Stavudine-loaded mannosylated liposomes: In-vitro anti-HIV-1 activity, tissue distribution and pharmacokinetics

Journal of Pharmacy and Pharmacology

Volumn 58, Issue 5, 2006, Pages 605-616

  Garg, Minakshi ^a   Asthana, Abhay ^a   Agashe, Hrushikesh B ^a   Agrawal, Govind Prasad ^a   Jain, Narendra Kumar ^a  

^a DR H S GOUR UNIVERSITY   (India)

Author keywords

[No Author keywords available]

Indexed keywords

HUMAN IMMUNODEFICIENCY VIRUS ANTIBODY; LIPOSOME; MANNOSE BINDING PROTEIN; STAVUDINE;

ANEMIA; ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; CELL VIABILITY; CONTROLLED STUDY; DOSE RESPONSE; DRUG CLEARANCE; DRUG DELIVERY SYSTEM; DRUG FORMULATION; DRUG HALF LIFE; DRUG LIVER LEVEL; DRUG TISSUE LEVEL; DRUG UPTAKE; HEMATOLOGICAL PARAMETERS; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VITRO STUDY; LEUKOPENIA; LIGAND BINDING; LIVER; LUNG PARENCHYMA; NONHUMAN; PROTEIN CARBOHYDRATE INTERACTION; RAT; SPLEEN; SYNTHESIS; TISSUE DISTRIBUTION;

ANIMALS; ANTI-HIV AGENTS; BLOOD CELL COUNT; CELL LINE; CELL SURVIVAL; CONCANAVALIN A; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG CARRIERS; HIV CORE PROTEIN P24; HIV-1; HUMANS; INJECTIONS, INTRAVENOUS; LIPOSOMES; MACROPHAGES; MANNOSE; RATS; RATS, SPRAGUE-DAWLEY; STAVUDINE; T-LYMPHOCYTES; TISSUE DISTRIBUTION;

EID: 33646439685     PISSN: 00223573     EISSN: None     Source Type: Journal    
DOI: 10.1211/jpp.58.5.0005     Document Type: Article

References (63)

1. Alving, C. R. (1983) Delivery of liposome-encapsulated drugs to macrophages. Pharmacol. Ther. 22: 407-422
2. Auger, M. J., Ross, J. A. (1992) The biology of macrophage. In: Lewis, C. E., Mcgee, J. O. D. (eds) The natural immune system: the macrophage. Oxford University Press, New York, pp 2-74
3. Bakker-Woudenberg, I. A. J. M. (1995) Liposomes in the treatment of parasitic, viral, fungal and bacterial infections. J. Lipos. Res. 5: 169-191
4. Banerjee, G., Bhaduri, A. N., Basu, M. K. (1994) Mannose-coated liposomal hamycin in the treatment of experimental leishmaniasis in hamsters. Biochem. Med. Metab. Biol. 53: 1-7
5. Barrat, G., Tenu, J. P., Yapo, A., Petit, J. F. (1986) Preparation and characterization of liposome containing mannosylated phospholipids capable of targeting to macrophages. Biochim. Biophys. Acta 862: 153-164
6. Bedoya, L. M., Sanchez-Palomino, S., Abad, M. J., Bermejo, P., Alcami, J. J. (2001) Anti-HIV activity of medicinal plant extracts. Ethnopharmacology 77: 113-116
7. Copland, M. J., Baird, M. A., Rades, T., McKenzie, J. L., Becker, B., Reck, F., Tyler, P. C., Davies, N. M. (2003) Liposomal delivery of antigen to human dendritic cells. Vaccine 21: 883-890
8. Desomeaux, A., Harvie, P., Perron, S., Makabi-Panzu, B., Beauchamp, D., Tremblay, M., Poulin, L., Bergeron, M. G. (1994) Antiviral efficacy, intracellular uptake and pharmacokinetics of free and liposome encapsulated 2′,3′-dideoxyinosine. AIDS 8: 1545-1553
9. Duncan, R., Dimitrijevic S., Eyagororou, E. G. (1996) The role of polymer conjugate in the diagnosis and treatment of cancer. STP Pharm. Sci. 6: 237-263
10. Dussere, N., Lessard, C., Paquette, N., Perron, S., Poulin, L., Tremblay, M., Beauchamp, D., Desormeaux, A., Bergeron, M. G. (1995) Encapsulation of foscarnet in liposomes modifies intracellular accumulation, in vitro anti-hIV-1 activity, tissue distribution and pharmacokinetics. AIDS 9: 833-841
11. Fidler, U., Brown, N. O., Hart, I. R. (1985) Species variability for toxicity of free and liposome-encapsulated muramyl peptides administered intravenously. J. Biol. Resp. Modif. 4: 298-309
12. Fry, D. W., White, J. C., Goldman, I. D. (1978) Rapid separation of low molecular weight solutes from liposomes without dilution. Anal. Biochem. 90: 809-815
13. Gregoriadis, G. (1988) Fate of injected liposomes: observation on entrapped solute tretinoin, vesicle clearance and tissue distribution in vivo. In: Gregoriadis, G. (ed.) Liposome as drug carriers: recent trends and progress. Wiley, Chichester, pp 3-18
14. Habash, J., Raftery, J., Nuttall, R., Price, H. J., Wilkinson, C., Kalb A. J., Helliwell, J. R. (2000) Direct determination of the positions of the deuterium atoms of the bound water in concanavalin a by neutron Laue crystallography. Acta Crystallogr. D Biol. Crystallogr. D56: 541-550
15. Hao, Y. L., Deng, Y. J., Chen, Y., Wang, K. Z., Hao, A. J., Zhang, Y. (2005) In-vitro cytotoxicity, in vivo biodistribution and antitumour effect of PEGylated liposomal topotecan. J. Pharm. Pharmacol. 57: 1279-1287
16. Harvie, P., Desormeaux, A., Gagne, N., Tremblay, M., Poulin, L., Beauchamp, D., Bergeron, G. (1995) Lymphoid tissue targeting of liposome encapsulated 2′,3′-dideoxyinosine (ddI). AIDS 9: 701-707
17. Herman, E., Rahman, A., Ferrans, V., Vick, J., Schein, P. (1983) Prevention of chronic doxorubicin cardiotoxicity in beagles by liposome entrapment. Cancer Res. 43: 5427-5432
18. Ho, D. D., Neumann, A. U., Perelson, A. S., Chen, W., Leonard, J. M., Markowitz, M. (1995) Rapid turnover of plasma virions and CD4 lymphocytes in HIV-1 infection. Nature 373: 123-126
19. Jansen, R. W., Molema, G., Ching, T. L., Oosting, R., Harms, G., Moolenaar, F., Hardonk, M. J., Meijer, D. K. (1991) Hepatic endocytosis of various types of mannose-terminated albumins. What is important, sugar recognition, net charge, or the combination of these features? J. Biol. Chem. 266: 3343-3348
20. Kanter, P. M., Bullard, G. A., Pilkiewicz, F. G., Mayer, L. D., Cullis, P. R., Pavelic, J. P. (1993) Preclinical toxicology study of liposome encapsulated doxorubicin: comparison with doxorubicin and empty liposomes in mice and dogs. In-Vivo 7: 85-95
21. Katragadda, A., Bridgman, R., Betageri, G. (2000) Effect of liposome composition and cholesterol on the cellular uptake of stavudine by human monocyte/macrophages. Cell. Mol. Biol. Lett. 5: 483-493
22. Kawakami, S., Wong, J., Sato, A., Hattori, Y., Yamashita, F., Hashida, M. (2000) Biodistribution characteristics of mannosylated, fucosylated, and galactosylated liposomes in mice. Biochim. Biophys. Acta 1524: 258-265
23. Konopka, K., Davis, B. R., Larsen, C. E., Alford, D. R., Debs, R. J., Duzgunes, N. (1990) Liposomes modulate human immunodeficiency virus infectivity. J. Gen. Virol. 71: 2899-2907
24. Lasic, D. (1992) Liposomes. Am. Scientist 80: 20-31
25. Lasic, D. D. (1993) Liposomes: from physics to applications. Elsevier, Amsterdam, pp 108-201
26. Levy, J. A. (1993) Pathogenesis of human immunodeficiency virus. Microbiol. Rev. 57: 183-289
27. 99mTc-labelled liposomes in patients with cancer. Cancer Res. 44: 375-378
28. Lopez-Berestein, G., McQueen, T., Mehta, K. (1985) Protective effect of liposomal amphotericin B against C. albicans infection. Cancer Drug Del. 2: 183-189
29. Lopez-Berestein, G., Bodey, G. P., Frankel, L. S., Mehat, K. (1987) Treatment of hepatosplenic candidiasis with liposomal amphotericin B. J. Clin. Oncol. 5: 310-317
30. Makabi-Panzu, B., Lessard, C., Perron, S., Desomeaux, A., Tremblay, M., Poulin, L., Beauchamp, D., Bergeron, M. G. (1994) Comparison of cellular accumulation, tissue distribution and anti-HIV activity of free and liposomal 2′,3′-dideoxycytidine. AIDS Res. Hum. Retroviruses 10: 1463-1470
31. Mayer, L., Tai, L., Bally, M. (1990) Characterization of liposomal systems containing doxorubicin. Biochim. Biophys. Acta 1025: 143-148
32. Medda, S., Mukherjee, S., Das, N., Naskar, K., Mahato, S. B., Basu, M. K. (1993) Sugar-coated liposomes: a novel delivery system for increased drug efficacy and reduced drug toxicity. Biotechnol. Appl. Biochem. 17: 37-47
33. Mehta, R. T., Hopfer, R. L., McQueen, T., Juliano, R. L., Lopez-Berestein, G. (1987) Toxicity and therapeutic effects in mice of liposome-encapsulated nystatin for systemic fungal infections. Antimicrob. Agents Chemother. 31: 1901-1913
34. Meltzer, M. S., Skillman, D. R., Gendelman, H. E. (1990) Macrophage and the immunodeficiency virus. Immunol. Today 6: 217-224
35. Mitra, S. K., Venkataranganna, M. V., Sundaram, R., Gopumadhavan, S. (1998) Protective effect of HD-03, a herbal formulation, against various hepatotoxic agents in rats. J. Ethnopharmacol. 63: 181-186
36. Muller, C. D., Schuber, F. (1989) Neo-mannosylated liposomes: synthesis and interaction with mouse kupffer cells and resident peritoneal macrophages. Biochim. Biophys. Acta Ser. Biomembr. 986: 97-105
37. Nassander, U. K., Storm, G., Peeters, P. A. M., Crommelin, D. J. A. (1990) Liposomes. In: Chasin, M., Langer, R. (eds) Biodegradable polymers as drug delivery systems. Marcel Dekker, New York, pp 261-338
38. New, R. R. C. (1990) Introduction and preparation of liposomes. In: New, R. R. C. (ed.) Liposomes: a practical approach. Oxford University Press, Oxford, pp 1-104
39. Pagano, R. E., Weinstein, J. N. (1978) Interactions of liposomes with mammalian cells. Ann. Rev. Biophys. Bioeng. 7: 435-468
40. Perelson, A. S., Neumann, A. U., Markowitz, M., Leonard, J. M., Ho, D. D. (1996) HIV-1 dynamics in vivo: virion clearance rate, infected cell life-span, and viral generation time. Science 271: 1582-1586
41. Polomino, E. (1994) Carbohydrate handles as natural resources in drug delivery. Adv. Drug. Deliv. Rev. 13: 311-323
42. Popescu, M. C., Swensen, C. E., Ginsberg, R. S. (1987) Liposome mediated treatment of viral, bacterial and protozoal infections. In: Ostro, M. J. (ed.) Liposomes: from biophysics to therapeutics. Marcel Dekker, New York, pp 219-251
43. Poste, G., Bucana, C., Raz, A., Bugelski, P., Kirsh, R., Fidler, U. (1982) Analysis of the fate of systemically administered liposomes and implications for their use in drug delivery. Cancer Res. 42: 1412-1422
44. Pretzer, E., Flasher, D., Duzgunes, N. (1997) Inhibition of human immunodeficiency virus type-1 replication in macrophages and h9 cells by free or liposomes encapsulated 1-689,502, an inhibitor of the viral pro tease. Antiviral Res. 34: 1-15
45. Rademacher, T. W., Parekh, R. B., Dwek, R. A. (1988) Glycobiology. Annu. Rev. Biochem. 57: 785-838
46. Rahman, A., White, G., More, N., Schein, P. S. (1995) Pharmacological, toxicological and therapeutic evaluation of doxorubicin entrapped in cardiolipin liposomes. Cancer Res. 45: 796-803
47. Roy, S., Wainberg, M. A. (1988) Role of mononuclear phagocyte system in the development of acquired immunodeficiency syndrome (AIDS). J. Leukoc. Biol. 43: 91-97
48. Salvatori, D., Vincenzetti, S., Maury, G., Gosselin, G., Gaubert, G., Vita, A. (2001) Maedi-Visna virus, a model for in vitro testing of potential anti-hiv drugs. Comp. Immunol. Microbiol. Infect. Dis. 24: 113-122
49. Sato, T., Sunamoto, J. (1992) Recent aspects in the use of liposomes in biotechnology and medicine. Prog. Lipid Res. 31: 345-372
50. Schroit, A. J., Madsen, J., Nayar, R. (1986) Liposome-cell interactions: in vitro discrimination of uptake mechanism and in vivo targeting strategies to mononuclear phagocytes. Chem. Phys. Lipids 40: 373-393
51. Senior, J. H. (1987) Fate and behavior of liposomes in vivo: a review of controlling factors. CRS Crit. Rev. Ther. Drug Carrier Sys. 3: 123-193
52. Slidregt, L. A. J. M., Rensen, P. C. N., Rump, E. T., Santbrink, P. J. V., Bijsterbosch, M. K., Valentijn, A. R. P. M., Van der Marel, G. A., Van Boom, J. H., Van Berkel, T. J. C., Biessen, E. A. L. (1999) Design and synthesis of novel amphiphilic dendritic galactosides for selective targeting of liposomes to the hepatic asialoglycoprotein receptor. J. Med. Chem. 42: 609-618
53. Stephen, C. P., Grace, K., Robert, E. W., Joseph, K., Judith, F., Richard T. T. D., Sangita, R., Henry, M., Michael, A. P. (1999) A multiple drug interaction study of stavudine with agents for opportunistic infections in human immunodeficiency virus-infected patients. Antimicrob. Agents Chemother. 43: 647-650
54. Sunamoto, J., Gato, M., Lida, T., Hara, K., Saito, A., Tomonega, A. (1985) Polymer coated liposomes for drug delivery to target specific organs. In: Gregoriadis, G., Senior, J., Trout, A. (eds) Receptor mediated targeting of drugs. Plenum, New York, pp 359-371
55. Szoka, F. C. (1991) Liposomal drug delivery: current status and future prospects. In: Wilschut, J., Hoekstra, D. (eds) Membrane fusion. Marcel Dekker, New York, pp 845-890
56. Szoka, F. C., Papahadjopoulos, D. (1978) Procedure for preparation of liposomes with large aqueous space and high capture by reverse-phase evaporation. Proc. Natl Acad. Sci. USA 75: 4194-4198
57. Szoka, F. C., Milhollan, D., Barza, M. (1987) Effect of lipid composition and liposome size on toxicity and in vitro fungicidal activity of liposome intercalated amphotericin B. Antimicrob. Agents Chemother. 31: 421-429
58. Treat, J., Greenspan, A. R., Rahman, A. (1989) Liposome-encapsulated doxorubicin: preliminary results of phase I and phase II trials. In: Lopez-Berestein, G., Fidler, I. J. (eds) Liposomes in the therapy of infectious diseases and cancer. Alan R. Liss, New York, pp 353-365
59. Vermon-Robert, B. (1972) The macrophage. In: Harrison, R. J., Meminn, R. M. H. (eds) Biological structure and function. Vol. 2, Cambridge University Press, London
60. Vlahakis, S. R., Villasis-Keever, A., Gomez, T., Bren, G. D., Paya, C. V. (2003) Human immunodeficiency virus-induced apoptosis of human hepatocytes via CXCR4. J. Infect. Dis. 188: 1455-1460
61. Wasan, K. M., Lopez-Berenstein, G. (1995) The past, present, and future uses of liposomes in treating infectious diseases. Immunopharmacol. Immunotoxicol. 17: 1-15
62. Weatherman, R. V., Mortell, K. H., Chervenak, M., Kiessling, L. L., Toone, E. J. (1996) Specificity of C-glycoside complexation by mannose/glucose specific lectins. Biochemistry 35: 3619-3624
63. Williams, C. L., Stancel, G. M. (1990) Antiviral agents. In: Gilman, A. G., Goodman, L. S., Rall, T. W., Murad, F. (eds) The pharmacological basis of therapeutics. 9th edn, Macmillan Publishing Co., New York, pp 1205