Mechanism of inhibition for N6022, a first-in-class drug targeting S-nitrosoglutathione reductase

Biochemistry

Volumn 51, Issue 10, 2012, Pages 2157-2168

  Green, Louis S ^a   Chun, Lawrence E ^b   Patton, Aaron K ^a   Sun, Xicheng ^a   Rosenthal, Gary J ^a   Richards, Jane P ^a  

^a N30 Pharmaceuticals LLC   (United States)

^b Emerald BioStructures   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL MODEL; CHRONIC OBSTRUCTIVE PULMONARY DISEASE; CLINICAL STUDY; COFACTORS; DRUG-TARGETING; INFLAMMATORY BOWEL DISEASE; INHIBITORY ACTIVITY; KINETIC ASSAY; OXIDATION AND REDUCTION; RELATED COMPOUNDS; S-NITROSOGLUTATHIONE; SUBSTRATE BINDING; TIGHT BINDING;

NITRIC OXIDE; PHYSIOLOGY; PULMONARY DISEASES; RESPIRATORY MECHANICS;

ENZYME INHIBITION;

FORMALDEHYDE; GLUTATHIONE DERIVATIVE; N 6022; NICOTINAMIDE ADENINE DINUCLEOTIDE; OXIDOREDUCTASE; OXIDOREDUCTASE INHIBITOR; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE; S HYDROXYMETHYLGLUTATHIONE; S NITROSOGLUTATHIONE REDUCTASE; S NITROSOGLUTATHIONE REDUCTASE INHIBITOR; UNCLASSIFIED DRUG;

ARTICLE; COMPETITIVE INHIBITION; CONTROLLED STUDY; DRUG MECHANISM; DRUG POTENCY; DRUG PROTEIN BINDING; DRUG SPECIFICITY; ENZYME ACTIVE SITE; ENZYME INHIBITION; ENZYME KINETICS; ENZYME SUBSTRATE; IC 50; OXIDATION REDUCTION REACTION; PRIORITY JOURNAL;

ALCOHOL OXIDOREDUCTASES; ALDEHYDE OXIDOREDUCTASES; BENZAMIDES; BINDING, COMPETITIVE; CATALYTIC DOMAIN; ENZYME INHIBITORS; HUMANS; KINETICS; MODELS, BIOLOGICAL; MODELS, MOLECULAR; PYRROLES; RECOMBINANT PROTEINS; S-NITROSOGLUTATHIONE;

ANIMALIA;

EID: 84863237651     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi201785u     Document Type: Article

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