Dynamic and influential interaction of cancer cells with normal epithelial cells in 3D culture

Cancer Cell International

Volumn 14, Issue 1, 2014, Pages

  Ivers, Laura P ^a   Cummings, Brendan ^a   Owolabi, Funke ^a   Welzel, Katarzyna ^a   Klinger, Rut ^a   Saitoh, Sayaka ^b   O'Connor, Darran ^a   Fujita, Yasuyuki ^b   Scholz, Dimitri ^a   Itasaki, Nobue ^a  

^a UNIVERSITY COLLEGE DUBLIN   (Ireland)

^b HOKKAIDO UNIVERSITY   (Japan)

Author keywords

3D culture; Cancer microenvironment; Cell cell interaction; MCF7; MDA MB 231; MDCK; Time lapse movie

Indexed keywords

GELATINASE A; MONOCARBOXYLATE TRANSPORTER 1;

ARTICLE; CANCER CELL; CELL AGGREGATION; CELL CULTURE; CELL INTERACTION; CELL METABOLISM; CELL PROLIFERATION; CELL ULTRASTRUCTURE; COCULTURE; CONTROLLED STUDY; EPITHELIUM CELL; GLYCOLYSIS; HUMAN; HUMAN CELL; IMMUNOCYTOCHEMISTRY; MOLECULAR DYNAMICS; PHAGOCYTOSIS; POPULATION DYNAMICS; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN SECRETION; SEQUENCE ALIGNMENT; THREE DIMENSIONAL IMAGING; TRANSMISSION ELECTRON MICROSCOPY; TUMOR MICROENVIRONMENT; ZYMOGRAPHY;

EID: 84920830847     PISSN: None     EISSN: 14752867     Source Type: Journal    
DOI: 10.1186/s12935-014-0108-6     Document Type: Article

References (48)

1. Schedin P, Elias A: Multistep tumorigenesis and the microenvironment. Breast Cancer Res 2004, 6:93-101.
2. Junttila MR, De Sauvage FJ: Influence of tumour micro-environment heterogeneity on therapeutic response. Nature 2013, 501:346-354.
3. Hogan C, Kajita M, Lawrenson K, Fujita Y: Interactions between normal and transformed epithelial cells: Their contributions to tumourigenesis. Int J Biochem Cell Biol 2011, 43:496-503.
4. Kajita M, Hogan C, Harris AR, Dupre-Crochet S, Itasaki N, Kawakami K, Charras G, Tada M, Fujita Y: Interaction with surrounding normal epithelial cells influences signalling pathways and behaviour of Src-transformed cells. J Cell Sci 2010, 123:171-180.
5. Dong-Le Bourhis X, Berthois Y, Millot G, Degeorges A, Sylvi M, Martin PM, Calvo F: Effect of stromal and epithelial cells derived from normal and tumorous breast tissue on the proliferation of human breast cancer cell lines in co-culture. Int J Cancer 1997, 71:42-48.
6. Spink BC, Cole RW, Katz BH, Gierthy JF, Bradley LM, Spink DC: Inhibition of MCF-7 breast cancer cell proliferation by MCF-10A breast epithelial cells in coculture. Cell Biol Int 2006, 30:227-238.
7. Toillon RA, Chopin V, Jouy N, Fauquette W, Boilly B, Le Bourhis X: Normal breast epithelial cells induce p53-dependent apoptosis and p53-independent cell cycle arrest of breast cancer cells. Breast Cancer Res Treat 2002, 71:269-280.
8. Toillon RA, Lagadec C, Page A, Chopin V, Sautiere PE, Ricort JM, Lemoine J, Zhang M, Hondermarck H, Le Bourhis X: Proteomics demonstration that normal breast epithelial cells can induce apoptosis of breast cancer cells through insulin-like growth factor-binding protein-3 and maspin. Mol Cell Proteomics 2007, 6:1239-1247.
9. Nguyen M, Lee MC, Wang JL, Tomlinson JS, Shao ZM, Alpaugh ML, Barsky SH: The human myoepithelial cell displays a multifaceted antiangiogenic phenotype. Oncogene 2000, 19:3449-3459.
10. Mathot L, Stenninger J: Behavior of seeds and soil in the mechanism of metastasis: a deeper understanding. Cancer Sci 2012, 103:626-631.
11. Kalluri R, Zeisberg M: Fibroblasts in cancer. Nat Rev Cancer 2006, 6:392-401.
12. Bhowmick NA, Neilson EG, Moses HL: Stromal fibroblasts in cancer initiation and progression. Nature 2004, 432:332-337.
13. Orimo A, Gupta PB, Sgroi DC, Arenzana-Seisdedos F, Delaunay T, Naeem R, Carey VJ, Richardson AL, Weinberg RA: Stromal fibroblasts present in invasive human breast carcinomas promote tumor growth and angiogenesis through elevated SDF-1/CXCL12 secretion. Cell 2005, 121:335-348.
14. Fidler IJ: The pathogenesis of cancer metastasis: the 'seed and soil' hypothesis revisited. Nat Rev Cancer 2003, 3:453-458.
15. Lehmann C, Jobs G, Thomas M, Burtscher H, Kubbies M: Established breast cancer stem cell markers do not correlate with in vivo tumorigenicity of tumor-initiating cells. Int J Oncol 2012, 41:1932-1942.
16. Weaver VM, Lelievre S, Lakins JN, Chrenek MA, Jones JC, Giancotti F, Werb Z, Bissell MJ: beta4 integrin-dependent formation of polarized threedimensional architecture confers resistance to apoptosis in normal and malignant mammary epithelium. Cancer Cell 2002, 2:205-216.
17. Brinkley BR, Beall PT, Wible LJ, Mace ML, Turner DS, Cailleau RM: Variations in cell form and cytoskeleton in human breast carcinoma cells in vitro. Cancer Res 1980, 40:3118-3129.
18. Lee GY, Kenny PA, Lee EH, Bissell MJ: Three-dimensional culture models of normal and malignant breast epithelial cells. Nat Methods 2007, 4:359-365.
19. Mendez MG, Kojima S, Goldman RD: Vimentin induces changes in cell shape, motility, and adhesion during the epithelial to mesenchymal transition. FASEB J 2010, 24:1838-1851.
20. Petersen OW, Ronnov-Jessen L, Howlett AR, Bissell MJ: Interaction with basement membrane serves to rapidly distinguish growth and differentiation pattern of normal and malignant human breast epithelial cells. Proc Natl Acad Sci U S A 1992, 89:9064-9068.
21. Debnath J, Muthuswamy SK, Brugge JS: Morphogenesis and oncogenesis of MCF-10A mammary epithelial acini grown in three-dimensional basement membrane cultures. Methods 2003, 30:256-268.
22. Elia N, Lippincott-Schwartz J: Culturing MDCK cells in three dimensions for analyzing intracellular dynamics. Curr Protoc Cell Biol 2009, Chapter 4: Unit 4 22.
23. Pinheiro C, Longatto-Filho A, Azevedo-Silva J, Casal M, Schmitt FC, Baltazar F: Role of monocarboxylate transporters in human cancers: state of the art. J Bioenerg Biomembr 2012, 44:127-139.
24. Sotgia F, Martinez-Outschoorn UE, Howell A, Pestell RG, Pavlides S, Lisanti MP: Caveolin-1 and cancer metabolism in the tumor microenvironment: markers, models, and mechanisms. Annu Rev Pathol 2012, 7:423-467.
25. Whitaker-Menezes D, Martinez-Outschoorn UE, Lin Z, Ertel A, Flomenberg N, Witkiewicz AK, Birbe RC, Howell A, Pavlides S, Gandara R, Pestell RG, Sotgia F, Philp NJ, Lisanti MP: Evidence for a stromal-epithelial "lactate shuttle" in human tumors: MCT4 is a marker of oxidative stress in cancerassociated fibroblasts. Cell Cycle 2011, 10:1772-1783.
26. Birsoy K, Wang T, Possemato R, Yilmaz OH, Koch CE, Chen WW, Hutchins AW, Gultekin Y, Peterson TR, Carette JE, Brummelkamp TR, Clish CB, Sabatini DM: MCT1-mediated transport of a toxic molecule is an effective strategy for targeting glycolytic tumors. Nat Genet 2012, 45:104-108.
27. Pinheiro C, Albergaria A, Paredes J, Sousa B, Dufloth R, Vieira D, Schmitt F, Baltazar F: Monocarboxylate transporter 1 is up-regulated in basal-like breast carcinoma. Histopathology 2010, 56:860-867.
28. Gallagher SM, Castorino JJ, Wang D, Philp NJ: Monocarboxylate transporter 4 regulates maturation and trafficking of CD147 to the plasma membrane in the metastatic breast cancer cell line MDA-MB-231. Cancer Res 2007, 67:4182-4189.
29. Barkan D, Green JE, Chambers AF: Extracellular matrix: a gatekeeper in the transition from dormancy to metastatic growth. Eur J Cancer 2010, 46:1181-1188.
30. Hotary KB, Allen ED, Brooks PC, Datta NS, Long MW, Weiss SJ: Membrane type I matrix metalloproteinase usurps tumor growth control imposed by the three-dimensional extracellular matrix. Cell 2003, 114:33-45.
31. Baum O, Hlushchuk R, Forster A, Greiner R, Clezardin P, Zhao Y, Djonov V, Gruber G: Increased invasive potential and up-regulation of MMP-2 in MDA-MB-231 breast cancer cells expressing the beta3 integrin subunit. Int J Oncol 2007, 30:325-332.
32. Hegedus L, Cho H, Xie X, Eliceiri GL: Additional MDA-MB-231 breast cancer cell matrix metalloproteinases promote invasiveness. J Cell Physiol 2008, 216:480-485.
33. Leppa S, Saarto T, Vehmanen L, Blomqvist C, Elomaa I: A high serum matrix metalloproteinase-2 level is associated with an adverse prognosis in node-positive breast carcinoma. Clin Cancer Res 2004, 10:1057-1063.
34. Hoeben A, Landuyt B, Highley MS, Wildiers H, Van Oosterom AT, De Bruijn EA: Vascular endothelial growth factor and angiogenesis. Pharmacol Rev 2004, 56:549-580.
35. Oliveras-Ferraros C, Vazquez-Martin A, Martin-Castillo B, Cufi S, Del Barco S, Lopez-Bonet E, Brunet J, Menendez JA: Dynamic emergence of the mesenchymal CD44(pos)CD24(neg/low) phenotype in HER2-gene amplified breast cancer cells with de novo resistance to trastuzumab (Herceptin). Biochem Biophys Res Commun 2010, 397:27-33.
36. Sheridan C, Kishimoto H, Fuchs RK, Mehrotra S, Bhat-Nakshatri P, Turner CH, Goulet R Jr, Badve S, Nakshatri H: CD44+/CD24-breast cancer cells exhibit enhanced invasive properties: an early step necessary for metastasis. Breast Cancer Res 2006, 8:R59.
37. Nakanishi T, Chumsri S, Khakpour N, Brodie AH, Leyland-Jones B, Hamburger AW, Ross DD, Burger AM: Side-population cells in luminal-type breast cancer have tumour-initiating cell properties, and are regulated by HER2 expression and signalling. Br J Cancer 2010, 102:815-826.
38. Monks J, Rosner D, Geske FJ, Lehman L, Hanson L, Neville MC, Fadok VA: Epithelial cells as phagocytes: apoptotic epithelial cells are engulfed by mammary alveolar epithelial cells and repress inflammatory mediator release. Cell Death Differ 2005, 12:107-114.
39. Ghoneum M, Seto Y, Sato S, Ghoneum A, Braga M, Gollapudi S: Gross thymic extract, Thymax, induces apoptosis in human breast cancer cells in vitro through the mitochondrial pathway. Anticancer Res 2008, 28:1603-1609.
40. Koren HS, Handwerger BS, Wunderlich JR: Identification of macrophagelike characteristics in a cultured murine tumor line. J Immunol 1975, 114:894-897.
41. Pawelek J, Chakraborty A, Lazova R, Yilmaz Y, Cooper D, Brash D, Handerson T: Co-opting macrophage traits in cancer progression: a consequence of tumor cell fusion? Contrib Microbiol 2006, 13:138-155.
42. Seyfried TN, Huysentruyt LC: On the origin of cancer metastasis. Crit Rev Oncog 2013, 18:43-73.
43. Luzzi KJ, MacDonald IC, Schmidt EE, Kerkvliet N, Morris VL, Chambers AF, Groom AC: Multistep nature of metastatic inefficiency: dormancy of solitary cells after successful extravasation and limited survival of early micrometastases. Am J Pathol 1998, 153:865-873.
44. Howard S, Deroo T, Fujita Y, Itasaki N: A Positive Role of Cadherin in Wnt/ beta-Catenin Signalling during Epithelial-Mesenchymal Transition. PLoS One 2011, 6:e23899.
45. Warburg O: On the origin of cancer cells. Science 1956, 123:309-314.
46. Frezza C: The role of mitochondria in the oncogenic signal transduction. Int J Biochem Cell Biol 2014, 48:11.
47. Bani D, Riva A, Bigazzi M, Bani Sacchi T: Differentiation of breast cancer cells in vitro is promoted by the concurrent influence of myoepithelial cells and relaxin. Br J Cancer 1994, 70:900-904.
48. Woessner JF Jr: Quantification of matrix metalloproteinases in tissue samples. Methods Enzymol 1995, 248:510-528.