Formulation of glutathione responsive anti-proliferative nanoparticles from thiolated Akt1 siRNA and disulfide-crosslinked PEI for efficient anti-cancer gene therapy

Colloids and Surfaces B: Biointerfaces

Volumn 126, Issue , 2015, Pages 322-327

  Muthiah, Muthunarayanan ^a   Che, Hui Lian ^a   Kalash, Santhosh ^a   Jo, Jihoon ^a   Choi, Seok Yong ^a   Kim, Won Jong ^b   Cho, Chong Su ^c   Lee, Jae Young ^d   Park, In Kyu ^a  

^a Chonnam National University   (South Korea)

^b Pohang University of Science and Technology (POSTECH)   (South Korea)

^c Seoul National University   (South Korea)

^d Gwangju Institute of Science and Technology (GIST)   (South Korea)

Author keywords

Akt1; Bioreducible PEI; Colon cancer; SiRNA; Thiol modification; Tumor suppression

Indexed keywords

BONDING; CELL DEATH; CELL PROLIFERATION; CELLS; DISEASES; MAMMALS; SULFUR COMPOUNDS; TUMORS;

AKT1; COLON CANCER; SIRNA; THIOL MODIFICATION; TUMOR SUPPRESSION;

GENE THERAPY;

GLUTATHIONE; NANOPARTICLE; POLYETHYLENEIMINE; PROTEIN AKT1; PROTEIN KINASE B; SMALL INTERFERING RNA; THIOL; UNCLASSIFIED DRUG; CROSS LINKING REAGENT; DISULFIDE; THIOL DERIVATIVE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CANCER GENE THERAPY; CELL PROLIFERATION; COLON CANCER; COMPLEX FORMATION; CONTROLLED STUDY; DISULFIDE BOND; DOWN REGULATION; DRUG FORMULATION; GENE DELIVERY SYSTEM; GENE REPRESSION; IN VITRO STUDY; IN VIVO STUDY; MOUSE; NONHUMAN; PARTICLE SIZE; SURFACE CHARGE; TUMOR GROWTH; ANIMAL; BAGG ALBINO MOUSE; BIOSYNTHESIS; CELL SURVIVAL; CHEMISTRY; COLONIC NEOPLASMS; DISEASE MODEL; DRUG EFFECTS; GENE THERAPY; GENETICS; PATHOLOGY; SYNTHESIS; TUMOR CELL LINE;

ANIMALS; APOPTOSIS; CELL LINE, TUMOR; CELL PROLIFERATION; CELL SURVIVAL; COLONIC NEOPLASMS; CROSS-LINKING REAGENTS; DISEASE MODELS, ANIMAL; DISULFIDES; GENETIC THERAPY; GLUTATHIONE; MICE; MICE, INBRED BALB C; NANOPARTICLES; POLYETHYLENEIMINE; PROTO-ONCOGENE PROTEINS C-AKT; RNA, SMALL INTERFERING; SULFHYDRYL COMPOUNDS;

EID: 84920662627     PISSN: 09277765     EISSN: 18734367     Source Type: Journal    
DOI: 10.1016/j.colsurfb.2014.12.022     Document Type: Article

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