Clinical and molecular characteristics of invasive community-acquired Staphylococcus aureus infections in Chinese children

BMC Infectious Diseases

Volumn 14, Issue 1, 2014, Pages

  Qiao, Yanhong ^a,b   Ning, Xue ^a   Chen, Qiang ^c   Zhao, Ruizhen ^d   Song, Wenqi ^a   Zheng, Yuejie ^d   Dong, Fang ^a   Li, Shipeng ^a   Li, Juan ^a   Wang, Lijuan ^a   Zeng, Ting ^a   Dong, Yanhong ^a   Yao, Kaihu ^a   Yu, Sangjie ^a   Yang, Yonghong ^a   Shen, Xuzhuang ^a  

^a CAPITAL MEDICAL UNIVERSITY   (China)

^b Aviation General Hospital   (China)

^c Jiangxi Children's Hospital   (China)

^d SHENZHEN CHILDREN'S HOSPITAL   (China)

Author keywords

Child; Community acquired; Invasive infection; Molecular epidemiology; Staphylococcus aureus

Indexed keywords

ANTIBIOTIC AGENT; C REACTIVE PROTEIN; VIRULENCE FACTOR;

ADOLESCENT; ARTICLE; BACTERIAL PNEUMONIA; BACTERIAL STRAIN; BACTERIAL VIRULENCE; BACTERIUM ISOLATE; CHILD; CHINESE; CLINICAL FEATURE; COMA; COMMUNITY ACQUIRED INFECTION; CONTROLLED STUDY; DISEASE SEVERITY; FEMALE; FEVER; HUMAN; HYPOTHERMIA; INFANT; LEUKOCYTE COUNT; MAJOR CLINICAL STUDY; MALE; MENINGITIS; METHICILLIN SUSCEPTIBLE STAPHYLOCOCCUS AUREUS; MOLECULAR DYNAMICS; MOLECULAR TYPING; MUSCULOSKELETAL INFECTION; NEUTROPHIL COUNT; PROSPECTIVE STUDY; QUANTITATIVE ANALYSIS; RISK FACTOR; SHOCK; STAPHYLOCOCCUS AUREUS; STAPHYLOCOCCUS INFECTION; THROMBOCYTOPENIA; BACTEREMIA; BACTERIAL GENE; CHINA; EPIDEMIOLOGY; GENETICS; GENOTYPE; INCIDENCE; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; MICROBIOLOGY; MORTALITY; MULTILOCUS SEQUENCE TYPING; NEWBORN; PRESCHOOL CHILD;

ADOLESCENT; BACTEREMIA; CHILD; CHILD, PRESCHOOL; CHINA; COMMUNITY-ACQUIRED INFECTIONS; FEMALE; GENES, BACTERIAL; GENOTYPE; HUMANS; INCIDENCE; INFANT; INFANT, NEWBORN; MALE; METHICILLIN-RESISTANT STAPHYLOCOCCUS AUREUS; MULTILOCUS SEQUENCE TYPING; STAPHYLOCOCCAL INFECTIONS; VIRULENCE FACTORS;

EID: 84920836359     PISSN: None     EISSN: 14712334     Source Type: Journal    
DOI: 10.1186/s12879-014-0582-4     Document Type: Article

References (44)

1. Lowy FD: Staphylococcus aureus infections. N Engl J Med 1998, 339:520-532.
2. Hadler JL, Petit S, Mandour M, Cartter ML: Trends in invasive infection with methicillin-resistant Staphylococcus aureus, Connecticut, USA, 2001-2010. Emerg Infect Dis 2012, 18:917-924.
3. Sola C, Paganini H, Egea AL, Moyano AJ, Garnero A, Kevric I, Culasso C, Vindel A, Lopardo H, Bocco JL: Spread of epidemic MRSA-ST5-IV clone encoding PVL as a major cause of community onset staphylococcal infections in Argentinean children. PLoS One 2012, 7:e30487.
4. Suryadevara M, Moro MR, Rosenbaum PF, Kiska D, Riddell S, Weiner LB, Shaw J: Incidence of invasive community-onset Staphylococcus aureus infections in children in Central New York. J Pediatr 2010, 156:152-154. e1.
5. Gonzalez BE, Martinez-Aguilar G, Hulten KG, Hammerman WA, Coss-Bu J, Avalos-Mishaan A, Mason EO Jr, Kaplan SL: Severe Staphylococcal sepsis in adolescents in the era of community-acquired methicillin-resistant Staphylococcus aureus. Pediatrics 2005, 115:642-648.
6. From the Centers for Disease Control and Prevention: Four pediatric deaths from community-acquired methicillin-resistant Staphylococcus aureus-Minnesota and North Dakota, 1997-1999. JAMA 1999, 282:1123-1125.
7. Cunnington A, Brick T, Cooper M, Danin J, Hunt D, Jeanes A, Kearns AM, Nolan M, Lyall H: Severe invasive Panton-Valentine Leucocidin positive Staphylococcus aureus infections in children in London, UK. J Infect 2009, 59:28-36.
8. Strand K, Søreide E, Aardal S, Flaatten H: A comparison of SAPS II and SAPS 3 in a Norwegian intensive care unit population. Acta Anaesthesiol Scand 2009, 53:595-600.
9. Pollack MM, Ruttimann UE, Getson PR: Pediatric risk of mortality (PRISM) score. Crit Care Med 1988, 16:1110-1116.
10. Pollack MM, Patel KM, Ruttimann U, Cuerdon T: Frequency of variable measurement in 16 pediatric intensive care units: influence on accuracy and potential for bias in severity of illness assessment. Crit Care Med 1996, 24:74-77.
11. Pollack MM, Patel KM, Ruttimann UE: PRISM III: an updated Pediatric Risk of Mortality score. Crit Care Med 1996, 24:743-752.
12. Martha VF, Garcia PC, Piva JP, Einloft PR, Bruno F, Rampon V: Comparison of two prognostic scores (PRISM and PIM) at a pediatric intensive care unit. J Pediatr (Rio J) 2005, 81:259-264.
13. Brady AR, Harrison D, Black S, Jones S, Rowan K, Pearson G, Ratcliffe J, Parry GJ, UK PICOS Study Group: Assessment and optimization of mortality prediction tools for admissions to pediatric intensive care in the United Kingdom. Pediatrics 2006, 117:e733-e742.
14. Gerardin P, Rogier C, Leteurtre S, Jouvencel P, Ka AS, Imbert P: Evaluation of Pediatric Risk of Mortality (PRISM) scoring in African children with falciparum malaria. Pediatr Crit Care Med 2006, 7:45-47.
15. Taori RN, Lahiri KR, Tullu MS: Performance of PRISM (Pediatric Risk of Mortality) score and PIM (Pediatric Index of Mortality) score in a tertiary care pediatric ICU. Indian J Pediatr 2010, 77:267-271.
16. Wehrhahn MC, Robinson JO, Pearson JC, O'Brien FG, Tan HL, Coombs GW, Pascoe EM, Lee R, Salvaris P, Salvaris R, New D, Murray RJ: Clinical and laboratory features of invasive community-onset methicillin-resistant Staphylococcus aureus infection: a prospective case-control study. Eur J Clin Microbiol Infect Dis 2010, 29:1025-1033.
17. Klevens RM, Morrison MA, Nadle J, Petit S, Gershman K, Ray S, Harrison LH, Lynfield R, Dumyati G, Townes JM, Craig AS, Zell ER, Fosheim GE, McDougal LK, Carey RB, Fridkin SK, Active Bacterial Core surveillance (ABCs) MRSA Investigators: Invasive methicillin-resistant Staphylococcus aureus infections in the United States. JAMA 2007, 298:1763-1771.
18. Dauwalder O, Lina G, Durand G, Bes M, Meugnier H, Jarlier V, Coignard B, Vandenesch F, Etienne J, Laurent F: Epidemiology of invasive methicillinresistant Staphylococcus aureus clones collected in France in 2006 and 2007. J Clin Microbiol 2008, 46:3454-3458.
19. Senn L, Basset P, Greub G, Prod'hom G, Frei R, Zbinden R, Gaia V, Balmelli C, Pfyffer GE, Mühlemann K, Zanetti G, Blanc DS: Molecular epidemiology of methicillin-resistant Staphylococcus aureus in Switzerland: sampling only invasive isolates does not allow a representative description of the local diversity of clones. Clin Microbiol Infect 2013, 19:E288-E290.
20. Qiao Y, Dong F, Song W, Wang L, Yang Y, Shen X: Hospital-and community-associated methicillin-resistant Staphylococcus aureus: a 6-year surveillance study of invasive infections in Chinese children. Acta Paediatr 2013, 102:1081-1086.
21. Grundmann H, Aanensen DM, van den Wijngaard CC, Spratt BG, Harmsen D, Friedrich AW, European Staphylococcal Reference Laboratory Working Group: Geographic distribution of Staphylococcus aureus causing invasive infections in Europe: a molecular-epidemiological analysis. PLoS Med 2010, 7:e1000215.
22. Wehrhahn MC, Robinson JO, Pascoe EM, Coombs GW, Pearson JC, O'Brien FG, Tan HL, New D, Salvaris P, Salvaris R, Murray RJ: Illness severity in community-onset invasive Staphylococcus aureus infection and the presence of virulence genes. J Infect Dis 2012, 205:1840-1848.
23. Hienz SA, Schennings T, Heimdahl A, Flock JI: Collagen binding of Staphylococcus aureus is a virulence factor in experimental endocarditis. J Infect Dis 1996, 174:83-88.
24. Otto M: MRSA virulence and spread. Cell Microbiol 2012, 14:1513-1521.
25. Otto M: A MRSA-terious enemy among us: end of the PVL controversy? Nat Med 2011, 17:169-170.
26. Montgomery CP, Boyle-Vavra S, Adem PV, Lee JC, Husain AN, Clasen J, Daum RS: Comparison of virulence in community-associated methicillin-resistant Staphylococcus aureus pulsotypes USA300 and USA400 in a rat model of pneumonia. J Infect Dis 2008, 198:561-570.
27. Boakes E, Kearns AM, Badiou C, Lina G, Hill RL, Ellington MJ: Do differences in Panton-Valentine leukocidin production among international methicillin-resistant Staphylococcus aureus clones affect disease presentation and severity? J Clin Microbiol 2012, 50:1773-1776.
28. Li M, Cheung GY, Hu J, Wang D, Joo HS, Deleo FR, Otto M: Comparative analysis of virulence and toxin expression of global communityassociated methicillin-resistant Staphylococcus aureus strains. J Infect Dis 2010, 202:1866-1876.
29. Li S, Sun J, Zhang J, Li X, Tao X, Wang L, Sun M, Liu Y, Li J, Qiao Y, Yu S, Yao K, Yang Y, Shen X: Comparative analysis of the virulence characteristics of epidemic methicillin-resistant Staphylococcus aureus (MRSA) strains isolated from Chinese children: ST59 MRSA highly expresses core gene-encoded toxin. APMIS 2014, 122:101-114.
30. Mongkolrattanothai K, Aldag JC, Mankin P, Gray BM: Epidemiology of community-onset Staphylococcus aureus infections in pediatric patients: an experience at a Children's Hospital in central Illinois. BMC Infect Dis 2009, 9:112.
31. Liu C, Bayer A, Cosgrove SE, Daum RS, Fridkin SK, Gorwitz RJ, Kaplan SL, Karchmer AW, Levine DP, Murray BE, J Rybak M, Talan DA, Chambers HF: Clinical practice guidelines by the infectious diseases society of america for the treatment of methicillin-resistant Staphylococcus aureus infections in adults and children: executive summary. Clin Infect Dis 2011, 52:285-292.
32. Wong CH, Chang HC, Pasupathy S, Khin LW, Tan JL, Low CO: Necrotizing fasciitis: clinical presentation, microbiology, and determinants of mortality. J Bone Joint Surg Am 2003, 85-A:1454-1460.
33. Li J, Wang L, Ip M, Sun M, Sun J, Huang G, Wang C, Deng L, Zheng Y, Fu Z, Li C, Shang Y, Zhao C, Yu S, Yao K, Yang Y, Shen X: Molecular and clinical characteristics of clonal complex 59 methicillin-resistant Staphylococcus aureus infections in Mainland China. PLoS One 2013, 8:e70602.
34. Dantes R, Mu Y, Belflower R, Aragon D, Dumyati G, Harrison LH, Lessa FC, Lynfield R, Nadle J, Petit S, Ray SM, Schaffner W, Townes J, Fridkin S, EmergingInfections Program-Active Bacterial Core Surveillance MRSA Surveillance Investigators: National Burden of Invasive Methicillin-Resistant Staphylococcus aureus Infections, United States, 2011. JAMA Intern Med 2013, 173:1970-1978.
35. Iwamoto M, Mu Y, Lynfield R, Bulens SN, Nadle J, Aragon D, Petit S, Ray SM, Harrison LH, Dumyati G, Townes JM, Schaffner W, Gorwitz RJ, Lessa FC: Trends in invasive methicillin-resistant Staphylococcus aureus infections. Pediatrics 2013, 132:e817-e824.
36. Chen CJ, Huang YC, Chiu CH, Su LH, Lin TY: Clinical features and genotyping analysis of community-acquired methicillin-resistant Staphylococcus aureus infections in Taiwanese children. Pediatr Infect Dis J 2005, 24:40-45.
37. Creel AM, Durham SH, Benner KW, Alten JA, Winkler MK: Severe invasive community-associated methicillin-resistant Staphylococcus aureus infections in previously healthy children. Pediatr Crit Care Med 2009, 10:323-327.
38. Jiménez JN, Ocampo AM, Vanegas JM, Rodriguez EA, Mediavilla JR, Chen L, Muskus CE, Vélez LA, Rojas C, Restrepo AV, Garcés C, Kreiswirth BN, Correa MM: A comparison of methicillin-resistant and methicillin-susceptible Staphylococcus aureus reveals no clinical and epidemiological but molecular differences. Int J Med Microbiol 2013, 303:76-83.
39. Rozgonyi F, Kocsis E, Kristof K, Nagy K: Is MRSA more virulent than MSSA? Clin Microbiol Infect 2007, 13:843-845.
40. Chen FJ, Siu LK, Lin JC, Wang CH, Lu PL: Molecular typing and characterization of nasal carriage and community-onset infection methicillin-susceptible Staphylococcus aureus isolates in two Taiwan medical centers. BMC Infect Dis 2012, 12:343.
41. Monecke S, Slickers P, Ellington MJ, Kearns AM, Ehricht R: High diversity of Panton-Valentine leukocidin-positive, methicillin-susceptible isolates of Staphylococcus aureus and implications for the evolution of communityassociated methicillin-resistant S. aureus. Clin Microbiol Infect 2007, 13:1157-1164.
42. Enright MC, Robinson DA, Randle G, Feil EJ, Grundmann H, Spratt BG: The evolutionary history of methicillin-resistant Staphylococcus aureus (MRSA). Proc Natl Acad Sci U S A 2002, 99:7687-7692.
43. Nair R, Ammann E, Rysavy M, Schweizer ML: Mortality among patients with methicillin-resistant Staphylococcus aureus USA300 versus Non-USA300 invasive infections: a meta-analysis. Infect Control Hosp Epidemiol 2014, 35:31-41.
44. Kobayashi SD, Malachowa N, Whitney AR, Braughton KR, Gardner DJ, Long D, Bubeck Wardenburg J, Schneewind O, Otto M, Deleo FR: Comparative analysis of USA300 virulence determinants in a rabbit model of skin and soft tissue infection. J Infect Dis 2011, 204:937-941.