Novel KCNJ5 mutations in sporadic aldosterone-producing adenoma reduce Kir3.4 membrane abundance

Journal of Clinical Endocrinology and Metabolism

Volumn 100, Issue 1, 2015, Pages E155-E163

  Cheng, Chih Jen ^a,d   Sung, Chih Chien ^a   Wu, Sheng Tang ^b   Lin, Yu Chun ^c   Sytwu, Huey Kang ^d   Huang, Chou Long ^e,f   Lin, Shih Hua ^a,d  

^a TRI SERVICE GENERAL HOSPITAL   (Taiwan)

^b Division of Urology   (United States)

^c Tri Service General Hospital   (United States)

^d Graduate Institute of Life Sciences   (United States)

^e NATIONAL DEFENSE MEDICAL CENTER   (Taiwan)

^f UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALDOSTERONE SYNTHASE; INWARDLY RECTIFYING POTASSIUM CHANNEL; INWARDLY RECTIFYING POTASSIUM CHANNEL KIR3.4; RENIN; UNCLASSIFIED DRUG; ALDOSTERONE; G PROTEIN COUPLED INWARDLY RECTIFYING POTASSIUM CHANNEL; KCNJ5 PROTEIN, HUMAN;

ADRENAL CORTEX CELL; ADULT; ARTICLE; BIOTINYLATION; CELL MEMBRANE DEPOLARIZATION; CHINESE; CONTROLLED STUDY; E125Q GENE; E246G GENE; FEMALE; GENE; GENE MUTATION; GENETIC SCREENING; HUMAN; IN VITRO STUDY; INHIBITION KINETICS; KCNJ5 GENE; LOSS OF FUNCTION MUTATION; MAJOR CLINICAL STUDY; MALE; PHENOTYPE; POTASSIUM CURRENT; PRIMARY HYPERALDOSTERONISM; PROTEIN EXPRESSION; R115W GENE; SODIUM CURRENT; SOMATIC MUTATION; WILD TYPE; ADENOMA; ADRENAL CORTEX ADENOMA; GENETICS; METABOLISM; MIDDLE AGED; MUTATION; PATHOLOGY; SECRETION (PROCESS);

ADENOMA; ADRENOCORTICAL ADENOMA; ADULT; ALDOSTERONE; FEMALE; G PROTEIN-COUPLED INWARDLY-RECTIFYING POTASSIUM CHANNELS; HUMANS; MALE; MIDDLE AGED; MUTATION;

EID: 84920628236     PISSN: 0021972X     EISSN: 19457197     Source Type: Journal    
DOI: 10.1210/jc.2014-3009     Document Type: Article

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