Acetylcholine release and choline availability in rat hippocampus: Effects of exogenous choline and nicotinamide

Journal of Pharmacology and Experimental Therapeutics

Volumn 282, Issue 3, 1997, Pages 1139-1145

  Köppen, Andrea ^a   Klein, Jochen ^a   Erb, Christina ^a   Löffelholz, Konrad ^a  

^a JOHANNES GUTENBERG UNIVERSITY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCHOLINE; ATROPINE; CHOLINE; NICOTINAMIDE;

ACETYLCHOLINE RELEASE; ANIMAL EXPERIMENT; ANIMAL TISSUE; AREA UNDER THE CURVE; ARTICLE; COGNITION; CONTROLLED STUDY; DIET SUPPLEMENTATION; DRUG POTENTIATION; HIPPOCAMPUS; INTRAPERITONEAL DRUG ADMINISTRATION; MALE; MICRODIALYSIS; NONHUMAN; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; RAT; SUBCUTANEOUS DRUG ADMINISTRATION;

ACETYLCHOLINE; ANIMALS; ATROPINE; CHOLINE; HIPPOCAMPUS; MALE; NIACINAMIDE; RATS; RATS, WISTAR;

EID: 0030886327     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (53)

1. ABDEL-LATIF, A. A. AND SMITH, J. P.: Studies on choline transport and metabolism in rat brain synaptosomes. Biochem. Pharmacol. 21: 3006-3021, 1972.
2. BARTUS, R. T., DEAN, R. L., GOAS, J. A. AND LIPPA, A. S.: Age-related changes in passive avoidance retention: modulation with dietary choline. Science 209: 301-303, 1980.
3. BARTUS, R. T., DEAN, R. L., BEER, B., LIPPA, A. S.: The cholinergic hypothesis of geriatric memory dysfunction. Science 217: 408-417, 1982.
4. BUYUKUSAL, R. L., ULUS, I. H., AYDIN, S. AND KIRAN, B. K.: 3,4-Diaminopyridine and choline increase in vivo acetylcholine release in rat striatum. Eur. J. Pharmacol. 281: 179-185, 1995.
5. DAY, J., DAMSMA, G. AND FIBIGER, H. C.: Cholinergic activity is the rat hippocampus, cortex and striatum correlates with locomotor activity: An in vivo microdialysis study. Pharmacol. Biochem. Behav. 38: 723-729, 1990.
6. FARBER, S. A., KISCHKA, U., MARSHALL, D. L. AND WURTMAN, R. J.: Potentiation by choline of basal and electrically evoked acetylcholine release, as studied using a novel device which both stimulates and perfuses rat corpus striatum. Brain Res. 607: 177-184, 1993.
7. HATTORI, H. AND KANFER, J. N.: Synaptosomal phospholipase D: Potential role in providing choline for acetylcholine synthesis. J. Neurochem. 45: 1578-1584, 1985.
8. HAUBRICH, D. R., WANG, P. F. L., CLODY, D. E. AND WEDEKIND, P. W.: Increase in rat brain acetylcholine induced by choline or deanol. Life Sci. 17: 975-980, 1975.
9. HIRSCH, M. J. AND WURTMAN, R. J.: Increase in striatal choline acetyltransferase activity after choline administration. Brain Res. 165: 358-361, 1979.
10. IKARASHI, Y., TAKAHASHI, A., ISHIMARU, H. AND MAHUYAMA, Y.: Striatal extracellular choline and acetylcholine in choline-free plasma rats. Brain Res. Bull. 34: 359-363, 1994.
11. JACKSON, D. A., KISCHKA, U. AND WURTMAN, R. J.: Choline enhances scopolamine-induced acetylcholine release in dorsal hippocampus of conscious, freely-moving rats. Life Sci. 56: 45-49, 1995.
12. JENDEN, D. J., RICE, K. M., ROCHE, M., BOOTH, R. A. AND LAURETZ, S. D.: Effects of nicotinamide on choline and acetylcholine levels in rats. Adv. Neurol. 51: 131-138, 1990.
13. JENDEN, D. J., VARGAS, H. M., BOOTH, R. A., ROCHE, M. AND RICE, K. M.: Conservation of brain choline by nicotinamide and related compounds. In Aging and Alzheimers disease, ed. by J. H. Growdon, S. Corkin, E. Ritter-Walker and R. J. Wurtman, pp. 553-561. Center for Brain Sciences and Metabolism Charitable Trust, Boston, MA, 1991.
14. JOPE, R. S.: Effects of phosphatidylcholine administration to rats on choline in blood and choline and acetylcholine in brain. J. Pharmacol. Exp. Ther. 220: 322-328, 1982.
15. JOPE, R. S. AND JENDEN, D. J.: Choline and phospholipid metabolism and the synthesis of acetylcholine in rat brain. J. Neurosci. Res. 4: 69-82, 1979.
16. KLEIN, J., KÖPPEN, A. AND LÖFFELHOLZ, K.: Small rises in plasma choline reverse the negative arteriovenous difference of brain choline. J. Neurochem. 55: 1231-1236, 1990.
17. KLEIN, J., KÖPPEN, A. AND LÖFFELHOLZ, K.: Uptake and storage of choline by rat brain: Influence of dietary choline supplementation. J. Neurochem. 57: 370-375, 1991.
18. KLEIN, J., KÖPPEN, A., LÖFFELHOLZ, K. AND SCHMITTHENNER, J.: Uptake and metabolism of choline by rat brain after acute choline administration. J. Neurochem. 58: 870-876, 1992.
19. KLEIN, J., LINDMAR, R. AND LÖFFELHOLZ, K.: Muscarinic activation of phosphatidylcholine hydrolysis. Prog. Brain Res. 109: 201-208, 1996.
20. KÖPPEN, A., KLEIN, J., HOLLER, T. AND LÖFFELHOLZ, K.: Synergistic effect of nicotinamide and choline administration on extracellular choline levels in the brain. J. Pharmacol. Exp. Ther. 266: 720-725, 1993.
21. KÖPPEN, A., KLEIN, J., SCHMIDT, B. H., VAN DER STAAY, F.-J. AND LÖFFELHOLZ, K.: Effects of nicotinamide on central cholinergic transmission and on spatial learning in rats. Pharmacol. Biochem. Behav. 53: 783-790, 1996.
22. KOSHIMURA, K., MIWA, S., LEE, K., HAYASHI, Y., HASEGAWA, H., HAMAHATA, K., FUJIWARA, M., KIMURA, M. AND ITOKAWA, Y.: Effects of choline administration on in vivo release and biosynthesis of acetylcholine in the rat striatum as studied by in vivo brain microdialysis. J. Neurochem. 54: 533-539, 1990.
23. KUMAR, V. AND CALACHE, M.: Treatment of Alzheimer's disease with cholinergic drugs. Int. J. Clin. Pharm. Ther. Tox. 29: 23-37, 1991.
24. LANMAN, R. C. AND SCHANKER, L. S.: Transport of choline out of the cranial cerebrospinal fluid spaces of the rabbit. J. Pharmacol. Exp. Ther. 215: 563-568, 1980.
25. LAPCHAK, P. A., JENDEN, D. J. AND HEFTI, F.: Compensatory elevation of acetylcholine synthesis in vivo by cholinergic neurons surviving partial lesions of the septohippocampal pathway. J. Neurosci. 11: 2821-2828, 1991.
26. LEANZA, G., NILSSON, O. G. AND BJÖRKLUND, A.: Compensatory changes in vivo acetylcholine and noradrenaline release in the hippocampus after partial deafferentation, as monitored by microdialysis. Brain Res. 615: 147-159, 1993.
27. LEE, H.-C., FELLENZ-MALONEY, M.-P., LISCOVITCH, M. AND BLUSZTAJN, J. K.: Phospholipase D-catalyzed hydrolysis of phosphatidylcholine provides the choline precursor for acetylcholine synthesis in a human neuronal cell line. Proc. Natl. Acad. Sci. U.S.A. 90: 10086-10090, 1993.
28. LINDMAR, R., LÖFFELHOLZ, K., WEIDE, W. AND WITZKE, J.: Neuronal uptake of choline following release of acetylcholine in the perfused heart. J. Pharmacol. Exp. Ther. 215: 710-715, 1980.
29. LIU, J. K. AND KATO, T.: Effect of physostigmine on relative acetylcholine output induced by systemic treatment with scopolamine in in vivo microdialysis of rat frontal cortex. Neurochem. Int. 24: 589-596, 1994.
30. LÖFFELHOLZ, K.: Commentary. Integr. Psych. 5: 242-244, 1987.
31. LÖFFELHOLZ, K., KLEIN, J. AND KÖPPEN, A.: Choline, a precursor of acetylcholine and phospholipids in the brain. Prog. Brain Res. 98: 197-200, 1993.
32. MAIRE, C. E. AND WURTMAN, R. J.: Effects of electrical stimulation and choline availability on the release and contents of acetylcholine and choline in superfused suces from rat striatum. J. Physiol. (Paris) 80: 189-195, 1985.
33. MARSHALL, D. L. AND WURTMAN, R. J.: Effect of choline on basal and stimulated acetylcholine release: an in vivo microdialysis study using a low neostigmine concentration. Brain Res. 269: 269-274, 1993.
34. MESSAMORE, E., WARPMAN, D., WILLIAMS, E. AND GIACOBINI, E.: Muscarinic receptors mediate attenuation of extracellular acetylcholine levels in rat cerebral cortex after cholinesterase inhibition. Neurosci. Lett. 158: 205-208, 1993.
35. NILSSON, O. G., KALEN, P., ROSENGREN, E. AND BJÖRKLUND, A.: Acetylcholine release in the rat hippocampus as studied by microdialysis is dependent on axonal impulse flow and increases during behavioural activation. Neuroscience 36: 325-338, 1990.
36. PAXINOS, G. AND WATSON, C.: The Rat Brain in Stereotaxis Coordinates. Academic Press, San Diego, CA, 1986.
37. PERRY, E. K.: The cholinergic hypothesis - ten years ago. Br. Med. Bull. 42: 63-69, 1986.
38. RADA, P. V., MARK, G. P. AND HOEBEL, B. G.: Effects of supplemental choline on extracellular acetylcholine in the nucleus accumbens during normal behavior and pharmacological acetylcholine depletion. Synapse 16: 211-218, 1994.
39. REINHARDT, R. R. AND WECKER, L.: Evidence for membrane-associated choline kinase activity in rat striatum. J. Neurochem. 41: 623-628, 1983.
40. RICHARDSON, P. J.: Choline uptake and metabolism in affinity-purified cholinergic nerve terminals from rat brain. J. Neurochem. 46: 1251-1255, 1986.
41. SANTIAGO, M. AND WESTERINK, B. H. C.: Characterization of the in vivo release of dopamine as recorded by different types of intracerebral microdialysis probes. Naunyn-Schmiedeberg Arch. Pharmacol. 342: 407-414, 1990.
42. SCHMIDT, D. E. AND WECKER, L.: CNS effects of choline administration: Evidence for temporal dependence. Neuropharmacology 20: 535-539, 1981.
43. SUZUKI, T., KASHIMA, Y. AND KAWASHIMA, K.: Hemicholinium-3-resistant choline uptake system linked to acetylcholine synthesis in the rat hippocampus. Neurosci. Lett. 105: 211-214, 1989.
44. TROMMER, B. A., SCHMIDT, D. E. AND WECKER, L.: Exogenous choline enhances the synthesis of acetylcholine only under conditions of increased cholinergic neuronal activity. J. Neurochem. 39: 1704-1709, 1982.
45. TUCEK, S.: Choline acetyltransferase and the synthesis of acetylcholine. In Handbook of Experimental Pharmacology, vol. 86: The Cholinergic Synapse, ed. by V. P. Whittaker, pp. 125-165, Springer Verlag, New York, NY, 1988.
46. ULUS, I. H., WURTMAN, R. J., MAURON, C. AND BLUSZTAJN, J. K.: Choline increases acetylcholine release and protects against the stimulation-induced decrease in phosphatide levels within membranes of rat corpus striatum. Brain Res. 484: 217-227, 1989.
47. VARGAS, H. M. AND JENDEN, D. J.: Elevation of cerebrospinal fluid choline levels by nicotinamide involves the enzymatic formation of N-methylnicotinamide in brain tissue. Life Sci 58: 1995-2002, 1996.
48. WECKER, L.: Neurochemical effects of choline supplementation. Can. J. Physiol. Pharmacol. 64: 329-333, 1985.
49. WECKER, L.: Choline utilization by central cholinergic neurons. In Nutrition and the Brain, vol. 8, ed. by R. J. Wurtman and J. J. Wurtman, pp. 147-162. Raven Press, New York, 1990.
50. WECKER, L.: The synthesis and release of acetylcholine by depolarized hippocampal slices is increased by increased choline available in vitro prior to stimulation. J. Neurochem. 57: 1119-1127, 1991.
51. WECKER, L., CAWLEY, G. AND ROTHERMEL, S.: Acute choline supplementation in vivo enhances acetylcholine synthesis in vitro when neurotransmitter release is increased by potassium. J. Neurochem. 52: 568-575, 1989.
52. WESTERINK, B. H. C. AND DE BOER, P.: Effect of choline administration on the release of acetylcholine from striatum as determined by microdialysis in awake rats. Neurosci. Lett. 112: 297-301, 1990.
53. WURTMAN, R. J., HEFTI, F. AND MELAMED, E.: Precursor control of neurotransmitter synthesis. Pharmacol. Rev. 32: 315-335, 1981.