Notch1-induced T cell leukemia can be potentiated by microenvironmental cues in the spleen

Journal of Hematology and Oncology

Volumn 7, Issue 1, 2014, Pages

  Ma, Shihui ^a   Shi, Yingxu ^a,c   Pang, Yakun ^a   Dong, Fang ^a   Cheng, Hui ^a   Hao, Sha ^a   Xu, Jing ^a   Zhu, Xiaofan ^a,b   Yuan, Weiping ^a,b   Cheng, Tao ^a,b   Zheng, Guoguang ^a,b  

^a INSTITUTE OF HEMATOLOGY AND BLOOD DISEASES HOSPITAL   (China)

^b PEKING UNION MEDICAL COLLEGE   (China)

^c Inner Mongolian Medicine College   (China)

Author keywords

Microenvironment; MIP 3 ; Spleen; Splenectomy; T cell acute lymphoblastic leukemia

Indexed keywords

CHEMOKINE RECEPTOR CCR7; MACROPHAGE INFLAMMATORY PROTEIN 3BETA; NOTCH1 RECEPTOR; NOTCH1 PROTEIN, MOUSE;

ACUTE LYMPHOBLASTIC LEUKEMIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BONE MARROW; CANCER SURVIVAL; CELL MIGRATION; CELL PROLIFERATION; CELLULAR DISTRIBUTION; COCULTURE; CONTROLLED STUDY; IN VITRO STUDY; LIFESPAN; MOUSE; NONHUMAN; PROTEIN EXPRESSION; SPLEEN; T CELL LEUKEMIA; T CELL LYMPHOBLASTIC LEUKEMIA CELL; TUMOR MICROENVIRONMENT; ANIMAL; C57BL MOUSE; FEMALE; METABOLISM; PATHOLOGY; SPLENECTOMY;

ANIMALS; FEMALE; MICE; MICE, INBRED C57BL; PRECURSOR T-CELL LYMPHOBLASTIC LEUKEMIA-LYMPHOMA; RECEPTOR, NOTCH1; SPLEEN; SPLENECTOMY; TUMOR MICROENVIRONMENT;

EID: 84920759900     PISSN: None     EISSN: 17568722     Source Type: Journal    
DOI: 10.1186/s13045-014-0071-7     Document Type: Article

References (49)

1. DuFort CC, Paszek MJ, Weaver VM: Balancing forces: Architectural control of mechanotransduction. Nat Rev Mol Cell Biol 2011, 12:308-319.
2. Chang AH, Parsonnet J: Role of bacteria in oncogenesis. Clin Microbiol Rev 2010, 23:837-857.
3. Lewis CE, Pollard JW: Distinct role of macrophages in different tumor microenvironments. Cancer Res 2006, 66:605-612.
4. Hu B, Castillo E, Harewood L, Ostano P, Reymond A, Dummer R, Raffoul W, Hoetzenecker W, Hofbauer GF, Dotto GP: Multifocal epithelial tumors and field cancerization from loss of mesenchymal CSL signaling. Cell 2012, 149:1207-1220.
5. Raaijmakers MH, Mukherjee S, Guo S, Zhang S, Kobayashi T, Schoonmaker JA, Ebert BL, Al-Shahrour F, Hasserjian RP, Scadden EO, Aung Z, Matza M, Merkenschlager M, Lin C, Rommens JM, Scadden DT: Bone progenitor dysfunction induces myelodysplasia and secondary leukaemia. Nature 2010, 464:852-857.
6. Colmone A, Amorim M, Pontier AL, Wang S, Jablonski E, Sipkins DA: Leukemic cells create bone marrow niches that disrupt the behavior of normal hematopoietic progenitor cells. Science 2008, 322:1861-1865.
7. Cairns RA, Harris IS, Mak TW: Regulation of cancer cell metabolism. Nat Rev Cancer 2011, 11:85-95.
8. Kiel MJ, Morrison SJ: Uncertainty in the niches that maintain haematopoietic stem cells. Nat Rev Immunol 2008, 8:290-301.
9. Mercier FE, Ragu C, Scadden DT: The bone marrow at the crossroads of blood and immunity. Nat Rev Immunol 2012, 12:49-60.
10. Ehninger A, Trumpp A: The bone marrow stem cell niche grows up: mesenchymal stem cells and macrophages move in. J Exp Med 2011, 208:421-428.
11. Ramakrishnan A, Deeg HJ: A novel role for the marrow microenvironment in initiating and sustaining hematopoietic disease. Expert Opin Biol Ther 2009, 9:21-28.
12. Liu N, Zhang J, Ji C: The emerging roles of Notch signaling in leukemia and stem cells. Biomark Res 2013, 1:23.
13. Zou J, Li P, Lu F, Liu N, Dai J, Ye J, Qu X, Sun X, Ma D, Park J, Ji C: Notch1 is required for hypoxia-induced proliferation, invasion and chemoresistance of T-cell acute lymphoblastic leukemia cells. J Hematol Oncol 2013, 6:3.
14. Lane SW, Scadden DT, Gilliland DG: The leukemic stem cell niche: current concepts and therapeutic opportunities. Blood 2009, 114:1150-1157.
15. Wang L, Cheng T, Zheng G: The impact of tumor microenvironments on stem cells. Transl Cancer Res 2013, 2:422-428.
16. Boyerinas B, Zafrir M, Yesilkanal AE, Price TT, Hyjek EM, Sipkins DA: Adhesion to osteopontin in the bone marrow niche regulates lymphoblastic leukemia cell dormancy. Blood 2013, 121:4821-4831.
17. Tian C, Zheng G, Cao Z, Li Q, Ju Z, Wang J, Yuan W, Cheng T: Hes1 mediates the different responses of hematopoietic stem and progenitor cells to T cell leukemic environment. Cell Cycle 2013, 12:322-331.
18. Allen SJ, Crown SE, Handel TM: Chemokine: Receptor structure, interactions, and antagonism. Annu Rev Immunol 2007, 25:787-820.
19. Bachmann MF, Kopf M, Marsland BJ: Chemokines: more than just road signs. Nat Rev Immunol 2006, 6:159-164.
20. Forster R, Davalos-Misslitz AC, Rot A: CCR7 and its ligands: Balancing immunity and tolerance. Nat Rev Immunol 2008, 8:362-371.
21. Srour EF, Jetmore A, Wolber FM, Plett PA, Abonour R, Yoder MC, Orschell-Traycoff CM: Homing, cell cycle kinetics and fate of transplanted hematopoietic stem cells. Leukemia 2001, 15:1681-1684.
22. Neill HCO: Niches for Extramedullary Hematopoiesis in the Spleen. Niche J 2012, 1:12-16.
23. Kaushansky K, Lichtman MA, Beutler E, Kipps TJ, Seligsohn U, Prchal JT: Williams Hematology. 8th edition. New York: McGraw-Hill; 2010.
24. Shuster JJ, Falletta JM, Pullen DJ, Crist WM, Humphrey GB, Dowell BL, Wharam MD, Borowitz M: Prognostic factors in childhood T-cell acute lymphoblastic leukemia: A Pediatric Oncology Group study. Blood 1990, 75:166-173.
25. Kienle DL: The spleen in hematologic malignancies. Ther Umsch 2013, 70:163-169.
26. Hu X, Shen H, Tian C, Yu H, Zheng G, XuFeng R, Ju Z, Xu J, Wang J, Cheng T: Kinetics of normal hematopoietic stem and progenitor cells in a Notch1-induced leukemia model. Blood 2009, 114:3783-3792.
27. Koch U, Radtke F: Notch and cancer: A double-edged sword. Cell Mol Life Sci 2007, 64:2746-2762.
28. Borovski T, De Sousa EMF, Vermeulen L, Medema JP: Cancer stem cell niche: The place to be. Cancer Res 2011, 71:634-639.
29. Campbell JJ, Bowman EP, Murphy K, Youngman KR, Siani MA, Thompson DA, Wu L, Zlotnik A, Butcher EC: 6-C-kine (SLC), a lymphocyte adhesion-Triggering chemokine expressed by high endothelium, is an agonist for the MIP-3beta receptor CCR7. J Cell Biol 1998, 141:1053-1059.
30. Buonamici S, Trimarchi T, Ruocco MG, Reavie L, Cathelin S, Mar BG, Klinakis A, Lukyanov Y, Tseng JC, Sen F, Gehrie E, Li M, Newcomb E, Zavadil J, Meruelo D, Lipp M, Ibrahim S, Efstratiadis A, Zagzag D, Bromberg JS, Dustin ML, Aifantis I: CCR7 signalling as an essential regulator of CNS infiltration in T-cell leukaemia. Nature 2009, 459:1000-1004.
31. Mirandola L, Chiriva-Internati M, Montagna D, Locatelli F, Zecca M, Ranzani M, Basile A, Locati M, Cobos E, Kast WM, Asselta R, Paraboschi EM, Comi P, Chiaramonte R: Notch1 regulates chemotaxis and proliferation by controlling the CC-chemokine receptors 5 and 9 in T cell acute lymphoblastic leukaemia. J Pathol 2012, 226:713-722.
32. Koch U, Radtke F: Mechanisms of T cell development and transformation. Annu Rev Cell Dev Biol 2011, 27:539-562.
33. Shaked Y, Cervi D, Neuman M, Chen L, Klement G, Michaud CR, Haeri M, Pak BJ, Kerbel RS, Ben-David Y: The splenic microenvironment is a source of proangiogenesis/inflammatory mediators accelerating the expansion of murine erythroleukemic cells. Blood 2005, 105:4500-4507.
34. Sugiyama T, Kohara H, Noda M, Nagasawa T: Maintenance of the hematopoietic stem cell pool by CXCL12-CXCR4 chemokine signaling in bone marrow stromal cell niches. Immunity 2006, 25:977-988.
35. Zhang B, Ho YW, Huang Q, Maeda T, Lin A, Lee SU, Hair A, Holyoake TL, Huettner C, Bhatia R: Altered microenvironmental regulation of leukemic and normal stem cells in chronic myelogenous leukemia. Cancer Cell 2012, 21:577-592.
36. Welch JS, Ley TJ, Link DC, Miller CA, Larson DE, Koboldt DC, Wartman LD, Lamprecht TL, Liu F, Xia J, Kandoth C, Fulton RS, McLellan MD, Dooling DJ, Wallis JW, Chen K, Harris CC, Schmidt HK, Kalicki-Veizer JM, Lu C, Zhang Q, Lin L, O'Laughlin MD, McMichael JF, Delehaunty KD, Fulton LA, Magrini VJ, McGrath SD, Demeter RT, Vickery TL, et al: The origin and evolution of mutations in acute myeloid leukemia. Cell 2012, 150:264-278.
37. Wang L, Zheng GG, Ma CH, Lin YM, Zhang HY, Ma YY, Chong JH, Wu KF: A special linker between macrophage and hematopoietic malignant cells: membrane form of macrophage colony-stimulating factor. Cancer Res 2008, 68:5639-5647.
38. Hanahan D, Weinberg RA: Hallmarks of cancer: The next generation. Cell 2011, 144:646-674.
39. Wels J, Kaplan RN, Rafii S, Lyden D: Migratory neighbors and distant invaders: Tumor-Associated niche cells. Genes Dev 2008, 22:559-574.
40. Payne D, Drinkwater S, Baretto R, Duddridge M, Browning MJ: Expression of chemokine receptors CXCR4, CXCR5 and CCR7 on B and T lymphocytes from patients with primary antibody deficiency. Clin Exp Immunol 2009, 156:254-262.
41. Kursar M, Hopken UE, Koch M, Kohler A, Lipp M, Kaufmann SH, Mittrucker HW: Differential requirements for the chemokine receptor CCR7 in T cell activation during Listeria monocytogenes infection. J Exp Med 2005, 201:1447-1457.
42. Shields JD, Fleury ME, Yong C, Tomei AA, Randolph GJ, Swartz MA: Autologous chemotaxis as a mechanism of tumor cell homing to lymphatics via interstitial flow and autocrine CCR7 signaling. Cancer Cell 2007, 11:526-538.
43. Zhang Q, Sun L, Yin L, Ming J, Zhang S, Luo W, Qiu X: CCL19/CCR7 upregulates heparanase via specificity protein-1 (Sp1) to promote invasion of cell in lung cancer. Tumour Biol 2013, 34:2703-2708.
44. Berndt B, Haverkampf S, Reith G, Keil S, Niggemann B, Zanker KS, Dittmar T: Fusion of CCL21 non-migratory active breast epithelial and breast cancer cells give rise to CCL21 migratory active tumor hybrid cell lines. Plos One 2013, 8:e63711.
45. Catusse J, Leick M, Groch M, Clark DJ, Buchner MV, Zirlik K, Burger M: Role of the atypical chemoattractant receptor CRAM in regulating CCL19 induced CCR7 responses in B-cell chronic lymphocytic leukemia. Mol Cancer 2010, 9:297.
46. Corcione A, Arduino N, Ferretti E, Pistorio A, Spinelli M, Ottonello L, Dallegri F, Basso G, Pistoia V: Chemokine receptor expression and function in childhood acute lymphoblastic leukemia of B-lineage. Leuk Res 2006, 30:365-372.
47. McAllister SS, Weinberg RA: The tumour-induced systemic environment as a critical regulator of cancer progression and metastasis. Nat Cell Biol 2014, 16:717-727.
48. Grabher C, von Boehmer H, Look AT: Notch 1 activation in the molecular pathogenesis of T-cell acute lymphoblastic leukaemia. Nat Rev Cancer 2006, 6:347-359.
49. Xie Y, Yin T, Wiegraebe W, He XC, Miller D, Stark D, Perko K, Alexander R, Schwartz J, Grindley JC, Park J, Haug JS, Wunderlich JP, Li H, Zhang S, Johnson T, Feldman RA, Li L: Detection of functional haematopoietic stem cell niche using real-Time imaging. Nature 2009, 457:97-101.