basic Clin Pharmacol Toxicol 2010;106:86-94.
21. Munk-Jorgensen P, Mortensen PB. The Danish Psychiatric Central Register. Dan Med Bull 1997;44:82-4. (Pubitemid 27110215)
22. Marsal K, Persson PH, Larsen T, Lilja H, Selbing A, Sultan B. Intrauterine growth curves based on ultrasonically estimated foetal weights. Acta Paediatr 1996;85:843-8. (Pubitemid 26267023)
23. Cnattingius S, Ericson A, Gunnarskog J, Kallen B. A quality study of a medical birth registry. Scand J Soc Med 1990;18:143-8. (Pubitemid 20183321)
24. Gissler M, Teperi J, Hemminki E, Merilainen J. Data quality after restructuring a national medical registry. Scand J Soc Med 1995;23:75-80.
25. Nickelsen TN. [Data validity and coverage in the Danish National Health Registry. A literature review]. Ugeskr Laeger 2001;164:33-7.
26. Elliott R. Non-adherence to medicines: not solved but solvable. J Health Serv Res Policy 2009;14:58-61.
27. Olesen C, Sondergaard C, Thrane N, Nielsen GL, de Jong-van den Berg L, Olsen J. Do pregnant women report use of dispensed medications? Epidemiology 2001;12:497-501. (Pubitemid 32761987)
28. Stephansson O, Granath F, Svensson T, Haglund B, Ekbom A, Kieler H. Drug use during pregnancy in Sweden-assessed by the Prescribed Drug Register and the Medical Birth Register. Clin Epidemiol 2011;3:43-50.
29. Eddahibi S, Raffestin B, Hamon M, Adnot S. Is the serotonin transporter involved in the pathogenesis of pulmonary hypertension? J Lab Clin Med 2002;139:194-201. (Pubitemid 34557354)
30. MacLean MR, Dempsie Y. Serotonin and pulmonary hypertension-from bench to bedside? Curr Opin Pharmacol 2009;9:281-6.
31. McMahon TJ, Hood JS, Nossaman BD, Kadowitz PJ. Analysis of responses to serotonin in the pulmonary vascular bed of the cat. J Appl Physiol 1993;75:93-102. (Pubitemid 23221961)
32. Runo JR, Loyd JE. Primary pulmonary hypertension. Lancet 2003;361:1533-44. (Pubitemid 36566349)
33. Suhara T, Sudo Y, Yoshida K, Okubo Y, Fukuda H, Obata T, et al. Lung as reservoir for antidepressants in pharmacokinetic drug interactions. Lancet 1998;351:332-5. (Pubitemid 28052699)
34. Yaron I, Shirazi I, Judovich R, Levartovsky D, Caspi D, Yaron M. Fluoxetine and amitriptyline inhibit nitric oxide, prostaglandin E2, and hyaluronic acid production in human synovial cells and synovial tissue cultures. Arthritis Rheum 1999;42:2561-8. (Pubitemid 30327172)