Detection of volatile organic compounds as biomarkers in breath analysis by different analytical techniques

Bioanalysis

Volumn 5, Issue 18, 2013, Pages 2287-2306

  Buszewski, Bogusław ^a   Grzywinski, Damian ^a   Ligor, Tomasz ^a   Stacewicz, Tadeusz ^b   Bielecki, Zygmunt ^c   Wojtas, Jacek ^c  

^a NICOLAUS COPERNICUS UNIVERSITY   (Poland)

^b UNIVERSITY OF WARSAW   (Poland)

^c MILITARY UNIVERSITY OF TECHNOLOGY   (Poland)

Author keywords

[No Author keywords available]

Indexed keywords

ALKANE DERIVATIVE; BENZENE DERIVATIVE; BIOLOGICAL MARKER; CARBON DIOXIDE; COPPER OXIDE; CYCLOHEXANE DERIVATIVE; NITRIC OXIDE; POLYANILINE; POLYFURAN; POLYINDOL; POLYMER; POLYPYRROLE; POLYTHIOPHENE; TITANIUM DIOXIDE; TUNGSTEN DERIVATIVE; TUNGSTEN TRIOXIDE; UNCLASSIFIED DRUG; VOLATILE ORGANIC COMPOUND; ZINC OXIDE;

ACCURACY; ANALYTIC METHOD; ANALYTICAL EQUIPMENT; BREAST CANCER; BREATH ANALYSIS; CAVITY RING DOWN SPECTROSCOPY; COMPARATIVE STUDY; DIABETES MELLITUS; ELECTRONIC NOSE; ELECTRONIC SENSOR; GAS CHROMATOGRAPHY; HUMAN; IRON MOLECULE REACTION MASS SPECTROMETRY; LASER ABSORPTION SPECTROSCOPY; LIMIT OF DETECTION; LIVER DISEASE; LUNG CANCER; MASS FRAGMENTOGRAPHY; MASS SPECTROMETRY; METABOLIC DISORDER; METAL OXIDE SEMICONDUCTOR; NONHUMAN; OPTICAL SENSOR; PATIENT MONITORING; POLYMER SENSOR; PROTON TRANSFER REACTION MASS SPECTROMETRY; QUARTZ CRYSTAL MICROBALANCE; REVIEW; SELECTED ION FLOW TUBE MASS SPECTROMETRY; SEMICONDUCTOR; SPECTROSCOPY; TIME OF FLIGHT MASS SPECTROMETRY; DEVICES; LASER; PROCEDURES;

BIOLOGICAL MARKERS; BREATH TESTS; CHROMATOGRAPHY, GAS; HUMANS; LASERS; MASS SPECTROMETRY; VOLATILE ORGANIC COMPOUNDS;

EID: 84885006315     PISSN: 17576180     EISSN: 17576199     Source Type: Journal    
DOI: 10.4155/bio.13.183     Document Type: Review

References (153)

1. Horvath I, Lazar Z, Gyulai N, Kollai M, Losonczy G. Exhaled biomarkers in lung cancer. Eur. Respir. J. 34(1), 261-275 (2009).
2. Ligor T. Analytical methods for breath investigation. Crit. Rev. Anal. Chem. 39(1), 2-12 (2009).
3. Buszewski B, Kesy M, Ligor T, Amann A. Human exhaled air analytics: biomarkers of diseases. Biomed. Chromatogr. 21(6), 553-566 (2007).
4. King J, Koc H, Unterkofler K et al. Physiological modeling of isoprene dynamics in exhaled breath. J. Theor. Biol. 267(4), 626-637 (2010).
5. Shaji J, Jadhav D. Breath biomarker for clinical diagnosis and different analysis technique. RJPBCS 1(3), 639-652 (2010).
6. Bajtarevic A, Ager C, Pienz M et al. Noninvasive detection of lung cancer by analysis of exhaled breath. BMC Cancer 9(348), 1471-2407 (2009).
7. Chan HP, Lewis C, Thomas PS. Exhaled breath analysis: novel approach for early detection of lung cancer. Lung Cancer 63(2), 164-168 (2009).
8. Patterson SG, Bayer CW, Hendry RJ et al. Breath analysis by mass spectrometry: a new tool for breast cancer detection? Am. Surg. 77(6), 747-751 (2011).
9. Dadamio J, Van Den Velde S, Laleman W et al. Breath biomarkers of liver cirrhosis. J. Chromatogr. B 905, 17-22 (2012).
10. Phillips M, Basa-Dalay V, Bothamley G et al. Breath biomarkers of active pulmonary tuberculosis. Tuberculosis 90(2), 145-151 (2010).
11. Phillips M, Basa-Dalay V, Blais J et al. Point-of-care breath test for biomarkers of active pulmonary tuberculosis. Tuberculosis 92(4), 314-320 (2012).
12. Kumar S, Huang J, Cushnir JR, Spanel P, Smith D, Hanna GB. Selected ion flow tube-ms analysis of headspace vapor from gastric content for the diagnosis of gastro-esophageal cancer. Anal. Chem. 84(21), 9550-9557 (2012).
13. Caldeira M, Perestrelo R, Barros AS et al. Allergic asthma exhaled breath metabolome: a challenge for comprehensive two-dimensional gas chromatography. J. Chromatogr. A 1254(0), 87-97 (2012).
14. Phillips M, Cataneo RN, Condos R et al. Volatile biomarkers of pulmonary tuberculosis in the breath. Tuberculosis 87(1), 44-52 (2007).
15. Buszewski B, Ulanowska A, Kowalkowski T, Cieslinski K. Investigation of lung cancer biomarkers by hyphenated separation techniques and chemometrics. Clin. Chem. Lab. Med. 50(3), 573-581 (2011).
16. Gaspar EM, Lucena AF, Duro Da Costa J, Chaves Das Neves H. Organic metabolites in exhaled human breath - a multivariate approach for identification of biomarkers in lung disorders. J. Chromatogr. A 1216(14), 2749-2756 (2009).
17. Fens N, Roldaan AC, Van Der Schee MP et al. External validation of exhaled breath profiling using an electronic nose in the discrimination of asthma with fixed airways obstruction and chronic obstructive pulmonary disease. Clin. Exp. Allergy. 41(10), 1371-1378 (2011).
18. Pauling L, Robinson AB, Teranishi R, Cary P. Quantitative analysis of urine vapor and breath by gas-liquid partition chromatography. Proc. Natl Acad. Sci. USA 68(10), 2374-2376 (1971).
19. Mazzone PJ. Exhaled breath volatile organic compound biomarkers in lung cancer. J. Breath Res. 6(2), 027106 (2012).
20. Ulanowska A, Trawinska E, Sawrycki P, Buszewski B. Chemotherapy control by breath profile with application of SPME-GC/MS method. J. Sep. Sci. 35(21), 2908-2913 (2012).
21. Van Den Velde S, Nevens F, Van Hee P, Van Steenberghe D, Quirynen M. GC-MS analysis of breath odor compounds in liver patients. J. Chromatogr. B 875(2), 344-348 (2008).
22. Buszewski B, Ligor T, Jezierski T, Wenda-Piesik A, Walczak M, Rudnicka J. Identification of volatile lung cancer markers by gas chromatography-mass spectrometry: comparison with discrimination by canines. Anal. Bioanal. Chem. 404(1), 141-146 (2012).
23. Buszewski B, Rudnicka J, Ligor T, Walczak M, Jezierski T, Amann A. Analytical and unconventional methods of cancer detection using odor. Trends Anal. Chem. 38, 1-12 (2012).
24. Boots AW, Van Berkel JJBN, Dallinga JW, Smolinska A, Wouters EF, Van Schoten FJ. The versatile use of exhaled volatile organic compounds in human health and disease. J. Breath Res. 6(2), 027108 (2012).
25. Miekisch W, Herbig J, Schubert JK. Data interpretation in breath biomarker research: pitfalls and directions. J. Breath Res. 6(3), 036007 (2012).
26. Sabo M, Matejcík Š. Corona discharge ion mobility spectrometry with orthogonal acceleration time of flight mass spectrometry for monitoring of volatile organic compounds. Anal. Chem. 84(12), 5327-5334 (2012).
27. Smith D, Spanel P. The challenge of breath analysis for clinical diagnosis and therapeutic monitoring. Analyst 132(5), 390-396 (2007).
28. Boshier PR, Cushnir JR, Mistry V et al. On-line, real time monitoring of exhaled trace gases by SIFT-MS in the perioperative setting: a feasibility study. Analyst 136(16), 3233-3237 (2011).
29. Tianshu W, Andriy P, Kseniya D, Patrik Š, David S. Analysis of breath, exhaled via the mouth and nose, and the air in the oral cavity. J. Breath Res. 2(3), 037013 (2008).
30. Čáp P, Dryahina K, Pehal F, Španěl P. Selected ion flow tube mass spectrometry of exhaled breath condensate headspace. Rapid Commun. Mass Spectrom. 22(18), 2844-2850 (2008).
31. Smith D, Španěl P. Selected ion flow tube mass spectrometry (SIFT-MS) for on-line trace gas analysis. Mass Spectrom Rev. 24(5), 661-700 (2005).
32. Spanel P, Smith D. Selected ion flow tube mass spectrometry for on-line trace gas analysis in biology and medicine. Eur. J. Mass Spectrom. 13(1), 77-82 (2007).
33. Smith D, Spanel P, Fryer AA, Hanna F, Ferns GA. Can volatile compounds in exhaled breath be used to monitor control in diabetes mellitus? J. Breath Res. 5(2), 022001 (2011).
34. Storer MK, Dummer JF, Lunt H et al. Measurement of breath acetone concentrations by selected ion flow tube mass spectrometry in type 2 diabetes. J. Breath Res. 5(4), 046011 (2011).
35. Dummer JF, Storer MK, Hu WP et al. Accurate, reproducible measurement of acetone concentration in breath using selected ion flow tube-mass spectrometry. J. Breath Res. 4(4), 046001 (2010).
36. Spanel P, Smith D. Progress in SIFT-MS: breath analysis and other applications. Mass Spectrom. Rev. 30(2), 236-267 (2011).
37. Smith D, Wang T, Pysanenko A, Spanel P. A selected ion flow tube mass spectrometry study of ammonia in mouth- and nose-exhaled breath and in the oral cavity. Rapid Commun. Mass Spectrom. 22(6), 783-789 (2008).
38. Turner C, Parekh B, Walton C, Španěl P, Smith D, Evans M. An exploratory comparative study of volatile compounds in exhaled breath and emitted by skin using selected ion flow tube mass spectrometry. Rapid Commun. Mass Spectrom. 22(4), 526-532 (2008).
39. Cikach Jr FS, Dweik RA. Cardiovascular biomarkers in exhaled breath. Prog. Cardiovasc. Dis. 55(1), 34-43 (2012).
40. Keck L, Hoeschen C, Oeh U. Effects of carbon dioxide in breath gas on proton transfer reaction-mass spectrometry (PTR-MS) measurements. Int. J. Mass Spectrom. 270(3), 156-165 (2008).
41. Wehinger A, Schmid A, Mechtcheriakov S et al. Lung cancer detection by proton transfer reaction mass-spectrometric analysis of human breath gas. Int. J. Mass Spectrom. 265(1), 49-59 (2007).
42. Beauchamp J, Kirsch F, Buettner A. Real-time breath gas analysis for pharmacokinetics: monitoring exhaled breath by on-line proton-transfer-reaction mass spectrometry after ingestion of eucalyptol-containing capsules. J. Breath Res. 4(2), 026006 (2010).
43. Schwarz K, Filipiak W, Amann A. Determining concentration patterns of volatile compounds in exhaled breath by PTR-MS. J. Breath Res. 3(2), 027002 (2009).
44. Kushch I, Arendackã B, Stolc S et al. Breath isoprene-aspects of normal physiology related to age, gender and cholesterol profile as determined in a proton transfer reaction mass spectrometry study. Clin. Chem. Lab Med. 46(7), 1011-1018 (2008).
45. Schwarz K, Pizzini A, Arendacka B et al. Breath acetone-aspects of normal physiology related to age and gender as determined in a PTR-MS study. J. Breath Res. 3(2), 027003 (2009).
46. Millonig G, Praun S, Netzer M et al. Non-invasive diagnosis of liver diseases by breath analysis using an optimized ion-molecule reaction-mass spectrometry approach: a pilot study. Biomarkers 15(4), 297-306 (2010).
47. Ligor T, Szeliga J, Jackowski M, Buszewski B. Preliminary study of volatile organic compounds from breath and stomach tissue by means of solid phase microextraction and gas chromatography-mass spectrometry. J. Breath Res. 1(1), 016001 (2007).
48. Song G, Qin T, Liu H et al. Quantitative breath analysis of volatile organic compounds of lung cancer patients. Lung Cancer 67(2), 227-231 (2010).
49. Kischkel S, Miekisch W, Sawacki A et al. Breath biomarkers for lung cancer detection and assessment of smoking related effects - confounding variables, influence of normalization and statistical algorithms. Clin. Chim. Acta 411(21-22), 1637-1644 (2010).
50. Fuchs P, Loeseken C, Schubert JK, Miekisch W. Breath gas aldehydes as biomarkers of lung cancer. Int. J. Cancer 126(11), 2663-2670 (2010).
51. Gennaro G, Dragonieri S, Longobardi F et al. Chemical characterization of exhaled breath to differentiate between patients with malignant plueral mesothelioma from subjects with similar professional asbestos exposure. Anal. Bioanal. Chem. 398(7-8), 3043-3050 (2010).
52. Shestivska V, Nemec A, Dřevínek P, Sovová K, Dryahina K, Španěl P. Quantification of methyl thiocyanate in the headspace of Pseudomonas aeruginosa cultures and in the breath of cystic fibrosis patients by selected ion flow tube mass spectrometry. Rapid Commun. Mass Spectrom. 25(17), 2459-2467 (2011).
53. Francis JG, Cyrus R, Webb AK et al. An investigation of suitable bag materials for the collection and storage of breath samples containing hydrogen cyanide. J. Breath Res. 6(3), 036004 (2012).
54. Enderby B, Smith D, Carroll W, Lenney W. Hydrogen cyanide as a biomarker for Pseudomonas aeruginosa in the breath of children with cystic fibrosis. Pediatr. Pulmonol. 44(2), 142-147 (2009).
55. Cristescu SM, Gietema HA, Blanchet L et al. Screening for emphysema via exhaled volatile organic compounds. J. Breath Res. 5(4), 046009 (2011).
56. Li CW, Wang GD. The research on artificial olfaction system-electronic nose. J. Phys. Conf. Ser. 48(1), 667 (2006).
57. Oh EH, Song HS, Park TH. Recent advances in electronic and bioelectronic noses and their biomedical applications. Enzyme Microb. Technol. 48(6-7), 427-437 (2011).
58. Rock F, Barsan N, Weimar U. Electronic nose: current status and future trends. Chem. Rev. 108(2), 705-725 (2008).
59. Dragonieri S, Van Der Schee MP, Massaro T et al. An electronic nose distinguishes exhaled breath of patients with malignant pleural mesothelioma from controls. Lung Cancer 75(3), 326-331 (2012).
60. Machado RF, Laskowski D, Deffenderfer O et al. Detection of lung cancer by sensor array analyses of exhaled breath. Am. J. Respir. Crit. Care Med. 171, 1286-1291 (2005).
61. Dragonieri S, Schot R, Mertens BJ et al. An electronic nose in the discrimination of patients with asthma and controls. J. Allergy Clin. Immunol. 120(4), 856-862 (2007).
62. Montuschi P, Santonico M, Mondino C et al. Diagnostic performance of an electronic nose, fractional exhaled nitric oxide, and lung function testing in asthma. Chest 137(4), 790-796 (2010).
63. Dragonieri S, Annema JT, Schot R et al. An electronic nose in the discrimination of patients with non-small cell lung cancer and COPD. Lung Cancer 64(2), 166-170 (2009).
64. Horvath I, Lazar Z, Gyulai N, Kollai M, Losonczy G. Exhaled biomarkers in lung cancer. Eur. Respir. J. 34(1), 261-275 (2009).
65. Wilson DA, Baietto M. Advances in electronic-nose technologies develop for biomedical applications. Sensors 11, 1105-1176 (2011).
66. Silva LIB, Freitas AC, Rocha-Santos TAP, Pereira ME, Duarte AC. Breath analysis by optical fiber sensor for the determination of exhaled organic compounds with a view to diagnostics. Talanta 83(5), 1586-1594 (2011).
67. Pennazza G, Marchetti E, Santonico M et al. Application of a quartz microbalance based gas sensor array for the study of halitosis. J. Breath Res. 2(1), 017009 (2008).
68. Fleischer M, Simon E, Rumpel E et al. Detection of volatile compounds correlated to human diseases through breath analysis with chemical sensors. Sens. Actuators B 83(1-3), 245-249 (2002).
69. Lu HH, Rao YK, Wu TZ, Tzeng YM. Direct characterization and quantification of volatile organic compounds by piezoelectric module chips sensor. Sens. Actuators B 137(2), 741-746 (2009).
70. Ayad MM, Torad NL. Alcohol vapours sensor based on thin polyaniline salt film and quartz crystal microbalance. Talanta 78(4-5), 1280-1285 (2009).
71. Matsuguchi M, Uno T. Molecular imprinting strategy for solvent molecules and its application for QCM-based VOC vapor sensing. Sens. Actuators B 113(1), 94-99 (2006).
72. Righettoni M, Tricoli A, Pratsinis SE. Si:WO3 sensors for highly selective detection of acetone for easy diagnosis of diabetes by breath analysis. Anal. Chem. 82(9), 3581-3587 (2010).
73. Luo J, Luo J, Wang L et al. Nanoparticle-structured thin film sensor arrays for breath sensing. Sens. Actuators B 161(1), 845-854 (2012).
74. Rogers PH, Benkstein KD, Semancik S. Machine learning applied to chemical analysis: sensing multiple biomarkers in simulated breath using a temperature-pulsed electronic-nose. Anal. Chem. 84(22), 9774-9781 (2012).
75. Konvalina G, Haick H. Effect of humidity on nanoparticle-based chemiresistors: a comparison between synthetic and real-world samples. ACS Appl. Mater. Interfaces 4(1), 317-325 (2011).
76. Wolfbeis OS. Fiber-optic chemical sensors and biosensors. Anal. Chem. 80, 4269-4283 (2008).
77. Silva LIB, Panteleitchouk AV, Freitas AC, Rocha-Santos TAP, Duarte AC. Microscale optical fiber sensor for BTEX monitoring in landfill leachate. Anal. Methods 1(2), 100-107 (2009).
78. Silva LIB, Rocha-Santos TAP, Duarte AC. Remote optical fibre microsensor for monitoring BTEX in confined industrial atmospheres. Talanta 78(2), 548-552 (2009).
79. Silva LIB, Rocha-Santos TAP, Duarte AC. Comparison of a gas chromatography-optical fiber (GC-OF) detector with a gas chromatography-flame ionization detector (GC-FID) for determination of alcoholic compounds in industrial atmospheres. Talanta 76(2), 395-399 (2008).
80. Silva LIB, Ferreira FDP, Freitas AC, Rocha-Santos TAP, Duarte AC. Optical fiber-based micro-analyzer for indirect measurements of volatile amines levels in fish. Food Chem. 123(3), 806-813 (2010).
81. Ferreira FDP, Silva LIB, Freitas AC, Rocha-Santos TAP, Duarte AC. High performance liquid chromatography coupled to an optical fiber detector coated with laccase for screening catecholamines in plasma and urine. J. Chromatogr. A 1216(42), 7049-7054 (2009).
82. Silva LIB, Ferreira FDP, Freitas AC, Rocha-Santos TAP, Duarte AC. Optical fiber biosensor coupled to chromatographic separation for screening of dopamine, norepinephrine and epinephrine in human urine and plasma. Talanta 80(2), 853-857 (2009).
83. Silva LIB, Rocha-Santos TAP, Duarte AC. Development of a fluorosiloxane polymer-coated optical fiber sensor for detection of organic volatile compounds. Sens. Actuators B 132(1), 280-289 (2008).
84. Mazzone PJ, Wang XF, Xu Y et al. Exhaled breath analysis with a colorimetric sensor array for the identification and characterization of lung cancer. J. Thorac. Oncol. 7(1), 137-142 (2012).
85. Kebabian PL, Wood EC, Herndon SC, Freedman A. A practical alternative to chemiluminescence-based detection of nitrogen dioxide: cavity attenuated phase shift spectroscopy. Environ. Sci. Technol. 42(16), 6040-6045 (2008).
86. Christensen D, Herron J. Optical system design for biosensors based on ccd detection. In: Biosensors and Biodetection. Rasooly A, Herold K (Eds). Humana Press, 239-258 (2009).
87. Kapoor R. CCD based fiber-optic spectrometer detection. In: Biosensors and Biodetection. Rasooly A, Herold K (Eds). Humana Press, 435-445 (2009).
88. Curie J, Curie P. An oscillating quartz crystal mass detector. Rendu 91, 294-297 (1880).
89. Si P, Mortensen J, Komolov A, Denborg J, Møller PJ. Polymer coated quartz crystal microbalance sensors for detection of volatile organic compounds in gas mixtures. Anal. Chim. Acta 597(2), 223-230 (2007).
90. Khot LR, Panigrahi S, Lin D. Development and evaluation of piezoelectric-polymer thin film sensors for low concentration detection of volatile organic compounds related to food safety applications. Sens. Actuators B 153(1), 1-10 (2011).
91. Andreeva N, Ishizaki T, Baroch P, Saito N. High sensitive detection of volatile organic compounds using superhydrophobic quartz crystal microbalance. Sens. Actuators B 164(1), 15-21 (2012).
92. Ju JF, Syu MJ, Teng HS, Chou SK, Chang YS. Preparation and identification of b-cyclodextrin polymer thin film for quartz crystal microbalance sensing of benzene, toluene, and p-xylene. Sens. Actuators B 132(1), 319-326 (2008).
93. Xu X, Cang H, Li C, Zhao ZK, Li H. Quartz crystal microbalance sensor array for the detection of volatile organic compounds. Talanta 78(3), 711-716 (2009).
94. Vashist SK, Vashist P. recent advances in quartz crystal microbalance-based sensors. J. Sensors 13 (2011).
95. Fine GF, Cavanagh LM, Afonja A, Binions R. Metal oxide semi-conductor gas sensors in environmental monitoring. Sensors 10(6), 5469-5502 (2010).
96. Ahn MW, Park KS, Heo JH et al. Gas sensing properties of defect-controlled ZnO-nanowire gas sensor. Appl. Phys. Lett. 93(26), 263103-263103 (2008).
97. Hübner M, Simion CE, Haensch A, Barsan N, Weimar U. CO sensing mechanism with WO3 based gas sensors. Sens. Actuators B 151(1), 103-106 (2010).
98. Wang C, Yin L, Zhang L, Xiang D, Gao R. Metal oxide gas sensors: sensitivity and influencing factors. Sensors 10(3), 2088-2106 (2010).
99. Prabhakar A, Iglesias RA, Shan X et al. Online sample conditioning for portable breath analyzers. Anal. Chem. 84(16), 7172-7178 (2012).
100. Kukla AL, Pavluchenko AS, Shirshov YM, Konoshchuk NV, Posudievsky OY. Application of sensor arrays based on thin films of conducting polymers for chemical recognition of volatile organic solvents. Sens. Actuators B 135(2), 541-551 (2009).
101. Yu JB, Byun HG, So MS, Huh JS. Analysis of diabetic patient's breath with conducting polymer sensor array. Sens. Actuators B 108(1-2), 305-308 (2005).
102. Bai H, Shi G. Gas sensors based on conducting polymers. Sensors 7(3), 267-307 (2007).
103. Strand N, Bhushan A, Schivo M, Kenyon NJ, Davis CE. Chemically polymerized polypyrrole for on-chip concentration of volatile breath metabolites. Sens. Actuators B 143(2), 516-523 (2010).
104. Kowalczyk P. Physics of molecules. Polish Scientific Publishers. Warsaw, Poland (2000).
105. Stacewicz T, Wojtas J, Bielecki Z et al. Cavity ring down spectroscopy: detection of trace amounts of substance. Opto-Electron. Rev. 20(1), 53-60 (2012).
106. Wojtas J, Mikolajczyk J, Nowakowski M, Rutecka B, Medrzycki R, Bielecki Z. Applying CEAS method to UV, VIS, and IR spectroscopy sensors. Bull. Pol. Ac. Tech. 59(4), 415 (2011).
107. O'keefe A, Deacon DAG. Cavity ring-down optical spectrometer for absorption measurements using pulsed laser sources. Rev. Sci. Instrum. 59(12), 2544-2551 (1988).
108. Busch KW, Busch MA. Cavity-Ringdown Spectrosocpy, an Ultratrace- Absorption Measurements Technique. ACS Symposium Series. American Chemical Society, Washington, DC, USA, volume 720 (1999).
109. Berden G, Engeln R. Cavity Ring-Down Spectrosocopy: Techniques and Applications. Wiley-Blackwell, Chichester, UK, (2009).
110. Bielecki Z, Stacewicz T. Optoelectronic Sensor of Nitrogen Dioxide, Analysis and Construction Requirements. Military University of Technology Publishing Office, Warsaw, Poland (2011).
111. Romanini D, Kachanov AA, Sadeghi N, Stoeckel F. CW cavity ring down spectroscopy. Chem. Phys. Lett. 264(3-4), 316-322 (1997).
112. Berden G, Peeters R, Meijer G. Cavity ring-down spectroscopy: experimental schemes and applications. Int. Rev. Phys. Chem. 19(4), 565-607 (2000).
113. Jun Y, Long-Sheng M, Hall JL. Ultrastable optical frequency reference at 1.064 μm using a C2HD molecular overtone transition. Instrumentation and Measurement. IEEE Transactions 46(2), 178-182 (1997).
114. Menzel L, Kosterev AA, Curl RF et al. Spectroscopic detection of biological NO with a quantum cascade laser. Appl. Phys. B 72(7), 859-863 (2001).
115. Dahnke H, Kleine D, Urban C, Hering P, Murtz M. Isotopic ratio measurement of methane in ambient air using mid-infrared cavity leak-out spectroscopy. Appl. Phys. B-Lasers O. 72, 121-125 (2001).
116. Halmer D, Thelen S, Hering P, Mürtz M. Online monitoring of ethane traces in exhaled breath with a difference frequency generation spectrometer. Appl. Phys. B 85(2-3), 437-443 (2006).
117. Halmer D, Von Basum G, Hering P, Murtz M. Mid-infrared cavity leak-out spectroscopy for ultrasensitive detection of carbonyl sulfide. Opt Lett. 30(17), 2314-2316 (2005).
118. Starecki T. Selected aspects of photoacoustic instruments optimization. BTC Legionowo (2009).
119. Mccurdy MR, Bakhirkin Y, Wysocki G, Tittel FK. Performance of an exhaled nitric oxide and carbon dioxide sensor using quantum cascade laser-based integrated cavity output spectroscopy. J. Biomed. Opt. 12(3), 034034 (2007).
120. Dahnke H, Von Basum G, Kleinermanns K, Hering P, Mürtz M. Rapid formaldehyde monitoring in ambient air by means of mid-infrared cavity leak-out spectroscopy. Appl. Phys. B 75(2-3), 311-316 (2002).
121. Heinrich K, Fritsch T, Hering P, Mürtz M. Infrared laser-spectroscopic analysis of 14NO and 15NO in human breath. Appl. Phys. B 95(2), 281-286 (2009).
122. Neri G, Lacquaniti A, Rizzo G, Donato N, Latino M, Buemi M. Real-time monitoring of breath ammonia during haemodialysis: use of ion mobility spectrometry (IMS) and cavity ring-down spectroscopy (CRDS) techniques. Nephrol. Dial. Transplant. 27(7), 2945-2952 (2012).
123. Chuji W, Mbi A, Shepherd M. A study on breath acetone in diabetic patients using a cavity ringdown breath analyzer: exploring correlations of breath acetone with blood glucose and glycohemoglobin A1C. Sensors Journal IEEE 10(1), 54-63 (2010).
124. Crosson ER, Ricci KN, Richman BA et al. Stable isotope ratios using cavity ring-down spectroscopy: determination of 13C/12C for carbon dioxide in human breath. Anal. Chem. 74(9), 2003-2007 (2002).
125. Marinov D, Rey JM, Müller MG, Sigrist MW. Spectroscopic investigation of methylated amines by a cavity-ringdown-based spectrometer. Appl. Opt. 46(19), 3981-3986 (2007).
126. Bakhirkin YA, Kosterev AA, Roller C, Curl RF, Tittel FK. Mid-infrared quantum cascade laser based off-axis integrated cavity output spectroscopy for biogenic nitric oxide detection. Appl. Opt. 43(11), 2257-2266 (2004).
127. Kosterev AA, Malinovsky AL, Tittel FK et al. Cavity ringdown spectroscopic detection of nitric oxide with a continuous-wave quantum-cascade laser. Appl. Opt. 40(30), 5522-5529 (2001).
128. Narasimhan LR, Goodman W, Patel CK. Correlation of breath ammonia with blood urea nitrogen and creatinine during hemodialysis. Proc. Natl Acad. Sci. USA 98(8), 4617-4621 (2001).
129. Van Herpen MMJW, Ngai AKY, Bisson SE, Hackstein JHP, Woltering EJ, Harren FJM. Optical parametric oscillator-based photoacoustic detection of CO2 at 4.23 μm allows real-time monitoring of the respiration of small insects. Appl. Phys. B 82(4), 665-669 (2006).
130. Angelmahr M, Miklós A, Hess P. Photoacoustic spectroscopy of formaldehyde with tunable laser radiation at the parts per billion level. Appl. Phys. B 85(2-3), 285-288 (2006).
131. Kamat PC, Roller CB, Namjou K et al. Measurement of acetaldehyde in exhaled breath using a laser absorption spectrometer. Appl. Opt. 46(19), 3969-3975 (2007).
132. Manne J, Sukhorukov O, Jäger W, Tulip J. Pulsed quantum cascade laser-based cavity ring-down spectroscopy for ammonia detection in breath. Appl. Opt. 45(36), 9230-9237 (2006).
133. Manne J, Jäger W, Tulip J. Sensitive detection of ammonia and ethylene with a pulsed quantum cascade laser using intra and interpulse spectroscopic techniques. Appl. Phys. B 94(2), 337-344 (2009).
134. Thorpe MJ, Balslev-Clausen D, Kirchner MS, Ye J. Cavity-enhanced optical frequency combspectroscopy: application to human breathanalysis. Opt. Express 16(4), 2387-2397 (2008).
135. Wysocki G, Mccurdy M, So S et al. Pulsed quantum-cascade laser-based sensor for trace-gas detection of carbonyl sulfide. Appl. Opt. 43(32), 6040-6046 (2004).
136. Claire SP, Lesley CM, Karen S et al. Dynamic study of oxidative stress in renal dialysis patients based on breath ethane measured by optical spectroscopy. J. Breath Res. 1(2), 026005 (2007).
137. Ciaffoni L, Grilli R, Hancock G, Orr-Ewing AJ, Peverall R, Ritchie GaD. 3.5-μm high-resolution gas sensing employing a LiNbO3 QPM-DFG waveguide module. Appl. Phys. B 94(3), 517-525 (2009).
138. Namjou K, Roller CB, Reich TE et al. Determination of exhaled nitric oxide distributions in a diverse sample population using tunable diode laser absorption spectroscopy. Appl. Phys. B 85(2-3), 427-435 (2006).
139. Airsense analytics.www.airsense.com
140. Alpha MOS. www.alpha-mos.com
141. Sacmi. www.sacmi.eu
142. Smith Group.www.smithsdetection.com
143. GSG Mess- und Analyseneräte.www.gsg-analytical.com
144. Appliedsensor.www.appliedsensor.com
145. Dr. Foedisch AG.www.foedisch.de
146. Gerstel GMBH & Co. KG.www.gerstel.com
147. RST-Rostock.www.rst-rostock.de
148. Sysca AG.www.sysca-ag.de
149. Chemsensing.www.chemsensing.com
150. Illumina.www.illumina.com
151. Scentrak.www.cogniscentinc.com
152. Microsensor systems Inc.www.microsensorsystems.com
153. Scensive technologies Ltd.www.scensive.com