Antibody to hepatitis B core antigen levels in the natural history of chronic hepatitis B: A prospective observational study

Medicine (United States)

Volumn 93, Issue 29, 2014, Pages e322-

  Liu, Dan ^a   Jia, Wei ^a   Song, Liu Wei ^b   Fang, Yu Qing ^a   Wu, Xiao Feng ^c   Liu, Dan Yang ^c   Xu, Chun ^c   Wang, Xiao Mei ^c   Wang, Wen ^c   Lv, Dong Xia ^c   Li, Jun ^a   Deng, Yong Qiong ^a   Wang, Yan ^a   Huo, Na ^a   Yu, Min ^a   Xi, Hong Li ^a   Zhou, Yi Xing ^a   Wang, Gui Qiang ^a   Xia, Ning Shao ^b   Zhang, Ming Xiang ^c  

^a PEKING UNIVERSITY FIRST HOSPITAL   (China)

^b XIAMEN UNIVERSITY   (China)

^c The Sixth People s Hospital of Sheyang   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE AMINOTRANSFERASE; HEPATITIS B CORE ANTIBODY; HEPATITIS B CORE ANTIGEN; HEPATITIS B SURFACE ANTIGEN; HEPATITIS B(E) ANTIGEN; HEPATITIS B ANTIBODY; VIRUS DNA;

ADULT; AGED; ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANTIBODY BLOOD LEVEL; ARTICLE; CONTROLLED STUDY; CORRELATIONAL STUDY; DIAGNOSTIC TEST ACCURACY STUDY; DOUBLE SANDWICH IMMUNOASSAY; FEMALE; HEPATITIS B; HEPATITIS C VIRUS; HUMAN; IMMUNE CLEARANCE; IMMUNOASSAY; IMMUNOLOGICAL PARAMETERS; IMMUNOLOGICAL TOLERANCE; LIMIT OF QUANTITATION; MAJOR CLINICAL STUDY; MALE; MIDDLE AGED; OBSERVATIONAL STUDY; PATHOGENESIS; PREDICTIVE VALUE; PRIORITY JOURNAL; PROSPECTIVE STUDY; SENSITIVITY AND SPECIFICITY; SERUM; VIRAL CLEARANCE; YOUNG ADULT; ADOLESCENT; BLOOD; CASE CONTROL STUDY; GENETICS; HEPATITIS B VIRUS; IMMUNOLOGY;

ADOLESCENT; ADULT; AGED; ALANINE TRANSAMINASE; CASE-CONTROL STUDIES; DNA, VIRAL; FEMALE; HEPATITIS B ANTIBODIES; HEPATITIS B CORE ANTIGENS; HEPATITIS B VIRUS; HEPATITIS B, CHRONIC; HUMANS; IMMUNE TOLERANCE; MALE; MIDDLE AGED; PROSPECTIVE STUDIES; YOUNG ADULT;

EID: 84920856096     PISSN: 00257974     EISSN: 15365964     Source Type: Journal    
DOI: 10.1097/MD.0000000000000322     Document Type: Article

References (26)

1. Fattovich G. Natural historysand prognosis of hepatitis B. Semin Liver Dis. 2003;23:47-58.
2. McMahon BJ. The natural history of chronic hepatitis B virus infection. Hepatology. 2009;49:S45-S55.
3. Nguyen T, Thompson AJ, Bowden S, et al. Hepatitis B surface antigen levels during the natural history of chronic hepatitis B: a perspective on Asia. J Hepatol. 2010;52:508-513.
4. Jaroszewicz J, Calle SB, Wursthorn K, et al. Hepatitis B surface antigen (HBsAg) levels in the natural history of hepatitis B virus (HBV)-infection: a European perspective. J Hepatol. 2010;52:514-522.
5. European Association for the Study of the Liver. EASL clinical practice guidelines: Management of chronic hepatitis B virus infection. J Hepatol. 2012;57:167-185.
6. Ren YY, Liu YZ, Ding YP, et al. Immune characteristics of different immune phases in natural course of chronic HBV infection. Hepatogastroenterology. 2013;60:789-795.
7. Liaw YF, Chu CM. Hepatitis B virus infection. Lancet. 2009;373: 582-592.
8. Perez-Rodriguez MT, Sopena B, Crespo M, et al. Clinical significance of "anti-HBc alone" in human immunodeficiency viruspositive patients. World J Gastroenterol. 2009;15:1237-1241.
9. Wedemeyer H, Cornberg M, Tegtmeyer B, et al. Isolated anti-HBV core phenotype in anti-HCV-positive patients is associated with hepatitis C virus replication. Clin Microbiol Infect. 2004;10:70-72.
10. Kobyashi M, Chayama K, Arase Y, et al. Progressive and sufficient decrease of hepatitis B core antibody can predict the disappearance of hepatitis B virus DNA in Japanese patients with hepatitis B surface antigen clearance. J Gastroenterol. 2000;35:753-757.
11. Li A, Yuan Q, Huang Z, et al. Novel double-antigen sandwich immunoassay for human hepatitis B core antibody. Clin Vaccine Immunol. 2010;17:464-469.
12. Yuan Q, Song LW, Liu CJ, et al. Quantitative hepatitis B core antibody level may help predict treatment response in chronic hepatitis B patients. Gut. 2013;62:182-184.
13. Papatheodoridis GV, Manesis EK, Manolakopoulos S, et al. Is there a meaningful serum hepatitis B virus DNA cutoff level for therapeutic decisions in hepatitis B e antigen-negative chronic hepatitis B virus infection? Hepatology. 2008;48:1451-1459.
14. Martinot-Peignoux M, Carvalho-Filho R, Lapalus M, et al. Hepatitis B surface antigen serum level is associated with fibrosis severity in treatment-naive, e antigen-positive patients. J Hepatol. 2013;58:1089-1095.
15. Brunetto MR, Moriconi F, Bonino F, et al. Hepatitis B virus surface antigen levels: a guide to sustained response to peginterferon alfa-2a in HBeAg-negative chronic hepatitis B. Hepatology. 2009;49:1141-1150.
16. Seto WK, Lam YF, Fung J, et al. Changes of HBsAg and HBV DNA levels in Chinese chronic hepatitis B patients after 5 years of entecavir treatment. J Gastroenterol Hepatol. 2014;29:1028-1034.
17. Dandri M, Locarnini S. New insight in the pathobiology of hepatitis B virus infection. Gut. 2012;61:i6-i17.
18. Liaw YF. Hepatitis flares and hepatitis B e antigen seroconversion: implication in anti-hepatitis B virus therapy. J Gastroenterol Hepatol. 2003;18:246-252.
19. Buster EH, Hansen BE, Lau GK, et al. Factors that predict response of patients with hepatitis B e antigen-positive chronic hepatitis B to peginterferon-alfa. Gastroenterology. 2009;137:2002-2009.
20. Perrillo RP, Lai CL, Liaw YF, et al. Predictors of HBeAg loss after lamivudine treatment for chronic hepatitis B. Hepatology. 2002;36:186-194.
21. Hsu YS, Chien RN, Yeh CT, et al. Long-term outcome after spontaneous HBeAg seroconversion in patients with chronic hepatitis B. Hepatology. 2002;35:1522-1527.
22. Hadziyannis SJ, Vassilopoulos D. Hepatitis B e antigen-negative chronic hepatitis B. Hepatology. 2001;34:617-624.
23. Brunetto MR, Oliveri F, Colombatto P, et al. Hepatitis B surface antigen serum levels help to distinguish active from inactive hepatitis B virus genotype D carriers. Gastroenterology. 2010;139:483-490.
24. Milich DR, McLachlan A. The nucleocapsid of hepatitis B virus is both a T-cell-independent and a T-cell-dependent antigen. Science. 1986;234:1398-1401.
25. Xiao P, Chen QF, Yang YL, et al. Serum soluble interleukin-2 receptor levels in patients with chronic hepatitis B virus infection and its relation with anti-HBc. World J Gastroenterol. 2006;12:482-484.
26. Urbani S, Fagnoni F, Missale G, et al. The role of anti-core antibody response in the detection of occult hepatitis B virus infection. Clin Chem Lab Med. 2010;48:23-29.