Detecting Tuberculosis Infection in HIV-infected Children: A Study of Diagnostic Accuracy, Confounding and Interaction

Pediatric Infectious Disease Journal

Volumn 32, Issue 3, 2013, Pages e111-e118

  Mandalakas, Anna M ^a   van Wyk, Susan ^a   Kirchner, H Lester ^a   Walzl, Gerhard ^a   Cotton, Mark ^a   Rabie, Helena ^a   Kriel, Belinda ^a   Gie, Robert P ^a   Schaaf, H Simon ^a   Hesseling, Anneke C ^a  

^a Baylor College of Medicine   (South Africa)

Author keywords

HIV; Interferon release assays; Latent tuberculosis infection; Pediatrics; Tuberculin skin test; Tuberculosis

Indexed keywords

ADOLESCENT; ARTICLE; BCG VACCINATION; CHILD; CHILDHOOD DISEASE; CONTROLLED STUDY; CYTOKINE RELEASE; DIAGNOSTIC ACCURACY; DIAGNOSTIC TEST ACCURACY STUDY; FEMALE; HEALTH CARE UTILIZATION; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; INFANT; INTERFERON GAMMA RELEASE ASSAY; MAJOR CLINICAL STUDY; MALE; MALNUTRITION; PRESCHOOL CHILD; PRIORITY JOURNAL; SCHOOL CHILD; SOUTH AFRICA; TUBERCULIN TEST; TUBERCULOSIS;

ADOLESCENT; CHILD; CHILD, PRESCHOOL; FEMALE; HIV INFECTIONS; HUMANS; INFANT; INTERFERON-GAMMA RELEASE TESTS; MALE; MYCOBACTERIUM TUBERCULOSIS; SENSITIVITY AND SPECIFICITY; SOUTH AFRICA; TUBERCULIN TEST; TUBERCULOSIS;

EID: 84876290518     PISSN: 08913668     EISSN: 15320987     Source Type: Journal    
DOI: 10.1097/INF.0b013e31827d77b7     Document Type: Article

References (45)

1. Dolin PJ, Raviglione MC, Kochi A. Global tuberculosis incidence and mortality during 1990-2000. Bull World Health Organ. 1994;72:213-220
2. Kasprowicz VO, Churchyard G, Lawn SD, et al. Diagnosing latent tuberculosis in high-risk individuals: rising to the challenge in high-burden areas. J Infect Dis. 2011;204(suppl 4):S1168-S1178
3. World Health Organization. Global Tuberculosis Control: WHO Report 2011 (WHO/HTM/TB/2011.16). 2011 Geneva, Switzerland World Health Organization
4. Nelson LJ, Wells CD. Global epidemiology of childhood tuberculosis. Int J Tuberc Lung Dis. 2004;8:636-647
5. Marais BJ, Gie RP, Schaaf HS, et al. The natural history of childhood intra-thoracic tuberculosis: a critical review of literature from the pre-chemotherapy era. Int J Tuberc Lung Dis. 2004;8:392-402
6. Mahairas GG, Sabo PJ, Hickey MJ, et al. Molecular analysis of genetic differences between Mycobacterium bovis BCG and virulent M. bovis. J Bacteriol. 1996;178:1274-1282
7. Harboe M, Oettinger T, Wiker HG, et al. Evidence for occurrence of the ESAT-6 protein in Mycobacterium tuberculosis and virulent Mycobacterium bovis and for its absence in Mycobacterium bovis BCG. Infect Immun. 1996;64:16-22
8. Lalvani A. Spotting latent infection: the path to better tuberculosis control. Thorax. 2003;58:916-918
9. Anderson P, Munk ME, Pollock JM, et al. Specific immune-base diagnosis of TB. Lancet. 2000;356:1099-1104
10. Wood PR, Jones SL. BOVIGAM: an in vitro cellular diagnostic test for bovine tuberculosis. Tuberculosis (Edinb). 2001;81:147-55
11. Mandalakas AM, Detjen AK, Hesseling AC, et al. Interferon-gamma release assays and childhood tuberculosis: systematic review and meta-analysis. Int J Tuberc Lung Dis. 2011;15:1018-1032
12. Machingaidze S, Wiysonge CS, Gonzalez-Angulo Y, et al. The utility of an interferon gamma release assay for diagnosis of latent tuberculosis infection and disease in children: a systematic review and meta-analysis. Pediatr Infect Dis J. 2011;30:694-700
13. Davies MA, Connell T, Johannisen C, et al. Detection of tuberculosis in HIV-infected children using an enzyme-linked immunospot assay. AIDS. 2009;23:961-969
14. Marais BJ, Graham SM, Cotton MF, et al. Diagnostic and management challenges for childhood tuberculosis in the era of HIV. J Infect Dis. 2007;196(suppl 1):S76-S85
15. Kumar A, Upadhyay S, Kumari G. Clinical Presentation, treatment outcome and survival among the HIV infected children with culture confirmed tuberculosis. Curr HIV Res. 2007;5:499-504
16. Liebeschuetz S, Bamber S, Ewer K, et al. Diagnosis of tuberculosis in South African children with a T-cell-based assay: a prospective cohort study. Lancet. 2004;364:2196-2203
17. Stavri H, Ene L, Popa GL, et al. Comparison of tuberculin skin test with a whole-blood interferon gamma assay and ELISA, in HIV positive children and adolescents with TB. Roum Arch Microbiol Immunol. 2009;68:14-19
18. Mandalakas AM, Hesseling AC, Chegou NN, et al. High level of discordant IGRA results in HIV-infected adults and children. Int J Tuberc Lung Dis. 2008;12:417-423
19. Kritzinger FE, den Boon S, Verver S, et al. No decrease in annual risk of tuberculosis infection in endemic area in Cape Town, South Africa. Trop Med Int Health. 2009;14:136-142
20. Shanaube K, Sismanidis C, Ayles H, et al. Annual risk of tuberculous infection using different methods in communities with a high prevalence of TB and HIV in Zambia and South Africa. PLoS ONE. 2009;4:e7749
21. Western Cape provincial EPI vaccination survey, 2005. Available at: http://www.capegateway.gov.za/Text/2007/6/cd_volume_7_childhood_diseases_overview.pdf. Accessed July 15, 2010
22. Mandalakas AM, Kirchner HL, Lombard C, et al. Well-quantified tuberculosis exposure is a reliable surrogate measure of tuberculosis infection. Int J Tuberc Lung Dis. 2012;16:1033-1039
23. Quantiferon-TB Gold In-Tube. Available at: http://www.cellestis.com/IRM/Content/usa/qftproducts_tbgoldintube.html. Accessed November 9, 2011
24. T-SPOT.TB. Available at: http://www.oxfordimmunotec.com/T-SPOT.TB_International. Accessed November 9, 2011
25. Marais BJ, Gie RP, Hesseling AC, et al. A refined symptom-based approach to diagnose pulmonary tuberculosis in children. Pediatrics. 2006;118:e1350-e1359
26. Marais BJ, Gie RP, Schaaf HS, et al. A proposed radiological classification of childhood intra-thoracic tuberculosis. Pediatr Radiol. 2004;34:886-894
27. Bossuyt PM, Reitsma JB, Bruns DE, et al.Standards for Reporting of Diagnostic Accuracy. Towards complete and accurate reporting of studies of diagnostic accuracy: the STARD initiative. BMJ. 2003;326:41-44
28. Landis JR, Koch GG. An application of hierarchical kappa-type statistics in the assessment of majority agreement among multiple observers. Biometrics. 1977;33:363-374
29. Woldehana S, Volmink J. Treatment of latent tuberculosis infection in HIV infected persons. Cochrane Databases Syst Rev. 2004:CD000171
30. Smieja MACP Journal Club. Review: oseltamivir relieves symptoms but does not reduce hospitalizations in influenza. Ann Intern Med. 2012;157:JC3-JC5
31. Martinson NA, Barnes GL, Moulton LH, et al. New regimens to prevent tuberculosis in adults with HIV infection. N Engl J Med. 2011;365:11-20
32. Mosimaneotsile B, Mathoma A, Chengeta B, et al. Isoniazid tuberculosis preventive therapy in HIV-infected adults accessing antiretroviral therapy: a Botswana Experience, 2004-2006. J Acquir Immune Defic Syndr. 2010;54:71-77
33. World Health Organization. Guidance for National Tuberculosis Programmes on the Management of Tuberculosis in Children (WHO/HTM/ TB/2006.371). 2006 Geneva, Switzerland World Health Organization
34. World Health Organization. Guidelines for Intensified Tuberculosis Case Finding and Isoniazid Preventive Therapy for People Living with HIV in Resource Constrained Settings. 2011 Geneva, Switzerland World Health Organization
35. Geldmacher C, Schuetz A, Ngwenyama N, et al. Early depletion of Mycobacterium tuberculosis-specific T helper 1 cell responses after HIV-1 infection. J Infect Dis. 2008;198:1590-1598
36. Thomas TA, Mondal D, Noor Z, et al. Malnutrition and helminth infection affect performance of an interferon gamma-release assay. Pediatrics. 2010;126:e1522-e1529
37. Freiman I, Geefhuysen JTuberculosis in Black children. A retrospective analysis of severe cases. S Afr Med J. 1975;49:1591-1594
38. Lloyd AV. Tuberculin test in children with malnutrition. Br Med J. 1968;3:529-531
39. Sinha DP, Bang FB. Protein and calorie malnutrition, cell-mediated immunity, and B.C.G. vaccination in children from rural West Bengal. Lancet. 1976;2:531-534
40. Detjen AK, Loebenberg L, Grewal HM, et al. Short-term reproducibility of a commercial interferon gamma release assay. Clin Vaccine Immunol. 2009;16:1170-1175
41. van Zyl-Smit RN, Pai M, Peprah K, et al. Within-subject variability and boosting of T-cell interferon-gamma responses after tuberculin skin testing. Am J Respir Crit Care Med. 2009;180:49-58
42. van Zyl-Smit RN, Zwerling A, Dheda K, et al. Within-subject variability of interferon-g assay results for tuberculosis and boosting effect of tuberculin skin testing: a systematic review. PLoS ONE. 2009;4:e8517
43. Cattamanchi A, Smith R, Steingart KR, et al. Interferon-gamma release assays for the diagnosis of latent tuberculosis infection in HIV-infected individuals: a systematic review and meta-analysis. J Acquir Immune Defic Syndr. 2011;56:230-238
44. Hesseling AC, Mandalakas AM, Kirchner HL, et al. Highly discordant T cell responses in individuals with recent exposure to household tuberculosis. Thorax. 2009;64:840-846
45. Lawn SD, Wood R. Tuberculosis in antiretroviral treatment services in resource-limited settings: addressing the challenges of screening and diagnosis. J Infect Dis. 2011;204(suppl 4):S1159-S1167