메뉴 건너뛰기




Volumn 125, Issue 2, 2015, Pages 304-315

Loss of TET2 has dual roles in murine myeloproliferative neoplasms: Disease sustainer and disease accelerator

Author keywords

[No Author keywords available]

Indexed keywords

DIOXYGENASE; JANUS KINASE 2; TET2 PROTEIN; UNCLASSIFIED DRUG; DNA BINDING PROTEIN; ONCOPROTEIN; TET2 PROTEIN, MOUSE;

EID: 84920950250     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2014-04-555508     Document Type: Article
Times cited : (68)

References (50)
  • 1
    • 17844383458 scopus 로고    scopus 로고
    • A unique clonal JAK2 mutation leading to constitutive signalling causes polycythaemia vera
    • James C, Ugo V, Le Couédic JP, et al. A unique clonal JAK2 mutation leading to constitutive signalling causes polycythaemia vera. Nature. 2005;434(7037):1144-1148.
    • (2005) Nature , vol.434 , Issue.7037 , pp. 1144-1148
    • James, C.1    Ugo, V.2    Le Couédic, J.P.3
  • 2
    • 20144363192 scopus 로고    scopus 로고
    • Acquired mutation of the tyrosine kinase JAK2 in human myeloproliferative disorders
    • Baxter EJ, Scott LM, Campbell PJ, et al Cancer Genome Project. Acquired mutation of the tyrosine kinase JAK2 in human myeloproliferative disorders. Lancet. 2005;365(9464):1054-1061.
    • (2005) Lancet , vol.365 , Issue.9464 , pp. 1054-1061
    • Baxter, E.J.1    Scott, L.M.2    Campbell, P.J.3
  • 3
    • 17644424955 scopus 로고    scopus 로고
    • A gain-of-function mutation of JAK2 in myeloproliferative disorders
    • Kralovics R, Passamonti F, Buser AS, et al. A gain-of-function mutation of JAK2 in myeloproliferative disorders. N Engl J Med. 2005;352(17):1779-1790.
    • (2005) N Engl J Med , vol.352 , Issue.17 , pp. 1779-1790
    • Kralovics, R.1    Passamonti, F.2    Buser, A.S.3
  • 4
    • 20244369569 scopus 로고    scopus 로고
    • Activating mutation in the tyrosine kinase JAK2 in polycythemia vera, essential thrombocythemia, and myeloid metaplasia with myelofibrosis
    • Levine RL, Wadleigh M, Cools J, et al. Activating mutation in the tyrosine kinase JAK2 in polycythemia vera, essential thrombocythemia, and myeloid metaplasia with myelofibrosis. Cancer Cell. 2005;7(4):387-397.
    • (2005) Cancer Cell , vol.7 , Issue.4 , pp. 387-397
    • Levine, R.L.1    Wadleigh, M.2    Cools, J.3
  • 5
    • 33746437130 scopus 로고    scopus 로고
    • MPLW515L is a novel somatic activating mutation in myelofibrosis with myeloid metaplasia
    • Pikman Y, Lee BH, Mercher T, et al. MPLW515L is a novel somatic activating mutation in myelofibrosis with myeloid metaplasia. PLoS Med. 2006;3(7):e270.
    • (2006) PLoS Med , vol.3 , Issue.7 , pp. e270
    • Pikman, Y.1    Lee, B.H.2    Mercher, T.3
  • 6
    • 84890328032 scopus 로고    scopus 로고
    • Somatic CALR mutations in myeloproliferative neoplasms with nonmutated JAK2
    • Nangalia J, Massie CE, Baxter EJ, et al. Somatic CALR mutations in myeloproliferative neoplasms with nonmutated JAK2. N Engl J Med. 2013;369(25):2391-2405.
    • (2013) N Engl J Med , vol.369 , Issue.25 , pp. 2391-2405
    • Nangalia, J.1    Massie, C.E.2    Baxter, E.J.3
  • 7
    • 84890372480 scopus 로고    scopus 로고
    • Somatic mutations of calreticulin in myeloproliferative neoplasms
    • Klampfl T, Gisslinger H, Harutyunyan AS, et al. Somatic mutations of calreticulin in myeloproliferative neoplasms. N Engl J Med. 2013;369(25):2379-2390.
    • (2013) N Engl J Med , vol.369 , Issue.25 , pp. 2379-2390
    • Klampfl, T.1    Gisslinger, H.2    Harutyunyan, A.S.3
  • 8
    • 33846660947 scopus 로고    scopus 로고
    • JAK2 exon 12 mutations in polycythemia vera and idiopathic erythrocytosis
    • Scott LM, Tong W, Levine RL, et al. JAK2 exon 12 mutations in polycythemia vera and idiopathic erythrocytosis. N Engl J Med. 2007;356(5):459-468.
    • (2007) N Engl J Med , vol.356 , Issue.5 , pp. 459-468
    • Scott, L.M.1    Tong, W.2    Levine, R.L.3
  • 9
    • 38949160429 scopus 로고    scopus 로고
    • Somatic mutations of JAK2 exon 12 in patients with JAK2 (V617F)-negative myeloproliferative disorders
    • Pietra D, Li S, Brisci A, et al. Somatic mutations of JAK2 exon 12 in patients with JAK2 (V617F)-negative myeloproliferative disorders. Blood. 2008;111(3):1686-1689.
    • (2008) Blood , vol.111 , Issue.3 , pp. 1686-1689
    • Pietra, D.1    Li, S.2    Brisci, A.3
  • 10
    • 43249084493 scopus 로고    scopus 로고
    • Ratio of mutant JAK2-V617F to wild-type Jak2 determines the MPD phenotypes in transgenic mice
    • Tiedt R, Hao-Shen H, Sobas MA, et al. Ratio of mutant JAK2-V617F to wild-type Jak2 determines the MPD phenotypes in transgenic mice. Blood. 2008;111(8):3931-3940.
    • (2008) Blood , vol.111 , Issue.8 , pp. 3931-3940
    • Tiedt, R.1    Hao-Shen, H.2    Sobas, M.A.3
  • 11
    • 46749137278 scopus 로고    scopus 로고
    • Transgenic expression of JAK2V617F causes myeloproliferative disorders in mice
    • Xing S, Wanting TH, Zhao W, et al. Transgenic expression of JAK2V617F causes myeloproliferative disorders in mice. Blood. 2008;111(10):5109-5117.
    • (2008) Blood , vol.111 , Issue.10 , pp. 5109-5117
    • Xing, S.1    Wanting, T.H.2    Zhao, W.3
  • 12
    • 38349035684 scopus 로고    scopus 로고
    • Development of ET, primary myelofibrosis and PV in mice expressing JAK2 V617F
    • Shide K, Shimoda HK, Kumano T, et al. Development of ET, primary myelofibrosis and PV in mice expressing JAK2 V617F. Leukemia. 2008;22(1):87-95.
    • (2008) Leukemia , vol.22 , Issue.1 , pp. 87-95
    • Shide, K.1    Shimoda, H.K.2    Kumano, T.3
  • 13
    • 77951759127 scopus 로고    scopus 로고
    • Conditional expression of heterozygous or homozygous Jak2V617F from its endogenous promoter induces a polycythemia vera-like disease
    • Akada H, Yan D, Zou H, Fiering S, Hutchison RE, Mohi MG. Conditional expression of heterozygous or homozygous Jak2V617F from its endogenous promoter induces a polycythemia vera-like disease. Blood. 2010;115(17):3589-3597.
    • (2010) Blood , vol.115 , Issue.17 , pp. 3589-3597
    • Akada, H.1    Yan, D.2    Zou, H.3    Fiering, S.4    Hutchison, R.E.5    Mohi, M.G.6
  • 14
    • 77956280929 scopus 로고    scopus 로고
    • Myeloproliferative neoplasm induced by constitutive expression of JAK2V617F in knock-in mice
    • Marty C, Lacout C, Martin A, et al. Myeloproliferative neoplasm induced by constitutive expression of JAK2V617F in knock-in mice. Blood. 2010;116(5):783-787.
    • (2010) Blood , vol.116 , Issue.5 , pp. 783-787
    • Marty, C.1    Lacout, C.2    Martin, A.3
  • 15
    • 77953274727 scopus 로고    scopus 로고
    • Physiological Jak2V617F expression causes a lethal myeloproliferative neoplasm with differential effects on hematopoietic stem and progenitor cells
    • Mullally A, Lane SW, Ball B, et al. Physiological Jak2V617F expression causes a lethal myeloproliferative neoplasm with differential effects on hematopoietic stem and progenitor cells. Cancer Cell. 2010;17(6):584-596.
    • (2010) Cancer Cell , vol.17 , Issue.6 , pp. 584-596
    • Mullally, A.1    Lane, S.W.2    Ball, B.3
  • 16
    • 77956578342 scopus 로고    scopus 로고
    • JAK2 V617F impairs hematopoietic stem cell function in a conditional knockin mouse model of JAK2 V617F-positive essential thrombocythemia
    • Li J, Spensberger D, Ahn JS, et al. JAK2 V617F impairs hematopoietic stem cell function in a conditional knockin mouse model of JAK2 V617F-positive essential thrombocythemia. Blood. 2010;116(9):1528-1538.
    • (2010) Blood , vol.116 , Issue.9 , pp. 1528-1538
    • Li, J.1    Spensberger, D.2    Ahn, J.S.3
  • 17
    • 84904531771 scopus 로고    scopus 로고
    • Focus on the epigenome in the myeloproliferative neoplasms
    • Kim E, Abdel-Wahab O. Focus on the epigenome in the myeloproliferative neoplasms. Hematology Am Soc Hematol Educ Program. 2013;2013:538-544.
    • (2013) Hematology Am Soc Hematol Educ Program , vol.2013 , pp. 538-544
    • Kim, E.1    Abdel-Wahab, O.2
  • 18
    • 66149146320 scopus 로고    scopus 로고
    • Conversion of 5-methylcytosine to 5-hydroxymethylcytosine in mammalian DNA by MLL partner TET1
    • Tahiliani M, Koh KP, Shen Y, et al. Conversion of 5-methylcytosine to 5-hydroxymethylcytosine in mammalian DNA by MLL partner TET1. Science. 2009;324(5929):930-935.
    • (2009) Science , vol.324 , Issue.5929 , pp. 930-935
    • Tahiliani, M.1    Koh, K.P.2    Shen, Y.3
  • 19
    • 78650175023 scopus 로고    scopus 로고
    • Impaired hydroxylation of 5-methylcytosine in myeloid cancers with mutant TET2
    • Ko M, Huang Y, Jankowska AM, et al. Impaired hydroxylation of 5-methylcytosine in myeloid cancers with mutant TET2. Nature. 2010;468(7325):839-843.
    • (2010) Nature , vol.468 , Issue.7325 , pp. 839-843
    • Ko, M.1    Huang, Y.2    Jankowska, A.M.3
  • 20
    • 79551587102 scopus 로고    scopus 로고
    • Tet1 and Tet2 regulate 5-hydroxymethylcytosine production and cell lineage specification in mouse embryonic stem cells
    • Koh KP, Yabuuchi A, Rao S, et al. Tet1 and Tet2 regulate 5-hydroxymethylcytosine production and cell lineage specification in mouse embryonic stem cells. Cell Stem Cell. 2011;8(2):200-213.
    • (2011) Cell Stem Cell , vol.8 , Issue.2 , pp. 200-213
    • Koh, K.P.1    Yabuuchi, A.2    Rao, S.3
  • 21
    • 67349124376 scopus 로고    scopus 로고
    • TET2 mutations and their clinical correlates in polycythemia vera, essential thrombocythemia and myelofibrosis
    • Tefferi A, Pardanani A, Lim KH, et al. TET2 mutations and their clinical correlates in polycythemia vera, essential thrombocythemia and myelofibrosis. Leukemia. 2009;23(5):905-911.
    • (2009) Leukemia , vol.23 , Issue.5 , pp. 905-911
    • Tefferi, A.1    Pardanani, A.2    Lim, K.H.3
  • 22
    • 67651065502 scopus 로고    scopus 로고
    • Genetic characterization of TET1, TET2, and TET3 alterations in myeloid malignancies
    • Abdel-Wahab O, Mullally A, Hedvat C, et al. Genetic characterization of TET1, TET2, and TET3 alterations in myeloid malignancies. Blood. 2009;114(1):144-147.
    • (2009) Blood , vol.114 , Issue.1 , pp. 144-147
    • Abdel-Wahab, O.1    Mullally, A.2    Hedvat, C.3
  • 23
    • 66249137734 scopus 로고    scopus 로고
    • Mutation in TET2 in myeloid cancers
    • Delhommeau F, Dupont S, Della Valle V, et al. Mutation in TET2 in myeloid cancers. N Engl J Med. 2009;360(22):2289-2301.
    • (2009) N Engl J Med , vol.360 , Issue.22 , pp. 2289-2301
    • Delhommeau, F.1    Dupont, S.2    Della Valle, V.3
  • 24
    • 70149101696 scopus 로고    scopus 로고
    • Analysis of the ten-eleven translocation 2 (TET2) gene in familial myeloproliferative neoplasms
    • Saint-Martin C, Leroy G, Delhommeau F, et al French Group of Familial Myeloproliferative Disorders. Analysis of the ten-eleven translocation 2 (TET2) gene in familial myeloproliferative neoplasms. Blood. 2009;114(8):1628-1632.
    • (2009) Blood , vol.114 , Issue.8 , pp. 1628-1632
    • Saint-Martin, C.1    Leroy, G.2    Delhommeau, F.3
  • 25
    • 74249096163 scopus 로고    scopus 로고
    • Analyses of TET2 mutations in post-myeloproliferative neoplasm acute myeloid leukemias
    • Couronné L, Lippert E, Andrieux J, et al. Analyses of TET2 mutations in post-myeloproliferative neoplasm acute myeloid leukemias. Leukemia. 2010;24(1):201-203.
    • (2010) Leukemia , vol.24 , Issue.1 , pp. 201-203
    • Couronné, L.1    Lippert, E.2    Andrieux, J.3
  • 26
    • 77950977381 scopus 로고    scopus 로고
    • Two routes to leukemic transformation after a JAK2 mutation-positive myeloproliferative neoplasm
    • Beer PA, Delhommeau F, LeCouédic JP, et al. Two routes to leukemic transformation after a JAK2 mutation-positive myeloproliferative neoplasm. Blood. 2010;115(14):2891-2900.
    • (2010) Blood , vol.115 , Issue.14 , pp. 2891-2900
    • Beer, P.A.1    Delhommeau, F.2    LeCouédic, J.P.3
  • 27
    • 76549109434 scopus 로고    scopus 로고
    • Genetic analysis of transforming events that convert chronic myeloproliferative neoplasms to leukemias
    • Abdel-Wahab O, Manshouri T, Patel J, et al. Genetic analysis of transforming events that convert chronic myeloproliferative neoplasms to leukemias. Cancer Res. 2010;70(2):447-452.
    • (2010) Cancer Res , vol.70 , Issue.2 , pp. 447-452
    • Abdel-Wahab, O.1    Manshouri, T.2    Patel, J.3
  • 28
    • 80052285127 scopus 로고    scopus 로고
    • Deletion of Tet2 in mice leads to dysregulated hematopoietic stem cells and subsequent development of myeloid malignancies
    • Li Z, Cai X, Cai CL, et al. Deletion of Tet2 in mice leads to dysregulated hematopoietic stem cells and subsequent development of myeloid malignancies. Blood. 2011;118(17):4509-4518.
    • (2011) Blood , vol.118 , Issue.17 , pp. 4509-4518
    • Li, Z.1    Cai, X.2    Cai, C.L.3
  • 29
    • 79960064353 scopus 로고    scopus 로고
    • Tet2 loss leads to increased hematopoietic stem cell self-renewal and myeloid transformation
    • Moran-Crusio K, Reavie L, Shih A, et al. Tet2 loss leads to increased hematopoietic stem cell selfrenewal and myeloid transformation. Cancer Cell. 2011;20(1):11-24.
    • (2011) Cancer Cell , vol.20 , Issue.1 , pp. 11-24
    • Moran-Crusio, K.1    Reavie, L.2    Shih, A.3
  • 30
    • 79960062301 scopus 로고    scopus 로고
    • TET2 inactivation results in pleiotropic hematopoietic abnormalities in mouse and is a recurrent event during human lymphomagenesis
    • Quivoron C, Couronné L, Della Valle V, et al. TET2 inactivation results in pleiotropic hematopoietic abnormalities in mouse and is a recurrent event during human lymphomagenesis. Cancer Cell. 2011;20(1):25-38.
    • (2011) Cancer Cell , vol.20 , Issue.1 , pp. 25-38
    • Quivoron, C.1    Couronné, L.2    Della Valle, V.3
  • 31
    • 84867403602 scopus 로고    scopus 로고
    • TET2 is essential for survival and hematopoietic stem cell homeostasis
    • Shide K, Kameda T, Shimoda H, et al. TET2 is essential for survival and hematopoietic stem cell homeostasis. Leukemia. 2012;26(10):2216-2223.
    • (2012) Leukemia , vol.26 , Issue.10 , pp. 2216-2223
    • Shide, K.1    Kameda, T.2    Shimoda, H.3
  • 32
    • 79959528659 scopus 로고    scopus 로고
    • R723, a selective JAK2 inhibitor, effectively treats JAK2V617F-induced murine myeloproliferative neoplasm
    • Shide K, Kameda T, Markovtsov V, et al. R723, a selective JAK2 inhibitor, effectively treats JAK2V617F-induced murine myeloproliferative neoplasm. Blood. 2011;117(25):6866-6875.
    • (2011) Blood , vol.117 , Issue.25 , pp. 6866-6875
    • Shide, K.1    Kameda, T.2    Markovtsov, V.3
  • 33
    • 27344435774 scopus 로고    scopus 로고
    • Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profiles
    • Subramanian A, Tamayo P, Mootha VK, et al. Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles. Proc Natl Acad Sci USA. 2005;102(43):15545-15550.
    • (2005) Proc Natl Acad Sci USA , vol.102 , Issue.43 , pp. 15545-15550
    • Subramanian, A.1    Tamayo, P.2    Mootha, V.K.3
  • 34
    • 84886850069 scopus 로고    scopus 로고
    • JAK2V617F expression in mice amplifies early hematopoietic cells and gives them a competitive advantage that is hampered by IFNα
    • Hasan S, Lacout C, Marty C, et al. JAK2V617F expression in mice amplifies early hematopoietic cells and gives them a competitive advantage that is hampered by IFNα. Blood. 2013;122(8):1464-1477.
    • (2013) Blood , vol.122 , Issue.8 , pp. 1464-1477
    • Hasan, S.1    Lacout, C.2    Marty, C.3
  • 35
    • 0021223477 scopus 로고
    • The total marrow mass of the mouse: A simplified method of measurement
    • Boggs DR. The total marrow mass of the mouse: a simplified method of measurement. Am J Hematol. 1984;16(3):277-286.
    • (1984) Am J Hematol , vol.16 , Issue.3 , pp. 277-286
    • Boggs, D.R.1
  • 36
    • 55449105991 scopus 로고    scopus 로고
    • Maximal STAT5-induced proliferation and self-renewal at intermediate STAT5 activity levels
    • Wierenga AT, Vellenga E, Schuringa JJ. Maximal STAT5-induced proliferation and self-renewal at intermediate STAT5 activity levels. Mol Cell Biol. 2008;28(21):6668-6680.
    • (2008) Mol Cell Biol , vol.28 , Issue.21 , pp. 6668-6680
    • Wierenga, A.T.1    Vellenga, E.2    Schuringa, J.J.3
  • 37
    • 34848896359 scopus 로고    scopus 로고
    • Elucidation of the phenotypic, functional, and molecular topography of a myeloerythroid progenitor cell hierarchy
    • Pronk CJ, Rossi DJ, M° ansson R, et al. Elucidation of the phenotypic, functional, and molecular topography of a myeloerythroid progenitor cell hierarchy. Cell Stem Cell. 2007;1(4):428-442.
    • (2007) Cell Stem Cell , vol.1 , Issue.4 , pp. 428-442
    • Pronk, C.J.1    Rossi, D.J.2    Mansson, R.3
  • 38
    • 35848943273 scopus 로고    scopus 로고
    • Hematopoietic fingerprints: An expression database of stem cells and their progeny
    • Chambers SM, Boles NC, Lin KY, et al. Hematopoietic fingerprints: an expression database of stem cells and their progeny. Cell Stem Cell. 2007;1(5):578-591.
    • (2007) Cell Stem Cell , vol.1 , Issue.5 , pp. 578-591
    • Chambers, S.M.1    Boles, N.C.2    Lin, K.Y.3
  • 39
    • 20044387231 scopus 로고    scopus 로고
    • Transgenic mice with pancellular enhanced green fluorescent protein expression in primitive hematopoietic cells and all blood cell progeny
    • Dominici M, Tadjali M, Kepes S, et al. Transgenic mice with pancellular enhanced green fluorescent protein expression in primitive hematopoietic cells and all blood cell progeny. Genesis. 2005;42(1):17-22.
    • (2005) Genesis , vol.42 , Issue.1 , pp. 17-22
    • Dominici, M.1    Tadjali, M.2    Kepes, S.3
  • 40
    • 33744490974 scopus 로고    scopus 로고
    • Expression of Jak2V617F causes a polycythemia vera-like disease with associated myelofibrosis in a murine bone marrow transplant model
    • Wernig G, Mercher T, Okabe R, Levine RL, Lee BH, Gilliland DG. Expression of Jak2V617F causes a polycythemia vera-like disease with associated myelofibrosis in a murine bone marrow transplant model. Blood. 2006;107(11):4274-4281.
    • (2006) Blood , vol.107 , Issue.11 , pp. 4274-4281
    • Wernig, G.1    Mercher, T.2    Okabe, R.3    Levine, R.L.4    Lee, B.H.5    Gilliland, D.G.6
  • 41
    • 33745721197 scopus 로고    scopus 로고
    • JAK2V617F expression in murine hematopoietic cells leads to MPD mimicking human PV with secondary myelofibrosis
    • Lacout C, Pisani DF, Tulliez M, Gachelin FM, Vainchenker W, Villeval JL. JAK2V617F expression in murine hematopoietic cells leads to MPD mimicking human PV with secondary myelofibrosis. Blood. 2006;108(5):1652-1660.
    • (2006) Blood , vol.108 , Issue.5 , pp. 1652-1660
    • Lacout, C.1    Pisani, D.F.2    Tulliez, M.3    Gachelin, F.M.4    Vainchenker, W.5    Villeval, J.L.6
  • 42
    • 34447642422 scopus 로고    scopus 로고
    • Molecular pathogenesis and therapy of polycythemia induced in mice by JAK2 V617F
    • Zaleskas VM, Krause DS, Lazarides K, et al. Molecular pathogenesis and therapy of polycythemia induced in mice by JAK2 V617F. PLoS ONE. 2006;1(1):e18.
    • (2006) PLoS ONE , vol.1 , Issue.1 , pp. e18
    • Zaleskas, V.M.1    Krause, D.S.2    Lazarides, K.3
  • 43
    • 33845798378 scopus 로고    scopus 로고
    • Characterization of murine JAK2V617F-positive myeloproliferative disease
    • Bumm TGP, Elsea C, Corbin AS, et al. Characterization of murine JAK2V617F-positive myeloproliferative disease. Cancer Res. 2006;66(23):11156-11165.
    • (2006) Cancer Res , vol.66 , Issue.23 , pp. 11156-11165
    • Bumm, T.G.P.1    Elsea, C.2    Corbin, A.S.3
  • 44
    • 84863589906 scopus 로고    scopus 로고
    • Distinct roles for long-term hematopoietic stem cells and erythroid precursor cells in a murine model of Jak2V617F-mediated polycythemia vera
    • Mullally A, Poveromo L, Schneider RK, Al-Shahrour F, Lane SW, Ebert BL. Distinct roles for long-term hematopoietic stem cells and erythroid precursor cells in a murine model of Jak2V617F-mediated polycythemia vera. Blood. 2012;120(1):166-172.
    • (2012) Blood , vol.120 , Issue.1 , pp. 166-172
    • Mullally, A.1    Poveromo, L.2    Schneider, R.K.3    Al-Shahrour, F.4    Lane, S.W.5    Ebert, B.L.6
  • 45
    • 84908258893 scopus 로고    scopus 로고
    • Myeloproliferative neoplasms can be initiated from a single hematopoietic stem cell expressing JAK2-V617F
    • Lundberg P, Takizawa H, Kubovcakova L, et al. Myeloproliferative neoplasms can be initiated from a single hematopoietic stem cell expressing JAK2-V617F. J Exp Med. 2014;211(11):2213-2230.
    • (2014) J Exp Med , vol.211 , Issue.11 , pp. 2213-2230
    • Lundberg, P.1    Takizawa, H.2    Kubovcakova, L.3
  • 46
    • 54049110222 scopus 로고    scopus 로고
    • The hematopoietic stem cell compartment of JAK2V617F-positive myeloproliferative disorders is a reflection of disease heterogeneity
    • James C, Mazurier F, Dupont S, et al. The hematopoietic stem cell compartment of JAK2V617F-positive myeloproliferative disorders is a reflection of disease heterogeneity. Blood. 2008;112(6):2429-2438.
    • (2008) Blood , vol.112 , Issue.6 , pp. 2429-2438
    • James, C.1    Mazurier, F.2    Dupont, S.3
  • 47
    • 84921045580 scopus 로고    scopus 로고
    • Single cell analysis of JAK2V617F positive MPN stem/progenitor cells in chronic phase and leukemic transformation
    • Williams DM, Rogers O, Morse S, et al. Single cell analysis of JAK2V617F positive MPN stem/progenitor cells in chronic phase and leukemic transformation. Blood. 2013;122(21):1609.
    • (2013) Blood , vol.122 , Issue.21 , pp. 1609
    • Williams, D.M.1    Rogers, O.2    Morse, S.3
  • 48
    • 84888116023 scopus 로고    scopus 로고
    • Deletion of Asxl1 results in myelodysplasia and severe developmental defects in vivo
    • Abdel-Wahab O, Gao J, Adli M, et al. Deletion of Asxl1 results in myelodysplasia and severe developmental defects in vivo. J Exp Med. 2013;210(12):2641-2659.
    • (2013) J Exp Med , vol.210 , Issue.12 , pp. 2641-2659
    • Abdel-Wahab, O.1    Gao, J.2    Adli, M.3
  • 49
    • 84879728130 scopus 로고    scopus 로고
    • Depletion of Jak2V617F myeloproliferative neoplasm-propagating stem cells by interferon-α in a murine model of polycythemia vera
    • Mullally A, Bruedigam C, Poveromo L, et al. Depletion of Jak2V617F myeloproliferative neoplasm-propagating stem cells by interferon-α in a murine model of polycythemia vera. Blood. 2013;121(18):3692-3702.
    • (2013) Blood , vol.121 , Issue.18 , pp. 3692-3702
    • Mullally, A.1    Bruedigam, C.2    Poveromo, L.3
  • 50
    • 77950388949 scopus 로고    scopus 로고
    • Clonal analysis of TET2 and JAK2 mutations suggests that TET2 can be a late event in the progression of myeloproliferative neoplasms
    • Schaub FX, Looser R, Li S, et al. Clonal analysis of TET2 and JAK2 mutations suggests that TET2 can be a late event in the progression of myeloproliferative neoplasms. Blood. 2010;115(10):2003-2007.
    • (2010) Blood , vol.115 , Issue.10 , pp. 2003-2007
    • Schaub, F.X.1    Looser, R.2    Li, S.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.