Novel double-antigen sandwich immunoassay for human hepatitis B core antibody

Clinical and Vaccine Immunology

Volumn 17, Issue 3, 2010, Pages 464-469

  Li, An ^a   Yuan, Quan ^a   Huang, Zhiyin ^a   Fan, Jian ^b   Guo, Ruyi ^c   Lou, Bin ^b   Zheng, Qin ^a   Ge, Shengxiang ^a   Chen, Yixin ^a   Su, Zhijun ^c   Yeo, Anthony E T ^a   Chen, Yu ^b   Zhang, Jun ^a   Xia, Ningshao ^a  

^a XIAMEN UNIVERSITY   (China)

^b ZHEJIANG UNIVERSITY SCHOOL OF MEDICINE   (China)

^c FUJIAN MEDICAL UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

HEPATITIS B CORE ANTIBODY; HEPATITIS B CORE ANTIGEN; VIRUS CAPSID ANTIGEN;

ANTIBODY DETECTION; ANTIGEN EXPRESSION; ARTICLE; CONTROLLED STUDY; DIAGNOSTIC ACCURACY; DOUBLE ANTIGEN SANDWICH IMMUNOASSAY; ENZYME IMMUNOASSAY; ESCHERICHIA COLI; GENE EXPRESSION SYSTEM; HEPATITIS B; HUMAN; INTERMETHOD COMPARISON; MAJOR CLINICAL STUDY; MICROPARTICLE ENZYME IMMUNOASSAY; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; SENSITIVITY AND SPECIFICITY; VIRUS CAPSID; VIRUS NEUTRALIZATION;

ANTIBODIES, MONOCLONAL; BLOTTING, WESTERN; CAPSID; ELECTROPHORESIS, POLYACRYLAMIDE GEL; ENZYME-LINKED IMMUNOSORBENT ASSAY; HEPATITIS B; HEPATITIS B ANTIBODIES; HEPATITIS B CORE ANTIGENS; HUMANS; MICROSCOPY, ELECTRON, TRANSMISSION; SENSITIVITY AND SPECIFICITY;

EID: 77649247356     PISSN: 15566811     EISSN: 1556679X     Source Type: Journal    
DOI: 10.1128/CVI.00457-09     Document Type: Article

References (28)

1. Alhababi, F., T. A. Sallam, and C. Y. Tong. 2003. The significance of 'anti-HBc only' in the clinical virology laboratory. J. Clin. Virol. 27:162-169.
2. Caspari, G., H. J. Beyer, G. Elbert, K. Koerner, P. Muss, F. W. Schunter, A. Uy, W. Gerlich, R. Thomssen, and H. Schmitt. 1989. Unsatisfactory specificities and sensitivities of six enzyme immunoassays for antibodies to hepatitis B core antigen. J. Clin. Microbiol. 27:2067-2072.
3. Czuczman, M. S., A. J. Grillo-Lopez, C. A. White, M. Saleh, L. Gordon, A. F. LoBuglio, C. Jonas, D. Klippenstein, B. Dallaire, and C. Varns. 1999. Treatment of patients with low-grade B-cell lymphoma with the combination of chimeric anti-CD20 monoclonal antibody and CHOP chemotherapy. J. Clin. Oncol. 17:268-276.
4. Dervite, I., D. Hober, and P. Morel. 2001. Acute hepatitis B in a patient with antibodies to hepatitis B surface antigen who was receiving rituximab. N. Engl. J Med. 344:68-69.
5. Dhedin, N., C. Douvin, M. Kuentz, M. F. Saint Marc, O. Reman, C. Rieux, F. Bernaudin, F. Norol, C. Cordonnier, D. Bobin, J. M. Metreau, and J. P. Vernant. 1998. Reverse seroconversion of hepatitis B after allogeneic bone marrow transplantation: a retrospective study of 37 patients with pretransplant anti-HBs and anti-HBc. Transplantation 66:616-619.
6. Di Marco, V., O. Lo Iacono, C. Camma, A. Vaccaro, M. Giunta, G. Martorana, P. Fuschi, P. L. Almasio, and A. Craxi. 1999. The long-term course of chronic hepatitis B. Hepatology 30:257-264.
7. Dusheiko, G., E. Song, S. Bowyer, M. Whitcutt, G. Maier, A. Meyers, and M. C. Kew. 1983. Natural history of hepatitis B virus infection in renal transplant recipients-a fifteen-year follow-up. Hepatology 3:330-336.
8. El-Zaatari, M., H. Kazma, M. Naboulsi-Majzoub, M. Haidar, F. Ramlawi, Z. Mahfoud, and S. Ramia. 2007. Hepatitis B virus DNA in serum of 'anti-HBc only'-positive healthy Lebanese blood donors: significance and possible implications. J. Hosp. Infect. 66:278-282.
9. Gaeta, G. B., G. Stornaiuolo, D. F. Precone, S. Lobello, M. Chiaramonte, T. Stroffolini, G. Colucci, and M. Rizzetto. 2003. Epidemiological and clinical burden of chronic hepatitis B virus/hepatitis C virus infection. A multicenter Italian study. J. Hepatol. 39:1036-1041.
10. Grob, P., W. Jilg, H. Bornhak, G. Gerken, W. Gerlich, S. Gunther, G. Hess, H. Hudig, A. Kitchen, H. Margolis, G. Michel, C. Trepo, H. Will, A. Zanetti, and I. Mushahwar. 2000. Serological pattern "anti-HBc alone": report on a workshop. J. Med. Virol. 62:450-455.
11. Joller-Jemelka, H. I., A. N. Wicki, and P. J. Grob. 1994. Detection of HBs antigen in "anti-HBc alone" positive sera. J. Hepatol. 21:269-272.
12. Kleinman, S. H., M. C. Kuhns, D. S. Todd, S. A. Glynn, A. McNamara, A. DiMarco, and M. P. Busch. 2003. Frequency of HBV DNA detection in US blood donors testing positive for the presence of anti-HBc: implications for transfusion transmission and donor screening. Transfusion 43:696-704.
13. Knoll, A., A. Hartmann, H. Hamoshi, K. Weislmaier, and W. Jilg. 2006. Serological pattern "anti-HBc alone": characterization of 552 individuals and clinical significance. World J. Gastroenterol. 12:1255-1260.
14. Nath, N., K. Hickman, S. Nowlan, D. Shah, J. Phillips, and S. Babler. 1992. Stability of the recombinant hepatitis B core antigen. J. Clin. Microbiol. 30:1617-1619.
15. Newman, M., F. M. Suk, M. Cajimat, P. K. Chua, and C. Shih. 2003. Stability and morphology comparisons of self-assembled virus-like particles from wild-type and mutant human hepatitis B virus capsid proteins. J. Virol. 77:12950-12960.
16. Ollier, L., C. Laffont, A. Kechkekian, A. Doglio, and V. Giordanengo. 2008. Detection of antibodies to hepatitis B core antigen using the Abbott ARCHITECT anti-HBc assay: analysis of borderline reactive sera. J. Virol. Methods 154:206-209.
17. Perez-Rodriguez, M. T., B. Sopena, M. Crespo, A. Rivera, T. Gonzalez del Blanco, A. Ocampo, and C. Martinez-Vazquez. 2009. Clinical significance of "anti-HBc alone" in human immunodeficiency virus-positive patients. World J. Gastroenterol. 15:1237-1241.
18. Robertson, E. F., J. A. Weare, R. Randell, P. V. Holland, G. Madsen, and R. H. Decker. 1991. Characterization of a reduction-sensitive factor from human plasma responsible for apparent false activity in competitive assays for antibody to hepatitis B core antigen. J. Clin. Microbiol. 29:605-610.
19. Sallberg, M., and L. O. Magnius. 1989. Enzyme immunoassay for antihepatitis B core (HBc) immunoglobulin G1 and significance of low-level results in competitive assays for anti-HBc. J. Clin. Microbiol. 27:849-853.
20. Vento, S., G. di Perri, R. Luzzati, M. Cruciani, T. Garofano, C. Mengoli, E. Concia, and D. Bassetti. 1989. Clinical reactivation of hepatitis B in anti-HBs-positive patients with AIDS. Lancet i:332-333.
21. Vitale, F., F. Tramuto, A. Orlando, G. Vizzini, V. Meli, G. Cerame, W. Mazzucco, R. Virdone, U. Palazzo, M. R. Villafrate, A. Tagger, and N. Romano. 2008. Can the serological status of anti-HBc alone be considered a sentinel marker for detection of occult HBV infection? J. Med. Virol. 80:577-582.
22. Wands, J. R., C. M. Chura, F. J. Roll, and W. C. Maddrey. 1975. Serial studies of hepatitis-associated antigen and antibody in patients receiving antitumor chemotherapy for myeloproliferative and lymphoproliferative disorders. Gastroenterology 68:105-112.
23. Weare, J. A., E. F. Robertson, G. Madsen, R. Hu, and R. H. Decker. 1991. Improvement in the specificity of assays for detection of antibody to hepatitis B core antigen. J. Clin. Microbiol. 29:600-604.
24. Weber, B., W. Melchior, R. Gehrke, H. W. Doerr, A. Berger, and H. Rabenau. 2001. Hepatitis B virus markers in anti-HBc only positive individuals. J. Med. Virol. 64:312-319.
25. Wedemeyer, H., M. Cornberg, B. Tegtmeyer, H. Frank, H. L. Tillmann, and M. P. Manns. 2004. Isolated anti-HBV core phenotype in anti-HCV-positive patients is associated with hepatitis C virus replication. Clin. Microbiol. Infect. 10:70-72.
26. Weinberger, K. M., T. Bauer, S. Bohm, and W. Jilg. 2000. High genetic variability of the group-specific a-determinant of hepatitis B virus surface antigen (HBsAg) and the corresponding fragment of the viral polymerase in chronic virus carriers lacking detectable HBsAg in serum. J. Gen. Virol. 81:1165-1174.
27. Wingfield, P. T., S. J. Stahl, R. W. Williams, and A. C. Steven. 1995. Hepatitis core antigen produced in Escherichia coli: subunit composition, conformational analysis, and in vitro capsid assembly. Biochemistry 34:4919-4932.
28. Zheng, J., F. Schodel, and D. L. Peterson. 1992. The structure of hepadnaviral core antigens. Identification of free thiols and determination of the disulfide bonding pattern. J. Biol. Chem. 267:9422-9429.