Patent analysis as a tool for research planning: Study on natural based therapeutics against cancer stem cells

Recent Patents on Anti-Cancer Drug Discovery

Volumn 10, Issue 1, 2015, Pages 72-86

  Arya, Richa ^a   Bhutkar, Smita ^a   Dhulap, Sivakami ^a   Hirwani, R R ^a  

^a CSIR Unit for Research and Development of Information Products   (India)

Author keywords

Analysis; Anti cancer; Bioactive; Cancer stem cells; Extract; Flavonoids; Natural product; Patent; Plant; Scaffolds; Target

Indexed keywords

(S) PERILLYL ALCOHOL; 4 ACETYL ANTROQUINONOL B; ALKALOID; ANTINEOPLASTIC AGENT; AVICIN D; BERBERINE; CAFFEIC ACID DERIVATIVE; CAMPTOTHECIN; CATECHIN; CD133 ANTIGEN; FATTY ACID; FLAVONE; FLAVONOID; HERBACEOUS AGENT; MACROCYCLIC LACTONE; METHYL DIHYDROJASMONATE; OLIGOMER PROCYANIDIN; ORGANIC COMPOUND; PEPTIDE; PLANT EXTRACT; POLYETHER; POLYPHENOL; PROTEIN; QUINONE DERIVATIVE; RUTOSIDE; TANNIN; TERPENOID; UNCLASSIFIED DRUG; UNINDEXED DRUG; VITAMIN; WOGONIN; BIOLOGICAL PRODUCTS;

ARTICLE; AYURVEDA; BIOASSAY; BIOLOGICAL ACTIVITY; CANCER CONTROL; CANCER RECURRENCE; CANCER STEM CELL; CHEMICAL STRUCTURE; DRUG EFFICACY; HUMAN; IC50; INTRACELLULAR SIGNALING; METASTASIS; NEOPLASM; NONHUMAN; PATENT; PHASE 2 CLINICAL TRIAL; PLANNING; PRIORITY JOURNAL; RESEARCH; TRADITIONAL MEDICINE; DRUG DISCOVERY; DRUG EFFECTS; HUMANS; METHODS; NEOPLASMS; NEOPLASTIC STEM CELLS; PATENTS AS TOPIC;

BIOLOGICAL PRODUCTS; DRUG DISCOVERY; HUMANS; NEOPLASMS; NEOPLASTIC STEM CELLS; PATENTS AS TOPIC;

EID: 84920831189     PISSN: 15748928     EISSN: 22123970     Source Type: Journal    
DOI: 10.2174/1574892809666140819153102     Document Type: Article

References (78)

1. Dib EG, Kidd MR, Saltman DC. Case reports and the fight against cancer. J Med Case Rep 2008; 2: 39
2. Nguyen DX, Bos PD, Massagué J. Metastasis: From dissemination to organ-specific colonization. Nat Rev Cancer 2009; 9 (4): 274-84
3. Johnstone RW. Histone-deacetylase inhibitors: Novel drugs for the treatment of cancer. Nat Rev Drug Discov 2002; 1: 287-99
4. Giordanetto F, Knerr L, Wallberg A. T-type calcium channels inhibitors: A patent review. Expert Opin Ther Pat 2011; 21(1): 85-101
5. Plunkett W, Huang P, Gandhi V. Preclinical characteristics of gemcitabine. Anticancer Drugs 1995; 6: 5-64
6. Shirasaka T, Shimamato Y, Ohshimo H, Yamaguchi M, Kato T, Yonekura K, et al. Development of a novel form of an oral 5-fluorouracil derivative (S-1) directed to the potentiation of the tumor selective cytotoxicity of 5-fluorouracil by two biochemical modulators. Anticancer Drugs 1996; 7(5): 503-620
7. Xu, Chun X. COX-2 inhibitors in cancer treatment and prevention, a recent development. Anticancer Drugs 2002; 13 (2): 127-37
8. Ruiter GA, Zerp SF, Bartelink H, van Blitterswijk WJ, Verheij M. Anti-cancer alkyl-phospholipids inhibit the phosphatidylinositol 3-kinase-Akt/PKB survival pathway. Anticancer Drugs 2003; 14 (2): 167-73
9. Seeliger H, Guba M, Kleespies A, Jauch KW, Bruns CJ. Role of mTOR in solid tumor systems: A therapeutical target against primary tumor growth, metastases, and angiogenesis. Cancer Metastasis Rev 2007; 26(3-4): 611-21
10. Coni S, Infante P, Gulino A. Control of stem cells and cancer stem cells by Hedgehog signaling: Pharmacologic clues from pathway dissection. Biochem Pharmacol 2013; 85(5): 623-8
11. Wicha MS, Liu S, Dontu G. Cancer stem cell: A paradigm shift. Cancer Res 2006; 66(4): 1883-90
12. Barnhart BC, Simon MC. Metastasis and stem cell pathways. Cancer Metastasis Rev 2007; 269 (2): 261-71
13. Singh SK, Clarke ID, Terasaki M, Bonn VE, Hawkins C, Squire J, et al. Identification of a cancer stem cell in human brain tumors. Cancer Res 2003; 63(18): 5821-8
14. Woodward WA, Sulman EP. Cancer stem cells: Markers or biomarkers? Cancer Metastasis Rev 2008; 27(3): 459-70
15. Burgos-Ojeda D, Rueda BR, Buckanovich RJ. Ovarian cancer stem cell markers: Prognostic and therapeutic implications. Cancer Lett 2012; 322(1): 1-7
16. Yi SY, Hao YB, Nan KJ, Fan TL. Cancer stem cell niche: A target for novel cancer therapeutics. Cancer Treat Rev 2013; 39(3): 290-6
17. Shu L, Cheung K-L, Khor T, Chen C, Kong A-N. Phytochemicals: Cancer chemoprevention and suppression of tumor onset and metastasis. Cancer Metastasis Rev 2010; 29(3): 483-502
18. Slichenmyer WJ, Von Hoff DD. Taxol: A new and effective anticancer drug. Anticancer Drugs 1991; 2(6): 513-606
19. Mukherjee AK, Basu S, Sarkar N, Ghosh AC. Advances in cancer therapy with plant based natural products. Curr Med Chem 2001; 8 (12): 1467-86
20. Park EJ, Pezzuto JM. Botanicals in cancer chemoprevention. Cancer Metastasis Rev 2002; 21: 231-25
21. Nobili S, Lippi D, Witort E, Donnini M, Bausi L, Mini E, et al. Natural compounds for cancer treatment and prevention. Pharmacol Res 2009; 59(6): 365-78
22. Vira D, Basak SK, Veena MS, Wang MB, Batra RK, Srivatsan ES. Cancer stem cells, microRNAs, and therapeutic strategies including natural products. Cancer Metastasis Rev 2012; 31(3-4): 733-51
23. Dandawate P, Padhye S, Ahmad A, Sarkar FH. Novel strategies targeting cancer stem cells through phytochemicals and their analogs. Drug Deliv Transl Res 2013; 3(2): 165-82
24. Li Y, Ahmad A, Kong D, Bao B, Sarkar FH. Recent progress on nutraceutical research in prostate cancer. Cancer Metastasis Rev 2014; 33(2-3): 629-40
25. Singh BN, Singh HB, Singh A, Naqvi AH, Singh BR. Dietary phytochemicals alter epigenetic events and signaling pathways for inhibition of metastasis cascade. Cancer Metastasis Rev 2014; 33(1): 41-85
26. Xie, X., Li, Z., Shen, Z., Wang, T. Pharmaceutical composition utilizing Berberine to inhibit cancer stem cell growth or cancer cell metastasis, and application thereof. CN102824344 (2012)
27. Han, W., Kim, J., Koh, E., Noh, D. Target therapeutic agent of cancer stem cells containing plant-derived berberine. KR2010011766 (2010)
28. Hsiu, M.H., Lee, C.Y., Shen, C.C., Wang, T.C. Berberine-containing pharmaceutical composition for inhibiting cancer stem cells growth or carcinoma metastasis and application thereof. TW201249453 (2012)
29. Diamandis, P., Tyers, M., Dirks, P.B. Compositions and methods for treating neurological disorders or damage. CA2606658 (2008)
30. Govindan, S.V., Goldenberg, D.M., Moon, S.J. Camptothecin-binding moiety conjugates. US20080166363 (2008)
31. Ruojing, L., Wanliang, L., Hongjuan, Y., Xue, Y., Yan, Z. Composite of all-trans-retinoic acid and liposome and application thereof. CN101843584 (2010)
32. Cheong J, Choi D. Methyl jasmonate as a vital substance in plants. Trends Genet 2003; 19(7): 409-13
33. Fehr Pereira Lopes, J.E. Compositions of jasmonate compounds and methods of use. US20130089615 (2013)
34. Xie, X., Li, Z., Shen, Z., Wang, T. Pharmaceutical composition for inhibiting cancer stem cell growth or cancer cell metastasis by using wogonin, and application thereof. CN102973550 (2013)
35. Inst Nat Sante Rech Med (INSERM). Use of Heterosidic flavonoid derivatives for therapy of stem cell cancers. EP2119434 (2009)
36. Hsieh, H.-M., Lee, C.-Y., Shen, C.-C., Wang, T.-C. Wogonincontaining pharmaceutical composition for inhibiting cancer stem cells growth and application thereof. US20130059907 (2013)
37. Chan, T.-H., Pamu, S., Dou, Q.P., Chen, D. Synthetic epigallocatechin gallate (EGCG) analogues. WO2012171114 (2012)
38. Cao, J., Cao, X., Sheng, X. Method for extracting total flavones from Fructus vitics simplicifoliae. CN103055048 (2013)
39. Alvero, A.B., Gold, D.P., Mor, G.G. Remission therapy of cancer with isoflavonoids. US20120251630 (2012)
40. Wang, T., Wang, Z.-H., Zhang, J., Sun, C., Guo, L., Gan, L., Zheng, Q.-S., Li, J., Liu, J.-H., Wang, X.-F. Use of isoliquiritigenin as medicament. CN101658513 (2010)
41. Yang S.-D., Fu, H.-H. Compositions for inhibiting protine-directed protein kinase Fa/glycogen synthesis kinase 3 alpha and use thereof. US2013035379 (2013)
42. Chiou, S.-H., Liu, T.-Y., Tsai, T.-H., Lo, J.-F., Yang, Y.-P.,Tsai, F.-T., Chen, Y.-C., Chien, C.-S. Medium and device for proliferation of stem cells and treatment of cancer-related stem cell with resveratrol. US8183297 (2010)
43. Priebe, W., Fokt, I., Szymanski, S., Madden, T., Myers, J., Conrad, C. Orally bioavailable caffeic acid related anticancer drugs. US20070232668 (2007)
44. Merchant, F. Treating cancer stem cells using targeted cargo proteins. WO2010031185 (2010)
45. Gerwick, W.H., Tidgewell, K., Valeriote, F.A. Compositions for ameliorating cell proliferative disorders and methods of making and using them. US20130045925 (2013)
46. Gupta, P., Onder, T.T., Lander, E.S., Weinberg, R., Mani, S., Liao, M.-J. Methods for identification and use of agents targeting cancer stem cells. WO2009126310 (2009)
47. Huang, C.-C., Chen, C.C., Chen, L.-G. Method for treating a cancer caused by cancer stem cells. US20130089627 (2013)
48. Huang, J., Chen, Z., Chen, L. Pharmaceutical composition for treating cancer. CN103083364 (2013)
49. Hu, X. Lithospermum active ingredients comprise Alkannin, a napthoquinone along with its derivations such as Lithospermum furans is effective for treating tumour stem cell. CN101194920 (2008)
50. Srivastava, R., Shankar, S. Compositions and methods for treating and preventing cancer by targeting and inhibiting cancer stem cells. WO2012159085 (2012)
51. Lee, S.J., Kim, M.J., Hyun, K.H., Lee, N.H., Hyun, J.W. A composition containing eckol for inhibiting a growth of cancer stem cells. KR2012053265 (2012)
52. Chen, T., Levin, D., Puppali, S. Pharmaceutical compositions comprising monoterpenes. US20110280860 (2011)
53. Cirrito, T.P., Bergstein, I. Cancer therapy with cantharidin and cantharidin analogues. WO2008030617 (2008)
54. Michels, P.C., Khmelnitsky, Y.L., Gutterman, J., Haridas, V., Mozhaev, V.M. Derivatives of avicin D and methods of making and using thereof. WO2013126730 (2013)
55. Abdul, M., Amin, M.S., Abu-Salah, K.M., Ismail, Z., Ahamed, M.K., Nassar, Z.D., Aisha, A.F.A., Mahamadsa, M., Abdul, M., Aman, S. Composition comprising Sandoricum Koetjape extracts and uses thereof. WO2013028051 (2013)
56. Wang, Y. Application of salinomycin in preparing medicament for resisting various human malignant tumors. CN102188418 (2011)
57. Choy, J.H., Park, D.H. Salinomycin/inorganic-hydroxide nanohybrid material, pharmaceutical composition including same, and cancer treatment method using same. WO2011059121 (2011)
58. Ma, W., Elliott, P., Padval M. Therapeutic compositions and related methods of use. WO2013085998 (2013)
59. Hsieh, H.-M., Lee, C.-Y. Medical composition for inhibiting the growth of cancer stem cell. US20110183015 (2011)
60. Dersimonian, H. Immunosuppressant extracts derived from Millettia laurentii or Pseudotsuga pinaceae.WO2011109353 (2011)
61. Xiumei, X., Zhengyu, L. Medicinal compositions for inhibiting growth of stem cells. CN102145071 (2011)
62. Xiumei, X., Zhengyu, L. Medicine compositions for suppressing growth of cancer stem cells. CN102670823 (2012)
63. Krasutsky, P.A., Kolomitsyn, I.V., Holy, J.M., Perkins, E.L., Packee, E.C., Kolomitsyna, O. Therapeutic triterpenoids. WO2007121352 (2007)
64. Zhou, Q. Application of Juncus effuses L. extract in preparing antitumor or angiogenesis-inhibiting medicament, health food or cosmetic. CN102188557 (2011)
65. Wilson, D., Scott, N., Rodney, J., Chappa, P., Hadjipanayis, C.G. Compositions comprising saccharide binding moieties and methods for targeted therapy. WO2012138694 (2012)
66. Nishitani, S., Yano, H. Potentiator of antitumor activity of chemotherapeutic agent. WO2012111790 (2012) & KR2014007898A (2014)
67. Hallett, R., Hassell, J. A method of treating cancer. WO2012106812 (2012)
68. Tao, C., Desai, N.P., Soon-Shiong, P. Combination therapy with nanoparticle compositions of taxane and hedgehog inhibitors. US20130045240 (2013)
69. Ling, M.T., Yap, W.N., Wong, Y.C., Yap, Y.L.D. Use of tocotrienol composition for the prevention of cancer. US20110195910 (2011)
70. Birnie, R., Maitland, N., Mistry, R. Agents. WO2008090355 (2008)
71. Wong C.-H., Wu, C.-Y., Yu, J., Yu, A. Globo H and related anticancer vaccines with novel glycolipid adjuvants. MX2010013932 (2013)
72. Lehrke, P. Therapeutic composition and uses thereof. NZ578305 (2012)
73. Ding, X. Biological and pharmacological effects and preparation process of liver protecting preparation containing vitamins. CN1706416 (2005)
74. Zhou, Q., Gu, Z., Jiang, X., Cao, Z., Zhu, F., Guo, C. Application of active ingredients of juncus effuses in preparation of medicaments for resisting tumors or inhibiting angiogenesis, health-care food or cosmetics. CN102178796 (2011)
75. Hu Y, Fu L. Targeting cancer stem cells: A new therapy to cure cancer patients. Am J Cancer Res 2012; 2(3): 340-56
76. Swarbrick A, Daly RJ. New insights into signaling networks regulating breast cancer stem cells. Breast Cancer Res 2012: 14: 321
77. Zlotogorski A, Dayan A, Dayan D, Chaushu G, Salo T, Vered M. Nutraceuticals as new treatment approaches for oral cancer-I: Curcumin. Oral Oncol 2013; 49(3): 187-91
78. Wargovich MJ, Morris J, Brown V, Ellis J, Logothetis B, Weber R. Nutraceutical use in late-stage cancer. Cancer Metastasis Rev 2010; 29(3): 503-10