Sphingosine-1-phosphate mediates COX-2 expression and PGE2/IL-6 secretion via c-Src-Dependent AP-1 activation

Journal of Cellular Physiology

Volumn 230, Issue 3, 2015, Pages 702-715

  Hsu, Chih Kai ^a   Lee, I Ta ^a   Lin, Chih Chung ^b   Hsiao, Li Der ^b   Yang, Chuen Mao ^a  

^a CHANG GUNG UNIVERSITY COLLEGE OF MEDICINE   (Taiwan)

^b CHANG GUNG UNIVERSITY   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

1,4 DIAMINO 1,4 BIS(2 AMINOPHENYLTHIO) 2,3 DICYANOBUTADIENE; 4 (4 FLUOROPHENYL) 2 (4 HYDROXYPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; 4 AMINO 7 TERT BUTYL 5 (4 METHYLPHENYL)PYRAZOLO[3,4 D]PYRIMIDINE; ANTHRA[1,9 CD]PYRAZOL 6(2H) ONE; CAY 10444; CELECOXIB; CYCLOOXYGENASE 2; FOCAL ADHESION KINASE 2; INTERLEUKIN 6; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE P38; N (2 CYCLOHEXYLOXY 4 NITROPHENYL)METHANESULFONAMIDE; PF 431396; PROSTAGLANDIN E2; PROTEIN C FOS; PROTEIN C JUN; PROTEIN TYROSINE KINASE; PYK2 INHIBITOR; RECEPTOR BLOCKING AGENT; SMALL INTERFERING RNA; SPHINGOSINE 1 PHOSPHATE; SPHINGOSINE 1 PHOSPHATE RECEPTOR; SPHINGOSINE 1 PHOSPHATE RECEPTOR 1; SPHINGOSINE 1 PHOSPHATE RECEPTOR 1 INHIBITOR; SPHINGOSINE 1 PHOSPHATE RECEPTOR 3; SPHINGOSINE 1 PHOSPHATE RECEPTOR 3 INHIBITOR; TANSHINONE IIA; TRANSCRIPTION FACTOR AP 1; UNCLASSIFIED DRUG; UNINDEXED DRUG; W 123; CSK TYROSINE-PROTEIN KINASE; IL6 PROTEIN, HUMAN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LYSOPHOSPHOLIPID; PTGS2 PROTEIN, HUMAN; SPHINGOSINE; SPHINGOSINE 1-PHOSPHATE;

ARTICLE; CONTROLLED STUDY; CYTOKINE RELEASE; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROMOTER REGION; PROSTAGLANDIN RELEASE; PROTEIN EXPRESSION; PROTEIN INDUCTION; ANALOGS AND DERIVATIVES; BIOSYNTHESIS; CELL LINE; DRUG EFFECTS; GENE EXPRESSION REGULATION; METABOLISM; SECRETION (PROCESS); SIGNAL TRANSDUCTION; SMOOTH MUSCLE FIBER; TRANSCRIPTION INITIATION;

CELL LINE; CYCLOOXYGENASE 2; DINOPROSTONE; GENE EXPRESSION REGULATION; HUMANS; INTERLEUKIN-6; LYSOPHOSPHOLIPIDS; MYOCYTES, SMOOTH MUSCLE; NF-KAPPA B; SIGNAL TRANSDUCTION; SPHINGOSINE; SRC-FAMILY KINASES; TRANSCRIPTION FACTOR AP-1; TRANSCRIPTIONAL ACTIVATION;

EID: 84920903618     PISSN: 00219541     EISSN: 10974652     Source Type: Journal    
DOI: 10.1002/jcp.24795     Document Type: Article

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