Predominance of β-cell neogenesis rather than replication in humans with an impaired glucose tolerance and newly diagnosed diabetes

Journal of Clinical Endocrinology and Metabolism

Volumn 98, Issue 5, 2013, Pages 2053-2061

  Yoneda, S ^a   Uno, S ^a   Iwahashi, H ^a   Fujita, Y ^a   Yoshikawa, A ^a   Kozawa, J ^a   Okita, K ^a   Takiuchi, D ^a   Eguchi, H ^a   Nagano, H ^a   Imagawa, A ^a   Shimomura, I ^a  

^a OSAKA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA GLUCOSIDASE INHIBITOR; DIPEPTIDYL PEPTIDASE IV INHIBITOR; GLUCAGON; GLUCOSE; INSULIN; KI 67 ANTIGEN; NESTIN; NEUROGENIN 3; ORAL ANTIDIABETIC AGENT; SOMATOSTATIN; SULFONYLUREA; TRANSCRIPTION FACTOR PDX 1;

ADULT; AGED; APOPTOSIS; ARTICLE; CELL DIVISION; CELL SIZE; CELLULAR PARAMETERS; CLINICAL ARTICLE; CONTROLLED STUDY; CROSS-SECTIONAL STUDY; DIABETES MELLITUS; DIABETOGENESIS; DISEASE DURATION; FEMALE; GLUCOSE TOLERANCE; HISTOPATHOLOGY; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IMPAIRED GLUCOSE TOLERANCE; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; ORAL GLUCOSE TOLERANCE TEST; PANCREAS ISLET BETA CELL; PANCREAS ISLET BETA CELL MASS; PANCREAS RESECTION; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION;

AGED; AGED, 80 AND OVER; APOPTOSIS; BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS; BIOLOGICAL MARKERS; CELL PROLIFERATION; CROSS-SECTIONAL STUDIES; DIABETES MELLITUS, TYPE 2; DISEASE PROGRESSION; FEMALE; GLUCOSE INTOLERANCE; HOMEODOMAIN PROTEINS; HUMANS; INSULIN-SECRETING CELLS; INTERMEDIATE FILAMENT PROTEINS; KI-67 ANTIGEN; MALE; MIDDLE AGED; NERVE TISSUE PROTEINS; PANCREAS; PREDIABETIC STATE; REGENERATION; TRANS-ACTIVATORS;

EID: 84877691201     PISSN: 0021972X     EISSN: 19457197     Source Type: Journal    
DOI: 10.1210/jc.2012-3832     Document Type: Article

References (40)

1. American Diabetes Association. Diagnosis and classification of diabetes mellitus. Diabetes Care. 2011;34:S62-S69
2. Polonsky KS. Dynamics of insulin secretion in obesity and diabetes. Int J Obes Relat Metab Disord. 2000;24(Suppl 2):S29 -S31.
3. Meier JJ, Menge BA, Breuer TG, et al. Functional assessment of pancreatic β-cell area in humans. Diabetes. 2009;58:1595-1603.
4. Butler AE, Janson J, Bonner-Weir S, Ritzel R, Rizza RA, Butler PC. β-Cell deficit and increasedβ-cell apoptosis in humans with type 2 diabetes. Diabetes. 2003;52:102-110.
5. Rahier J, Guiot Y, Goebbels RM, Sempoux C, Henquin JC. Pancreatic β-cell mass in European subjects with type 2 diabetes. Diabetes Obes Metab. 2008; 10(suppl 4):32- 42.
6. Sakuraba H, Mizukami H, Yagihashi N, Wada R, Hanyu C, Yagihashi S. Reduced β-cell mass and expression of oxidative stress-related DNA damage in the islet of Japanese type II diabetic patients. Diabetologia. 2002;45:85-96.
7. Hanley SC, Austin E, Assouline-Thomas B, et al. β-Cell mass dynamics and islet cell plasticity in human type 2 diabetes. Endocrinology. 2010;151:1462- 1472.
8. Saisho Y, Manesso E, Butler AE, et al. Ongoing β-cell turnover in adult nonhumanprimates is not adaptively increased in streptozotocin-induced diabetes. Diabetes. 2011;60:848-856.
9. Meier JJ, Butler AE, Saisho Y, et al. β-Cell replication is the primary mechanism subserving the postnatal expansion of β-cell mass in humans. Diabetes. 2008; 57:1584-1594.
10. Menge BA, Tannapfel A, Belyaev O, et al. Partial pancreatectomy in adult humans does not provoke β-cell regeneration. Diabetes. 2008;57:142-149.
11. Xu X, D'Hoker J, Stangé G, et al. β Cells can be generated from endogenous progenitors in injured adult mouse pancreas. Cell. 2008;132:197-207.
12. Waguri M, Yamamoto K, Miyagawa JI, et al. Demonstration of two different processes of β-cell regeneration in a new diabetic mouse model induced by selective perfusion of alloxan. Diabetes. 1997;46:1281-1290.
13. Brüning JC, Winnay J, Bonner-Weir S, Taylor SI, Accili D, Kahn CR. Development of a novel polygenic model of NIDDMin mice heterozygous for IR and IRS-1 null alleles. Cell. 1997;88:561-572.
14. Bock T, Pakkenberg B, Buschard K. Increased islet volume but unchanged islet number in ob/ob mice. Diabetes. 2003;52:1716-1722.
15. Bonner-Weir S, Baxter LA, Schuppin GT, Smith FE. A second pathway for regeneration of adult exocrine and endocrine pancreas. A possible recapitulation of embryonic development. Diabetes. 1993;42:1715-1720.
16. Li WC, Rukstalis JM, Nishimura W, et al. Activation of pancreatic-ductderived progenitor cells during pancreas regeneration in adult rats. J Cell Sci. 2010;123:2792-2802.
17. Sharma A, Zangen DH, Reitz P, et al. The homeodomain protein IDX-1 increases after an early burst of proliferation during pancreatic regeneration. Diabetes. 1999;48:507-513.
18. Butler AE, Cao-Minh L, Galasso R, et al. Adaptive changes in pancreatic β cell fractional area and beta cell turnover in human pregnancy. Diabetologia. 2010;53:2167-2176.
19. Meier JJ, Breuer TG, Bonadonna RC, et al. Pancreatic diabetes manifests when β cell area declines by approximately 65% in humans. Diabetologia. 2012; 55:1346-1354.
20. Alberti KG, Zimmet PZ. Definition, diagnosis and classification of diabetes mellitus and its complications. Part 1: diagnosis and classification of diabetes mellitus provisional report of a WHO consultation. Diabet Med. 1998;15: 539-553.
21. Kashiwagi A, Kasuga M, Araki E, et al. Committee on the Standardization of Diabetes Mellitus-Related Laboratory Testing of Japan Diabetes Society. International clinical harmonization of glycated hemoglobin in Japan: from Japan Diabetes Society to National Glycohemoglobin Standardization Program values. J Diabetes Invest. 2012;3:39-40.
22. Sayama K, Imagawa A, Okita K, et al. Pancreatic β and α cells are both decreased in patients with fulminant type 1 diabetes: a morphometrical assessment. Diabetologia. 2005;48:1560-1564.
23. Imagawa A, Hanafusa T, Tamura S, et al. Pancreatic biopsy as a procedure for detecting in situ autoimmune phenomena in type 1 diabetes: close correlation between serological markers and histological evidence of cellular autoimmunity. Diabetes. 2001;50:1269-1273.
24. Li M, Miyagawa J, Moriwaki M, et al. Analysis of expression profiles of islet-associated transcription and growth factors duringβ-cell neogenesis from duct cells in partially duct-ligated mice. Pancreas. 2003;27:345-355.
25. Montanya E, Téllez N. Pancreatic remodeling: β-cell apoptosis, proliferation and neogenesis, and the measurement of β-cell mass and of individual β-cell size. Methods Mol Biol. 2009;560:137-158.
26. Bouwens L, Pipeleers DG. Extra-insular β cells associated with ductules are frequent in adult human pancreas. Diabetologia. 1998;41:629-633.
27. Jurgens CA, Toukatly MN, Fligner CL, et al. β-Cell loss and β-cell apoptosis in human type 2 diabetes are related to islet amyloid deposition. Am J Pathol. 2011;178:2632-2640.
28. Riedel MJ, Asadi A, Wang R, Ao Z, Warnock GL, Kieffer TJ. Immunohistochemical characterisation of cells co-producing insulin and glucagon in the developing human pancreas. Diabetologia. 2012;55:372-381.
29. Meier JJ, Köhler CU, Alkhatib B, et al. β-Cell development and turnover during prenatal life in humans. Eur J Endocrinol. 2010;162:559-568.
30. Jeon J, Correa-Medina M, Ricordi C, Edlund H, Diez JA. Endocrine cell clustering during human pancreas development. J Histochem Cytochem. 2009; 57:811-824.
31. Lyttle BM, Li J, Krishnamurthy M, et al. Transcription factor expression in the developing human fetal endocrine pancreas. Diabetologia. 2008;51:1169- 1180.
32. Kuroda A, Yamasaki Y, Imagawa. A β-cell regeneration in a patient with type 1 diabetes mellitus who was receiving immunosuppressive therapy. Ann Intern Med. 2003;139:W81.
33. Thorel F, Népote V, Avril I, et al. Conversion of adult pancreatic β-cells to β-cells after extreme β-cell loss. Nature. 2010;464:1149-1154.
34. Lumelsky N, Blondel O, Laeng P, Velasco I, Ravin R, McKay R. Differentiation of embryonic stem cells to insulin-secreting structures similar to pancreatic islets. Science. 2001;292:1389-1394.
35. Zulewski H, Abraham EJ, Gerlach MJ, et al. Multipotential nestin-positive stem cells isolated from adult pancreatic islets differentiate ex vivo into pancreatic endocrine, exocrine, and hepatic phenotypes. Diabetes. 2001;50:521- 533.
36. Martin-Pagola A, Sisino G, Allende G, et al. Insulin protein and proliferation in ductal cells in the transplanted pancreas of patients with type 1 diabetes and recurrence of autoimmunity. Diabetologia. 2008;51:1803-1813.
37. Solar M, Cardalda C, Houbracken I, et al. Pancreatic exocrine duct cells give rise to insulin-producing β cells during embryogenesis but not after birth. Dev Cell. 2009;17:849-860.
38. Kopp JL, Dubois CL, Schaffer AE, et al. Sox9+ ductal cells are multipotent progenitors throughout development but do not produce new endocrine cells in the normal or injured adult pancreas. Development. 2011;138:653-665.
39. Pannala R, Basu A, Petersen GM, Chari ST. New-onset diabetes: a potential clue to the early diagnosis of pancreatic cancer. Lancet Oncol. 2009;10:88-95.
40. Figler RA, Wang G, Srinivasan S, et al. Links between insulin resistance, adenosine A2B receptors, and inflammatory markers in mice and humans. Diabetes. 2011;60:669-679.