Human adipose tissue conditioned media from lean subjects is protective against H2O2 induced neurotoxicity in human SH-SY5Y neuronal cells

International Journal of Molecular Sciences

Volumn 16, Issue 1, 2015, Pages 1221-1231

  Wan, Zhongxiao ^a   Mah, Dorrian ^a   Simtchouk, Svetlana ^a   Kluftinger, Andreas ^a   Little, Jonathan P ^a  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

Adipokine; Alzheimer s disease; Obesity; Oxidative stress

Indexed keywords

ADIPOCYTOKINE RECEPTOR; ADIPONECTIN; HEAT SENSITIVE FACTOR; HYDROGEN PEROXIDE; LEPTIN; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PROTEIN; PROTEIN KINASE B; STRESS ACTIVATED PROTEIN KINASE; UNCLASSIFIED DRUG; 2-(2-AMINO-3-METHOXYPHENYL)-4H-1-BENZOPYRAN-4-ONE; 2-(4-MORPHOLINYL)-8-PHENYL-4H-1-BENZOPYRAN-4-ONE; ANTHRA(1,9-CD)PYRAZOL-6(2H)-ONE; ANTHRACENE DERIVATIVE; CHROMONE DERIVATIVE; CULTURE MEDIUM; FLAVONOID; MORPHOLINE DERIVATIVE; NEUROPROTECTIVE AGENT; PHOSPHATIDYLINOSITOL 3 KINASE;

ADIPOSE TISSUE; ADULT; ARTICLE; BODY MASS; CELL VIABILITY; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; HUMAN; HUMAN CELL; HUMAN TISSUE; MTT ASSAY; NERVE CELL; NEUROTOXICITY; NORMAL HUMAN; OXIDATIVE STRESS; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; WESTERN BLOTTING; ALZHEIMER DISEASE; ANTAGONISTS AND INHIBITORS; CELL SURVIVAL; CULTURE MEDIUM; CYTOLOGY; DRUG EFFECTS; METABOLISM; NEUROBLASTOMA; PATHOLOGY; PHARMACOLOGY; PHOSPHORYLATION; TUMOR CELL LINE;

ADIPOSE TISSUE; ALZHEIMER DISEASE; ANTHRACENES; CELL LINE, TUMOR; CELL SURVIVAL; CHROMONES; CULTURE MEDIA, CONDITIONED; FLAVONOIDS; HUMANS; HYDROGEN PEROXIDE; JNK MITOGEN-ACTIVATED PROTEIN KINASES; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; MORPHOLINES; NEUROBLASTOMA; NEUROPROTECTIVE AGENTS; OXIDATIVE STRESS; PHOSPHATIDYLINOSITOL 3-KINASES; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-AKT; SIGNAL TRANSDUCTION;

EID: 84920520629     PISSN: 16616596     EISSN: 14220067     Source Type: Journal    
DOI: 10.3390/ijms16011221     Document Type: Article

References (28)

1. Reitz, C.; Brayne, C.; Mayeux, R. Epidemiology of Alzheimer disease. Nat. Rev. Neurol. 2011, 7, 137-152.
2. Rosen, E.D.; Spiegelman, B.M. Adipocytes as regulators of energy balance and glucose homeostasis. Nature 2006, 444, 847-853.
3. Maury, E.; Brichard, S.M. Adipokine dysregulation, adipose tissue inflammation and metabolic syndrome. Mol. Cell Endocrinol. 2010, 314, 1-16.
4. Thundyil, J.; Pavlovski, D.; Sobey, C.G.; Arumugam, T.V. Adiponectin receptor signalling in the brain. Br. J. Pharmacol. 2012, 165, 313-327.
5. Leshan, R.L.; Bjornholm, M.; Munzberg, H.; Myers, M.G., Jr. Leptin receptor signaling and action in the central nervous system. Obesity 2006, 14, S208-S212.
6. Benomar, Y.; Gertler, A.; de Lacy, P.; Crepin, D.; Ould Hamouda, H.; Riffault, L.; Taouis, M. Central resistin overexposure induces insulin resistance through Toll-like receptor 4. Diabetes 2013, 62, 102-114.
7. Chan, K.H.; Lam, K.S.; Cheng, O.Y.; Kwan, J.S.; Ho, P.W.; Cheng, K.K.; Chung, S.K.; Ho, J.W.; Guo, V.Y.; Xu, A. Adiponectin is protective against oxidative stress induced cytotoxicity in amyloid-beta neurotoxicity. PLoS One 2012, 7, e52354.
8. Greco, S.J.; Sarkar, S.; Johnston, J.M.; Zhu, X.; Su, B.; Casadesus, G.; Ashford, J.W.; Smith, M.A.; Tezapsidis, N. Leptin reduces Alzheimer’s disease-related tau phosphorylation in neuronal cells. Biochem. Biophys. Res. Commun. 2008, 376, 536-541.
9. Rosini, M.; Simoni, E.; Milelli, A.; Minarini, A.; Melchiorre, C. Oxidative stress in Alzheimer’s disease: Are we connecting the dots? J. Med. Chem. 2013, 57, 2821-2831.
10. Brazil, D.P.; Yang, Z.Z.; Hemmings, B.A. Advances in protein kinase B signalling: AKTion on multiple fronts. Trends Biochem. Sci. 2004, 29, 233-242.
11. Hanada, M.; Feng, J.; Hemmings, B.A. Structure, regulation and function of PKB/AKT—A major therapeutic target. Biochim. Biophys. Acta 2004, 1697, 3-16.
12. Azmi, N.H.; Ismail, N.; Imam, M.U.; Ismail, M. Ethyl acetate extract of germinated brown rice attenuates hydrogen peroxide-induced oxidative stress in human SH-SY5Y neuroblastoma cells: Role of anti-apoptotic, pro-survival and antioxidant genes. BMC Complement. Altern. Med. 2013, 13, 177.
13. 2. Mol. Cell. Biochem. 2012, 371, 9-22.
14. Lu, S.; Lu, C.; Han, Q.; Li, J.; Du, Z.; Liao, L.; Zhao, R.C. Adipose-derived mesenchymal stem cells protect PC12 cells from glutamate excitotoxicity-induced apoptosis by upregulation of XIAP through PI3-K/Akt activation. Toxicology 2011, 279, 189-195.
15. D’Esposito, V.; Passaretti, F.; Hammarstedt, A.; Liguoro, D.; Terracciano, D.; Molea, G.; Canta, L.; Miele, C.; Smith, U.; Beguinot, F., et al. Adipocyte-released insulin-like growth factor-1 is regulated by glucose and fatty acids and controls breast cancer cell growth in vitro. Diabetologia 2012, 55, 2811-2822.
16. Rehman, J.; Traktuev, D.; Li, J.; Merfeld-Clauss, S.; Temm-Grove, C.J.; Bovenkerk, J.E.; Pell, C.L.; Johnstone, B.H.; Considine, R.V.; March, K.L. Secretion of angiogenic and antiapoptotic factors by human adipose stromal cells. Circulation 2004, 109, 1292-1298.
17. Doherty, G.H.; Beccano-Kelly, D.; Yan, S.D.; Gunn-Moore, F.J.; Harvey, J. Leptin prevents hippocampal synaptic disruption and neuronal cell death induced by amyloid beta. Neurobiol. Aging 2013, 34, 226-237.
18. Niedowicz, D.M.; Studzinski, C.M.; Weidner, A.M.; Platt, T.L.; Kingry, K.N.; Beckett, T.L.; Bruce-Keller, A.J.; Keller, J.N.; Murphy, M.P. Leptin regulates amyloid beta production via the gamma-secretase complex. Biochim. Biophys. Acta 2013, 1832, 439-444.
19. Zeng, X.J.; Yu, S.P.; Zhang, L.; Wei, L. Neuroprotective effect of the endogenous neural peptide apelin in cultured mouse cortical neurons. Exp. Cell Res. 2010, 316, 1773-1783.
20. Chen, D.B.; Wang, L.; Wang, P.H. Insulin-like growth factor I retards apoptotic signaling induced by ethanol in cardiomyocytes. Life Sci. 2000, 67, 1683-1693.
21. Rollero, A.; Murialdo, G.; Fonzi, S.; Garrone, S.; Gianelli, M.V.; Gazzerro, E.; Barreca, A.; Polleri, A. Relationship between cognitive function, growth hormone and insulin-like growth factor I plasma levels in aged subjects. Neuropsychobiology 1998, 38, 73-79.
22. Granato, M.; Santarelli, R.; Lotti, L.V.; di Renzo, L.; Gonnella, R.; Garufi, A.; Trivedi, P.; Frati, L.; D’Orazi, G.; Faggioni, A., et al. JNK and macroautophagy activation by bortezomib has a pro-survival effect in primary effusion lymphoma cells. PLoS One 2013, 8, e75965.
23. Ahmad, A.; Schaack, J.B.; White, C.W.; Ahmad, S. Adenosine A2A receptor-dependent proliferation of pulmonary endothelial cells is mediated through calcium mobilization, PI3-kinase and ERK1/2 pathways. Biochem. Biophys. Res. Commun. 2013, 434, 566-571.
24. Groeger, G.; Doonan, F.; Cotter, T.G.; Donovan, M. Reactive oxygen species regulate prosurvival ERK1/2 signaling and bFGF expression in gliosis within the retina. Investig. Ophthalmol. Vis. Sci. 2012, 53, 6645-6654.
25. Carswell, K.A.; Lee, M.J.; Fried, S.K. Culture of isolated human adipocytes and isolated adipose tissue. Methods Mol. Biol. 2012, 806, 203-214.
26. Wan, Z.; Perry, C.G.R.; Macdonald, T.; Chan, C.B.; Holloway, G.P.; Wright, D.C. IL-6 is not necesssary for the regulation of adipose tissue mitochondrial content. PLoS One 2012, 7, e51233.
27. Klegeris, A.; McGeer, P.L. Toxicity of human monocytic THP-1 cells and microglia toward SH-SY5Y neuroblastoma cells is reduced by inhibitor of 5-lipoxygenase and its activating protein FLAP. J. Leukoc. Biol. 2003, 73, 369-378.
28. Wan, Z.; Durrer, C.; Mah, D.; Simtchouk, S.; Robinson, E.; Little, J.P. Reduction of AMPK activity and altered MAPKs signalling in peripheral blood mononuclear cells in response to acute glucose ingestion following a short-term high fat diet in young healthy men. Metabolism 2014, 63, 1209-1216.