Channels and pumps in aldosterone-producing adenomas

Journal of Clinical Endocrinology and Metabolism

Volumn 99, Issue 4, 2014, Pages 1152-1156

  Gomez Sanchez, Celso E ^a  

^a UNIVERSITY OF MISSISSIPPI MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOMA; ADRENAL CORTEX NEOPLASMS; ALDOSTERONE; HUMANS; HYPERALDOSTERONISM; POTASSIUM CHANNELS, TANDEM PORE DOMAIN;

EID: 84898406626     PISSN: 0021972X     EISSN: 19457197     Source Type: Journal    
DOI: 10.1210/jc.2014-1062     Document Type: Review

References (26)

1. Spat A, Hunyady L. Control of aldosterone secretion: a model for convergence in cellular signaling pathways. Physiol Rev. 2004;84: 489-539.
2. Kanazirska MV, Vassilev PM, Quinn SJ, Tillotson DL, Williams GH. Single K+ channels in adrenal zona glomerulosa cells. II. Inhibition by angiotensin II. Am J Physiol. 1992;263:E760-E765.
3. Gomez-Sanchez CE, Oki K. Minireview: potassium channels and aldosterone dysregulation: is primary aldosteronism a potassium channelopathy? Endocrinology. 2014;155:47-55.
4. Guagliardo NA, Yao J, Hu C, Barrett PQ. Minireview: aldosterone biosynthesis: electrically gated for our protection. Endocrinology. 2012;153:3579-3586.
5. Choi M, Scholl UI, Yue P, et al. K+ channel mutations in adrenal aldosterone-producing adenomas and hereditary hypertension. Science. 2011;331:768-772.
6. Scholl UI, Nelson-Williams C, Yue P, et al. Hypertension with or without adrenal hyperplasia due to different inherited mutations in the potassium channel KCNJ5. Proc Natl Acad Sci USA. 2012;109: 2533-2538.
7. Mulatero P, Tauber P, Zennaro MC, et al. KCNJ5 mutations in European families with nonglucocorticoid remediable familial hy-peraldosteronism. Hypertension. 2012;59:235-240.
8. Murthy M, XuS, Massimo G, etal. Role for germline mutations and a rare coding single nucleotide polymorphism within the KCNJ5 potassium channel in a large cohort of sporadic cases of primary aldosteronism [published online January 13, 2014]. Hypertension. doi: 10.1161/HYPERTENSIONAHA.113.02234.
9. Oki K, Plonczynski MW, Luis Lam M, Gomez-Sanchez EP, Gomez-Sanchez CE. Potassium channel mutant KCNJ5 T158A expression in HAC-15 cells increases aldosterone synthesis. Endocrinology. 2012;153:1774-1782.
10. Boulkroun S, Golib Dzib JF, Samson-Couterie B, et al. KCNJ5 mutations in aldosterone producing adenoma and relationship with adrenal cortex remodeling. Mol Cell Endocrinol. 2013;371:221-227.
11. Beuschlein F, Boulkroun S, Osswald A, et al. Somatic mutations in ATP1A1 and ATP2B3 lead to aldosterone-producing adenomas and secondary hypertension. Nat Genet. 2013;45:440-444, 444e1-2.
12. Azizan EA, Poulsen H, Tuluc P, et al. Somatic mutations in ATP1A1 and CACNA1D underlie a common subtype of adrenal hypertension. Nat Genet. 2013;45:1055-1060.
13. Scholl UI, Goh G, Stolting G, et al. Somatic and germline CACNA1D calcium channel mutations in aldosterone-producing adenomas and primary aldosteronism. Nat Genet. 2013;45:1050-1054.
14. Lenzini L, Caroccia B, Campos AG, et al. Lower expression of the TWIK-related acid-sensitive K+ channel 2 (TASK-2) gene is a hallmark of aldosterone producing adenoma causing human primary aldosteronism. J Clin Endocrinol Metab. 2014;99:E674-E682.
15. Bandulik S, Penton D, Barhanin J, Warth R. TASK1 and TASK3 potassium channels: determinants of aldosterone secretion and ad-renocortical zonation. Horm Metab Res. 2010;42:450-457.
16. Davies LA, Hu C, Guagliardo NA, et al. TASK channel deletion in mice causes primary hyperaldosteronism. Proc Natl Acad Sci USA. 2008;105:2203-2208.
17. Heitzmann D, Derand R, Jungbauer S, et al. Invalidation of TASK1 potassium channels disrupts adrenal gland zonation and mineralo-corticoid homeostasis. EMBO J. 2008;27:179-187.
18. Nogueira EF, Gerry D, Mantero F, Mariniello B, Rainey WE. The role of TASK1 in aldosterone production and its expression in normal adrenal and aldosterone-producing adenomas. Clin Endocrinol (Oxf). 2010;73:22-29.
19. Romero DG, Plonczynski MW, Carvajal CA, Gomez-Sanchez EP, Gomez-Sanchez CE. Microribonucleic acid-21 increases aldosterone secretion and proliferation in H295R human adrenocortical cells. Endocrinology. 2008;149:2477-2483.
20. Krill KT, Gurdziel K, Heaton JH, Simon DP, Hammer GD. Dicer deficiency reveals microRNAs predicted to control gene expression in the developing adrenal cortex. Mol Endocrinol. 2013;27:754-768.
21. Robertson S, MacKenzie SM, Alvarez-Madrazo S, et al. MicroRNA-24 is a novel regulator of aldosterone and cortisol production in the human adrenal cortex. Hypertension. 2013;62:572-578.
22. Murthy M, Azizan EA, Brown MJ, O'Shaughnessy KM. Characterization of a novel somatic KCNJ5 mutation delI157 in an aldo-sterone-producing adenoma. J Hypertens. 2012;30:1827-1833.
23. Akerstrom T, Crona J, Delgado Verdugo A, et al. Comprehensive re-sequencing of adrenal aldosterone producing lesions reveal three somatic mutations near the KCNJ5 potassium channel selectivity filter. PLoS One. 2012;7:e41926.
24. Charmandari E, Sertedaki A, Kino T, et al. A novel point mutation in the KCNJ5 gene causing primary hyperaldosteronism and early-onset autosomal dominant hypertension. JClin Endocrinol Metab. 2012;97:E1532-E1539.
25. Monticone S, Hattangady NG, Penton D, et al. A novel Y152C KCNJ5 mutation responsible for familial hyperaldosteronism type III. JClin Endocrinol Metab. 2013;98:E1861-E1865.
26. Williams TA, Monticone S, Schack VR, et al. Somatic ATP1A1, ATP2B3, and KCNJ5 mutations in aldosterone-producing adenomas. Hypertension. 2014;63:188-195.