Phenotype of asthmatics with increased airway S-nitrosoglutathione reductase activity

European Respiratory Journal

Volumn 45, Issue 1, 2015, Pages 87-97

  Marozkina, Nadzeya V ^a   Wang, Xin Qun ^b   Stsiapura, Vitali ^b   Fitzpatrick, Anne ^c   Carraro, Silvia ^d   Hawkins, Gregory A ^e   Bleecker, Eugene ^e   Meyers, Deborah ^e   Jarjour, Nizar ^f   Fain, Sean B ^f   Wenzel, Sally ^g   Busse, William ^f   Castro, Mario ^h   Panettieri, Reynold A ⁱ   Moore, Wendy ^e   Lewis, Stephen J ^a   Palmer, Lisa A ^b   Altes, Talissa ^b   De Lange, Eduard E ^b   Erzurum, Serpil ^j   Teague, W Gerald ^b   Gaston, Benjamin ^a   more..

^a CASE WESTERN RESERVE UNIVERSITY   (United States)

^b UNIVERSITY OF VIRGINIA   (United States)

^c EMORY UNIVERSITY   (United States)

^d UNIVERSITY OF PADOVA   (Italy)

^e WAKE FOREST SCHOOL OF MEDICINE   (United States)

^f UNIVERSITY OF WISCONSIN SCHOOL OF MEDICINE AND PUBLIC HEALTH   (United States)

^g UNIVERSITY OF PITTSBURGH   (United States)

^h WASHINGTON UNIVERSITY   (United States)

ⁱ UNIVERSITY OF PENNSYLVANIA   (United States)

^j LERNER RESEARCH INSTITUTE   (United States)

more..

Author keywords

[No Author keywords available]

Indexed keywords

IMMUNOGLOBULIN E; INTERLEUKIN 13; OXIDOREDUCTASE; S NITROSOGLUTATHIONE REDUCTASE; UNCLASSIFIED DRUG; ALDEHYDE DEHYDROGENASE; FORMALDEHYDE DEHYDROGENASE, GLUTATHIONE-INDEPENDENT;

ADULT; AGE DISTRIBUTION; ARTICLE; ASTHMA; ATOPY; BRONCHOSCOPY; BRONCHUS BIOPSY; BRONCHUS MUCOSA; CLINICAL ARTICLE; CLINICAL FEATURE; CONTROLLED STUDY; DISEASE SEVERITY; ENZYME ACTIVITY; ENZYME ANALYSIS; FEMALE; GENETIC ANALYSIS; GENETIC ASSOCIATION; GENETIC HETEROGENEITY; GENOTYPE; HUMAN; HUMAN CELL; HUMAN TISSUE; LUNG ALVEOLUS CELL; MALE; PHENOTYPIC VARIATION; PROTEIN EXPRESSION; RESPIRATORY AIRFLOW; RESPIRATORY EPITHELIUM; SINGLE NUCLEOTIDE POLYMORPHISM; SMOOTH MUSCLE; TISSUE SPECIFICITY; ADOLESCENT; BIOPSY; BLOOD; BRONCHUS; CASE CONTROL STUDY; CELL CULTURE; CHILD; ENZYMOLOGY; GENE EXPRESSION REGULATION; IMMUNOHISTOCHEMISTRY; LUNG; LUNG LAVAGE; METABOLISM; MIDDLE AGED; NUCLEAR MAGNETIC RESONANCE IMAGING; PHENOTYPE; YOUNG ADULT;

ADOLESCENT; ADULT; ALDEHYDE OXIDOREDUCTASES; ASTHMA; BIOPSY; BRONCHI; BRONCHOALVEOLAR LAVAGE; BRONCHOSCOPY; CASE-CONTROL STUDIES; CELLS, CULTURED; CHILD; FEMALE; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GENOTYPE; HUMANS; IMMUNOGLOBULIN E; IMMUNOHISTOCHEMISTRY; INTERLEUKIN-13; LUNG; MAGNETIC RESONANCE IMAGING; MALE; METABOLISM; MIDDLE AGED; MUSCLE, SMOOTH; PHENOTYPE; POLYMORPHISM, SINGLE NUCLEOTIDE; YOUNG ADULT;

EID: 84920570321     PISSN: 09031936     EISSN: 13993003     Source Type: Journal    
DOI: 10.1183/09031936.00042414     Document Type: Article

References (35)

1. Gaston B, Reilly J, Drazen JM, et al. Endogenous nitrogen oxides and bronchodilator S-nitrosothiols in human airways. Proc Natl Acad Sci USA 1993; 90: 10957-10961.
2. Gaston B, Drazen JM, Jansen A, et al. Relaxation of human bronchial smooth muscle by S-nitrosothiols in vitro. J Pharmacol Exp Ther 1994; 268: 978-984.
3. Whalen EJ, Foster MW, Matsumoto A, et al. Regulation of β-adrenergic receptor signalling by S-nitrosylation of G-protein-coupled receptor kinase 2. Cell 2007; 129: 511-522.
4. Gaston B, Doctor A, Singel D, et al. S-nitrosothiol signaling in respiratory biology. Am J Respir Crit Care Med 2006; 173: 1186-1193.
5. Foster M, Yang Z, Potts E, et al. S-nitrosoglutathione supplementation to ovalbumin-sensitized and -challenged mice ameliorates methacholine-induced bronchoconstriction. Am J Phyisol Lung Cell Mol Physiol 2011; 301: 739-744.
6. Fang K, Johns R, Macdonald T, et al. S-nitrosoglutathione breakdown prevents airway smooth muscle relaxation in the guinea pig. Am J Physiol Lung Cell Molec Physiol 2000; 279: L716-L721.
7. Forster MW, Hess DT, Stamler JS. Protein S-nitrosylation in health and disease: a current perspective. Trends Mol Med 2009; 15: 391-404.
8. Liu L, Hausladen A, Zeng M, et al. A metabolic enzyme for S-nitrosothiol conserved from bacteria to humans. Nature 2001; 410: 490-494.
9. Que LG, Liu L, Yan Y, et al. Protection from experimental asthma by an endogenous bronchodilator. Science 2005; 308: 1618-1621.
10. Que L, Zhonghui Y, Stamler JS, et al. S-nitrosoglutathione reductase: an important regulator inhuman asthma. Am J Respir Crit Care Med 2009; 180: 226-231.
11. Xiong Y, Uys JD, Tew KD, et al. S-glutathionylation: from molecular mechanisms to health outcomes. Antioxid Redox Signal 2011; 15: 233-270.
12. Kuipers I, Louis R, Manise M, et al. Increased glutaredoxin-1 and decreased protein S-glutathionylation in sputum of asthmatics. Eur Respir J 2013; 41: 469-472.
13. Gaston B, Sears S, Woods J, et al. Bronchodilator S-nitrosothiol deficiency in asthmatic respiratory failure. Lancet 1998; 351: 1317-1319.
14. Wu H, Romieu I, Sienra-Monge JJ, et al. Genetic variation in S-nitrosoglutathione reductase (GSNOR) and childhood asthma. J Allergy Clin Immunol 2007; 120: 322-328.
15. Moore PE, Ryckman KK, Williams SM, et al. Genetic variants of GSNOR and ADRB2 influence response to albuterol in African-American children with severe asthma. Pediatr Pulmonol 2009; 44: 649-654.
16. Choudhry S, Que LG, Yang Z, et al. GSNO reductase and β2-adrenergic receptor gene-gene interaction: bronchodilator responsiveness to albuterol. Pharmacogenet and Genomics 2010; 20: 351-358.
17. Green LS, Chun LE, Patton AK, et al. Mechanism of inhibition for N6022, a first-in-class drug targeting S-nitrosoglutathione reductase. Biochem 2012; 51: 2157-2168.
18. Palmer L, Doctor A, Chhabra P, et al. S-nitrosothiols signal hypoxia-mimetic vascular pathology. J Clin Invest 2007; 117: 2592-2601.
19. Marozkina NV, Wei C, Yemen S, et al. S-nitrosoglutathione reductase in human lung cancer. Am J Respir Cell Mol Biol 2012; 46: 63-70.
20. Wei W, Li B, Hanes MA, et al. S-nitrosylation from GSNOR deficiency impairs DNA repair and promotes hepatocarcinogenesis. Sci Transl Med 2010; 2: 19ra13
21. Moore WC, Bleecker ER, Curran-Everett DC, et al. Characterization of the severe asthma phenotype by the National Heart, Lung. and Blood Institutes's Severe Asthma Research Program. J Allergy Clin Immunol 2007; 119: 405-413.
22. Busse WW, Banks-Schlegel S, Wenzel SE. Pathophysiology of severe asthma. J Allergy Clin Immunol 2000; 106: 1033-1042.
23. Chung KF, Wenzel SE, Brozek JL, et al. International ERS/ATS guidelines on definition, evaluation and treatment of severe asthma. Eur Respir J 2014; 43: 343-373.
24. de Lange EE, Altes TA, Patrie JT, et al. Changes in regional airflow obstruction over time in the lungs of patients with asthma: evaluation with 3He MR imaging. Radiology 2009; 250: 567-575.
25. Moore WC, Evans MD, Bleecker ER, et al. Safety of investigative bronchoscopy in the Severe Asthma Research Program. J Allerg Clin Immunol 2011; 128: 328-336.
26. Fitzpatrick AM, Brown LA, Holguin F, et al. Levels of nitric oxide oxidation products are increased in the epithelial lining fluid of children with severe asthma. J Allergy Clin Immunol 2009; 124: 990-996.
27. Fain SB, Gonzalez-Fernandez G, Peterson ET, et al. Evaluation of structure-function relationships in asthma using multi-detector CT (MDCT) and hyperpolarized (HP) He-3 MRI. Acad Radiol 2008; 15: 753-762.
28. Gow A, Doctor A, Mannick J, et al. S-nitrosothiol measurements in biological systems. J Chromatog B Analyt Technol Biomed Life Sci 2007; 851: 140-151.
29. Amrani Y, Syed F, Huang C, et al. Expression and activation of the oxytocin receptor in airway smooth muscle cells: regulation by TNFα and IL-13. Respir Res 2010; 11: 104
30. Marozkina NV, Yemen S, Borowitz M, et al. Hsp70/Hsp 90 organizing protein as a nitrosylation target of corrector therapy in cystic fibrosis therapy. Proc Natl Acad Sci USA 2010; 107: 11393-11398.
31. Greenwald R, Fitzpatrick AM, Gaston B, et al. Breath formate is a marker of airway S-nitrosothiol depletion in severe asthma. PLoS One 2010; 5: e11919
32. Bannenberg G, Xue J, Engman L, et al. Characterization of bronchodilator effects and fate of S-nitrosothiols in the isolated perfused and ventilated guinea pig lung. J Pharmacol Exp Ther 1995; 272: 1238-1245.
33. Janssen LJ, Premji M, Lu-Chao H, et al. NO+ but not NO radical relaxes airway smooth muscle via cGMP-independent release of internal Ca2+. Am J Physiol Lung Cell Mol Physiol 2000; 278: 899-905.
34. Perkins W, Pabelick C, Warner DO, et al. cGMP-independent mechanism of airway smooth muscle relaxation induced by S-nitrosoglutathione. Am J Physiol 1998; 275: 468-474.
35. Snyder A, McPherson ME, Hunt JF, et al. Acute effects of aerosolized S-nitrosoglutathione in cystic fibrosis. Am J Respir Crit Care Med 2002; 165: 922-926.