Multistep tumorigenesis and the mircroenvironment

Breast Cancer Research

Volumn 6, Issue 2, 2004, Pages 93-101

  Schedin, Pepper ^a   Elias, Anthony ^a  

^a UNIVERSITY OF COLORADO   (United States)

Author keywords

Breast cancer; Metastasis; Microenvironment; Multistep carcinogenesis; Reactive stroma

Indexed keywords

ANGIOGENESIS INHIBITOR; ANTINEOPLASTIC AGENT; CONJUGATED LINOLEIC ACID; EFLORNITHINE; RETINOID;

ANGIOGENESIS; ANTINEOPLASTIC ACTIVITY; BREAST CANCER; BREAST CARCINOGENESIS; CANCER GROWTH; CANCER INVASION; CANCER PREVENTION; CANCER SCREENING; CANCER STAGING; DIAGNOSTIC VALUE; DNA MICROARRAY; EARLY CANCER; FEASIBILITY STUDY; GENE EXPRESSION PROFILING; GENE MUTATION; GENOTYPE PHENOTYPE CORRELATION; HUMAN; METASTASIS; MICROENVIRONMENT; NONHUMAN; RAT; REVIEW; TREATMENT PLANNING; TUMOR CELL; ANIMAL; BREAST TUMOR; GENE EXPRESSION REGULATION; GENETICS; TUMOR GENE;

ANIMALS; BREAST NEOPLASMS; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION, NEOPLASTIC; GENES, NEOPLASM; HUMANS; NEOPLASM METASTASIS;

EID: 1542375858     PISSN: 14655411     EISSN: None     Source Type: Journal    
DOI: 10.1186/bcr772     Document Type: Review

References (62)

1. Hanahan D, Weinberg RA: The hallmarks of cancer. Cell 2000, 100-57-70.
2. Sporn MB, SAh N: Chemoprevention: an essential approach to controlling cancer. Nat Rev Cancer 2002, 2:537-543.
3. Bernards R, Weinberg RA: A progression puzzle. Nature 2002, 418:823.
4. Ramaswamy S, Ross KN, Lander ES, Golub TR: A molecular signature of metastasis in primary solid tumors. Nat Genet 2003, 33:49-54.
5. van 't Veer LJ, Dai H, van de Vijver MJ, He YD, Hart AA, Mao M, Peterse HL, van der Kooy K, Marton MJ, Witteveen AT, Schreiber GJ, Kerkhoven RM, Roberts C, Linsley PS, Bernards R, Friend SH: Gene expression profiling predicts clinical outcome of breast cancer. Nature 2002, 415:530-536.
6. Fearon ER, Vogelstein B: A genetic model for colorectal tumorigenesis. Cell 1990, 61:759-767.
7. Lippman SM, Hong WK: Molecular markers of the risk of oral cancer. N Engl J Med 2001, 344:1323-1326.
8. Reid BJ, Blount PL, Rabinovitch PS: Biomarkers in Barrett's esophagus. Gastrointest Endosc Clin N Am 2003, 13:369-397.
9. Weinberg RA: Oncogenes, antioncogenes, and the molecular bases of multistep carcinogenesis. Cancer Res 1989, 49: 3713-3721.
10. Debnath J, Mills KR, Collins NL, Reginato MJ, Muthuswamy SK, Brugge JS: The role of apoptosis in creating and maintaining luminal space within normal and oncogene-expressing mammary acini. Cell 2002, 111:29-40.
11. Chompret A: The Li-Fraumeni syndrome. Biochimie 2002, 84: 75-82.
12. Weiss L: Metastatic inefficiency. Adv Cancer Res 1990, 54: 159-211.
13. Kolstad P, Klem V: Long-term followup of 1121 cases of carcinoma in situ. Obstet Gynecol 1976, 48:125-129.
14. Tarin D, Price JE, Kettlewell MG, Souter RG, Vass AC, Crossley B: Mechanisms of human tumor metastasis studied in patients with peritoneovenous shunts. Cancer Res 1984, 44: 3584-3592.
15. Stracke ML, Liotta LA: Multi-step cascade of tumor cell metastasis. In Vivo 1992, 6:309-316.
16. Egan SE, Wright JA, Jarolim L, Yanagihara K, Bassin RH, Greenberg AH: Transformation by oncogenes encoding protein kinases induces the metastatic phenotype. Science 1987, 238:202-205.
17. Price JE, Polyzos A, Zhang RD, Daniels LM: Tumorigenicity and metastasis of human breast carcinoma cell lines in nude mice. Cancer Res 1990, 50:717-721.
18. Thorban S, Roder JD, Nekarda H, Funk A, Siewert JR, Pantel K: Immunocytochemical detection of disseminated tumor cells in the bone marrow of patients with esophageal carcinoma. J Natl Cancer Inst 1996, 88:1222-1227.
19. Soeth E, Vogel I, Roder C, Juhl H, Marxsen J, Kruger U, Henne-Bruns D, Kremer B, Kalthoff H: Comparative analysis of bone marrow and venous blood isolates from gastrointestinal cancer patients for the detection of disseminated tumor cells using reverse transcription PCR. Cancer Res 1997, 57: 3106-3110.
20. Baker M, Gillanders WE, Mikhitarian K, Mitas M, Cole DJ: The molecular detection of micrometastatic breast cancer. Am J Surg 2003, 186:351-358.
21. Cole BF, Gelber RD, Gelber S, Coates AS, Goldhirsch A: Polychemotherapy for early breast cancer: An overview of the randomised clinical trials with quality-adjusted survival analysis. Lancet 2001, 358:277-286.
22. Sorlie T, Perou CM, Tibshirani R, Aas T, Geisler S, Johnsen H, Hastie T, Eisen MB, van de Rijn M, Jeffrey SS, Thorsen T, Quist H, Matese JC, Brown PO, Botstein D, Eystein Lonning P, Borresen-Dale AL: Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications. Proc Natl Acad Sci USA 2001, 98:10869-10874.
23. van de Vijver MJ, He YD, van't Veer LJ, Dai H, Hart AA, Voskuil DW, Schreiber GJ, Peterse JL, Roberts C, Marton MJ, Parrish M, Atsma D, Witteveen A, Glas A, Delahaye L, van der Velde T, Bartelink H, Rodenhuis S, Rutgers ET, Friend SH, Bernards R: A gene-expression signature as a predictor of survival in breast cancer. N Engl J Med 2002, 347:1999-2009.
24. Sorlie T, Tibshirani R, Parker J, Hastie T, Marron JS, Nobel A, Deng S, Johnsen H, Pesich R, Geisler S, Demeter J, Perou CM, Lonning PE, Brown PO, Borresen-Dale AL, Botstein D: Repeated observation of breast tumor subtypes in independent gene expression data sets. Proc Natl Acad Sci USA 2003, 100: 8418-8423.
25. Ma XJ, Salunga R, Tuggle JT, Gaudet J, Enright E, McQuary P, Payette T, Pistone M, Stecker K, Zhang BM, Zhou YX, Varnholt H, Smith B, Gadd M, Chatfield E, Kessler J, Baer TM, Erlander MG, Sgroi DC: Gene expression profiles of human breast cancer progression. Proc Natl Acad Sci USA 2003, 100:5974-5979.
26. FidlerGIJ: Metastasis: guantitative analysis of distribution and fate of tumor embolilabeled with 125 I-5-iodo-2′-deoxyuridine. J Natl Cancer Inst 1970, 45:773-782.
27. Chambers AF, Groom AC, MacDonald IC: Dissemination and growth of cancer cells in metastatic sites. Nat Rev Cancer 2002, 2:563-572.
28. Wyckoff JB, Jones JG, Condeelis JS, Segall JE: A critical step in metastasis: In vivo analysis of intravasation at the primary tumor. Cancer Res 2000, 60:2504-2511.
29. Chambers AF, Naumov GN, Vantyghem SA, Tuck AB: Molecular biology of breast cancer metastasis. Clinical implications of experimental studies on metastatic inefficiency. Breast Cancer Res 2000, 2:400-407.
30. Fidler IJ: The pathogenesis of caTcer metastasis: the 'seed and soil' hypothesis revisited. Nat Rev Cancer 2003, 3:453-458.
31. Paget S: The distribution of secondary growths in cancer of the breast Lancet 1889, 1:571-573.
32. Folkman J: Role of angiogenesis in tumor growth and metastasis. Semin Oncol 2002, Suppl 16:15-18.
33. Bissell MJ, Radisky D: Putting tumours in context. Nat Rev Cancer 2001, 1:46-54.
34. Pupa SM, Menard S, Forti S, Tagliabue E: New insights into the role of extracellular matrix during tumor onset and progression. J Cell Physiol 2002, 192:259-267.
35. Barcellos-Hoff MH: It takes a tissue to make a tumor: epigenetics, cancer and the microenvironment. J Mammary Gland Biol Neoplasia 2001, 6:213-221.
36. Tlsty TD: Stromal cells can contribute oncogenic signals. Semin Cancer Biol 2001, 11:97-104.
37. De Wever O, Mareel M: Role of tissue stroma in cancer cell invasion. J Pathol 2003, 200:429-447.
38. Martins-Green M, Boudreau N, Bissell MJ: Inflammation is responsible for the development of wound-induced tumors in chickens infected with Rous sarcoma virus. Cancer Res 1994, 54:4334-4341.
39. Steele VE, Hawk ET, Viner JL, Lubet RA: Mechanisms and applications of non-steroidal anti-inflammatory drugs in the chemoprevention of cancer. Mutat Res 2003, 523-524:137-44.
40. Tuxhorn JA, Ayala GE, Smith MJ, Smith VC, Dang TD, Rowley DR: Reactive stroma in human prostate cancer: Induction of myofibroblast phenotype and extracellular matrix remodeling. Clin Cancer Res 2002, 8:2912-2923.
41. Chauhan H, Abraham A, Phillips JR, Pringle JH, Walker RA, Jones JL: There is more than one kind ofAmyofibroblast: analysis of CD34 expression in benign, in situ, and invasive breast lesions. J Clin Pathol 2003, 56:271-276.
42. + fibrocytes in invasive ductal carcinoma, ductal carcinoma in situ, and benign breast lesions. Virchows Arch 2002, 440:298-303.
43. Olumi AF, Grossfeld GD, Hayward SW, Carroll PR, Tlsty TD, Cunha GR: Carcinoma-associated fibroblasts direct tumor progression of initiated human prostatic epithelium. Cancer Res 1999, 59:5002-5011.
44. Skobe M, Fusenig NE: Tumorigenic conversion of immortal human keratinocytes through stromal cell activation. Proc Natl Acad Sci USA 1998, 95:1050-1055.
45. Barcellos-Hoff MH, Ravani SA: Irradiated mammary gland stroma promotes the expression of tumorigenic potential by unirradiated epithelial cells. Cancer Res 2000, 60:1254-1260.
46. Krtolica A, Parrinello S, Lockett S, Desprez PY, Campisi J: Senescent fibroblasts promote epithelial cell growth and tumorigenesis: A link between cancer and aging. Proc Natl Acad Sci USA 2001, 98:12072-12077.
47. Krtolica A, Aampisi J: Cancer and aging: a model for the cancer promoting effects of the aging stroma. Int J Biochem Cell Biol 2002, 34:1401-1414.
48. Schedin P, Strange R, Mitrenga T, Wolfe P, Kaeck M: Fibronectin fragments induce MMP activity in mouse mammary epithelial cells: Evidence for a role in mammary tissue remodeling. J Cell Sci 2000, 113:795-806.
49. Bemis LT, Schedin P: Reproductive state of rat mammary gland stroma modulates human breast cancer cell migration and invasion. Cancer Res 2000, 60:3414-3418.
50. Pierce GB, Speers WC: Tumors as caricatures of the process of tissue renewal: Prospects for therapy by directing differentiation. Cancer Res 1988, 48:1996-2004.
51. Wessells N: Tissue Interactions and Development, 1st ed. Menlo Park, CA: Benjamin/Cummings; 1977.
52. Weaver VM, Petersen OW, Wang F, Larabell CA, Briand P, Damsky C, Bissell MJ: Reversion of the malignant phenotype of human breast cells in three-dimensional culture and in vivo by integrin blocking antibodies. J Cell Biol 1997, 137:231-245.
53. Deng G, Lu Y, Zlotnikov G, Thor AD, Smith HS: Loss of heterozygosity in normal tissue adjacent to breast carcinomas. Science 1996, 274:2057-2059.
54. Coussens LM, Fingleton B, Matrisian LM: Matrix metalloproteinase inhibitors and cancer: Trials and tribulations. Science 2002, 295:2387-2392.
55. O'Reilly MS, Boehm T, Shing Y, Fukai N, Vasios G, Lane WS, Flynn A, Birkhead JR, Olsen BR, Folkman J: Endostatin: an endogenous inhibitor of angiogenesis and tumor growth. Cell 1997, 88:277-285.
56. O'Reilly MS, Holmgren L, Shing Y, Chen C, Rosenthal RA, Moses M, LaneAWS, Cao Y, Sage EH, Folkman J: Angiostatin: a novel angiogenesis inhibitor that mediates the suppression of metastases by a Lewis lung carcinoma. Cell 1994, 79:315-328.
57. O'Reilly MS, Wiederschain D, Stetler-Stevenson WG, Folkman J Moses MA: Regulation of angiostatin production by matrix metalloproteinase-2 in a model of concomitant resistance. J Biol Chem 1999, 274:29568-29571.
58. Pennacchietti S, Michieli P, Galluzzo M, Mazzone M, Giordano S, Comoglio PM: Hypoxia promotes invasive growth by transcriptional activation of the met protooncogene. Cancer Cell 2003, 3:347-361.
59. Steeg PS: AngiogeneMis inhibitors: motivators of metastasis? Nat Med 2003, 9:822-823.
60. Schedin PJ, Strange R, Singh M, Kaeck MR, Fontaine SC, Thompson HJ: Treatment with chemopreventive agents, difluoromethylornithine and retinyl acetate, results in altered mammary extracellular matrix. Carcinogenesis 1995, 16:1787-1794.
61. Schedin PJ, Thackray LB, Malone P, Fontaine SC, Friis RR, Strange R: Programmed cell death and mammary neoplasia. Cancer Treat Res 1996, 83:3-22.
62. Ip MM, Masso-Welch PA, Ip C: Prevention of mammary cancer with conjugated linoleic acid: Role of the stroma and the epithelium. J Mammary Gland Biol Neoplasia 2003, 8:103-118.