Lactoferrin- and antitransferrin-modified liposomes for brain targeting of the NK3 receptor agonist senktide: Preparation and in vivo evaluation

International Journal of Pharmaceutics

Volumn 479, Issue 1, 2015, Pages 129-137

  De Luca, Maria Antonietta ^a   Lai, Francesco ^a   Corrias, Francesco ^a   Caboni, Pierluigi ^a   Bimpisidis, Zisis ^a   Maccioni, Elias ^a   Fadda, Anna Maria ^a   Di Chiara, Gaetano ^a,b  

^a UNIVERSITY OF CAGLIARI   (Italy)

^b CNR   (Italy)

Author keywords

Blood brain barrier; Dopamine; In vivo brain microdialysis; Liposomes; Senktide; Targeting

Indexed keywords

ANTITRANSFERRIN; LACTOFERRIN; LIPOSOME; SENKTIDE; TRANSFERRIN; UNCLASSIFIED DRUG; MONOCLONAL ANTIBODY; NEUROKININ 3 RECEPTOR; PEPTIDE FRAGMENT; SUBSTANCE P; TRANSFERRIN RECEPTOR;

ANIMAL EXPERIMENT; ARTICLE; BLOOD BRAIN BARRIER; CENTRAL NERVOUS SYSTEM; CONTROLLED STUDY; DRUG DELIVERY SYSTEM; DRUG STRUCTURE; ENCAPSULATION; MALE; MICRODIALYSIS; NONHUMAN; NUCLEUS ACCUMBENS; PRIORITY JOURNAL; RAT; TRANSMISSION ELECTRON MICROSCOPY; ZETA POTENTIAL; AGONISTS; ANALOGS AND DERIVATIVES; ANIMAL; BRAIN; CHEMISTRY; DRUG FORMULATION; IMMUNOLOGY; LIVER; METABOLISM; SPRAGUE DAWLEY RAT;

ANIMALS; ANTIBODIES, MONOCLONAL; BRAIN; DRUG COMPOUNDING; LACTOFERRIN; LIPOSOMES; LIVER; MALE; MICRODIALYSIS; PEPTIDE FRAGMENTS; RATS, SPRAGUE-DAWLEY; RECEPTORS, NEUROKININ-3; RECEPTORS, TRANSFERRIN; SUBSTANCE P;

EID: 84920768353     PISSN: 03785173     EISSN: 18733476     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2014.12.057     Document Type: Article

References (50)

1. T. Anda, H. Yamashita, H. Fujita, Y. Tokunaga, and S. Shibata Basic experiment of BBB permeability of cisplatin encapsulated in liposome by means of in vitro BBB Drug Deliv. Syst. 10 1995 425 430
2. V. Bassareo, M.A. De Luca, and G. Di Chiara Differential expression of motivational stimulus properties by dopamine in nucleus accumbens shell versus core and prefrontal cortex J. Neurosci. 22 2002 4709 4719
3. D.J. Begley Delivery of therapeutic agents to the central nervous system: the problems and the possibilities Pharmacol. Ther. 104 2004 29 45
4. N. Bodor, and P. Buchwald Recent advances in the brain targeting of neuropharmaceuticals by chemical delivery systems Adv. Drug Deliv. Rev. 36 1999 229 254
5. Y. Chen, and L. Liu Modern methods for delivery of drugs across the blood-brain barrier Adv. Drug Deliv. Rev. 64 2012 640 665
6. H. Chen, L. Tang, Y. Qin, Y. Yin, J. Tang, W. Tang, X. Sun, Z. Zhang, J. Liu, and Q. He Lactoferrin-modified procationic liposomes as a novel drug carrier for brain delivery Eur. J. Pharm. Sci. 40 2010 94 102
7. H. Chen, Y. Qin, Q. Zhang, W. Jiang, L. Tang, J. Liu, and Q. He Lactoferrin modified doxorubicin-loaded procationic liposomes for the treatment of gliomas Eur. J. Pharm. Sci. 44 2011 164 173
8. L. Costantino, G. Tosi, B. Ruozi, L. Bondioli, M.A. Vandelli, and F. Forni Chapter 3 - colloidal systems for CNS drug delivery Prog. Brain Res. 180 2009 35 69
9. A. Désormeaux, and M.G. Bergeron Liposomes as drug delivery system: a strategic approach for the treatment of HIV infection J. Drug Target. 6 1998 1 15
10. M.T.G. Da Cruz, S. Simões, and M.C.P. de Lima Improving lipoplex-mediated gene transfer into C6 glioma cells and primary neurons Exp. Neurol. 187 2004 65 75
11. L.A. Dawson, and P.W. Smith Therapeutic utility of NK3 receptor antagonists for the treatment of schizophrenia Curr. Pharm. Des. 16 2010 344 357
12. De Luca, M.A.; Bimpisidis, Z.; Ballard, T.; Ratni, F.; Di Chiara, G.; 2011. poster 568.07/Z10.De Luca M.A, Bimpisidis Z.; Ballard T.; Ratni, F, Di Chiara, G. Characterization of the in vivo efficacy on dopaminergic and noradrenergic neurotransmission of a novel NK3 receptor antagonist: RO5313520. (2011) poster 568.07/Z10; Washington, DC: 41st Society for Neuroscience Annual Meeting, Nov. 12-16, 2011.
13. M.A. De Luca, M. Solinas, Z. Bimpisidis, S.R. Goldberg, and G. Di Chiara Cannabinoid facilitation of behavioral and biochemical hedonic taste responses Neuropharmacology 63 2012 161 168
14. G. Di Chiara, and A. Imperato Drugs abused by humans preferentially increase synaptic dopamine concentrations in the mesolimbic system of freely moving rats Proc. Natl. Acad. Sci. 85 1988 5274 5278
15. G. Di Chiara, V. Bassareo, S. Fenu, M.A. De Luca, L. Spina, C. Cadoni, E. Acquas, E. Carboni, V. Valentini, and D. Lecca Dopamine and drug addiction: the nucleus accumbens shell connection Neuropharmacology 47 2004 227 241
16. M. Fresta, G. Puglisi, C. Di Giacomo, and A. Russo Liposomes as in-vivo carriers for citicoline: effects on rat cerebral post-ischaemic reperfusion J. Pharm. Pharmacol. 46 1994 974 981
17. M. Garg, A. Asthana, H.B. Agashe, G.P. Agrawal, and N.K. Jain Stavudine-loaded mannosylated liposomes: in-vitro anti-HIV-I activity, tissue distribution and pharmacokinetics J. Pharm. Pharmacol. 58 2006 605 616
18. R. Huang, W. Ke, Y. Qu, J. Zhu, Y. Pei, and C. Jiang Characterization of lactoferrin receptor in brain endothelial capillary cells and mouse brain J. Biomed. Sci. 14 2007 121 128
19. J. Huwyler, D. Wu, and W.M. Pardridge Brain drug delivery of small molecules using immunoliposomes Proc. Natl. Acad. Sci. 93 1996 14164 14169
20. J. Huwyler, J. Yang, and W.M. Pardridge Receptor mediated delivery of daunomycin using immunoliposomes: pharmacokinetics and tissue distribution in the rat J. Pharmacol. Exp. Ther. 282 1997 1541 1546
21. W.A. Jefferies, M.R. Brandon, S.V. Hunt, A.F. Williams, K.C. Gatter, and D.Y. Mason Transferrin receptor on endothelium of brain capillaries Nature 312 1984 162 163
22. B. Ji, J. Maeda, M. Higuchi, K. Inoue, H. Akita, H. Harashima, and T. Suhara Pharmacokinetics and brain uptake of lactoferrin in rats Life Sci. 78 2006 851 855
23. K. Kakinuma, R. Tanaka, H. Takahashi, Y. Sekihara, M. Watanabe, and M. Kuroki Drug delivery to the brain using thermosensitive liposome and local hyperthermia Int. J. Hyperthermia 12 1996 157 165
24. Y.S. Kang, R.J. Boado, and W.M. Pardridge Pharmacokinetics and organ clearance of a 3′-biotinylated: internally [32P]-labeled phosphodiester oligodeoxynucleotide coupled to a neutral avidin/monoclonal antibody conjugate Drug Metab. Dispos. 23 1995 55 59
25. F. Lai, A.M. Fadda, and C. Sinico Liposomes for brain delivery Expert Opin. Drug Deliv. 10 2013 1003 1022
26. X. Langlois, C. Wintmolders, P. te Riele, J.E. Leysen, and M. Jurzak Detailed distribution of Neurokinin 3 receptors in the rat, guinea pig and gerbil brain: a comparative autoradiographic study Neuropharmacology 40 2001 242 253
27. J. Lichota, T. Skjørringe, L.B. Thomsen, and T. Moos Macromolecular drug transport into the brain using targeted therapy J. Neurochem. 113 2010 1 13
28. N. Marco, A. Thirion, G. Mons, I. Bougault, G. Le Fur, P. Soubrié, and R. Steinberg Activation of dopaminergic and cholinergic neurotransmission by tachykinin NK3 receptor stimulation: an in vivo microdialysis approach in guinea pig Neuropeptides 32 1998 481 488
29. H. Meltzer, and A. Prus NK3 receptor antagonists for the treatment of schizophrenia Drug Discov. Today Ther. Strateg. 3 2006 555 560
30. H.Y. Meltzer, and S.M. Stahl The dopamine hypothesis of schizophrenia: a review Schizophr. Bull. 2 1976 19 76
31. D. Mileusnic, J.M. Lee, D.J. Magnuson, M.J. Hejna, J.E. Krause, J.B. Lorens, and S.A. Lorens Neurokinin-3 receptor distribution in rat and human brain: an immunohistochemical study Neuroscience 89 1999 1269 1290
32. L. Montenegro, A. Campisi, M.G. Sarpietro, C. Carbone, R. Acquaviva, G. Raciti, and G. Puglisi In vitro evaluation of idebenone-loaded solid lipid nanoparticles for drug delivery to the brain Drug Dev. Ind. Pharm. 37 2011 737 746
33. N. Mori, A. Kurokouchi, K. Osonoe, H. Saitoh, K. Ariga, K. Suzuki, and Y. Iwata Liposome-entrapped phenytoin locally suppresses amygdaloid epileptogenic focus created by db-cAMP/EDTA in rats Brain Res. 703 1995 184 190
34. E. Nalivaiko, J.C. Michaud, P. Soubrié, G. Le Fur, and P. Feltz Tachykinin neurokinin-1 and neurokinin-3 receptor-mediated responses in guinea-pig substantia nigra: an in vitro electrophysiological study Neuroscience 78 1997 745 757
35. W.M. Pardridge The blood-brain barrier: bottleneck in brain drug development NeuroRx 2 2005 3 14
36. W.M. Pardridge Drug and gene targeting to the brain via blood-brain barrier receptor-mediated transport systems Int. Congr. Ser. 1277 2005 49 62
37. W.M. Pardridge Blood-brain barrier delivery Drug Discov. Today 12 2007 54 61
38. Paxinos, G.; Watson, C.; The rat brain in stereotaxic coordinates, 6th Edition (2006), Academic Press
39. H. Ratni, T.M. Ballard, C. Bissantz, T. Hoffmann, P. Jablonski, F. Knoflach, H. Knust, P. Malherbe, M. Nettekoven, A. Patiny-Adam, C. Riemer, M. Schmitt, and W. Spooren Rational design of novel pyrrolidine derivatives as orally active neurokinin-3 receptor antagonists Bioorg. Med. Chem. Lett. 20 2010 6735 6738
40. G.R. Seabrook, B.J. Bowery, and R.G. Hill Pharmacology of tachykinin receptors on neurones in the ventral tegmental area of rat brain slices Eur. J. Pharmacol. 273 1995 113 119
41. K.B. Simonsen, K. Juhl, B. Steiniger-Brach, and S.M. Nielsen Novel NK(3) receptor antagonists for the treatment of schizophrenia and other CNS indications Curr. Opin. Drug Discov. Devel. 13 2010 379 388
42. V. Soni, S.K. Jain, and D. Kohli Potential of transferrin and transferrin conjugates of liposomes in drug delivery and targeting Am. J. Drug Deliv. 3 2005 155 170
43. W. Spooren, C. Riemer, and H. Meltzer Opinion: NK3 receptor antagonists: the next generation of antipsychotics? Nat. Rev. Drug Discov. 4 2005 967 975
44. T. Terasaki, and K. Hosoya The blood-brain barrier efflux transporters as a detoxifying system for the brain Adv. Drug Deliv. Rev. 36 1999 195 209
45. K. Ulbrich, T. Hekmatara, E. Herbert, and J. Kreuter Transferrin- and transferrin-receptor-antibody-modified nanoparticles enable drug delivery across the blood-brain barrier (BBB) Eur. J. Pharm. Biopharm. 71 2009 251 256
46. A. Villringer, A. Them, U. Lindauer, K. Einhäupl, and U. Dirnagl Capillary perfusion of the rat brain cortex An in vivo confocal microscopy study Circ. Res. 75 1994 55 62
47. M.S. Webb, P. Rebstein, W. Lamson, and M.B. Bally Liposomal drug delivery: recent patents and emerging opportunities Recent Pat. Drug Deliv. Formul. 1 2007 185 194
48. X. Zhang, J. Xie, S. Li, X. Wang, and X. Hou The study on brain targeting of the amphotericin B liposomes J. Drug Target. 11 2003 117 122
49. G.J. Ziere, M.C. van Dijk, M.K. Bijsterbosch, and T.J. van Berkel Lactoferrin uptake by the rat liver. Characterization of the recognition site and effect of selective modification of arginine residues J. Biol. Chem. 267 1992 11229 11235
50. G.J. Ziere, M.K. Bijsterbosch, and T.J. van Berkel Removal of 14 N-terminal amino acids of lactoferrin enhances its affinity for parenchymal liver cells and potentiates the inhibition of beta - very low density lipoprotein binding J. Biol. Chem. 268 1993 27069 27075