Suppression of post-angioplasty restenosis with an Akt1 siRNA-embedded coronary stent in a rabbit model

Biomaterials

Volumn 33, Issue 33, 2012, Pages 8548-8556

  Che, Hui Lian ^a,b   Bae, In Ho ^b   Lim, Kyung Seob ^b   Song, In Taek ^c   Lee, Haeshin ^c   Muthiah, Muthunarayanan ^a   Namgung, Ran ^d   Kim, Won Jong ^d   Kim, Dong Gon ^e   Ahn, Youngkeun ^b   Jeong, Myung Ho ^b   Park, In Kyu ^a,b  

^a Chonnam National University Medical School   (South Korea)

^b Chonnam National University Medical School   (South Korea)

^c Korea Advanced Institute of Science and Technology (KAIST)   (South Korea)

^d Pohang University of Science and Technology (POSTECH)   (South Korea)

^e MI Tech Co Ltd   (South Korea)

Author keywords

Akt1 siRNA; Disulfide cross linked low molecular PEI; Hyaluronic acid (HA) coated stent; Restenosis; Vascular smooth muscle cells

Indexed keywords

AKT1 SIRNA; CELLULAR PROLIFERATIONS; CELLULAR VIABILITY; CORONARY STENTS; DELIVERY TECHNIQUES; DISULFIDE BONDS; EXTRACELLULAR ENVIRONMENTS; GENE DELIVERY; GENE SILENCING; HYALURONIC ACIDS; ILIAC ARTERIES; IN-VIVO; INTRACELLULAR UPTAKE; IONIC INTERACTION; LUCIFERASE ASSAYS; POLYACRYLAMIDE GEL ELECTROPHORESIS; POLYETHYLENEIMINE; POST-IMPLANTATION; RABBIT MODELS; RESTENOSIS; SMOOTH MUSCLE CELLS; SMOOTH MUSCLES; SUSTAINED RELEASE; TIME-DEPENDENT; TRANSFECTION EFFICIENCY; TRANSGENE EXPRESSION; VASCULAR SMOOTH MUSCLE CELLS; WESTERN BLOTS;

CELL PROLIFERATION; COVALENT BONDS; DISEASES; ELECTROPHORESIS; ENZYME ACTIVITY; GENE EXPRESSION; GENE TRANSFER; NANOPARTICLES; ORGANIC ACIDS;

STENTS;

DISULFIDE; HYALURONIC ACID; LUCIFERASE; NANOPARTICLE; PLASMID DNA; POLYETHYLENEIMINE; PROTEIN KINASE B; PROTEIN KINASE B 1; PROTEIN SERINE THREONINE KINASE; SMALL INTERFERING RNA; UNCLASSIFIED DRUG;

ANGIOPLASTY; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTERY INJURY; ARTICLE; CELL ADHESION; CELL VIABILITY; CONTROLLED STUDY; CORONARY STENT; CROSS LINKING; CYTOTOXICITY; DRUG RELEASE; ENZYME REPRESSION; EXPERIMENTAL RABBIT; GENE DELIVERY SYSTEM; GENE EXPRESSION; GENE SILENCING; GENETIC TRANSFECTION; ILIAC ARTERY; IMMOBILIZED CELL; MICRO-COMPUTED TOMOGRAPHY; NONHUMAN; PARTICLE SIZE; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; RESTENOSIS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SMOOTH MUSCLE FIBER; SURFACE CHARGE; TRANSGENE; VASCULAR SMOOTH MUSCLE; WESTERN BLOTTING;

ANIMALS; CELL LINE; CELL SURVIVAL; CORONARY RESTENOSIS; DRUG-ELUTING STENTS; PROTO-ONCOGENE PROTEINS C-AKT; RABBITS; RATS; RNA, SMALL INTERFERING;

ORYCTOLAGUS CUNICULUS;

EID: 84866158740     PISSN: 01429612     EISSN: 18785905     Source Type: Journal    
DOI: 10.1016/j.biomaterials.2012.07.045     Document Type: Article

References (23)

1. Liu M.W., Roubin G.S., King S.B. Restenosis after coronary angioplasty. Potential biologic determinants and role of intimal hyperplasia. Circulation 1989, 79:1374-1387.
2. Califf R.M., Fortin D.F., Frid D.J., Harlan W.R., Ohman E.M., Bengtson J.R., et al. Restenosis after coronary angioplasty: an overview. J Am Coll Cardiol 1991, 17:2B-13B.
3. Bengali Z., Rea J.C., Shea L.D. Gene expression and internalization following vector adsorption to immobilized proteins: dependence on protein identity and density. J Gene Med 2007, 9:668-678.
4. Bengali Z., Pannier A.K., Segura T., Anderson B.C., Jang J.H., Mustoe T.A., et al. Gene delivery through cell culture substrate adsorbed DNA complexes. Biotechnol Bioeng 2005, 90:290-302.
5. Segura T., Volk M.J., Shea L.D. Substrate-mediated DNA delivery: role of the cationic polymer structure and extent of modification. J Control Release 2003, 93:69-84.
6. Bengali Z., Rea J.C., Gibly R.F., Shea L.D. Efficacy of immobilized polyplexes and lipoplexes for substrate-mediated gene delivery. Biotechnol Bioeng 2009, 102:1679-1691.
7. Koo H., Jin G.W., Kang H., Lee Y., Nam K., Zhe Bai C., et al. Biodegradable branched poly(ethylenimine sulfide) for gene delivery. Biomaterials 2010, 31:988-997.
8. Luo D., Saltzman W.M. Enhancement of transfection by physical concentration of DNA at the cell surface. Nat Biotechnol 2000, 18:893-895.
9. Boussif O., Lezoualch F., Zanta M.A., Mergny M.D., Scherman D., Demeneix B., et al. A versatile vector for gene and oligonucleotide transfer into cells in culture and in-vivo - polyethylenimine. Proc Natl Acad Sci USA 1995, 92:7297-7301.
10. Jiang H.L., Hong S.H., Kim Y.K., Islam M.A., Kim H.J., Choi Y.J., et al. Aerosol delivery of spermine-based poly(amino ester)/Akt1 shRNA complexes for lung cancer gene therapy. Int J Pharm 2011, 420:256-265.
11. Jere D., Arote R., Jiang H.L., Kim Y.K., Cho M.H., Cho C.S. Biodegradable nano-polymeric system for efficient Akt1 siRNA delivery. J Nanosci Nanotechnol 2010, 10:3366-3369.
12. Jiang H.L., Xu C.X., Kim Y.K., Arote R., Jere D., Lim H.T., et al. The suppression of lung tumorigenesis by aerosol-delivered folate-chitosan-graft-polyethylenimine/Akt1 shRNA complexes through the Akt signaling pathway. Biomaterials 2009, 30:5844-5852.
13. Duguay D., deBlois D. Differential regulation of Akt, caspases and MAP kinases underlies smooth muscle cell apoptosis during aortic remodelling in SHR treated with amlodipine. Br J Pharmacol 2007, 151:1315-1323.
14. Jere D., Jiang H.L., Kim Y.K., Arote R., Choi Y.J., Yun C.H., et al. Chitosan-graft-polyethylenimine for Akt1 siRNA delivery to lung cancer cells. Int J Pharm 2009, 378:194-200.
15. Remuzzi A., Mantero S., Colombo M., Morigi M., Binda E., Camozzi D., et al. Vascular smooth muscle cells on hyaluronic acid: culture and mechanical characterization of an engineered vascular construct. Tissue Eng 2004, 10:699-710.
16. Travis J.A., Hughes M.G., Wong J.M., Wagner W.D., Geary R.L. Hyaluronan enhances contraction of collagen by smooth muscle cells and adventitial fibroblasts - role of CD44 and implications for constrictive remodeling. Circ Res 2001, 88:77-83.
17. Heublein B., Evagorou E.G., Rohde R., Ohse S., Meliss R.R., Barlach S., et al. Polymerized degradable hyaluronan - a platform for stent coating with inherent inhibitory effects on neointimal formation in a porcine coronary model. Int J Artif Organs 2002, 25:1166-1173.
18. You I, Kang SM, Byun Y, Lee H. Enhancement of blood compatibility of poly(urethane) substrates by mussel-inspired adhesive heparin coating. Bioconjug Chem;22(7):1264-1269.
19. Gilles M.A., Hudson A.Q., Borders C.L. Stability of water-soluble carbodiimides in aqueous solution. Anal Biochem 1990, 184:244-248.
20. Fishbein I., Alferiev I.S., Nyanguile O., Gaster R., Vohs J.M., Wong G.S., et al. Bisphosphonate-mediated gene vector delivery from the metal surfaces of stents. Proc Natl Acad Sci USA 2006, 103:159-164.
21. Lee H., Dellatore S.M., Miller W.M., Messersmith P.B. Mussel-inspired surface chemistry for multifunctional coatings. Science 2007, 318(5849):426-430.
22. Lee Y., Lee H., Kim Y.B., Kim J., Hyeon T., Park H., et al. Bioinspired surface immobilization of hyaluronic acid on monodisperse magnetite nanocrystals for targeted cancer imaging. Adv Mater 2008, 20(21):4154-4157.
23. Park S, Bhang SH, La WG, Seo J, Kim BS, Char K. Dual roles of hyaluronic acids in multilayer films capturing nanocarriers for drug-eluting coatings. Biomaterials;33(21):5468-5477.